Inhibition of lymphocyte capping by fatty acids in mouse and man.

Abstract:

:Lipid-enriched diets have been related to a high cancer incidence in experimental animals for many years, and more recently, to assorted defects on the immune response. We investigated the effect of incubating human or murine (C3H/HEJ) lymphocytes with saturated (16:0) and unsaturated (18:1, 18:2, 18:3, 20:4) fatty acids (12 micrograms for each 10(7) cells), on the ability to cap with antihuman or antimouse anti-IgM, mu-chain specific antibody. Capping was also tested in obese (ob/ob, C57BL/6J) mice. Capping at 30 and 60 min was reduced by fatty acid incubation to 10-30% of control values in humans (p less than .001), and to 30% of control values in mice (p less than .01), regardless of degree of unsaturation. ob/ob capped normally. A lymphocyte membrane effect caused by fatty acids is observed in these experiments. Whether this is related to the dysimmunity caused by lipid diets cannot be assessed from our data, especially since all fatty acids, regardless of unsaturation, reduced the capping phenomenon.

journal_name

Lipids

journal_title

Lipids

authors

Santiago-Delpín EA,Román-Franco AA,Colón JI

doi

10.1007/BF02534659

subject

Has Abstract

pub_date

1982-10-01 00:00:00

pages

727-32

issue

10

eissn

0024-4201

issn

1558-9307

journal_volume

17

pub_type

杂志文章

相关文献

LIPIDS文献大全
  • Measurements of Singlet Oxygen-Quenching Activity of Vitamin E Homologs and Palm Oil and Soybean Extracts in a Micellar Solution.

    abstract::Recently, a new assay method that can quantify the singlet oxygen-absorption capacity (SOAC) of antioxidants (AO) and food extracts in homogeneous organic solvents has been proposed. In the present study, second-order rate constants (kQ ) for the reaction of singlet oxygen (1 O2 ) with vitamin E homologs (α-, β-, γ-, ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1002/lipd.12053

    authors: Mukai K,Ishikawa E,Ouchi A,Nagaoka SI,Abe K,Suzuki T,Izumisawa K

    更新日期:2018-06-01 00:00:00

  • Conjugated linoleic acid supplementation in humans: effects on circulating leptin concentrations and appetite.

    abstract::Conjugated linoleic acid (CLA) has been demonstrated to reduce body fat in animals. However, the mechanism by which this reduction occurs is unknown. Leptin may mediate the effect of CLA to decrease body fat. We assessed the effects of 64 d of CLA supplementation (3 g/d) on circulating leptin, insulin, glucose, and la...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-000-0586-y

    authors: Medina EA,Horn WF,Keim NL,Havel PJ,Benito P,Kelley DS,Nelson GJ,Erickson KL

    更新日期:2000-07-01 00:00:00

  • Polyunsaturated fatty acids in tissues of rats fed trielaidin and high or low levels of linolenic acid.

    abstract::Male and female weanling rats that were born to dams fed a diet low in linolenic acid received diets of 15% lipids by weight containing 45% elaidic acid (as trielaidin) and 8.5% or 0.1% linolenic acid for 10 weeks. Four other groups, in which palmitic or oleic acid replaced elaidic acid in the diet, served as controls...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536444

    authors: Astorg PO,Chevalier J

    更新日期:1987-12-01 00:00:00

  • Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats.

    abstract::The effects of conjugated linoleic acid (CLA) on the levels of chemical mediators in peritoneal exudate cells, spleen and lung, and the concentration of immunoglobulins in mesenteric lymph node and splenic lymphocytes and in serum were examined in rats. After feeding diets containing either 0 (control), 0.5 or 1.0% CL...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-998-0236-4

    authors: Sugano M,Tsujita A,Yamasaki M,Noguchi M,Yamada K

    更新日期:1998-05-01 00:00:00

  • Comparison of the effects of dietary alpha-linolenic, stearidonic, and eicosapentaenoic acids on production of inflammatory mediators in mice.

    abstract::The effects of dietary stearidonic acid (18:4n-3) on inflammatory mediator release in whole blood and splenocytes was investigated in Balb/c mice, and the effects were compared with those of two other n-3 PUFA: alpha-linolenic acid (18:3n-3) and EPA (20:5n-3). TAG mixtures containing 10% of 18:4n-3, 18:3n-3, or 20:5n-...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-002-0921-3

    authors: Ishihara K,Komatsu W,Saito H,Shinohara K

    更新日期:2002-05-01 00:00:00

  • Stereospecific analysis of triacylglycerols rich in long-chain polyunsaturated fatty acids.

