Abstract:
:Omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) are essential components of the diet of all vertebrates. The major dietary source of n-3 LC-PUFA for humans has been fish and seafood but, paradoxically, farmed fish are also reliant on marine fisheries for fish meal and fish oil (FO), traditionally major ingredients of aquafeeds. Currently, the only sustainable alternatives to FO are vegetable oils, which are rich in C18 PUFA, but devoid of the eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) abundant in FO. Two new n-3 LC-PUFA sources obtained from genetically modified (GM) Camelina sativa containing either EPA alone (ECO) or EPA and DHA (DCO) were compared to FO and wild-type camelina oil (WCO) in juvenile sea bream. Neither ECO nor DCO had any detrimental effects on fish performance, although final weight of ECO-fed fish (117 g) was slightly lower than that of FO- and DCO-fed fish (130 and 127 g, respectively). Inclusion of the GM-derived oils enhanced the n-3 LC-PUFA content in fish tissues compared to WCO, although limited biosynthesis was observed indicating accumulation of dietary fatty acids. The expression of genes involved in several lipid metabolic processes, as well as fish health and immune response, in both liver and anterior intestine were altered in fish fed the GM-derived oils. This showed a similar pattern to that observed in WCO-fed fish reflecting the hybrid fatty acid profile of the new oils. Overall the data indicated that the GM-derived oils could be suitable alternatives to dietary FO in sea bream.
journal_name
Lipidsjournal_title
Lipidsauthors
Betancor MB,Sprague M,Montero D,Usher S,Sayanova O,Campbell PJ,Napier JA,Caballero MJ,Izquierdo M,Tocher DRdoi
10.1007/s11745-016-4191-4subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1171-1191issue
10eissn
0024-4201issn
1558-9307pii
10.1007/s11745-016-4191-4journal_volume
51pub_type
杂志文章相关文献
LIPIDS文献大全abstract::Various derivatives and isosteres of neolignans of the 2,5-diaryl tetrahydrofuran type have been synthesized as antagonists of platelet-activating factor (PAF). A detailed analysis of their structure-activity relationship (SAR) has revealed a clear preference for an asymmetrical molecular configuration with a high deg...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02536521
更新日期:1991-12-01 00:00:00
abstract::The purpose of this study was to compare fish intake and plasma phospholipid concentrations of n-3 fatty acids, in particular of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), among representative population samples of Québecers, James Bay Cree, and Inuit of Nunavik (Canada). The relationships between the...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-003-1070-4
更新日期:2003-04-01 00:00:00
abstract::Factors involved in reduced glutathione (GSH) and vitamin E-mediated inhibition of NADPH-dependent rat liver microsomal lipid peroxidation were examined. Lipid peroxidation was monitored over a time-course of 180 min by thiobarbituric acid reactive product formation. The addition of 5 mM GSH to the reaction system con...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02544533
更新日期:1989-11-01 00:00:00
abstract::In offspring exposed in utero to a maternal diet high in fat (HF), we have previously demonstrated that despite similar birth weights, HF adult offspring at 6 months of age had significantly higher body weights, greater adiposity, and increased triacylglycerol (TAG) levels as compared to controls. We hypothesized that...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-015-4018-8
更新日期:2015-06-01 00:00:00
abstract::Two electrophoretically different forms of sterol ester hydrolase (EC 3.1.1.13) were obtained from the cytoplasmic extract of the mycelia of Fusarium oxysporum. The entities, estimated at 60,000 (I) and 15,000 (II) molecular weights, were obtained in Sephadex G100 column chromatography of the ammonium sulfate precipit...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535686
更新日期:1981-02-01 00:00:00
abstract::[1-14C]alpha-Linolenic acid was incubated with a particulate fraction of homogenate of leaves of the meadow buttercup (Ranunculus acris L.). The main product was a divinyl ether fatty acid, which was identified as 12-[1'(Z),3'(Z)-hexadienyloxy]-9(Z),11(E)-dodecadienoic acid. Addition of glutathione peroxidase and redu...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-998-0306-7
更新日期:1998-11-01 00:00:00
abstract::One of the main biological systems that can be used as a model for studying the molecular mechanisms involved in membrane fusion is the formation of the nuclear envelope (NE). NE assembly to form the male pronucleus at fertilization occurs by binding of NE membrane precursor vesicles to chromatin and their fusion. MV1...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5045-2
