Enzymatic acylation of ether and ester lysophospholipids in rat liver microsomes.

Abstract:

:The acylation of lysophospholipids by rat liver acyltransferases was studied. A comparison between ester and ether lysophospholipids as substrates revealed large differences in substrate properties. For instance, oleic acid from oleoyl-CoA and arachidonic acid from arachidonoyl-CoA were not incorporated into 1-O-octadecyl-sn-glycero-3-phosphocholine under experimental conditions that allowed an optimal transfer of oleic acid and arachidonic acid to 1-O-palmitoyl-sn-glycero-3-phosphocholine. However, we observed an acyl-CoA-independent transfer of arachidonic acid from 1-O-stearoyl-2-O-arachidonoyl-sn-glycero-3-phosphoinositol to 1-O-octadecyl-sn-glycero-3-phosphocholine.

journal_name

Lipids

journal_title

Lipids

authors

Neumüller W,Fleer EA,Unger C,Eibl H

doi

10.1007/BF02535535

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

808-12

issue

11

eissn

0024-4201

issn

1558-9307

journal_volume

22

pub_type

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