    abstract::Six oils of marine, algal, and microbial origin were analyzed for stereospecific distribution of component fatty acids. The general procedure involved preparation of sn-1,2-(2,3)-diacylglycerols by partial deacylation with ethylmagnesium bromide or pancreatic lipase, separation of X-1,3- and sn-1,2(2,3)-diacylglycerol...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522622

    authors: Myher JJ,Kuksis A,Geher K,Park PW,Diersen-Schade DA

    更新日期:1996-02-01 00:00:00

  • Phosphorylation of chloroform soluble compounds in plasma membranes of human epidermoid carcinoma A431 cells.

    abstract::This study investigated a possible role for the epidermal growth factor (EGF) receptor protein tyrosine kinase in phosphoinositide metabolism with plasma membrane vesicles from human epidermoid carcinoma (A431) cells. We found a novel chloroform-soluble product radiolabeled with [gamma-32P]ATP that did not migrate fro...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534242

    authors: Brautigan DL,Randazzo P,Shriner C,Fain JN

    更新日期:1985-07-01 00:00:00

  • Solubilization and partial purification of cholinephosphotransferase in hamster tissues.

    abstract::CDPcholine:1,2-diacylglycerol cholinephosphotransferase (EC 2.7.8.2) is located on the cytoplasmic side of the endoplasmic reticulum, and catalyzes the final step in the synthesis of phosphatidylcholine via the CDPcholine pathway. The enzyme was solubilized from hamster liver microsomes by 3% Triton QS-15, and partial...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02562217

    authors: O KM,Choy PC

    更新日期:1990-02-01 00:00:00

  • Intestinal absorption of ester and ether glycerophospholipids in guinea pig. Role of a phospholipase A2 from brush border membrane.

    abstract::In vivo intestinal perfusion was used to follow the absorption of three different choline glycerophospholipids (CGP) in guinea pig. These included 1-[3H]palmitoyl-2-acyl-sn-glycero-3-phosphocholine (diacyl-GPC), 1-[3H]-O-hexadecyl-2-acyl-sn-glycero-3-phosphocholine (alkylacyl-GPC) and 1,2-di-O-hexadecyl-sn-glycero-3-p...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534872

    authors: Diagne A,Mitjavila S,Fauvel J,Chap H,Douste-Blazy L

    更新日期:1987-01-01 00:00:00

  • Influence of trichloroacetic acid-phosphotungstic acid on the thin layer chromatographic mobility of gangliosides.

    abstract::Trichloroacetic acid (TCA)-phosphotungstic acid (PTA) precipitation has been used as a faster procedure than dialysis for the isolation of gangliosides, but the TCA-PTA treatment causes striking abnormalities in the thin layer chromatographic mobilities of the gangliosides. However, a normal chromatographic pattern ca...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533321

    authors: Seyfried TN,Weber EJ,Yu RK

    更新日期:1977-11-01 00:00:00

  • Sterols of cucurbitaceae: The configurations at C-24 of 24-Alkyl-Δ(5)-,Δ(7)- and Δ(8)-sterols.

    abstract::The major sterols of the seeds ofBenincasa cerifera, Cucumis sativus, Cucurbita maxima, C. pepo andTrichosanthes japonica and of the mature plant tissues (leaves and stems) ofCitrullus battich, Cucumis sativus andGynostemma pentaphyllum of the family Cucurbitaceae were 24-ethyl-Δ(7)-sterols which were accompanied by s...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534301

    authors: Akihisa T,Thakur S,Rosenstein FU,Matsumoto T

    更新日期:1986-01-01 00:00:00

  • Effects of administration of hypolipidemic agent, 2,2'''- [ (1-methyl-4, 4-diphenylbutylidene) bis (p-phenyleneoxy)] bistriethylamine oxalate (SQ 10,591) upon cholesterol esterification by aorta, adrenal, and testes of cholesterol-fed rabbits].

    abstract::Administration of 2,2'''-([1-methyl-4, 4-diphenylbutylidene] bis(p-phenyl-eneoxy]) bistriethylamine oxalate (SQ 10,591) at 20 mg/Kg daily for 5 days to cholesterol-fed rabbits resulted in no change in aortic microsomal cholesterol esterification with a palmitoyl coenzyme A substrate or of aortic mitochondrial choleste...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532164

    authors: Morin RJ

    更新日期:1975-02-01 00:00:00

  • Interrelationship between dietary trans Fatty acids and the 6- and 9-desaturases in the rat.

    abstract::Studies are reported on the effects of dietary trans fatty acids on the 6- and 9-acyl desaturase activities in the liver microsomes of rats fed essential fatty acid (EFA)-deficient and non-EFA-deficient diets. In experiment I, weanling male rats were fed a semisynthetic diet with either 10% safflower oil (SAF) or 10% ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535118

    authors: De Schrijver R,Privett OS

    更新日期:1982-01-01 00:00:00

  • Phospholipid profile and production of prostanoids by murine colonic epithelium: effect of dietary fat.

