Pooling of blood in postischemic shock is modulated by platelet-activating factor (PAF).

Abstract:

:In experiments on dogs, i.v. administration of platelet-activating factor (PAF) (500 ng/kg) was shown to induce hypotension which, apart from decreased myocardial contractility, was characterized by blood pooling in veins (82.6 +/- 6.8 mL/kg). This was accompanied by restriction of venous return to the heart and reduction of cardiac output (CO). During postischemic shock the cardio- and hemodynamic disturbances were similar to those induced by i.v. administration of PAF. In the postischemic shock model, preliminary blockage of PAF receptors with the PAF receptor antagonist BN 52021 (6 mg/kg, i.v.) significantly decreased the amount of blood pooled in shock from 38.7 +/- 5 to 18.3 +/- 2 mL/kg (p less than 0.01). Simultaneously, the reduction of CO and blood pressure, induced by reperfusion of the continuously ischemized tissues of a rear limb, was less significant in pretreated vs. the nontreated group. The data suggest that PAF may be involved in postischemic blood pooling and that PAF antagonists could be used to correct postischemic cardio- and hemodynamic disturbances.

journal_name

Lipids

journal_title

Lipids

authors

Sagach VF,Dmitrieva AV,Braquet P

doi

10.1007/BF02536575

subject

Has Abstract

pub_date

1991-12-01 00:00:00

pages

1400-3

issue

12

eissn

0024-4201

issn

1558-9307

journal_volume

26

pub_type

杂志文章

相关文献

LIPIDS文献大全
  • Free fatty acid inhibition of the insulin induction of glucose-6-phosphate dehydrogenase in rat hepatocyte monolayers.

    abstract::Rat hepatocytes in monolayer culture were utilized to determine if the decrease in glucose-6-phosphate dehydrogenase (G6PD) activity resulting from the ingestion of fat can be mimicked by the addition of fatty acids to a chemically, hormonally defined medium. G6PD activity in cultured hepatocytes was induced several-f...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535302

    authors: Salati LM,Adkins-Finke B,Clarke SD

    更新日期:1988-01-01 00:00:00

  • A lack of correlation between linoleate and arachidonate in human breast milk.

    abstract::The levels of arachidonic acid and linoleic acid found in the lipid fraction of human milk samples were compared. No correlation was found between the level of precursor linoleate and product arachidonate in 80 samples of colostrum (day 3-5) or 60 samples of mature breast milk. We attempted to test the hypothesis that...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02537411

    authors: Gibson RA,Kneebone GM

    更新日期:1984-06-01 00:00:00

  • Sesame seed and its lignans produce marked enhancement of vitamin E activity in rats fed a low alpha-tocopherol diet.

    abstract::Three series of experiments demonstrated that sesame seed and its lignans cause significant elevation of alpha-tocopherol content in rats. In Experiment 1, 20% sesame seed (with a negligible amount of alpha-tocopherol) supplementing 10 (low), 50 (normal), or 250 (high) mg/kg alpha-tocopherol diets (protein and fat con...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536287

    authors: Yamashita K,Iizuka Y,Imai T,Namiki M

    更新日期:1995-11-01 00:00:00

  • Lipid peroxidation during n-3 fatty acid and vitamin E supplementation in humans.

    abstract::The purpose of this study was to investigate in healthy humans the effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake, alone or in combination with dL-alpha-tocopherol acetate (vitamin E) supplements on lipid peroxidation. Eighty men were randomly assigned in a double-blind fashion to take dai...

    journal_title:Lipids

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s11745-997-0068-2

    authors: Allard JP,Kurian R,Aghdassi E,Muggli R,Royall D

    更新日期:1997-05-01 00:00:00

  • Intermembrane cholesterol transfer: role of sterol carrier proteins and phosphatidylserine.

    abstract::The effect of phosphatidylserine and sterol carrier proteins on cholesterol exchange was determined using an assay not requiring separation of donor and acceptor membrane vesicles. Sterol carrier protein-2 (SCP2, also called nonspecific lipid transfer protein), but not fatty acid binding protein (FABP, also called ste...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02544032

    authors: Schroeder F,Butko P,Hapala I,Scallen TJ

    更新日期:1990-11-01 00:00:00

  • Comparative study of lipogenic enzymes in several vertebrates.

    abstract::The liver lipogenic enzymes are compared among rats, chickens, frogs and fish. Although the apparent Km values of glucose-6-phosphate dehydrogenase for glucose-6-phosphate are not much different among all the species, those of malic enzyme for malate are much higher in chickens and fish than in rats and frogs. Glucose...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534511

    authors: Iritani N,Ikeda Y,Fukuda H,Katsurada A

    更新日期:1984-11-01 00:00:00

  • Curcumin Attenuates Lipopolysaccharide-Induced Hepatic Lipid Metabolism Disorder by Modification of m6 A RNA Methylation in Piglets.

