Lipid and fatty acid composition is altered in plaque tissue from multiple sclerosis brain compared with normal brain white matter.

abstract：:Acetate supplementation increases plasma acetate, brain acetyl-CoA, histone acetylation, phosphocreatine levels, and is anti-inflammatory in models of neuroinflammation and neuroborreliosis. Although radiolabeled acetate is incorporated into the cellular lipid pools, the effect that acetate supplementation has on lipi...

journal_title：Lipids

authors： Bhatt DP,Rosenberger TA

更新日期：2014-07-01 00:00:00

abstract：:The synthesis of thioether phospholipids, which represent a new class of antitumor agents, is reported here. In particular, the route of synthesis of 3-hexadecylmercapto-2-methoxymethylpropyl-2'-trimethylammoni o-ethyl phosphate (BM 41.440, Ilmofosine), one of the most potent cytostatic/cytotoxic derivatives, is descr...

journal_title：Lipids

authors： Bosies E,Herrmann DB,Bicker U,Gall R,Pahlke W

更新日期：1987-11-01 00:00:00

abstract：:Some studies focused on the effect of the dietary glycemic index on lipoproteins and apolipoproteins in adults; however, little evidence exists among adolescents regarding the effect of a low glycemic index (LGI) diet on apolipoproteins and lipoprotein (a) (Lpa). This study was conducted to evaluate the effect of an L...

journal_title：Lipids

authors： Rouhani MH,Kelishadi R,Hashemipour M,Esmaillzadeh A,Azadbakht L

更新日期：2013-12-01 00:00:00

abstract：:Rat hepatocytes in monolayer culture were utilized to determine if the decrease in glucose-6-phosphate dehydrogenase (G6PD) activity resulting from the ingestion of fat can be mimicked by the addition of fatty acids to a chemically, hormonally defined medium. G6PD activity in cultured hepatocytes was induced several-f...

journal_title：Lipids

authors： Salati LM,Adkins-Finke B,Clarke SD

更新日期：1988-01-01 00:00:00

abstract：:The distribution of dolichol in rat liver was studied. Upon high-speed centrifugation, 9% of the total tissue dolichol was recovered in the supernatant. Dolichol was enclosed in vesicles and in lipidic particles which were isolated by gel filtration and density gradient centrifugation. The particles had a diameter of ...

journal_title：Lipids

authors： Löw P,Peterson E,Edlund C,Brunk U,Appelkvist EL

更新日期：1992-01-01 00:00:00

abstract：:The effects of beta-muricholic acid and hyocholic acid on cholesterol cholelithiasis were examined in two animal models. The following experiments were carried out: A) In a gallstone prevention study, prairie dogs were fed the lithogenic diet with or without 0.1% beta-muricholic or 0.1% hyocholic acid for eight weeks....

journal_title：Lipids

authors： Cohen BI,Mikami T,Ayyad N,Ohshima A,Infante R,Mosbach EH

更新日期：1995-09-01 00:00:00

abstract：:During ruminal biohydrogenation of α-linolenic acid, a non-conjugated non-methylene interrupted dienoic acid is formed containing a t10 double bond, namely t10,c15-18:2. The present study was designed to examine whether t10,c15-18:2 would exert similar anti-adipogenic effects compared to t10,c12-18:2 in 3T3-L1 adipocy...

journal_title：Lipids

authors： Vahmani P,Meadus WJ,Rolland DC,Duff P,Dugan ME

更新日期：2016-11-01 00:00:00

abstract：:CLA inhibits mammary cancer and reduces body fat accumulation in rodents. It is not known whether uncoupling proteins (UCP), which are modulators of energy balance and metabolism, play a role in these actions of CLA. To determine the effects of dietary CLA on the expression of UCP in various tissues, 5-wk-old Sprague-...

journal_title：Lipids

authors： Ealey KN,El-Sohemy A,Archer MC

更新日期：2002-09-01 00:00:00

abstract：:Recovery of beta-sitosterol, glycerol triether (1-hexadecyl-2,3-didodecyl glycerol triether), and chromic oxide was studied in African green monkeys and stumptail macaques consuming diets containing 0.75 mg/Cal cholesterol and 38% of calories as safflower oil or butter. Following oral administration of these compounds...

journal_title：Lipids

authors： St Clair RW,Lehner ND,Hamm TE

更新日期：1975-01-01 00:00:00

abstract：:Two simple methods for the synthesis of phosphatidylcholine (lecithin) isotopically labeled in the methyl group of the choline moiety are described. Phosphatidylcholine is converted to phosphatidyl-ethanolamine by enzymic transphosphatidylation, and this is methylated using either methyl iodide or diazomethane to give...

