Dietary fat and colon cancer: animal model studies.

Abstract:

:Since it was first suggested that high dietary fat is a risk factor in colon cancer, there have been several studies to test this hypothesis. Epidemiologic studies suggested a positive association between dietary fat and colon cancer. Laboratory animal model studies demonstrated that not only the amount of fat, but also types of fat differing in fatty acid composition are important determining factors in colon tumor development. Chemically-induced colon tumor incidence was increased in rats fed the semipurified diets containing 23% corn oil, safflower oil, lard or beef tallow (high-fat) as compared to those fed 5% corn oil, safflower oil, lard or beef tallow diets (low-fat). Diets containing 23% coconut oil, olive oil or fish oil, or high-fat diets containing varying levels of trans fat, had no colon tumor-enhancing effect compared to their respective low fat diets. The stage at which the effect of dietary fat is exerted appears to be mostly during the post-initiation phase of colon carcinogenesis. Lack of a colon tumor enhancing effect of dietary fish oil is observed both during the initiation and postinitiation phases. The mechanisms by which various dietary fats increase colon carcinogenesis are not fully understood. In most instances, however, the high-fat diet appears to enhance tumorigenesis through elevation of agents, such as secondary bile acids, that act as promoters of tumor development. Lack of colon tumor promotion by dietary fish oil and trans fat appears to be mediated through their effect on mucosal ornithine decarboxylase activity, colonic secondary bile acids and/or prostaglandin synthesis.

journal_name

Lipids

journal_title

Lipids

authors

Reddy BS

doi

10.1007/BF02535855

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

807-13

issue

10

eissn

0024-4201

issn

1558-9307

journal_volume

27

pub_type

杂志文章,评审

相关文献

LIPIDS文献大全
  • Effects of ethionine and phenobarbital on the phosphatidylcholines of rat liver.

    abstract::The diglyceride species of phosphatidylcholines from livers of male rats after treatment of the animals with ethionine (1 mg/g divided among 4 doses 2 hr apart), phenobarbital (80 mg/kg each day for 3 days), or a combination of the two drugs were determined using gas chromatography. Ethionine treatment greatly elevate...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533307

    authors: Dyer RA,Klopfenstein WE

    更新日期:1977-11-01 00:00:00

  • Lipid and fatty acid composition is altered in plaque tissue from multiple sclerosis brain compared with normal brain white matter.

    abstract::Plaques and white matter from brains of multiple sclerosis (MS) patients were analyzed for lipid content, class composition, and fatty acid composition of total lipid, together with the fatty acid composition of plaque glycerophospholipids, and the results were compared with white matter from normal brain. Plaques con...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02544017

    authors: Wilson R,Tocher DR

    更新日期:1991-01-01 00:00:00

  • Preparation ofcis,cis,cis-5,8,11-eicosatrienoic acid from arachidonic acid.

    abstract::Arachidonic acid was reduced by hydrazine to yield isomeric eicosatrienoic acids with other products. Methylcis,cis,cis-5,8,11-eicosatrienoate was isolated from the products by silver ion chromatography and preparative gas liquid chromatography in 8% yield. The structure was confirmed by spectral studies and oxidative...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534947

    authors: Ghosh A,Koley M,Dutta J

    更新日期:1982-04-01 00:00:00

  • Effects of dehydroepiandrosterone (DHEA) on hepatic lipid metabolism parameters and lipogenic gene mRNA expression in broiler chickens.

    abstract::The aim of the present study was to identify the effects of dehydroepiandrosterone (DHEA) on hepatic lipid metabolism parameters and lipogenic gene mRNA expression in broiler chickens. A total of 72 1-day-old broiler chicks received a common basal diet with DHEA added at either 0 (control), 5 or 20 mg/kg feed. In the ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-007-3104-y

    authors: Tang X,Ma H,Zou S,Chen W

    更新日期:2007-11-01 00:00:00

  • Thin-layer chromatographic separation of dimethylphosphatidates derived from lecithins.

    abstract::The separation of lecithin derivatives based on their fatty acid substituents has been investigated. Several synthetic and natural lecithins were converted to their corresponding dimethylphosphatidates by hydrolysis with phospholipase D (phosphatidylcholine phospholipase D (phosphatidylcholine phosphatidohydrolase, EC...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532546

    authors: Wurster CF Jr,Copenhaver JH Jr

    更新日期:1966-11-01 00:00:00

  • Apolipoprotein E polymorphism: automated determination of apolipoprotein E2, E3, and E4 isoforms.

    abstract::Apolipoprotein E (apo E) plays an essential role in lipoprotein metabolism, where it is involved in the clearance of chylomicrons and very low density lipoproteins. Apart from some rare variants, apo E exists in three common isoforms (E2, E3, and E4). The different isoforms have not only been associated with different...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-000-0500-7

    authors: Wiebe C,Holzem G,Wielckens K,Klingler KR

    更新日期:2000-01-01 00:00:00

  • Apparent lack of effect of obesity on the soluble phosphatidic acid phosphatase activity in human adipose tissue.

