Evaluation of apolipoprotein A-I kinetics in rabbits in vivo using in situ and exogenous radioiodination methods.

abstract：:Recently, a number of inhibitors of the enzyme oxidosqualene cyclase (OSC; EC 5.4.99.7), a key enzyme in sterol biosynthesis, were shown to inhibit in mammalian cells the multiplication of Trypanosoma cruzi, the parasite agent of Chagas' disease. The gene coding for the OSC of T. cruzi has been cloned and expressed in...

journal_title：Lipids

authors： Oliaro-Bosso S,Ceruti M,Balliano G,Milla P,Rocco F,Viola F

更新日期：2005-12-01 00:00:00

abstract：:A novel phospholipid containing a chromanol structure at its polar head group was synthesized from egg yolk phosphatidylcholine and 2,5,7,8-tetramethyl-6-hydroxy-2-(hydroxyethyl)chroman by transphosphatidylation catalyzed by phospholipase D from Streptomyces lydicus. The structure of the product synthesized was shown ...

journal_title：Lipids

authors： Koga T,Nagao A,Terao J,Sawada K,Mukai K

更新日期：1994-02-01 00:00:00

abstract：:The effect of ethanol on the fatty acid desaturation by rat liver has been studied using liquid diets of different composition. Acute ethanol administration increased triacylglycerols of total liver lipids, but did not modify significantly the lipidic composition of microsomes. The delta 6 and delta 5 desaturases were...

journal_title：Lipids

authors： Nervi AM,Peluffo RO,Brenner RR,Leikin AI

更新日期：1980-04-01 00:00:00

abstract：:Apolipoprotein (apoB) plays a fundamental role in the transport and metabolism of plasma triacylglycerols (TAGs) and cholesterol. Several apoB polymorphic sites have been studied for their potential use as markers for coronary heart disease in the population. In view of the importance of apoB in postprandial metabolis...

journal_title：Lipids

authors： Pérez-Martínez P,Pérez-Jiménez F,Ordovás JM,Moreno JA,Marín C,Moreno R,Jiménez-Gómez Y,Paniagua JA,López-Miranda J

更新日期：2007-03-01 00:00:00

abstract：:We have investigated the regulation of cholesterol synthesis in isolated human small intestine epithelial cells (enterocytes). It was established that the amount of cholesterol synthesized increased linearly with the incubation time and the number of cells in the incubation mixture; the synthesis was suppressed by 7-k...

journal_title：Lipids

authors： Sviridov DD,Safonova IG,Talalaev AG,Repin VS,Smirnov VN

更新日期：1986-12-01 00:00:00

abstract：:Vegetable oils are an extremely important agricultural commodity. Their use has risen inexorably for the last 50 years and will undoubtedly be even more prevalent in the future. They have a role not only in foodstuffs but also as renewable chemicals. However, our understanding of their metabolism, and particularly its...

journal_title：Lipids

authors： Chen G,Woodfield HK,Pan X,Harwood JL,Weselake RJ

更新日期：2015-11-01 00:00:00

abstract：:This study was undertaken to investigate the total plasma fatty acid composition and the relationship between plasma triacylglycerol (TG) levels and liver delta 9 desaturase activity in mice fed n-3 and/or n-6 fatty acid or hydrogenated coconut oil (HCO) (maximum 25 mg/g) supplemented diets. Generally, plasma TG level...

journal_title：Lipids

authors： de Antueno RJ,Cantrill RC,Huang YS,Elliot M,Horrobin DF

更新日期：1993-04-01 00:00:00

abstract：:The anesthetic potency of four derivatives of n-octane was measured by tadpole righting reflex and expressed as effective millimolar concentration of drug in membrane, EDM50. Potency diminished (ED50 increased) in this order: 1-octanol, EDM50 = 5.5; 1-(2-methoxyethoxy)octane, EDM50 = 28; 1-methoxyoctane, EDM50 = 61; a...

journal_title：Lipids

authors： Brockerhoff H,Brockerhoff S,Box LL

更新日期：1986-06-01 00:00:00

abstract：:The physiological role of long-chain fatty acyl-CoA is thought to be primarily in intermediary metabolism of fatty acids. However, recent data show that nM to microM levels of these lipophilic molecules are potent regulators of cell functions in vitro. Although long-chain fatty acyl-CoA are present at several hundred ...

journal_title：Lipids

authors： Gossett RE,Frolov AA,Roths JB,Behnke WD,Kier AB,Schroeder F

更新日期：1996-09-01 00:00:00

abstract：:Lipids were extracted from four dog adipose tissue sites, perirenal, pericardial, inguinal subcutaneous, and mesenteric. The triglycerides were purified by thin-layer chromatography and the sub-classes separated by silver nitrate-silica gel plates. Gas chromatography was used to delineate the fatty acid composition of...