    abstract::Dietary fat and abnormal production of various prostanoids have been linked to various disease states of the large bowel, including cancer of the colon. Studies were conducted to determine the effect of dietary fat (beef tallow or corn oil) on the lipid composition and prostanoid production of the murine colon. Female...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02537344

    authors: Robblee NM,Farnworth ER,Bird RP

    更新日期:1988-04-01 00:00:00

  • Comparison of ultracentrifugation and gel filtration for the isolation of bovine lipoproteins.

    abstract::Lipoproteins from the plasma of three nonlactating Holstein cows were isolated using either preparative ultracentrifugation or gel filtration chromatography. Lipoprotein classes obtained by ultracentrifugation were very low density plus chylomicra, less than 1.006 g/ml; low density, 1.007-1.039 g/ml; high density1, 1....

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534638

    authors: Grummer RR,Davis CL,Hegarty HM

    更新日期:1983-11-01 00:00:00

  • The effect of an energy restricted low glycemic index diet on blood lipids, apolipoproteins and lipoprotein (a) among adolescent girls with excess weight: a randomized clinical trial.

    abstract::Some studies focused on the effect of the dietary glycemic index on lipoproteins and apolipoproteins in adults; however, little evidence exists among adolescents regarding the effect of a low glycemic index (LGI) diet on apolipoproteins and lipoprotein (a) (Lpa). This study was conducted to evaluate the effect of an L...

    journal_title:Lipids

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11745-013-3834-y

    authors: Rouhani MH,Kelishadi R,Hashemipour M,Esmaillzadeh A,Azadbakht L

    更新日期:2013-12-01 00:00:00

  • Polyunsaturated fatty acids inhibit hepatic stearoyl-CoA desaturase-1 gene in diabetic mice.

    abstract::Insulin and dietary fructose independently induce stearoyl-CoA desaturase 1 (SCD1) gene expression in diabetic mouse liver. In the present study, we again used diabetic mice and supplemented a high fructose diet with polyunsaturated fatty acids (PUFA) to determine the selective repression of SCD1 gene expression by di...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02637047

    authors: Waters KM,Ntambi JM

    更新日期:1996-03-01 00:00:00

  • Effect of peanut oil and randomized peanut oil on cholesterol and oleic acid absorption, transport, and distribution in the lymph of the rat.

    abstract::Peanut oil was shown to be atherogenic in cholesterol-fed rats, rabbits, and monkeys. However, after randomization, a process in which the fatty acids in peanut oil are randomly rearranged, its atherogenicity was significantly reduced in cholesterol-fed rabbits and monkeys. The mechanism for this effect remains unknow...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-999-0482-5

    authors: Satchithanandam S,Flynn TJ,Calvert RJ,Kritchevsky D

    更新日期:1999-12-01 00:00:00

  • Changes in cultured arterial smooth muscle cells isolated from chicks upon cholesterol feeding.

    abstract::We have developed cultures of smooth muscle cells (SMC) isolated from arterial hypercholesterolemic chicks (cholesterol-SMC). These cultures are suitable for the study at the molecular level of the changes in arterial SMC induced by a cholesterol diet. By using a strong dose of cholesterol (5%) for 10 d, we obtained v...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-998-0194-x

    authors: Carazo A,Alejandre J,Diaz R,Ríos A,Castillo M,Linares A

    更新日期:1998-02-01 00:00:00

  • Age-related changes in the lipid metabolism of Fisher 344 rats.

    abstract::Lipid metabolism of male Fisher 344 rats aged 2-24 months was studied. Serum and liver cholesterol levels did not display the age-related gradual increase seen in other rat strains. An increase in the serum plus liver cholesterol pool from 2 to 6 months was followed by a plateau through 18 months and then another incr...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532876

    authors: Story JA,Tepper SA,Kritchevsky D

    更新日期:1976-08-01 00:00:00

  • Oxidized lipoprotein(a) increases endothelial cell monolayer permeability via ROS generation.

    abstract::Oxidized lipoprotein(a) (oxLp(a)) is a more potent marker of atherogenesis than native Lp(a). However, the molecular mechanisms of oxLp(a) activity are not clear. Reactive oxygen species (ROS) have recently been suggested as acting as intracellular second messengers. In this study, the effects of oxLp(a) on endothelia...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-013-3795-1

    authors: Wei DH,Zhang XL,Wang R,Zeng JF,Zhang K,Yang J,Li S,Lin XL,Jiang ZS,Wang GX,Wang Z

    更新日期:2013-06-01 00:00:00

  • An Unprecedented Occurrence of Δ5,9- and Δ9,15-Dienoic Fatty Acids in Ovaries of the Archaeogastropod Limpet Cellana toreuma.