    abstract::N6 -methyladenosine (m6 A) regulates gene expression and affects cellular metabolism. In this study, we checked whether the regulation of lipid metabolism by curcumin is associated with m6 A RNA methylation. We investigated the effects of dietary curcumin supplementation on lipopolysaccharide (LPS)-induced liver injur...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1002/lipd.12023

    authors: Lu N,Li X,Yu J,Li Y,Wang C,Zhang L,Wang T,Zhong X

    更新日期:2018-01-01 00:00:00

  • Metabolic profile of linoleic acid in stored apples: formation of 13(R)-hydroxy-9(Z),11(E)-octadecadienoic acid.

    abstract::During our ongoing project on the biosynthesis of R-(+)-octane-1,3-diol the metabolism of linoleic acid was investigated in stored apples after injection of [1-14C]-, [9,10,12,13-3H]-,13C18- and unlabeled substrates. After different incubation periods the products were analyzed by gas chromatography-mass spectroscopy ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-999-0375-7

    authors: Beuerle T,Schwab W

    更新日期:1999-04-01 00:00:00

  • Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis.

    abstract::Antioxidants may have a role in the prevention of atherosclerosis. In the present trial, we investigated the antioxidant properties of Palm Vitee, a gamma-tocotrienol-, and alpha-tocopherol enriched fraction of palm oil, in patients with carotid atherosclerosis. Serum lipids, fatty acid peroxides, platelet aggregation...

    journal_title:Lipids

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02536621

    authors: Tomeo AC,Geller M,Watkins TR,Gapor A,Bierenbaum ML

    更新日期:1995-12-01 00:00:00

  • Synthesis of thioether phosphocholine analogues.

    abstract::The synthesis of thioether phospholipids, which represent a new class of antitumor agents, is reported here. In particular, the route of synthesis of 3-hexadecylmercapto-2-methoxymethylpropyl-2'-trimethylammoni o-ethyl phosphate (BM 41.440, Ilmofosine), one of the most potent cytostatic/cytotoxic derivatives, is descr...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535561

    authors: Bosies E,Herrmann DB,Bicker U,Gall R,Pahlke W

    更新日期:1987-11-01 00:00:00

  • High-Fat Diet from Weaning until Early Adulthood Impairs T Cell Development in the Thymus.

    abstract::The growing prevalence of childhood obesity has become a serious health problem over the past few decades. Although the immune system is greatly affected by childhood obesity, whether obesity influences the T cell development in the thymus is poorly understood. In this study, we used a high-fat diet (HFD)-induced obes...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1002/lipd.12193

    authors: Li H,Wetchapinant C,Zhang L,Wu K

    更新日期:2020-01-01 00:00:00

  • Slow recovery of the fatty acid composition of sciatic nerve in rats fed a diet initially low in n-3 fatty acids.

    abstract::The sciatic nerve of rats fed sunflower oil (6 mg 18:3-n-3/100 g of diet) presented dramatic alterations in the long chain polyunsaturated fatty acids in comparison with those fed soy oil (130 mg 18:3n-3/100 g of diet). In both 15-day-old and 60-day-old animals fed sunflower oil, 22:6n-3 (cervonic acid) was four-fold ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02540371

    authors: Bourre JM,Youyou A,Durand G,Pascal G

    更新日期:1987-07-01 00:00:00

  • Oleic acid attenuates trans-10,cis-12 conjugated linoleic acid-mediated inflammatory gene expression in human adipocytes.

    abstract::The weight loss supplement conjugated linoleic acid (CLA) consists of an equal mixture of trans-10,cis-12 (10,12) and cis-9,trans-11 (9,11) isomers. However, high levels of mixed CLA isomers, or the 10,12 isomer, causes chronic inflammation, lipodystrophy, or insulin resistance. We previously demonstrated that 10,12 C...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-012-3711-0

    authors: Reardon M,Gobern S,Martinez K,Shen W,Reid T,McIntosh M

    更新日期:2012-11-01 00:00:00

  • Comparison of lipid composition of Aedes aegypti and Aedes albopictus cells obtained from logarithmic and stationary phases of growth.