journal_title：Lipids

authors： Gold M

更新日期：1968-11-01 00:00:00

abstract：:A quantitative method for the simultaneous determination of alk-l-enyl- and alkyl-glyceryl ethers is described. Complete hydrogenolysis of carboxylate and phosphate esters of neutral lipids and phospholipids was achieved with lithium aluminum hydride. The hydrogenolysis products of the glyceryl ether containing lipids...

journal_title：Lipids

authors： Wood R,Snyder F

更新日期：1968-03-01 00:00:00

abstract：:This study evaluated the effects of conjugated linoleic acids (CLA) on tissue fatty acid composition and ex vivo prostaglandin E2 (PGE2) production in rats given diets varying in n-6 and n-3 fatty acids. Four groups of rats were given a basal semipurified diet (AIN-93G) containing 70 g/kg of added fat for 42 d. The fa...

journal_title：Lipids

authors： Li Y,Watkins BA

更新日期：1998-04-01 00:00:00

abstract：:A group of Angus beef cattle was removed from temperate pastures and fed a very low beta-carotene cereal-based ration in a feedlot for over 300 d. Half the group was supplemented weekly with retinyl palmitate (at the rate of 60,000 IU vitamin A/100 live weight (LW)/day), sufficient to offset clinical vitamin A deficie...

journal_title：Lipids

authors： Siebert BD,Kruk ZA,Davis J,Pitchford WS,Harper GS,Bottema CD

更新日期：2006-04-01 00:00:00

abstract：:Growth hormone (GH) has many metabolic effects, but its mechanism(s) of action are not fully understood. We studied the short-term effects of endogenously produced GH on liver delta 6-desaturase activity and adipose and liver lipid fraction fatty acid composition in transgenic mice. MG101 transgenic mice ages 73-114 d...

journal_title：Lipids

authors： Nakamura MT,Phinney SD,Tang AB,Oberbauer AM,German JB,Murray JD

更新日期：1996-02-01 00:00:00

abstract：:Bioassay-guided fractionation of a collection of Moorea bouillonii from Papua New Guinea led to the isolation of a new alkyl amide, mooreamide A (1), along with the cytotoxic apratoxins A-C and E. The planar structure of 1 was elucidated by NMR spectroscopy and mass spectrometry analysis. Structural homology between m...

journal_title：Lipids

authors： Mevers E,Matainaho T,Allara' M,Di Marzo V,Gerwick WH

更新日期：2014-11-01 00:00:00

abstract：:Peroxidation of intact human erythrocytes by t-butylhydroperoxide (tBHP)) was studied. By incubation of the erythrocytes with 1 mM tBHP, reduced glutathione (GSH) was exhausted within 1 min, and tocopherols (Toc) and phospholipids (PL) decreased to nearly their lowest levels (in this study) within 5 min. The rate of d...

journal_title：Lipids

authors： Mawatari S,Murakami K

更新日期：2001-01-01 00:00:00

abstract：:Competitive inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase improve hypercholesterolemia. However, reports about the effects of these agents on bile acid synthesis, the metabolic pathway of cholesterol, are conflicting. We studied the short-term effect on one of these agents, pravastatin, on bile acid synthesis...

journal_title：Lipids

authors： Yoshida T,Honda A,Shoda J,Abei M,Matsuzaki Y,Tanaka N,Miyazaki H,Osuga T

更新日期：1997-08-01 00:00:00

abstract：:Cholesteryl esterase activities were determined in homogenates of rat heart (ventricles), isolated, calcium-tolerant, cardiac myocytes and aortic tissue and were compared with acid and neutral triglyceride lipase activities in these fractions. Using cholesteryl oleate/phosphatidylcholine/taurocholate emulsions and dig...

journal_title：Lipids

authors： Stam H,Broekhoven-Schokker S,Schoonderwoerd K,Hülsmann WC

更新日期：1987-02-01 00:00:00

abstract：:In this paper, evidence is presented on the capacity of Ehrlich ascites cells to synthesize in vitro monounsaturated fatty acids from radioactive palmitate. Localization of the double bond was determined by ozonolysis and subsequent reduction of the ozonides to aldesters followed by gas liquid chromatography. These re...

journal_title：Lipids

authors： Mercuri O,De Tomás ME,de Antueno RJ

更新日期：1981-12-01 00:00:00

abstract：:Acid cholesteryl ester hydrolase (CEH) activity was assayed in mononuclear cells of patients with symptomatic atherosclerosis (transient ischemic attacks, TIA) and in age-matched controls showing no evidence of atherosclerosis. The acid CEH level of TIA patients was significantly lower than that of controls (1074 +/- ...

