Abstract:
:In this study, we investigated the effect of various types of fats on heart lipid peroxidation status and on blood lipid parameters. Rats were fed either a low-fat diet (2.2% lard plus 2.2% corn oil), a corn oil diet (17%), a salmon oil diet (12.5%) supplemented with 4.5% corn oil, or a lard diet (15%) supplemented with 2% corn oil. All diets were supplemented with 1% cholesterol. Rats were fed for eight weeks. When compared with the low-fat diet, the salmon oil-diet intake resulted in a lower blood cholesterol, triglyceride and phospholipid concentrations (-50, -56 and -30%, respectively). Corn oil only tended to lower blood lipids; this decrease was significant for triglycerides only (-40%). The hypocholesterolemic effect of salmon oil diet is even more pronounced, if blood cholesterol values are compared with those of rats fed the lard diet. Heart lipid composition was not affected by dietary manipulations. Fatty acid composition of cardiac phosphatidylcholines and phosphatidylethanolamines, however, were altered by high-fat diets. In phosphatidylcholine, salmon oil induced a twelvefold decrease in the n-6/n-3 ratio and a 26% increase in the unsaturation index. For phosphatidylethanolamine, the n-6/n-3 ratio decreased 7.7-fold and the unsaturation index increased by 13%. A 50% decrease of the n-6/n-3 ratio was observed in animals fed the lard diet. Ultramicroscopic examination of ventricles revealed that those of the salmon oil group significantly accumulated lipofuscin-like or ceroid material, whereas this accumulation was barely detectable in hearts of the other groups.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Lipidsjournal_title
Lipidsauthors
Nalbone G,Leonardi J,Termine E,Portugal H,Lechene P,Pauli AM,Lafont Hdoi
10.1007/BF02535232subject
Has Abstractpub_date
1989-03-01 00:00:00pages
179-86issue
3eissn
0024-4201issn
1558-9307journal_volume
24pub_type
杂志文章相关文献
LIPIDS文献大全abstract::The objective of this study was to establish the impact of caloric restriction on high fat diet-induced alterations on regulators of skeletal muscle growth. We hypothesized that caloric restriction would reverse the negative effects of high fat diet-induced obesity on REDD1 and mTOR-related signaling. Following an ini...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-016-4168-3
更新日期:2016-08-01 00:00:00
abstract::Commercial preparations of Candida rugosa lipase (CRL) are mixtures of lipase isoforms used for the hydrolysis and synthesis of various esters. The presence of variable isoforms and the amount of lipolytic protein in the crude lipase preparations lead to a lack of reproducibility of biocatalytic reactions. Purificatio...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-004-1258-7
更新日期:2004-06-01 00:00:00
abstract::Experimental studies have suggested an important role of the spleen in lipid metabolism, although with controversial results. Our purpose was to analyze the effect of a nutritionally balanced (NB) diet and a diet containing pork fat (PF) as source of lipids on the lipid profile of rats submitted to splenic surgery. Si...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-009-3302-x
更新日期:2009-06-01 00:00:00
abstract::Dietary fat and abnormal production of various prostanoids have been linked to various disease states of the large bowel, including cancer of the colon. Studies were conducted to determine the effect of dietary fat (beef tallow or corn oil) on the lipid composition and prostanoid production of the murine colon. Female...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537344
更新日期:1988-04-01 00:00:00
abstract::To test the effects of eicosapentaenoic acid (EPA) infusion on pulmonary edema induced by coronary ligation and reperfusion, extravascular lung water (EVLW) was measured in situ by the thermal-dye double indicator dilution method in dogs. In the control group of five dogs, 30 mL of a 10% soybean oil emulsion was infus...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-997-0015-2
更新日期:1997-01-01 00:00:00
abstract::In view of the findings that omega 3 fatty acids inhibit the synthesis of prostaglandins (PG) from arachidonic acid (20:4 omega 6) and that among immunologically active cells, the macrophage is a major producer of PG, we undertook a study of the effect of dietary alpha-linolenic acid (18:3 omega 3) on PG synthesis in ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535390