journal_title：Lipids

authors： Smith GA,Montecucco C,Bennett JP

更新日期：1978-01-01 00:00:00

abstract：:We examined the effect of dietary alpha-linolenic acid (ALA) on the indices of lipid and coagulation status and on the fatty acid composition of serum and peripheral blood mononuclear cell (PBMNC) lipids in ten healthy men (age 21-37 yr) who consumed all their meals at the Western Human Nutrition Research Center for 1...

journal_title：Lipids

authors： Kelley DS,Nelson GJ,Love JE,Branch LB,Taylor PC,Schmidt PC,Mackey BE,Iacono JM

更新日期：1993-06-01 00:00:00

abstract：:A one-carbon degradation of long-chain fatty acids, which was found to occur in the brains of rats in vivo, has been investigated in a brain microsomal fraction in vitro. Decarboxylation of the alpha-hydroxy acid, a possible intermediate product between the substrate and the next shorter acid, in the presence of brain...

journal_title：Lipids

authors： Macdonald RC,Mead JF

更新日期：1968-05-01 00:00:00

abstract：:The contents and compositions of the 1-O-alk-1'-enyl-2-acyl, 1-O-alkyl-2-acyl, and 1,2-diacyl glycerophospholipids in the muscle and viscera of the ascidian Halocynthia roretzi, and of the gonad of the sea urchin Strongylocentrotus intermedius, which are eaten to some extent in Alaska and in Asia, were analyzed by gas...

journal_title：Lipids

authors： Jeong BY,Ohshima T,Koizumi C

更新日期：1996-01-01 00:00:00

abstract：:Phospholipids are integral constituents of the milk fat globule membranes and they play a central role in infants' immune and inflammatory responses. A methodology employing liquid chromatography coupled with evaporative light scattering detector has been optimized and validated to quantify the major phospholipids cla...

journal_title：Lipids

authors： Giuffrida F,Cruz-Hernandez C,Flück B,Tavazzi I,Thakkar SK,Destaillats F,Braun M

更新日期：2013-10-01 00:00:00

abstract：:Water and lipid contents, fatty acid distribution, and lipoprotein lipase activity were determined in 11 samples taken from the Omentum Majus of five dry Alpine goats. Samples were chosen to standardize sampling sites using geometric guide marks representative of different adipose tissue sites. Sample location explain...

journal_title：Lipids

authors： Bas P,Gallouin F,Morand-Fehr P

更新日期：1992-06-01 00:00:00

abstract：:In an attempt to correlate the incorporation of fatty acids (FA) of different chain length into liver and biliary lipids, isolated rat livers were perfused for 2 h with Krebs-Ringer bicarbonate containing 1% albumin and 10 mumol of [1-14C]-labeled FA: C2, C8, C10, C12, C16, and C18:1. One to 1.36 mumol of medium-chain...

journal_title：Lipids

authors： Rubin M,Pakula R,Gilat T,Tietz A

更新日期：1999-06-01 00:00:00

abstract：:The hypothesis that the essential oil from Tagetes minuta L. can interact with biological membranes was investigated by assessing its ability of perturbing the binding of a benzodiazepine [flunitrazepam (FNTZ)] to crude members from chick brains. The essential oil from T. minuta L. inhibited [3H]FNTZ specific binding ...

journal_title：Lipids

authors： García DA,Perillo MA,Zygadlo JA,Martijena ID

更新日期：1995-12-01 00:00:00

abstract：:Bile acids solubilize proteins from liver plasma membrane both in vivo and in vitro. The ability to solubilize the proteins is dependent on the species of bile acid. In this paper, the effect of phospholipid on the solubilization of a membrane-bound enzyme by bile acids was investigated in vitro. Taurocholate (TC) and...

journal_title：Lipids

authors： Nokubo M

更新日期：1987-01-01 00:00:00

abstract：:Dysregulation of adipokines is a hallmark of obesity. Polyunsaturated fatty acids in fish oil may exert anti-inflammatory effects on adipose tissue mitigating the dysregulation of adipokines thereby preventing obesity. This study investigated the effects of high-fat diets containing different amounts of n3 polyunsatur...

journal_title：Lipids

authors： Sundaram S,Bukowski MR,Lie WR,Picklo MJ,Yan L

更新日期：2016-05-01 00:00:00

abstract：:Fish easily accumulate n-3 PUFA of exogenous origin, but the underlying mechanisms are not well established in the whole animal. This study was undertaken to investigate whether this feature was physiologically associated with mitochondrial and peroxisomal capacities that differentially affect FA oxidation. For this p...

journal_title：Lipids

authors： Du ZY,Demizieux L,Degrace P,Gresti J,Moindrot B,Liu YJ,Tian LX,Cao JM,Clouet P

