Abstract:
:U-57,908 (RHC 80267) was shown to inhibit lipoprotein lipase (LPL) activity in cardiac myocytes from rat hearts; the concentrations required for inhibition to 50% of control activity were 1.1 microM and 2.5 microM for myocyte homogenates and a post-heparin medium preparation, respectively. The inhibition of LPL activity by U-57,908 was not changed when the concentration of the triolein substrate and apolipoprotein CII activator in the assay was reduced. The availability of U-57,908 as a potent and selective LPL inhibitor may provide a useful experimental approach in studies on lipoprotein metabolism.
journal_name
Lipidsjournal_title
Lipidsauthors
Carroll R,Severson DLdoi
10.1007/BF02536481subject
Has Abstractpub_date
1992-04-01 00:00:00pages
305-7issue
4eissn
0024-4201issn
1558-9307journal_volume
27pub_type
杂志文章相关文献
LIPIDS文献大全abstract::Azaserine induced two phenotypically different populations of foci, namely, acidophilic and basophilic foci. The effects of dietary modification during the post-initiation phase of carcinogenesis were examined. A diet of 20% (w/w) unsaturated fat (unsat) compared to a 20% saturated fat (sat) diet or a control diet (5%...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536413
更新日期:1986-04-01 00:00:00
abstract::We describe a method for the quantitative analysis of molecular species of diacylglycerol and alkylacylglycerol as their diradylglycerobenzoate derivatives. Synthetic internal standards were used to provide quantitative determinations of the low levels of diacylglycerol and alkylacylglycerol and their individual molec...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02544045
更新日期:1990-11-01 00:00:00
abstract::Administration of 2,2'''-([1-methyl-4, 4-diphenylbutylidene] bis(p-phenyl-eneoxy]) bistriethylamine oxalate (SQ 10,591) at 20 mg/Kg daily for 5 days to cholesterol-fed rabbits resulted in no change in aortic microsomal cholesterol esterification with a palmitoyl coenzyme A substrate or of aortic mitochondrial choleste...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532164
更新日期:1975-02-01 00:00:00
abstract::A one-carbon degradation of long-chain fatty acids, which was found to occur in the brains of rats in vivo, has been investigated in a brain microsomal fraction in vitro. Decarboxylation of the alpha-hydroxy acid, a possible intermediate product between the substrate and the next shorter acid, in the presence of brain...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02531201
更新日期:1968-05-01 00:00:00
abstract::Groups of C57Bl/6J mice, fed either a cis (C-Diet) or trans diet (T-Diet) were milked without preconditioning at 6, 8, 10 and 12 days postpartum. On day 10, groups of mice were also milked 4, 6 and 18 h after separation of the pups. Except for the 18-h separation, all T-Diet fed animals produced milk of lower fat cont...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535872
更新日期:1992-11-01 00:00:00
abstract::Flaxseed oil is an alpha linolenic acid source important in the growth and body development stage; furthermore, this acid acts on adipose tissue and bone health. The aim of this study was to evaluate body composition, fatty acid composition, hormone profile, retroperitoneal adipocyte area and femur structure of pups a...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-016-4165-6
更新日期:2016-08-01 00:00:00
abstract::Triglycerides from normal liver, host liver, and heptoma of rats maintained on chow and fat-free diets were subjected to sterospecific analysis. Normal and host liver triglycerides from animals on the same diet did not exhibit significant differences. Fat-free diet reduced polyunsaturated fatty acids in normal and i...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532444
更新日期:1975-07-01 00:00:00
abstract::Omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) are essential components of the diet of all vertebrates. The major dietary source of n-3 LC-PUFA for humans has been fish and seafood but, paradoxically, farmed fish are also reliant on marine fisheries for fish meal and fish oil (FO), traditionally major ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-016-4191-4
更新日期:2016-10-01 00:00:00
abstract::The relationship between LCAT mediated HDL modification and the redistribution of lipoprotein-unassociated apoA-IV to HDL was investigated in vitro. Immunoaffinity-isolated rat lipoprotein-unassociated apoA-IV was added to apoB-, apoE-, apoA-IV depleted, [3H]cholesterol labelled rat plasma and incubated at 37 degrees ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02544075
