Inhibition of myocardial lipoprotein lipase by U-57,908 (RHC 80267).

Abstract:

:U-57,908 (RHC 80267) was shown to inhibit lipoprotein lipase (LPL) activity in cardiac myocytes from rat hearts; the concentrations required for inhibition to 50% of control activity were 1.1 microM and 2.5 microM for myocyte homogenates and a post-heparin medium preparation, respectively. The inhibition of LPL activity by U-57,908 was not changed when the concentration of the triolein substrate and apolipoprotein CII activator in the assay was reduced. The availability of U-57,908 as a potent and selective LPL inhibitor may provide a useful experimental approach in studies on lipoprotein metabolism.

journal_name

Lipids

journal_title

Lipids

authors

Carroll R,Severson DL

doi

10.1007/BF02536481

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

305-7

issue

4

eissn

0024-4201

issn

1558-9307

journal_volume

27

pub_type

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