Effects of dietary conjugated linoleic acid on the expression of uncoupling proteins in mice and rats.

Abstract:

:CLA inhibits mammary cancer and reduces body fat accumulation in rodents. It is not known whether uncoupling proteins (UCP), which are modulators of energy balance and metabolism, play a role in these actions of CLA. To determine the effects of dietary CLA on the expression of UCP in various tissues, 5-wk-old Sprague-Dawley rats and C57Bl/6 mice were fed diets containing 1% CLA for 3 wk. CLA treatment reduced adipose depot weights in both rats and mice but had no significant effects on body weight. There was a species-specific effect of CLA on the expression of UCP. Whereas CLA did not affect the expression of UCP in most tissues in rats, mice fed CLA had increased expression of UCP2 in the mammary gland, brown adipose tissue (BAT), and white adipose tissue (WAT). Furthermore, UCP1 and UCP3 mRNA and protein levels in BAT were significantly lower in CLA-fed mice compared to controls. Skeletal muscle UCP3 mRNA was unchanged, but UCP3 protein levels were significantly increased in mice, suggesting translational or posttranslational regulation of this protein. Results from this study suggest that alterations in the expression of UCP in mice may be related to the previously reported effects of dietary CLA in lowering adiposity and increasing FA oxidation. In rats, however, induction of UCP is not likely to be responsible for fat reduction or for the inhibitory action of CLA on mammary carcinogenesis.

journal_name

Lipids

journal_title

Lipids

authors

Ealey KN,El-Sohemy A,Archer MC

doi

10.1007/s11745-002-0971-6

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

853-61

issue

9

eissn

0024-4201

issn

1558-9307

journal_volume

37

pub_type

杂志文章

相关文献

LIPIDS文献大全
  • High density lipoprotein level is negatively associated with the increase of oxidized low density lipoprotein lipids after a fatty meal.

    abstract::Recent reports show that a fatty meal can substantially increase the concentration of oxidized lipids in low density lipoprotein (LDL). Knowing the LDL-specific antioxidant effects of high density lipoprotein (HDL), we aimed to investigate whether HDL can modify the postprandial oxidative stress after a fatty meal. Su...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-014-3963-y

    authors: Tiainen S,Ahotupa M,Ylinen P,Vasankari T

    更新日期:2014-12-01 00:00:00

  • Comparative study of lipogenic enzymes in several vertebrates.

    abstract::The liver lipogenic enzymes are compared among rats, chickens, frogs and fish. Although the apparent Km values of glucose-6-phosphate dehydrogenase for glucose-6-phosphate are not much different among all the species, those of malic enzyme for malate are much higher in chickens and fish than in rats and frogs. Glucose...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534511

    authors: Iritani N,Ikeda Y,Fukuda H,Katsurada A

    更新日期:1984-11-01 00:00:00

  • Effect of ingestion of thermally oxidized frying oil on peroxidative criteria in rats.

    abstract::Thermally oxidized rapeseed oils (4 levels of deterioration; used by a manufacturer of fried fish paste in a conventional manner) were fed to rats at a practical level of concentration. Rats were fed a diet ad libitum for 13 weeks that contained 15% of a test oil. The effects of the diet on several biochemical criteri...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534782

    authors: Izaki Y,Yoshikawa S,Uchiyama M

    更新日期:1984-05-01 00:00:00

  • Sterol composition of phaeodactylum tricornutum as influenced by growth temperature and light spectral quality.

    abstract::In a detailed sterol analysis of the marine diatom Phaeodactylum tricornutum, free sterols as well as esterified and glycosylated conjugates were found. When the alga was grown under standard conditions (i.e., at 13 degrees C under white light), 64% of total sterols were steryl glycosides. In all sterol classes, excep...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522694

    authors: Véron B,Billard C,Dauguet JC,Hartmann MA

    更新日期:1996-09-01 00:00:00

  • Olive oil consumption and reduced incidence of hypertension: the SUN study.

    abstract::Olive oil, a major component of the Mediterranean diet, has been associated in some small clinical trials and cross-sectional studies with a reduction in blood pressure. The objective of this study was to assess the association of olive oil consumption with the incidence of hypertension in an epidemiologic cohort, the...

    journal_title:Lipids

    pub_type: 临床试验,杂志文章

    doi:10.1007/s11745-004-1352-x

    authors: Alonso A,Martínez-González MA

    更新日期:2004-12-01 00:00:00

  • Composition of lipids of bovine optic nerve.