    abstract::A detailed structural diversity of dienoic fatty acids (FA), including non-methylene-interrupted dienoic FA, of triacylglycerols and polar lipids in ovaries of Cellana toreuma was clarified for the first time by using capillary gas chromatography-mass spectrometry of their 3-pyridylcarbinol esters and argentation thin...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-015-4107-8

    authors: Kawashima H,Ohnishi M

    更新日期:2016-02-01 00:00:00

  • Activation of the phospholipase A1 activity of lipoprotein lipase by apoprotein C-II.

    abstract::The effect of apo very low density lipoprotein (apo VLDL) and apoprotein C-II on the phospholipase A1 activity associated with lipoprotein lipase (E.C.3.1.1.3) was studied using purified bovine milk lipoprotein lipase. The enzyme degraded 14C phosphatidylcholine (PC) to 14C 2-acyl lysophosphatidylcholine at a rate of ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02540967

    authors: Stocks J,Galton DJ

    更新日期:1980-03-01 00:00:00

  • Fecal steroids in diarrhea: IV. Cholera.

    abstract::Fecal bile acid and neutral sterol patterns were studied in eight healthy adult volunteers who were challenged with Vibrio cholerae classical Ogawa 395 strain in the course of vaccine development studies. Bacterial 7 alpha-dehydroxylation of cholic and chenodeoxycholic acids was not altered during experimentally induc...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535367

    authors: Huang CT,Levine MM,Daoud GS,Nalin DR,Nichols BL

    更新日期:1982-09-01 00:00:00

  • Inhibition of myocardial lipoprotein lipase by U-57,908 (RHC 80267).

    abstract::U-57,908 (RHC 80267) was shown to inhibit lipoprotein lipase (LPL) activity in cardiac myocytes from rat hearts; the concentrations required for inhibition to 50% of control activity were 1.1 microM and 2.5 microM for myocyte homogenates and a post-heparin medium preparation, respectively. The inhibition of LPL activi...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536481

    authors: Carroll R,Severson DL

    更新日期:1992-04-01 00:00:00

  • Linolenate 9R-dioxygenase and allene oxide synthase activities of Lasiodiplodia theobromae.

    abstract::Jasmonic acid (JA) is synthesized from linolenic acid (18:3n-3) by sequential action of 13-lipoxygenase, allene oxide synthase (AOS), and allene oxide cyclase. The fungus Lasiodiplodia theobromae can produce large amounts of JA and was recently reported to form the JA precursor 12-oxophytodienoic acid. The objective o...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-011-3622-5

    authors: Jernerén F,Eng F,Hamberg M,Oliw EH

    更新日期:2012-01-01 00:00:00

  • Changes in host animal plasma lipids during hepatoma growth.

    abstract::The concentrations of the major neutral lipid and phospholipid classes in the plasma of rats bearing hepatoma 7288CTC were determined at various times after transplantation. The fatty acid composition of each lipid class was also analyzed quantitatively as tumor growth progressed. Generally, most lipid classes exhibit...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534066

    authors: Matocha M,Wood R

    更新日期:1980-06-01 00:00:00

  • The effects of trans fatty acids on fatty acyl delta 5 desaturation by human skin fibroblasts.

    abstract::The effectiveness of different fatty acids as inhibitors of fatty acyl delta 5 desaturation activity in human skin fibroblasts has been investigated. When incubated with 2.25 microM [14C] eicosatrienoate (20:3 omega 6) in otherwise lipid-free medium, these cells rapidly incorporate the radiolabeled fatty acid into cel...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534517

    authors: Rosenthal MD,Doloresco MA

    更新日期:1984-11-01 00:00:00

  • Aerobic Training in Young Men Increases the Transfer of Cholesterol to High Density Lipoprotein In Vitro: Impact of High Density Lipoprotein Size.

    abstract::Exercise training not only improves the plasma lipid profile but also reduces risk of developing coronary heart disease. We investigate whether plasma lipids and high density lipoprotein (HDL) metabolism are affected by aerobic training and whether the high-density lipoprotein cholesterol (HDL-C) levels at baseline in...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1002/lipd.12155

    authors: da Silva JL,Maranhão RC,Silva MSM,Dias RG,Freitas FR,Bolani W,Lemos Junior JR,Alves CR,Oliveira PA,Alves GB,Oliveira EM,Negrao CE,Krieger JE,Pereira AC,Silva GA,Souza JP,Vinagre CGC

    更新日期:2019-06-01 00:00:00

  • Preparation and properties of various salt forms of plant phosphatidyl inositols.

    abstract::The Ca and Mg content of flax and corn phosphatidyl inositol fractions has been determined. Procedures were devised to prepare various salt forms of phosphatidyl inositol. The divalent cations were exchanged for monovalent ions (Na or K) on chelating resin columns. With the Folch wash procedure the Na or K forms of ph...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02668119

    authors: Carter HE,Weber EJ

    更新日期:1966-01-01 00:00:00