更新日期:1989-12-01 00:00:00
abstract::The total lipid content, composition of main lipid classes, composition of sterols and composition of fatty acids in the main glycerolipids of Perna viridis were analyzed through four seasons using TLC-FID and GLC. Mussel samples were collected during different seasons between 2003 and 2004 from Shengsi Island, Zhejia...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-007-3078-9
更新日期:2007-08-01 00:00:00
abstract::The molecular species in mixtures of phospholipid hydroperoxides are difficult to separate and identify by typical chromatographic and mass spectrometric techniques. As reported by Havrilla and coworkers, silver ion coordination ion-spray mass spectrometry (CIS-MS) has proven to be a powerful technique for the identif...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-001-0841-2
更新日期:2001-11-01 00:00:00
abstract::Vegetable oils are an extremely important agricultural commodity. Their use has risen inexorably for the last 50 years and will undoubtedly be even more prevalent in the future. They have a role not only in foodstuffs but also as renewable chemicals. However, our understanding of their metabolism, and particularly its...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-015-4069-x
更新日期:2015-11-01 00:00:00
abstract::Racemic cis-9,10-epoxystearic acid was isolated from total lipids of human leukocytes. Identification of the epoxy acid was based mainly on gas liquid chromatographic-mass spectrometric analysis and on its chemical conversion into threo-9,10-dihydroxystearic acid. A mass spectrometric method for quantitative determina...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535645
更新日期:1988-11-01 00:00:00
abstract::The antioxidant effects of natural estrogens (estrone, E1; 17 beta-estradiol), synthetic estrogens (17 alpha-ethynylestradiol, EE2; mestranol, MES; diethylstilbestrol, DES) and catecholestrogens (2-hydroxyestradiol; 4-hydroxyestradiol, 4-OHE2) on lipid peroxidation induced by different means in rat liver microsomes we...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02538267
更新日期:1995-02-01 00:00:00
abstract::Water and lipid contents, fatty acid distribution, and lipoprotein lipase activity were determined in 11 samples taken from the Omentum Majus of five dry Alpine goats. Samples were chosen to standardize sampling sites using geometric guide marks representative of different adipose tissue sites. Sample location explain...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536391
更新日期:1992-06-01 00:00:00
abstract::The lipid quality of ruminant products is largely determined by the extent of rumen microbial biohydrogenation (BH) of polyunsaturated fatty acids (FAs) and the substances formed thereby. In vitro batch incubations with mixed rumen bacteria were tracked over 24 h to characterize the profiles and kinetics of the BH pro...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-007-3032-x
更新日期:2007-04-01 00:00:00
abstract::A simple method for the determination of bile acids in adult human fecal samples using GC-MS is described. Bile acids are directly extracted from feces by ethanol (95%) containing 0.1 N NaOH. Extracts are purified by passage through a reversed-phase C18 silica cartridge and then analyzed by GC-MS. The present study ha...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-002-1005-0
更新日期:2002-11-01 00:00:00
abstract::Pulmonary surfactant, the major surface-active component of which in the adult is dipalmitoylglycerophosphocholine, can be obtained by lavaging lungs with physiological saline. We have previously shown that there is an increase in the amount of phosphatidylcholine in fetal rabbit lung lavage during the latter part of ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533333
更新日期:1977-12-01 00:00:00
abstract::Adipocere formation is well known as a later postmortem change. We collected adipocere from five male victims which had been submerged under the sea or fresh water for 1 mon to 4 yr. Fresh subcutaneous fat of a male victim who died from a cerebral contusion was used as the control. The samples were homogenized, and th...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-997-0148-3
更新日期:1997-11-01 00:00:00