    abstract::In view of previous reports that the activity of the Mg(++)-dependent phosphatidic acid phosphatase in adipose tissues of rat and mouse is elevated in obesity, we attempted to assay this activity in biopsies of human omental adipose tissue obtained from normal-weight and morbidly obese subjects in connection with oper...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02544078

    authors: Björkhem I,al-Shurbaji A,Backman L,Arner P

    更新日期:1989-12-01 00:00:00

  • Uptake and metabolism of exogenous eicosa-8,11,14-trienoic acid in minimal deviation hepatoma 7288 C cells.

    abstract::Minimal deviation hepatoma 7288 C cells were cultured in Swim's medium containing 10% serum for 48 hr. The growth medium was replaced with serum free media containing different concentrations of [1-14C] eicosa-8,11,14-trienoic acid and the cells were incubated for 24 hr. Incorporation into cell lipids, oxidation to CO...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532312

    authors: Gaspar G,de Alaniz MJ,Brenner RR

    更新日期:1975-12-01 00:00:00

  • The absolute configurations of hydroxy fatty acids from the royal jelly of honeybees (Apis mellifera).

    abstract::9-Hydroxy-2E-decenoic acid (9-HDA) is a precursor of the queen-produced substance, 9-oxo-2E-decenoic acid (9-ODA), which has various important functions and roles for caste maintenance in honeybee colonies (Apis mellifera). 9-HDA in royal jelly is considered to be a metabolite of 9-ODA produced by worker bees, and it ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-010-3497-x

    authors: Kodai T,Nakatani T,Noda N

    更新日期:2011-03-01 00:00:00

  • Dietary docosahexaenoic acid and immunocompetence in young healthy men.

    abstract::The purpose of this study was to examine the effect of dietary docosahexaenoic acid (DHA), in the absence of eicosapentaenoic acid, on human immune response (IR). A 120-d study with 11 healthy men was conducted at the Metabolic Research Unit of the Western Human Nutrition Research Center. Four subjects (control group)...

    journal_title:Lipids

    pub_type: 临床试验,杂志文章

    doi:10.1007/s11745-998-0240-8

    authors: Kelley DS,Taylor PC,Nelson GJ,Mackey BE

    更新日期:1998-06-01 00:00:00

  • High-Fat Diets Containing Different Amounts of n3 and n6 Polyunsaturated Fatty Acids Modulate Inflammatory Cytokine Production in Mice.

    abstract::Dysregulation of adipokines is a hallmark of obesity. Polyunsaturated fatty acids in fish oil may exert anti-inflammatory effects on adipose tissue mitigating the dysregulation of adipokines thereby preventing obesity. This study investigated the effects of high-fat diets containing different amounts of n3 polyunsatur...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-015-4093-x

    authors: Sundaram S,Bukowski MR,Lie WR,Picklo MJ,Yan L

    更新日期:2016-05-01 00:00:00

  • Linoleic acid amides: effect on cholesteremia and atherosclerosis.

    abstract::Several of a series of linoleic acid amides have been reported to inhibit cholesterol-induced atherosclerosis in rabbits. The three amides which have been studied to the greatest extent are (in order of increasing activity) N-cyclohexyl linoleamide (AC23), N(alpha methylbenzyl) linoleamide (AC223), and N[aplha-phenyl-...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532966

    authors: Kritchevsky D,Tepper SA,Story JA

    更新日期:1977-01-01 00:00:00

  • Dietary CLA-induced lipolysis is delayed in soy oil-fed mice compared to coconut oil-fed mice.

    abstract::Conjugated linoleic acid (CLA) has been shown to cause a reduction in obesity in several species. CLA-induced body fat loss is enhanced when mice are fed coconut oil (CO) and involves increased lipolysis. The objective of this paper was to determine if the CLA-induced lipolysis in mice fed with different oil sources w...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-013-3835-x

    authors: Ippagunta S,Angius Z,Sanda M,Barnes KM

    更新日期:2013-11-01 00:00:00

  • High-performance liquid chromatographic separation of enantiomeric alkyl glycerol ethers.

    abstract::The resolution of a series of racemic 1-alkyl-3-trityl-rac-glycerols and 1-alkyl-2-benzyl-rac-glycerols into their enantiomers by high-performance liquid chromatography (HPLC) was investigated. Of the racemic glycerol derivatives studied, only three (1,2-0-isopropylidene-rac-glycerol, 1,2-0-isopropylidene-3-benzyl-rac...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535629

    authors: Foglia TA,Maeda K

    更新日期:1991-09-01 00:00:00

  • Effects of high alpha-linolenate and linoleate diets on erythrocyte deformability and hematological indices in rats.