更新日期：2004-09-01 00:00:00

abstract：:The oxidation of free DHA, DHA mixed with PC, and DHA incorporated into PC, PE, or TG was evaluated to determine which lipid provided DHA with the best protection against oxidation. DHA was either situated at the sn-1 position, sn-2 position, or both positions of the phospholipid, whereas the TG contained DHA at all p...

journal_title：Lipids

authors： Lyberg AM,Fasoli E,Adlercreutz P

更新日期：2005-09-01 00:00:00

abstract：:The objective of this study was to examine whether whole body oxidation rates of dietary linoleic, alpha-linolenic and oleic acids differ when the acids are provided in identical quantities. Male rats were fed for 10 wk a 15% fat (w/w) diet containing equal amounts of linoleic, alpha-linolenic and oleic acids (22.7, 2...

journal_title：Lipids

authors： Jones PJ

更新日期：1994-07-01 00:00:00

abstract：:FA ethyl esters (FAEE) are nonoxidative metabolites of ethanol produced by the esterification of FA and ethanol. FAEE have been implicated as mediators of ethanol-induced organ damage in vivo and in vitro, and are markers of ethanol intake. Upon ethanol intake, FAEE are synthesized in the liver and pancreas in signifi...

journal_title：Lipids

authors： Hasaba A,Cluette-Brown JE,Laposata M

更新日期：2003-10-01 00:00:00

abstract：:Sterols, which are biosynthesized via the cytoplasmic mevalonate (MVA) pathway, are important structural components of the plasma membrane and precursors of steroid hormones in both vertebrates and plants. Ergosterol and cholesterol are the major sterols in yeast and vertebrates, respectively. In contrast, plants prod...

journal_title：Lipids

authors： Suzuki M,Muranaka T

更新日期：2007-02-01 00:00:00

abstract：:Subcellular membranes were analyzed for their lipid composition and protein content at two developmental points representing the third instar wandering larvae and prepupal stages of Drosophila. At both stages, phosphatidylethanolamine (PE) and phosphatidylcholine (PC) were the major constituents with phosphatidylinosi...

journal_title：Lipids

authors： Jones HE,Harwood JL,Bowen ID,Griffiths G

更新日期：1992-12-01 00:00:00

abstract：:Selected aspects of total parenteral nutrition in man are reviewed with emphasis on carbohydrate, lipid, and hormonal interactions. In an experiment to test for the essentiality of a specific amino acid, a normal adult man received all major and minor nutrients, except lipids, by intravenous alimentation for 48 days. ...

journal_title：Lipids

authors： Wixom RL,Sheng YB,Anderson HL,Yamanaka WK,Terry BE

更新日期：1976-04-01 00:00:00

abstract：:Cnidaria (Calycopsis borchgrevinki, Diphyes antarctica, Stygiomedusa gigantea, Atolla wyvillei, Dimophyes arctica) and Ctenophora (Beroe cucumis, B. forskalii, Pleurobrachia pileus, Bolinopsis infundibulum) were collected near Elephant Island, South Shetland Islands, during January and February 1997 and 1998. Total li...

journal_title：Lipids

authors： Nelson MM,Phleger CF,Mooney BD,Nichols PD

更新日期：2000-05-01 00:00:00

abstract：:Thermally oxidized rapeseed oils (4 levels of deterioration; used by a manufacturer of fried fish paste in a conventional manner) were fed to rats at a practical level of concentration. Rats were fed a diet ad libitum for 13 weeks that contained 15% of a test oil. The effects of the diet on several biochemical criteri...

journal_title：Lipids

authors： Izaki Y,Yoshikawa S,Uchiyama M

更新日期：1984-05-01 00:00:00

abstract：:In guinea pigs, total plasma cholesterol concentrations increased above the control values after single intravenous injections and after 3 days of continuous subcutaneous administration of neurotensin (NT). A high dose of NT (125 pmol/100 g body weight) induced tachycardia and severe respiratory distress; the lowest d...

journal_title：Lipids

authors： Peric-Golia L,Gardner CF,Wilson DE,Peric-Golia M

更新日期：1984-10-01 00:00:00

abstract：:Stearoyl-coenzyme A desaturase-1 (SCD1) is a rate-limiting enzyme that catalyzes the biosynthesis of monounsaturated fatty acids from saturated fatty acids. Recently, SCD1 down-regulation has been implicated in the prevention of obesity, and the improvement of insulin and leptin sensitivity. In this study, we examined...

journal_title：Lipids

authors： Beppu F,Hosokawa M,Yim MJ,Shinoda T,Miyashita K

更新日期：2013-05-01 00:00:00