abstract::The combustion method has been modified to increase the recovery of tritiated water after combustion of a tritium-labeled tissue sample. This was accomplished by cooling the bottom of the combustion flask in a dry ice-acetone bath while irradiating the top with an infrared lamp. The procedure resulted in at least 92% ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02531191
更新日期:1968-05-01 00:00:00
abstract::A specific radioimmunoassay for platelet-activating factor (PAF) sensitive in the range 10-1000 pg (0.02-2 pmoles) has been developed. Detailed quantitative hapten inhibition studies showed specificity for the acetyl group at C-2 of PAF, a requirement for the ether linkage at C-1 and some tolerance for substituents on...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536517
更新日期:1991-12-01 00:00:00
abstract::Oxidized low density lipoprotein (Ox-LDL) is a well-established risk factor in atherosclerosis and lysophosphatidylcholine (LysoPtdCho) is considered to be one of the major atherogenic component of Ox-LDL. The purpose of this work was to investigate the effects of two membrane n-3 long chain polyunsaturated fatty acid...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-009-3284-8
更新日期:2009-03-01 00:00:00
abstract::Mevalonic acid-derived intermediates in the cholesterol biosynthetic pathway have been recognized as being critical to the isoprenylation of a variety of growth-regulating proteins, including those of the RAS superfamily. Treatment of cells with lovastatin, a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-002-0879-1
更新日期:2002-02-01 00:00:00
abstract::The skin surface lipid of the dog has been reported to contain a high proportion of diol diesters having a lower mobility on thin layer chromatography than diesters from other species in spite of containing similar fatty acid and diol components. In the present study, dog skin surface lipid was separated by preparativ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533265
更新日期:1977-10-01 00:00:00
abstract::An increased amount of phospholipids remained attached on delipidated apolipoprotein B originated from oxidized low density lipoprotein (LDL). 31P nuclear magnetic resonance analysis of such apolipoprotein showed an organic phosphorus peak at -0.55 ppm, which suggests the formation of adducts (most probably Schiff bas...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-998-0318-3
更新日期:1998-12-01 00:00:00
abstract::Bioassay-guided fractionation of a collection of Moorea bouillonii from Papua New Guinea led to the isolation of a new alkyl amide, mooreamide A (1), along with the cytotoxic apratoxins A-C and E. The planar structure of 1 was elucidated by NMR spectroscopy and mass spectrometry analysis. Structural homology between m...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3949-9
更新日期:2014-11-01 00:00:00
abstract::Despite the potential use of long chain polyunsaturated fatty acid (LCPUFA) supplementation to promote growth and neural development of the infant, little is known about potential harmful effects of the supplementation. The present study determined whether supplementation with arachidonic acid (AA) and/or docosahexaen...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-999-0388-2
更新日期:1999-05-01 00:00:00
abstract::Acetate supplementation increases plasma acetate, brain acetyl-CoA, histone acetylation, phosphocreatine levels, and is anti-inflammatory in models of neuroinflammation and neuroborreliosis. Although radiolabeled acetate is incorporated into the cellular lipid pools, the effect that acetate supplementation has on lipi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3911-x
更新日期:2014-07-01 00:00:00
abstract::With the passage of the U.S. Dietary Supplement Health and Education Act of 1994, dehydroepiandrosterone (DHEA, 5-androsten-3beta-ol-17-one) has become widely available, and a large and growing market has developed for this "fountain of youth." DHEA has been shown to have significant beneficial effects in animals, whi...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-000-0529-7
更新日期:2000-03-01 00:00:00
abstract::Two simple methods for the synthesis of phosphatidylcholine (lecithin) isotopically labeled in the methyl group of the choline moiety are described. Phosphatidylcholine is converted to phosphatidyl-ethanolamine by enzymic transphosphatidylation, and this is methylated using either methyl iodide or diazomethane to give...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533373
更新日期:1978-01-01 00:00:00