    abstract::Rats were fed either a high alpha-linolenate diet or a high linoleate diet from weaning to 4 mon of age. Soybean oil was used as a control. Phospholipid compositions of erythrocytes from the three dietary groups were not significantly different. However, the difference in the alpha-linolenate (18:3n-3)/linoleate (18:2...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535899

    authors: Sakai K,Okuyama H,Kon K,Maeda N,Sekiya M,Shiga T,Reitz RC

    更新日期:1990-12-01 00:00:00

  • Dietary phospholipids are more efficient than neutral lipids for long-chain polyunsaturated fatty acid supply in European sea bass Dicentrarchus labrax larval development.

    abstract::We evaluated the effects of dietary lipid class (phospholipid vs. neutral lipid) and level of n-3 long-chain PUFA (LC-PUFA) on the growth, digestive enzymatic activity, and histological organization of the intestine and liver in European sea bass larvae. Fish were fed from the onset of exogenous feeding at 7 to 37 d p...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-005-1422-0

    authors: Gisbert E,Villeneuve L,Zambonino-Infante JL,Quazuguel P,Cahu CL

    更新日期:2005-06-01 00:00:00

  • Protein engineering and applications of Candida rugosa lipase isoforms.

    abstract::Commercial preparations of Candida rugosa lipase (CRL) are mixtures of lipase isoforms used for the hydrolysis and synthesis of various esters. The presence of variable isoforms and the amount of lipolytic protein in the crude lipase preparations lead to a lack of reproducibility of biocatalytic reactions. Purificatio...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-004-1258-7

    authors: Akoh CC,Lee GC,Shaw JF

    更新日期:2004-06-01 00:00:00

  • Hydrocarbon chain distribution of ether phospholipids of the ascidian Halocynthia roretzi and the sea urchin Strongylocentrotus intermedius.

    abstract::The contents and compositions of the 1-O-alk-1'-enyl-2-acyl, 1-O-alkyl-2-acyl, and 1,2-diacyl glycerophospholipids in the muscle and viscera of the ascidian Halocynthia roretzi, and of the gonad of the sea urchin Strongylocentrotus intermedius, which are eaten to some extent in Alaska and in Asia, were analyzed by gas...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522404

    authors: Jeong BY,Ohshima T,Koizumi C

    更新日期:1996-01-01 00:00:00

  • Effect of continuous enteral medium-chain fatty acid infusion on lipid metabolism in rats.

    abstract::This study compared (i) the relative effects of long-chain triglycerides (LCT) and medium-chain triglycerides (MCT), (ii) the influence of amount of MCT, and (iii) the impact of medium-chain fatty acid position, on plasma and lymphatic triglycerides and portal vein free fatty acids. The animals were fed approximately ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-998-0204-z

    authors: You YQ,Ling PR,Qu Z,Bistrian BR

    更新日期:1998-03-01 00:00:00

  • Incorporation of lipids labeled with various fatty acids into the cytoskeleton of aggregating platelets.

    abstract::Earlier studies showed that during the first 20 to 25 seconds of aggregation induced by thrombin (0.1 U/mL) or adenosine diphosphate (ADP) (2 microM) of rabbit or human platelets prelabeled with [3H]palmitic acid, labeled lipid became associated with the cytoskeleton (isolated after lysis with 1% Triton X-100, 5 mM EG...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536590

    authors: Packham MA,Guccione MA,Bryant NL,Livne A

    更新日期:1991-07-01 00:00:00

  • Preferential reduction in adipose tissue alpha-linolenic acid (18:3 omega 3) during very low calorie dieting despite supplementation with 18:3 omega 3.

    abstract::We have previously reported that the relative content of 18:3 omega 3 in adipose triglyceride (TG) of women was reduced following major weight loss while on a very low calorie diet (VLCD). In an attempt to prevent this loss of 18:3 omega 3 reserves, we have tested two VLCD supplemented with varying amounts of 18:3 ome...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02537119

    authors: Tang AB,Nishimura KY,Phinney SD

    更新日期:1993-11-01 00:00:00

  • DGAT1, DGAT2 and PDAT expression in seeds and other tissues of epoxy and hydroxy fatty acid accumulating plants.

    abstract::Triacylglycerol (TAG) is the main storage lipid in plants. Acyl-CoA: diacylglycerol acyltransferase (DGAT1 and DGAT2) and phospholipid: diacylglycerol acyltransferase (PDAT) can catalyze TAG synthesis. It is unclear how these three independent genes are regulated in developing seeds, and particularly if they have spec...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-010-3385-4

    authors: Li R,Yu K,Hildebrand DF

    更新日期:2010-02-01 00:00:00

  • Digestion of Ceramide 2-Aminoethylphosphonate, a Sphingolipid from the Jumbo Flying Squid Dosidicus gigas, in Mice.