    abstract::Lipids from bovine optic nerve were analyzed. The total content of 16.5% by weight included 27.2% nonpolar lipids, 26.1% glycolipids, and 46.7% phospholipids by weight. Free cholesterol was the major component of the nonpolar lipid fraction. The cerebrosides, 73.5% of total glycolipids, were separated by thin layer ch...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533745

    authors: Das SK,Steen ME,McCullough MS,Bhattacharyya DK

    更新日期:1978-10-01 00:00:00

  • Solubilization and stabilization of carotenoids using micelles: delivery of lycopene to cells in culture.

    abstract::The use of the organic cosolvents tetrahydrofuran and dimethylsulfoxide was found to be unsuitable for prostate tumor cell cultures because of solvent cytotoxicity and the poor solubility and instability of lycopene. For example, the half-life of lycopene in organic/aqueous solution was found to be less than 2 h. Ther...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-999-0454-9

    authors: Xu X,Wang Y,Constantinou AI,Stacewicz-Sapuntzakis M,Bowen PE,van Breemen RB

    更新日期:1999-10-01 00:00:00

  • Identification of a novel all-cis-5,9,12-heptadecatrienoic acid in the cellular slime mold Polysphondylium pallidum.

    abstract::The all-cis-5,9,12-heptadecatrienoic acid was identified in the cellular slime mold Polysphondylium pallidum. The structural elucidation was accomplished by capillary gas chromatography, argentation thin-layer chromatography, and gas chromatography/mass spectrometry. This fatty acid has not been reported previously. ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522934

    authors: Saito T,Ochiai H

    更新日期:1996-04-01 00:00:00

  • Pooling of blood in postischemic shock is modulated by platelet-activating factor (PAF).

    abstract::In experiments on dogs, i.v. administration of platelet-activating factor (PAF) (500 ng/kg) was shown to induce hypotension which, apart from decreased myocardial contractility, was characterized by blood pooling in veins (82.6 +/- 6.8 mL/kg). This was accompanied by restriction of venous return to the heart and reduc...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536575

    authors: Sagach VF,Dmitrieva AV,Braquet P

    更新日期:1991-12-01 00:00:00

  • Evaluation of chromic oxide, glycerol triether, and beta-sitosterol as fecal flow markers in two species of nonhuman primates.

    abstract::Recovery of beta-sitosterol, glycerol triether (1-hexadecyl-2,3-didodecyl glycerol triether), and chromic oxide was studied in African green monkeys and stumptail macaques consuming diets containing 0.75 mg/Cal cholesterol and 38% of calories as safflower oil or butter. Following oral administration of these compounds...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532190

    authors: St Clair RW,Lehner ND,Hamm TE

    更新日期:1975-01-01 00:00:00

  • Cardiopathogenicity of rapeseed oils and oil blends differing in erucic, linoleic, and linolenic acid content.

    abstract::Male Wistar rats were fed semipurifed diets containing 20% fat for 25 weeks. Ten different oils or oil blends were employed, including rapessed oils, simulated rapeseed-type oils, and modified rapeseed-type oils. Safflower, soybean, and hydrogenated coconut oils served as control oils. Histopathological examination of...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532900

    authors: McCutcheon JS,Umermura T,Bhatnager MK,Walker BL

    更新日期:1976-07-01 00:00:00

  • Hydrophilic bile acids: prevention and dissolution experiments in two animal models of cholesterol cholelithiasis.

    abstract::The effects of beta-muricholic acid and hyocholic acid on cholesterol cholelithiasis were examined in two animal models. The following experiments were carried out: A) In a gallstone prevention study, prairie dogs were fed the lithogenic diet with or without 0.1% beta-muricholic or 0.1% hyocholic acid for eight weeks....

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533962

    authors: Cohen BI,Mikami T,Ayyad N,Ohshima A,Infante R,Mosbach EH

    更新日期:1995-09-01 00:00:00

  • Conjugated linoleic acids and CLA-containing phospholipids inhibit NO formation in aortic endothelial cells.

    abstract::This study examined the effects of five CLA isomers and the non-conjugated LA on nitric oxide (NO) production, an important modulator of vasodilation, inflammation, and cytotoxicity. Bovine aortic endothelial cells (BAECs) were pretreated with pure CLAs (c9, c11-, c9, t11-, t9, t11-, t10, c12-, c11, c13-CLA) and the n...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-008-3160-y

    authors: Jenko KJ,Vanderhoek JY

    更新日期:2008-04-01 00:00:00

  • De novo fatty acid synthesis and fatty acid elongation catalyzed by subcellular fractions from hog and human aorta.

    abstract::De novo synthesis and mitochondrial elongation of fatty acids have been demonstrated in subcellular fractions from hog and human aorta. Microsomal fatty acid elongation has been shown in hog aorta. The activity catalyzing the formation of fatty acids from acetyl and malonyl CoA was associated with a high molecular wei...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533461

    authors: Slakey LL,Ferrick TJ,Ness GC,Porter JW

    更新日期:1979-05-01 00:00:00

  • The effect of modest vitamin E supplementation on lipid peroxidation products and other cardiovascular risk factors in diabetic patients.