    abstract::The total lipids, total neutral lipids, and total phospholipids from Aedes aegypti and aedes albopictus cells cultivated in vitro in a medium containing fetal calf serum were analyzed. The mosquito cells were harvested in the logarithmic and stationary phases of growth. The fatty acid profiles of the lipids showed dif...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532163

    authors: McMeans E,Yang TK,Anderson LE,Jenkin HM

    更新日期:1975-02-01 00:00:00

  • Flaxseed treatments to reduce biohydrogenation of alpha-linolenic acid by rumen microbes in cattle.

    abstract::Enrichment of beef muscle with n-3 fatty acids (FA) is one means to introduce these FA into the diet, but ruminal biohydrogenation limits their bioavailability. To address this problem, we evaluated the ability of condensed tannin (quebracho), in the presence or absence of casein, to protect 18:3n-3 in flaxseed from h...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-007-3126-5

    authors: Kronberg SL,Scholljegerdes EJ,Barceló-Coblijn G,Murphy EJ

    更新日期:2007-12-01 00:00:00

  • Lipase-catalyzed hydrolysis of TG containing acetylenic FA.

    abstract::Hydrolysis of symmetrical acetylenic TG of type AAA [viz., glycerol tri-(4-decynoate), glycerol tri-(6-octadecynoate), glycerol tri-(9-octadecynoate), glycerol tri-(10-undecynoate), and glycerol tri-(13-docosynoate)] in the presence of eight microbial lipases was studied. Novozyme 435 (Candida antarctica), an efficien...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-006-0992-1

    authors: Jie MS,Fua X,Lau MM,Chye ML

    更新日期:2002-10-01 00:00:00

  • Oxidized lipoprotein(a) increases endothelial cell monolayer permeability via ROS generation.

    abstract::Oxidized lipoprotein(a) (oxLp(a)) is a more potent marker of atherogenesis than native Lp(a). However, the molecular mechanisms of oxLp(a) activity are not clear. Reactive oxygen species (ROS) have recently been suggested as acting as intracellular second messengers. In this study, the effects of oxLp(a) on endothelia...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-013-3795-1

    authors: Wei DH,Zhang XL,Wang R,Zeng JF,Zhang K,Yang J,Li S,Lin XL,Jiang ZS,Wang GX,Wang Z

    更新日期:2013-06-01 00:00:00

  • Sterol composition of phaeodactylum tricornutum as influenced by growth temperature and light spectral quality.

    abstract::In a detailed sterol analysis of the marine diatom Phaeodactylum tricornutum, free sterols as well as esterified and glycosylated conjugates were found. When the alga was grown under standard conditions (i.e., at 13 degrees C under white light), 64% of total sterols were steryl glycosides. In all sterol classes, excep...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522694

    authors: Véron B,Billard C,Dauguet JC,Hartmann MA

    更新日期:1996-09-01 00:00:00

  • Fatty acids of cerebrosides in different regions of the developing foetal brain.

    abstract::The fatty acid composition of cerebrosides of developing foetal human brain and regional variations, if any, during intrauterine life were studied. While palmitic and stearic acids were the predominant normal fatty acids throughout intrauterine life, long chain fatty acids, like lignoceric and nervonic acids, which we...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533635

    authors: Rao PS

    更新日期:1977-04-01 00:00:00

  • Postprandial lipemia is modified by the presence of the APOB-516C/T polymorphism in a healthy Caucasian population.

    abstract::Apolipoprotein (apoB) plays a fundamental role in the transport and metabolism of plasma triacylglycerols (TAGs) and cholesterol. Several apoB polymorphic sites have been studied for their potential use as markers for coronary heart disease in the population. In view of the importance of apoB in postprandial metabolis...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-007-3027-7

    authors: Pérez-Martínez P,Pérez-Jiménez F,Ordovás JM,Moreno JA,Marín C,Moreno R,Jiménez-Gómez Y,Paniagua JA,López-Miranda J

    更新日期:2007-03-01 00:00:00

  • Effect of ethanol administration on fatty acid desaturation.

    abstract::The effect of ethanol on the fatty acid desaturation by rat liver has been studied using liquid diets of different composition. Acute ethanol administration increased triacylglycerols of total liver lipids, but did not modify significantly the lipidic composition of microsomes. The delta 6 and delta 5 desaturases were...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535837

    authors: Nervi AM,Peluffo RO,Brenner RR,Leikin AI

    更新日期:1980-04-01 00:00:00

  • Purification and properties of aortic cholesteryl ester hydrolase.

    abstract::The enzyme(s) present in acetonedried powder of rat and rabbit aortas, which catalyzes the synthesis and hydrolysis of cholesteryl ester, was purified partially by acid precipitation, acetone fractionation, O-(diethylaminoethyl) cellulose chromatography, and Sephadex G-100 filtration. The synthetic activity was purifi...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532453

    authors: Kothari HV

    更新日期:1975-06-01 00:00:00

  • Accumulation of docosahexaenoic acid in phosphatidylserine is selectively inhibited by chronic ethanol exposure in C-6 glioma cells.

