Abstract:
:The effect of ethanol on the fatty acid desaturation by rat liver has been studied using liquid diets of different composition. Acute ethanol administration increased triacylglycerols of total liver lipids, but did not modify significantly the lipidic composition of microsomes. The delta 6 and delta 5 desaturases were inhibited by ethanol whereas the delta 9 desaturase and fatty acid synthetase were apparently modified only by diet composition. NADH-cytochrome (cyt.) c reductase was partially inhibited, whereas NADH-cyt. b5 reductase remained practically unaltered and NADPH-cyt. c reductase activity was enhanced. Decreased electrons supplied by the microsomal cyt. b5 electron transport chain would not be the reason for the inhibition of delta 6 and delta 5 desaturases by ethanol.
journal_name
Lipidsjournal_title
Lipidsauthors
Nervi AM,Peluffo RO,Brenner RR,Leikin AIdoi
10.1007/BF02535837subject
Has Abstractpub_date
1980-04-01 00:00:00pages
263-8issue
4eissn
0024-4201issn
1558-9307journal_volume
15pub_type
杂志文章相关文献
LIPIDS文献大全abstract::The effects of 2-hexadecynoic acid on the growth and lipid metabolism of cultured 7288 (HTC) cells have been evaluated. Growth was inhibited by the acetylenic acid: the LD50 was 35-85 microM as determined by two methods at low and high cell densities. Reduced growth did not result from damaged plasma membranes as dete...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534955
更新日期:1981-05-01 00:00:00
abstract::Plaques and white matter from brains of multiple sclerosis (MS) patients were analyzed for lipid content, class composition, and fatty acid composition of total lipid, together with the fatty acid composition of plaque glycerophospholipids, and the results were compared with white matter from normal brain. Plaques con...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02544017
更新日期:1991-01-01 00:00:00
abstract::A rat liver cytosolic cholesteryl ester hydrolase (CEH) was purified 12,600-fold by ammonium sulfate precipitation, cation exchange chromatography and gel permeation high-performance liquid chromatography, with an overall yield of 20%. Its properties are compared to those of pancreatic CEH, with which it has sometimes...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536160
更新日期:1991-10-01 00:00:00
abstract::Bile acid contents were determined for isolated rat hepatocytes. During the course of isolating the hepatocytes, perfusion of rat liver with buffer containing 2% albumin eluted a significant amount of bile acids. The elution was proportional to the volume of the buffer and attributable to albumin in the buffer. The is...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535094
更新日期:1982-03-01 00:00:00
abstract::Diacylglycerol acyltransferase (DGAT) catalyzes the final step of triacylglycerol (TAG) synthesis, and is considered as a potential target to control hypertriglyceridemia or other metabolic disorders. In this study, we found that the extract of rose petals suppressed TAG synthesis in cultured cells, and that the extra...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-011-3559-8
更新日期:2011-08-01 00:00:00
abstract::Two unusual lipid classes were detected by thin-layer chromatography in the neutral lipids derived from goat cauda-epididymal sperm plasma membrane. The lipids were identified as wax esters and 1-O-alkyl-2,3-diacylglycerols based on chromatographic properties, identity of their hydrolysis products, and infrared/1H nuc...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537065
更新日期:1992-01-01 00:00:00
abstract::A test meal (300 mg casein, 600 mg sucrose, 100 mg corn oil, tracer dose of 9.10(3)H oleic acid) was given to fasting adult rats with intestinal lymph fistulas. One group received an acute oral dose of ethanol (3.2 g/kg body weight) simultaneously with the test meal. Controls received 2.5 ml of water instead of ethano...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532991
更新日期:1976-12-01 00:00:00
abstract::The present study was conducted to evaluate the ontogeny and kinetic of CPT I in several tissues of the Chinese sucker Myxocyprinus asiaticus. To this end, liver, muscle and intestine tissues were examined at five various developmental stages of Chinese sucker: newly-hatched larvae, 68-day-old, 4-month-old, 1- and 2-y...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-013-3864-5