    abstract::Ceramide 2-aminoethylphosphonate (CAEP), a sphingophosphonolipid containing a carbon-phosphorus bond, is frequently found in marine organisms and has a unique triene type of sphingoid base in its structure. CAEP has not been evaluated as a food ingredient, although it is generally contained in Mollusca organisms such ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-017-4239-0

    authors: Tomonaga N,Manabe Y,Sugawara T

    更新日期:2017-04-01 00:00:00

  • High Sucrose Intake Ameliorates the Accumulation of Hepatic Triacylglycerol Promoted by Restraint Stress in Young Rats.

    abstract::Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder. Stress promotes the onset of the NAFLD with a concomitant increment in the activity of the hepatic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1). However, the interaction between the stress and a carbohydrate-enriched diet for t...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-015-4066-0

    authors: Corona-Pérez A,Díaz-Muñoz M,Rodríguez IS,Cuevas E,Martínez-Gómez M,Castelán F,Rodríguez-Antolín J,Nicolás-Toledo L

    更新日期:2015-11-01 00:00:00

  • Lipoprotein subfraction profile and HDL-associated enzymes in sickle cell disease patients.

    abstract::Although hypocholesterolemia is a reported finding in sickle cell disease (SCD), low-density lipoprotein (LDL)/high-density lipoprotein (HDL) subfractions and HDL-associated enzymes have not been determined in SCD patients. Blood was collected from 38 hemoglobin (Hb)A volunteers and 45 homozygous HbSS patients who had...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-013-3849-4

    authors: Ozturk OH,Can Y,Yonden Z,Motor S,Oktay G,Kaya H,Aslan M

    更新日期:2013-12-01 00:00:00

  • Phospholipid synthesizing enzymes of dermatophytes: II. Characterization of choline kinase.

    abstract::Choline kinase was located in the cytosolic fractions of the filamentous, pathogenic fungi,Microsporum gypseum andEpidermophyton floccosum. A broad pH optima (6.0-9.0) was observed for theM. gypseum enzyme, but theE. floccosum enzyme was active at pH 8.4 as well as 10.5, the activity being higher at pH 8.4. Enzyme fro...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534540

    authors: Kasinathan C,Govindarajan U,Chopra A,Khuller GK

    更新日期:1983-10-01 00:00:00

  • The structure-activity relationship of lipoxygenase products of long-chain polyunsaturated fatty acids: effects on human platelet aggregation.

    abstract::The effect of hydroperoxy and hydroxy derivatives of various fatty acids on human platelet aggregation was determined to delineate potencies and structure-activity function. In this regard, the 22-carbon n-3 fatty acids are the most potent inhibitors in comparison to the n-6 lipoxygenase derivatives. Submicromolar lev...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02637097

    authors: Karanian JW,Kim HY,Salem N Jr

    更新日期:1996-03-01 00:00:00

  • Biosynthesis of molecular species of CDP-diglyceride from endogenously-labeled phosphatidate in rat liver microsomes.

    abstract::The biosynthesis of [14C] CDP-diglyceride was studied using rat liver microsomes which were endogenously labeled with [14C] phosphatidic acid by preincubation of unlabeled microsomes with sn-[14C] glycerol-3-phosphate and appropriate cofactors. The formation of CDP-diglyceride from radioactive phosphatidate showed an ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02544050

    authors: Holub BJ,Piekarski J

    更新日期:1976-04-01 00:00:00

  • Replacement of dietary fish oil with increasing levels of linseed oil: modification of flesh fatty acid compositions in Atlantic salmon (Salmo salar) using a fish oil finishing diet.

    abstract::Five groups of salmon, of initial mean weight 127 +/- 3 g, were fed increasing levels of dietary linseed oil (LO) in a regression design. The control diet contained capelin oil (FO) only, and the same oil was blended with LO to provide the experimental diets. After an initial period of 40 wk, all groups were switched ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-004-1223-5

    authors: Bell JG,Henderson RJ,Tocher DR,Sargent JR

    更新日期:2004-03-01 00:00:00

  • Preparation of functional liposomes with peptide ligands and their binding to cell membranes.

    abstract::Two novel lipopeptides, which have the peptide ligands [alpha-melanocyte stimulating hormone (alpha-MSH)] sequence and repeated [Gly-Arg-Gly-Asp-Se (GRGDS) sequence], are designed, synthesized by the solid-phase method, and introduced into liposome membranes by the freeze-thaw method. These liposomes bearing the pepti...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-000-0572-4

    authors: Yagi N,Ogawa Y,Kodaka M,Okada T,Tomohiro T,Konakahara T,Okuno H

    更新日期:2000-06-01 00:00:00