更新日期:2006-10-01 00:00:00
abstract::The anesthetic potency of four derivatives of n-octane was measured by tadpole righting reflex and expressed as effective millimolar concentration of drug in membrane, EDM50. Potency diminished (ED50 increased) in this order: 1-octanol, EDM50 = 5.5; 1-(2-methoxyethoxy)octane, EDM50 = 28; 1-methoxyoctane, EDM50 = 61; a...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534936
更新日期:1986-06-01 00:00:00
abstract::A recent study on the metabolism of 1-14C-alpha-linolenic acid in the guinea pig revealed that the fur had the highest specific activity of all tissues examined, 48 h after dosing. The present study investigated the pattern of tissue lipid labeling following an oral dose of 1-14C-linoleic acid after the animals had be...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-001-0715-7
更新日期:2001-03-01 00:00:00
abstract::In this study, we investigated the effect of various types of fats on heart lipid peroxidation status and on blood lipid parameters. Rats were fed either a low-fat diet (2.2% lard plus 2.2% corn oil), a corn oil diet (17%), a salmon oil diet (12.5%) supplemented with 4.5% corn oil, or a lard diet (15%) supplemented wi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535232
更新日期:1989-03-01 00:00:00
abstract::Apolipoprotein (apoB) plays a fundamental role in the transport and metabolism of plasma triacylglycerols (TAGs) and cholesterol. Several apoB polymorphic sites have been studied for their potential use as markers for coronary heart disease in the population. In view of the importance of apoB in postprandial metabolis...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-007-3027-7
更新日期:2007-03-01 00:00:00
abstract::Polar lipids of bacteria from the class Thermomicrobia are known to contain long-chain 1,2-diols instead of glycerol, although the nature of polar head groups has not been investigated. We have studied phospholipid classes of two species from the class Thermomicrobia-Sphaerobacter thermophilus and Thermomicrobia sp. W...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3979-3
更新日期:2015-03-01 00:00:00
abstract::This review covers the work of our laboratory on the antineoplastic activity of some ether lipids and derivatives that are related to platelet-activating factor (PAF). Various 1-O-alkyl lysophospholipid derivatives (ALP) show therapeutic activity in mouse transplant tumor models and in metastatic 3-Lewis lung carcinom...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02535567
更新日期:1987-11-01 00:00:00
abstract::It has been shown that different lysophosphatidylcholines (LPC) possess relaxing properties in vascular strips. We report on the effect of intraatrial injection of LPC micelles into white New Zealand rabbits. Changes in renal and coronary flow were determined by radioactive microspheres. Coronary blood flow increased ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02543975
更新日期:1991-03-01 00:00:00
abstract::Plant sterols were found by gas liquid chromatography in the sterols of five species of aquatic vertebrates; mackerel (Scomber japonicus), rainbow trout (Salmo gairdnerii), smelt (Osmerus dentex), sardine (Sardinops melanosticta) and chimera (Chimera phantasma). The sterols of chimera liver, sardine flesh and sardine ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533558
更新日期:1979-01-01 00:00:00
abstract::The rare phospholipid fatty acids 3,7,11-trimethyldodecanoic (1), 5,9-hexadecadienoic (2) and 12-methyl-hexadecanoic (3) were identified in the marine spongeXestospongia muta. Branched fatty acids inX. muta accounted for 35% of the total fatty acid mixture. It was observed that the occurrence of the 5,9-hexadecadienoi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535668
更新日期:1988-07-01 00:00:00
abstract::The molecular species in mixtures of phospholipid hydroperoxides are difficult to separate and identify by typical chromatographic and mass spectrometric techniques. As reported by Havrilla and coworkers, silver ion coordination ion-spray mass spectrometry (CIS-MS) has proven to be a powerful technique for the identif...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-001-0841-2
更新日期:2001-11-01 00:00:00
abstract::The activity of the platelet-activating factor (PAF)-synthesizing enzyme, 1-O-alkyl-sn-glycero-3-phosphocholine (lysoPAF):acetyl-CoA acetyltransferase (EC 2.3.1.67) in alveolar macrophage lysate was found to be elevated after warming the cells to 37 degrees C. Such an increase in enzyme activity was detectable only wh...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535968
更新日期:1991-11-01 00:00:00