    abstract::Neuronal membranes are highly enriched with docosahexaenoic acid (22:6n-3), and its content can be altered by ethanol consumption. We have previously reported that the 22:6n-3 status in membrane affects the biosynthesis of phosphatidylserine (PS), a phospholipid class which contains an exceptionally high proportion of...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02664769

    authors: Kim HY,Hamilton J

    更新日期:2000-02-01 00:00:00

  • Decrease in alkaline triglyceride lipase in primary cultured hepatocytes from mice with sarcoma 180.

    abstract::Primary cultured hepatocytes from normal mice and mice with Sarcoma 180 were characterized. The viability of freshly isolated hepatocytes from both sources was over 90% and the cells had a relatively stable population of DNA for a minimum of three days. After incubation with (3H)leucine, the syntheses and secretions o...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534229

    authors: Masuno H,Okuda H

    更新日期:1985-07-01 00:00:00

  • Enrichment of LDL with EPA and DHA decreased oxidized LDL-induced apoptosis in U937 cells.

    abstract::Oxidized LDL (oxLDL) may contribute to the accumulation of apoptotic cells in atherosclerotic plaques. Although it is well established in monophasic chemical systems that the highly unsaturated EPA and DHA will oxidize more readily than FA that contain fewer double bonds, our previous studies showed that enrichment of...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-002-0962-7

    authors: Wu T,Geigerman C,Lee YS,Wander RC

    更新日期:2002-08-01 00:00:00

  • Evaluation of apolipoprotein A-I kinetics in rabbits in vivo using in situ and exogenous radioiodination methods.

    abstract::The kinetics of in vivo clearance of apolipoprotein (apo) A-I radioiodinated by the iodine monochloride (ICI) method of McFarlane [McFarlane, A.S. (1958) Efficient Trace-Labelling of Proteins with Iodine, Nature 182, 53] as modified by Bilheimer and co-workers [Bilheimer, D.W., Eisenberg, S., and Levy, R.I. (1972) The...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-003-1053-5

    authors: Zhang B,Shimoji E,Tanaka H,Saku K

    更新日期:2003-03-01 00:00:00

  • 24-Methylenelanost-9(11)-en-3beta-ol, new triterpene alcohol from shea butter.

    abstract::A new triterpene alcohol was isolated fron shea butter and its structure was shown to be 24-methylenelanost-9(11)-en-3beta-ol. Gas chromatographic correlations between this triterpene alcohol and other related compounds are discussed. ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532428

    authors: Itoh T,Tamura T,Matsumoto T

    更新日期:1975-08-01 00:00:00

  • Dietary sunflower oil reduces plasma and liver triacylglycerols in fasting rats and is associated with decreased liver microsomal phosphatidate phosphohydrolase activity.

    abstract::Plasma and liver lipids were studied in male weanling rats fed diets containing moderate levels of fat (6% by weight) as sunflower oil (SF diet, rich in linoleic acid), salmon oil (SM diet, rich in long-chain n-3 fatty acids), or a blend of peanut and rapeseed oil (PR diet, rich in oleic acid). After nine weeks of fee...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522983

    authors: Frémont L,Gozzelino MT

    更新日期:1996-08-01 00:00:00

  • Solubilization and stabilization of carotenoids using micelles: delivery of lycopene to cells in culture.

    abstract::The use of the organic cosolvents tetrahydrofuran and dimethylsulfoxide was found to be unsuitable for prostate tumor cell cultures because of solvent cytotoxicity and the poor solubility and instability of lycopene. For example, the half-life of lycopene in organic/aqueous solution was found to be less than 2 h. Ther...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-999-0454-9

    authors: Xu X,Wang Y,Constantinou AI,Stacewicz-Sapuntzakis M,Bowen PE,van Breemen RB

    更新日期:1999-10-01 00:00:00

  • Tissue Specific Effects of Dietary Carbohydrates and Obesity on ChREBPα and ChREBPβ Expression.

    abstract::Carbohydrate response element binding protein (ChREBP) regulates insulin-independent de novo lipogenesis. Recently, a novel ChREBPβ isoform was identified. The purpose of the current study was to define the effect of dietary carbohydrates (CHO) and obesity on the transcriptional activity of ChREBP isoforms and their r...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-015-4090-0

    authors: Stamatikos AD,da Silva RP,Lewis JT,Douglas DN,Kneteman NM,Jacobs RL,Paton CM

    更新日期:2016-01-01 00:00:00