Abstract:
:SRI 62-834, an analog of the antitumor agent ET-18-OCH3 in which the oxygen atom at carbon atom 2 has been incorporated into a five-membered heterocycle, has been prepared and evaluated as an antitumor agent. The compound exhibited good cytotoxicity in vitro against a variety of tumor cell lines and was as effective as ET-18-OCH3 given orally in the mouse Meth A sarcoma model. SRI 62-834 was shown to be an inhibitor of platelet-derived growth factor (PDGF), possibly at the receptor level, and platelet-activating factor (PAF) at the receptor level.
journal_name
Lipidsjournal_title
Lipidsauthors
Houlihan WJ,Lee ML,Munder PG,Nemecek GM,Handley DA,Winslow CM,Happy J,Jaeggi Cdoi
10.1007/BF02535549subject
Has Abstractpub_date
1987-11-01 00:00:00pages
884-90issue
11eissn
0024-4201issn
1558-9307journal_volume
22pub_type
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