更新日期:2014-02-01 00:00:00
abstract::Using an experimental model that enables the effects of alcohol to be distinguished from the effects of the nonalcoholic components present in wine, we determined whether wine has effects other than those of alcohol on the metabolism of cholesterol. Male rats were fed a standard diet and had free access to water and e...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-001-0732-6
更新日期:2001-04-01 00:00:00
abstract::Oxidized lipoprotein(a) (oxLp(a)) is a more potent marker of atherogenesis than native Lp(a). However, the molecular mechanisms of oxLp(a) activity are not clear. Reactive oxygen species (ROS) have recently been suggested as acting as intracellular second messengers. In this study, the effects of oxLp(a) on endothelia...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-013-3795-1
更新日期:2013-06-01 00:00:00
abstract::Cholesterol itself has very few structural/chemical features suitable for real-time imaging in living cells. Thus, the advent of dehydroergosterol [ergosta-5,7,9(11),22-tetraen-3beta-ol, DHE] the fluorescent sterol most structurally and functionally similar to cholesterol to date, has proven to be a major asset for re...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-008-3194-1
更新日期:2008-12-01 00:00:00
abstract::Type 2 diabetes and dyslipidemia are risk factors for cardiovascular disease. However, mechanisms by which hypertriglyceridemia influences atherogenesis remain unclear. We examined effects of dyslipidemic diabetic serum on macrophage lipid accumulation as a model of foam cell formation. Normal human macrophages were c...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-011-3578-5
更新日期:2011-10-01 00:00:00
abstract::The monoazaaromatics, pyridine (1), hexyl nicotinate (2), and quinoline (3) and diazaaromatics, pyrimidine (4) and purine (5), readily act as photo-initiators for the peroxidation of methyl linoleate in 0.50 M SDS at 37 degrees C giving free radical chain oxidations of linoleate. Quantitative kinetic runs on the order...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-997-0030-3
更新日期:1997-03-01 00:00:00
abstract::Among many factors, elevated lipids and lipid peroxide levels in blood are major risk factors in the development of cardiovascular disease in diabetic patients. This study has examined whether oral supplementation of vitamin E, an antioxidant, has any effect on blood lipid peroxidation products (LP) and lipid profile ...
journal_title:Lipids
pub_type: 临床试验,杂志文章
doi:10.1007/BF02637057
更新日期:1996-03-01 00:00:00
abstract::The wax material in the secretion of a scale insect,Ceroplastes pseudoceriferus Green was analyzed chemically with special interest to the composition of higher fatty acids and higher alcohols. The wax consists of 34.2% fatty acids, 27.1% unsaponifiable matter and 29.5% resin acids. The fatty acids were found to be a ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532669
更新日期:1966-09-01 00:00:00
abstract::CLA mixtures are now commercially available. They differ from each other with respect to their content of CLA isomers and their degree of purification. As a group of natural FA, CLA have been widely assumed to be safe. However, the suspected presence of both impurities and particular isomers might induce undesirable s...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-002-0995-y
更新日期:2002-11-01 00:00:00
abstract::Over 50 years of research has sought to define the role dietary fat plays in cardiovascular disease (CVD) risk. Although optimal dietary fat quantity has been keenly pursued over past decades, attention has recently centered on the value of dietary fat quality. The purpose of the present review is to provide a critica...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-010-3524-y
更新日期:2011-03-01 00:00:00
abstract::Olive oil, a major component of the Mediterranean diet, has been associated in some small clinical trials and cross-sectional studies with a reduction in blood pressure. The objective of this study was to assess the association of olive oil consumption with the incidence of hypertension in an epidemiologic cohort, the...