    abstract::Among many factors, elevated lipids and lipid peroxide levels in blood are major risk factors in the development of cardiovascular disease in diabetic patients. This study has examined whether oral supplementation of vitamin E, an antioxidant, has any effect on blood lipid peroxidation products (LP) and lipid profile ...

    journal_title:Lipids

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02637057

    authors: Jain SK,McVie R,Jaramillo JJ,Palmer M,Smith T,Meachum ZD,Little RL

    更新日期:1996-03-01 00:00:00

  • Sulfur-substituted and alpha-methylated fatty acids as peroxisome proliferator-activated receptor activators.

    abstract::FA with varying chain lengths and an alpha-methyl group and/or a sulfur in the beta-position were tested as peroxisome proliferator-activated receptor (PPAR)alpha, -delta(beta), and -gamma ligands by transient transfection in COS-1 cells using chimeric receptor expression plasmids, containing cDNAs encoding the ligand...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-005-1359-3

    authors: Larsen LN,Granlund L,Holmeide AK,Skattebøl L,Nebb HI,Bremer J

    更新日期:2005-01-01 00:00:00

  • Oxidized lipoprotein(a) increases endothelial cell monolayer permeability via ROS generation.

    abstract::Oxidized lipoprotein(a) (oxLp(a)) is a more potent marker of atherogenesis than native Lp(a). However, the molecular mechanisms of oxLp(a) activity are not clear. Reactive oxygen species (ROS) have recently been suggested as acting as intracellular second messengers. In this study, the effects of oxLp(a) on endothelia...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-013-3795-1

    authors: Wei DH,Zhang XL,Wang R,Zeng JF,Zhang K,Yang J,Li S,Lin XL,Jiang ZS,Wang GX,Wang Z

    更新日期:2013-06-01 00:00:00

  • Chemical composition of subcellular particles from cultured cells of human tissue.

    abstract::Chemical composition of subcellular components of HeLa, KB, human heart and liver tissue-culture cell lines have been studied.The concentration of RNA, protein and phospholipid (mug/mug of DNA) of total subcellular particles was similar for all four cell lines studied. The greatest RNA concentration and lowest protein...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02531999

    authors: Tsao SS,Cornatzer WE

    更新日期:1967-01-01 00:00:00

  • Lymphatic transport of α-linolenic acid and its conversion to long chain n-3 fatty acids in rats fed microemulsions of linseed oil.

    abstract::In the present study we evaluated the uptake of ALA and its conversion to EPA + DHA in rats given linseed oil (LSO) in native form or as a microemulsion in whey protein or in lipoid. In a single oral dose study in which rats maintained on rodent pellets deficient in ω-3 fatty acids were intubated with 0.35 g LSO in li...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-013-3873-4

    authors: Sugasini D,Devaraj VC,Ramesh M,Lokesh BR

    更新日期:2014-03-01 00:00:00

  • Metabolism of 2,4-3H-14alpha-methyl-5alpha-ergost-8-enol and 2,4-3H-5alpha-ergosta-8,14-dienol in Ochromonas malhamensis.

    abstract::Tritium-labeled 14alpha-methyl-5alpha-ergost-8-enol and 5alpha-ergosta-8,14-dienol were converted to brassicasterol and poriferasterol in Ochromonas malhamensis. This indicates that the organism can rearrange these sterol structures so that they contain the naturally occurring 5(6) double bond, and suggests that O. ma...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532878

    authors: Adler JH,Patterson GW

    更新日期:1976-08-01 00:00:00

  • Conversion of linoleic acid hydroperoxide by soybean lipoxygenase in the presence of guaiacol: identification of the reaction products.

    abstract::Linoleic acid hydroperoxide formed by soybean lipoxygenase was metabolized by the same enzyme in the presence of guaiacol. The products of this reaction included, trihydroxyoctadecenoic acids, hydroperoxydihydroxyoctadecenoic acids, hydroxyepoxyoctadecenoic acids, dihydroxyoctadecenoic acids, hydroxyoctadecadienoic ac...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532331

    authors: Streckert G,Stan HJ

    更新日期:1975-12-01 00:00:00

  • Dietary monounsaturated fatty acids are protective against metabolic syndrome and cardiovascular disease risk factors.

    abstract::Over 50 years of research has sought to define the role dietary fat plays in cardiovascular disease (CVD) risk. Although optimal dietary fat quantity has been keenly pursued over past decades, attention has recently centered on the value of dietary fat quality. The purpose of the present review is to provide a critica...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-010-3524-y

    authors: Gillingham LG,Harris-Janz S,Jones PJ

    更新日期:2011-03-01 00:00:00

  • Comparison of antioxidant activities of tocol and its methyl derivatives.

