Involvement of phospholipids in apolipoprotein B modification during low density lipoprotein oxidation.

Abstract:

:An increased amount of phospholipids remained attached on delipidated apolipoprotein B originated from oxidized low density lipoprotein (LDL). 31P nuclear magnetic resonance analysis of such apolipoprotein showed an organic phosphorus peak at -0.55 ppm, which suggests the formation of adducts (most probably Schiff bases) of oxidized phospholipids with apolipoprotein B. The above reaction occurs in parallel with the hydrolysis of oxidized phospholipids, catalyzed by the LDL-attached platelet-activating factor acetylhydrolase, and may contribute to the proatherogenic effect of oxidatively modified low density lipoprotein.

journal_name

Lipids

journal_title

Lipids

authors

Karakatsani AI,Liapikos TA,Troganis AN,Tsoukatos DC

doi

10.1007/s11745-998-0318-3

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

1159-62

issue

12

eissn

0024-4201

issn

1558-9307

journal_volume

33

pub_type

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