abstract::The initial steps in the autoxidation of CLA methyl ester are poorly understood. The aim of this study was to determine the stereochemistry of the hydroperoxides formed during autoxidation of CLA methyl ester in the presence of a good hydrogen atom donor. For this purpose, 9-cis,11-trans CLA methyl ester was autoxidiz...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-002-0929-8
更新日期:2002-06-01 00:00:00
abstract::This work reports the effect of the apolipoproteins A-I and A-II (apoA-I and apoA-II) on the release of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-8, and IL-1 receptor antagonist (IL-1Ra) and on the oxidative burst of human neutrophils. By themselves, apoA-I and apoA-II do not affect the basal liber...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-002-0981-4
更新日期:2002-09-01 00:00:00
abstract::The composition of the glycosphingolipids of the human gastrointestinal tract was studied. The major neutral glycosphingolipids were ceramide monohexosides (e.g., GalCer, GlcCer), LacCer, Gb3Cer, Gb4Cer and more polar ones with more than four sugars, whereas neither Gg3Cer nor Gg4Cer were present. The acidic glycosphi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535996
更新日期:1993-08-01 00:00:00
abstract::Serum high density lipoprotein is increasingly recognized as a negative risk for cardiovascular disease. The distribution and interrelationship of serum lipids, lipoproteins, anthropometric measurements and blood pressures were determined in some 5,000 children. Children had mean +/- S.D. alpha-lipoprotein cholesterol...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533576
更新日期:1979-01-01 00:00:00
abstract::The schweinfurthins have potent antiproliferative activity in multiple glioblastoma multiforme (GBM) cell lines; however, the mechanism by which growth is impeded is not fully understood. Previously, we demonstrated that the schweinfurthins reduce the level of key isoprenoid intermediates in the cholesterol biosynthet...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-015-4083-z
更新日期:2015-12-01 00:00:00
abstract::The growth inhibitory effects of 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine (ET-18-OCH3) and various liposome compositions of ET-18-OCH3 were compared in a standardized growth inhibition assay utilizing a diverse tumor cell line panel including cell lines expressing multidrug resistance. ET-18-OCH3 and ELL-1...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-997-0135-8
更新日期:1997-10-01 00:00:00
abstract::Plasma fatty acid (FA) composition is known to be an indicator of dietary fat quality, but the associations of other dietary factors with plasma FA composition remain unknown in children. We investigated the cross-sectional associations of food consumption with the proportions of FA and estimated desaturase activities...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3894-7
更新日期:2014-05-01 00:00:00
abstract::The effect of age and dietary fat type on tocopherol status was investigated using young and old C57BL/6Nia mice fed semipurified diets containing 5% (by weight) fish, corn or coconut oils and supplemented with 30, 100 or 500 ppm dl-alpha-tocopheryl acetate for 6 wk. Tocopherol levels in the diets, plasma, liver, kidn...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534004
更新日期:1987-05-01 00:00:00
abstract::Material dealing with the chemistry, biochemistry, and biological activities of oxysterols is reviewed for the period 1987-1995. Particular attention is paid to the presence of oxysterols in tissues and foods and to their physiological relevance. ...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02522641
更新日期:1996-05-01 00:00:00
abstract::Male Sprague-Dawley rats were fed diets for 1 or 16 weeks, containing 20% by weight vegetable oils differing widely in their oleic, linoleic and linolenic acid content. No significant changes were observed in the level of the cardiac lipid classes. The fatty acid composition of the 2 major phospholipids, phosphatidylc...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534015
更新日期:1980-09-01 00:00:00
abstract::The diglyceride species of phosphatidylcholines from livers of male rats after treatment of the animals with ethionine (1 mg/g divided among 4 doses 2 hr apart), phenobarbital (80 mg/kg each day for 3 days), or a combination of the two drugs were determined using gas chromatography. Ethionine treatment greatly elevate...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533307
更新日期:1977-11-01 00:00:00
abstract::The tail gland of the red fox (Vulpes vulpes) secretes lipids containing volatile terpenes used in social communication. We have analysed lipids extracted from fur of the tail gland, body (flanks) and muzzle of foxes. GC-MS showed a novel group of iso-valerate and tiglate monoesters of alkane-1,2-diols (C18:0-22:0). T...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-017-4270-1
更新日期:2017-07-01 00:00:00