    abstract::In tests with purified menhaden oil at 37C and with squalene at 37C and 50C, unsubstituted tocol, 7,8-dimethyl tocol (gamma-tocol), and 8-methyl tocol (sigma-tocol) were superior antioxidants to 5,7-dimethyl tocol and 5,7,8-trimethyl tocol (alpha-tocol). In contrast to previous reports, there were no differences in th...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02530934

    authors: Olcott HS,Van der Veen J

    更新日期:1968-07-01 00:00:00

  • Blood polyunsaturated fatty acids in patients with peroxisomal disorders. A multicenter study.

    abstract::The purpose of the study was to compare the polyunsaturated fatty acid (PUFA) status in patients with X-linked adrenoleukodystrophy or adrenomyeloneuropathy (X-ALD/AMN) with that in disorders of peroxisome biogenesis (PB). Total fatty acids and plasmalogens were quantified in plasma and red cells from 28 patients with...

    journal_title:Lipids

    pub_type: 杂志文章,多中心研究

    doi:10.1007/BF02536332

    authors: Martinez M,Mougan I,Roig M,Ballabriga A

    更新日期:1994-04-01 00:00:00

  • Clinical trial results support a preference for using CLA preparations enriched with two isomers rather than four isomers in human studies.

    abstract::CLA mixtures are now commercially available. They differ from each other with respect to their content of CLA isomers and their degree of purification. As a group of natural FA, CLA have been widely assumed to be safe. However, the suspected presence of both impurities and particular isomers might induce undesirable s...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-002-0995-y

    authors: Gaullier JM,Berven G,Blankson H,Gudmundsen O

    更新日期:2002-11-01 00:00:00

  • Inhibition of 12- and 15-lipoxygenase activities and protection of human and tilapia low density lipoprotein oxidation by I-Tiao-Gung (Glycine tomentella).

    abstract::I-Tiao-Gung, Glycine tomentella, has been used extensively as a traditional herbal medicine to relieve physical pain, but its bioactivity has not been studied systematically. Ninety-five percent ethanol extracts of G. tomentella (GT-E) showed antioxidant activity in human plasma by prolonging the lag phase (+Tlag) of ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-005-1482-1

    authors: Chen TY,Shiao MS,Pan BS

    更新日期:2005-11-01 00:00:00

  • The HMG-CoA reductase gene and lipid and lipoprotein levels: the multi-ethnic study of atherosclerosis.

    abstract::HMG-CoA reductase (HMGCR) is an enzyme involved in cholesterol synthesis. To investigate the contribution of the HMGCR gene to lipids and lipoprotein subfractions in different ethnicities, we performed an association study in the Multi-Ethnic Study of Atherosclerosis (MESA). In total, 2,444 MESA subjects [597 African-...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-009-3314-6

    authors: Chen YC,Chen YD,Li X,Post W,Herrington D,Polak JF,Rotter JI,Taylor KD

    更新日期:2009-08-01 00:00:00

  • Preferential redistribution of lipoprotein-unassociated apoA-IV to an HDL subpopulation with a high degree of LCAT modification.

    abstract::The relationship between LCAT mediated HDL modification and the redistribution of lipoprotein-unassociated apoA-IV to HDL was investigated in vitro. Immunoaffinity-isolated rat lipoprotein-unassociated apoA-IV was added to apoB-, apoE-, apoA-IV depleted, [3H]cholesterol labelled rat plasma and incubated at 37 degrees ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02544075

    authors: Lefevre M,Goudey-Lefevre JC,Roheim PS

    更新日期:1989-12-01 00:00:00

  • Effect of ethanol administration on fatty acid desaturation.

    abstract::The effect of ethanol on the fatty acid desaturation by rat liver has been studied using liquid diets of different composition. Acute ethanol administration increased triacylglycerols of total liver lipids, but did not modify significantly the lipidic composition of microsomes. The delta 6 and delta 5 desaturases were...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535837

    authors: Nervi AM,Peluffo RO,Brenner RR,Leikin AI

    更新日期:1980-04-01 00:00:00

  • Enzymatic acylation of ether and ester lysophospholipids in rat liver microsomes.

    abstract::The acylation of lysophospholipids by rat liver acyltransferases was studied. A comparison between ester and ether lysophospholipids as substrates revealed large differences in substrate properties. For instance, oleic acid from oleoyl-CoA and arachidonic acid from arachidonoyl-CoA were not incorporated into 1-O-octad...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535535

    authors: Neumüller W,Fleer EA,Unger C,Eibl H

    更新日期:1987-11-01 00:00:00