journal_title：Lipids

authors： Yatsu FM,Hagemenas FC,Manaugh LC,Galambos T

更新日期：1980-12-01 00:00:00

abstract：:Mevalonic acid-derived intermediates in the cholesterol biosynthetic pathway have been recognized as being critical to the isoprenylation of a variety of growth-regulating proteins, including those of the RAS superfamily. Treatment of cells with lovastatin, a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibi...

journal_title：Lipids

authors： Ownby SE,Hohl RJ

更新日期：2002-02-01 00:00:00

abstract：:Triacylglycerols containing linoleate and linolenate found in vegetable oils were synthesized in gram quantities for oxidation studies. Two acylation methods were examined to convert diacylglycerols or monoacylglycerols to the desired triacylglycerols. Acylations with fatty acid and 1,1'-dicyclohexylcarbodiimide in th...

journal_title：Lipids

authors： Awl RA,Frankel EN,Weisleder D

更新日期：1989-10-01 00:00:00

abstract：:This study investigated the influence of PUFA on the properties of mouse skin. Mice (3 wk old) were given free access to oils high in linoleic acid, CLA, or DHA for 4 wk. At the end of the experiment, their skins were compared by both biochemical and histological methods. No significant differences in lipid and collag...

journal_title：Lipids

authors： Oikawa D,Nakanishi T,Nakamura Y,Takahashi Y,Yamamoto T,Shiba N,Tobisa M,Takagi T,Iwamoto H,Tachibana T,Furuse M

更新日期：2003-06-01 00:00:00

abstract：:A simple method for the determination of bile acids in adult human fecal samples using GC-MS is described. Bile acids are directly extracted from feces by ethanol (95%) containing 0.1 N NaOH. Extracts are purified by passage through a reversed-phase C18 silica cartridge and then analyzed by GC-MS. The present study ha...

journal_title：Lipids

authors： Perwaiz S,Mignault D,Tuchweber B,Yousef IM

更新日期：2002-11-01 00:00:00

abstract：:A method is described for the determination of the positions and geometric configurations of double bonds in polyunsaturated fatty acids. The procedure consists of three steps: 1) Partial reduction of the double bonds with hydrazine under conditions which give high yields of monoenes. 2) Isolation of thecis- and thetr...

journal_title：Lipids

authors： Privett OS,Nickell EC

更新日期：1966-03-01 00:00:00

abstract：:The effect of phosphatidylserine and sterol carrier proteins on cholesterol exchange was determined using an assay not requiring separation of donor and acceptor membrane vesicles. Sterol carrier protein-2 (SCP2, also called nonspecific lipid transfer protein), but not fatty acid binding protein (FABP, also called ste...

journal_title：Lipids

authors： Schroeder F,Butko P,Hapala I,Scallen TJ

更新日期：1990-11-01 00:00:00

abstract：:Both diacyl GPC (glycerylphosphorylcholine) and diacyl GPE (glycerylphosphorylethanolamine) are synthesized in human placental tissue from their respective monoacyl precursors. The origin of the monacyl phosphatides is apparently not the result of placental phosphatide acyl-hydrolase activity. The most likely source i...

journal_title：Lipids

authors： Robertson A,Sprecher H

更新日期：1967-09-01 00:00:00

abstract：:Triacylglycerol (TAG) is the main storage lipid in plants. Acyl-CoA: diacylglycerol acyltransferase (DGAT1 and DGAT2) and phospholipid: diacylglycerol acyltransferase (PDAT) can catalyze TAG synthesis. It is unclear how these three independent genes are regulated in developing seeds, and particularly if they have spec...

journal_title：Lipids

authors： Li R,Yu K,Hildebrand DF

更新日期：2010-02-01 00:00:00

abstract：:Pulmonary surfactant, the major surface-active component of which in the adult is dipalmitoylglycerophosphocholine, can be obtained by lavaging lungs with physiological saline. We have previously shown that there is an increase in the amount of phosphatidylcholine in fetal rabbit lung lavage during the latter part of ...

journal_title：Lipids

authors： Rooney SA,Gobran LI

更新日期：1977-12-01 00:00:00

abstract：:Choline is an essential nutrient required for the biosynthesis of membrane lipid phosphatidylcholine (PtdCho). Here we elucidate the mechanism of how palmitic acid (PAM) and oleic acid (OLA) regulate choline transporter-like protein 1 (CTL1/SLC44A1) function. We evaluated the mechanism of extracellular and intracellul...

journal_title：Lipids

authors： Schenkel LC,Bakovic M

更新日期：2014-08-01 00:00:00