journal_title:Lipids
pub_type: 临床试验,杂志文章
doi:10.1007/s11745-004-1352-x
更新日期:2004-12-01 00:00:00
abstract::The diurnal variation in lysosomal acid cholesteryl ester hydrolase (Acid CEH), (EC 3.1.1.13) has been examined in fed, fasted and adrenalectomized rats. The Acid CEH activity of normal rat liver exhibits a diurnal rhythm with maxima at 06.00 hours and minima at 18.00 hours, but such a rhythm was not observed in splee...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534362
更新日期:1985-01-01 00:00:00
abstract::This study was undertaken to investigate the total plasma fatty acid composition and the relationship between plasma triacylglycerol (TG) levels and liver delta 9 desaturase activity in mice fed n-3 and/or n-6 fatty acid or hydrogenated coconut oil (HCO) (maximum 25 mg/g) supplemented diets. Generally, plasma TG level...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536312
更新日期:1993-04-01 00:00:00
abstract::Isolated rat hepatocytes were preincubated with egg lecithin liposomes containing [3H]dolichol and [3H]dolichyl ester, and the intracellular levels and distributions of these lipids were subsequently determined after incubation in a liposome-free medium. [3H]Dolichol was recovered initially mainly in microsomes, and n...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536470
更新日期:1992-04-01 00:00:00
abstract::This study examined the effects of five CLA isomers and the non-conjugated LA on nitric oxide (NO) production, an important modulator of vasodilation, inflammation, and cytotoxicity. Bovine aortic endothelial cells (BAECs) were pretreated with pure CLAs (c9, c11-, c9, t11-, t9, t11-, t10, c12-, c11, c13-CLA) and the n...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3160-y
更新日期:2008-04-01 00:00:00
abstract::Weanling rats were fed essential fatty acid-deficient diets, either completely fat-free, or with partially hydrogenated fish oil (PHFO, 28 wt %), or with fractions derived from PHFO containing primarily positional isomers of trans-eicosenoate (20:1, 3 wt %) or trans-docosenoate (22:1, 3 wt %). Control animals were fed...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532855
更新日期:1976-03-01 00:00:00
abstract::A simple and sensitive method to analyze mixtures of desmosterol, 7-dehydrocholesterol and cholesterol is described. The method involves the oxidative conversion of the sterols with cholesterol oxidase, followed by high performance liquid chromatographic (HPLC) analysis. A C18 reversed phase column (3 microns, 75 X 4....
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535083
更新日期:1989-07-01 00:00:00
abstract::The use of the organic cosolvents tetrahydrofuran and dimethylsulfoxide was found to be unsuitable for prostate tumor cell cultures because of solvent cytotoxicity and the poor solubility and instability of lycopene. For example, the half-life of lycopene in organic/aqueous solution was found to be less than 2 h. Ther...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-999-0454-9
更新日期:1999-10-01 00:00:00
abstract::The kinetics of in vivo clearance of apolipoprotein (apo) A-I radioiodinated by the iodine monochloride (ICI) method of McFarlane [McFarlane, A.S. (1958) Efficient Trace-Labelling of Proteins with Iodine, Nature 182, 53] as modified by Bilheimer and co-workers [Bilheimer, D.W., Eisenberg, S., and Levy, R.I. (1972) The...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-003-1053-5
更新日期:2003-03-01 00:00:00
abstract::Lipoprotein(a) [Lp(a)] represents a class of lipoprotein particles having as a protein moiety apoB-100 linked by a single disulfide bond to apolipoprotein(a) [apo(a)], a multikringle structure with a high degree of homology with plasminogen. A recognized feature of Lp(a) is its instability on storage caused by attenda...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-004-1268-5
更新日期:2004-06-01 00:00:00
abstract::In an attempt to clarify the mechanism of lipid accumulation inMortierella ramanniana var.angulispora, diacylglycerol acyltransferase (DGAT) in the membrane fraction from this fungus was characterized. The enzyme had an optimum pH of 7.0-7.5, and enzyme activity was blocked by SH-reagents. Metal ions were not essentia...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536050
更新日期:1993-07-01 00:00:00
abstract::In vivo intestinal perfusion was used to follow the absorption of three different choline glycerophospholipids (CGP) in guinea pig. These included 1-[3H]palmitoyl-2-acyl-sn-glycero-3-phosphocholine (diacyl-GPC), 1-[3H]-O-hexadecyl-2-acyl-sn-glycero-3-phosphocholine (alkylacyl-GPC) and 1,2-di-O-hexadecyl-sn-glycero-3-p...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534872
更新日期:1987-01-01 00:00:00
abstract::We have investigated the regulation of cholesterol synthesis in isolated human small intestine epithelial cells (enterocytes). It was established that the amount of cholesterol synthesized increased linearly with the incubation time and the number of cells in the incubation mixture; the synthesis was suppressed by 7-k...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535408
更新日期:1986-12-01 00:00:00