更新日期:1983-08-01 00:00:00
abstract::The rare phospholipid fatty acids 3,7,11-trimethyldodecanoic (1), 5,9-hexadecadienoic (2) and 12-methyl-hexadecanoic (3) were identified in the marine spongeXestospongia muta. Branched fatty acids inX. muta accounted for 35% of the total fatty acid mixture. It was observed that the occurrence of the 5,9-hexadecadienoi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535668
更新日期:1988-07-01 00:00:00
abstract::The proximate and fatty acid compositions of the commercially important fish species (Engraulis encrasicolus, Alosa alosa, Belone belone, Scorpaena porcus, Pomatomus saltatrix, Mullus barbatus) from the Sinop region of the Black Sea were examined. The fat contents ranged from 1.26% (for scorpion fish) to 18.12% (for s...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-012-3658-1
更新日期:2012-06-01 00:00:00
abstract::Decreased triacylglycerol synthesis within hepatocytes due to decreased diacylglycerol acyltransferase (DGAT) activity has been suggested to be an important mechanism by which diets rich in fish oil lower plasma triacylglycerol levels. New findings suggest that eicosapentaenoic acid (EPA), and not docosahexaenoic acid...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-999-0445-x
更新日期:1999-09-01 00:00:00
abstract::Plasma phospholipid transfer protein (PLTP) mediates both net transfer and exchange of phospholipids between different lipoproteins. Animal studies have shown that it is closely related to the development of atherosclerosis. Although many studies have indicated that PLTP activity is increased in diabetes mellitus, the...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-010-3384-5
更新日期:2010-02-01 00:00:00
abstract::A new triterpene alcohol was isolated fron shea butter and its structure was shown to be 24-methylenelanost-9(11)-en-3beta-ol. Gas chromatographic correlations between this triterpene alcohol and other related compounds are discussed. ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532428
更新日期:1975-08-01 00:00:00
abstract::The aim of this study was to develop a simple method for simultaneous determination of selected cis/cis PUFA-LNA (18:2), ALA (18:3), GLA (18:3), EPA (20:5), and DHA (22:6) by silver ion high-performance liquid chromatography coupled to a diode array detector (Ag-HPLC-DAD). The separation was performed on three Luna SC...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-016-4133-1
更新日期:2016-04-01 00:00:00
abstract::Lecithin-cholesterol acyltransferase (LCAT, EC 2.3.1.43) was assayed in vitro in plasma from normal man, rat, rabbit and dog by following the formation of 14C-cholesteryl esters subsequent to labeling the plasma with 14C-cholesterol in vitro. In all species examined, various local anesthetics were found to inhibit LCA...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534370
更新日期:1980-10-01 00:00:00
abstract::A simple and sensitive method to analyze mixtures of desmosterol, 7-dehydrocholesterol and cholesterol is described. The method involves the oxidative conversion of the sterols with cholesterol oxidase, followed by high performance liquid chromatographic (HPLC) analysis. A C18 reversed phase column (3 microns, 75 X 4....
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535083
更新日期:1989-07-01 00:00:00
abstract::The anesthetic potency of four derivatives of n-octane was measured by tadpole righting reflex and expressed as effective millimolar concentration of drug in membrane, EDM50. Potency diminished (ED50 increased) in this order: 1-octanol, EDM50 = 5.5; 1-(2-methoxyethoxy)octane, EDM50 = 28; 1-methoxyoctane, EDM50 = 61; a...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534936
更新日期:1986-06-01 00:00:00
abstract::In the present study, the structural characteristics that impart antibacterial activity to C16 alkynoic fatty acids (aFA) were further investigated. The syntheses of hexadecynoic acids (HDA) containing triple bonds at C-3, C-6, C-8, C-9, C-10, and C-12 were carried out in four steps and with an overall yield of 34-78%...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1002/lipd.12213
更新日期:2020-03-01 00:00:00
abstract::Epoxidation of the double bond in methyl oleate, octadec-11E-en-9-ynoate, ricinoleate (12-hydroxy-octadec-9Z-enoate), iso-ricinoleate (9-hydroxy-octadec-12Z-enoate), and 12-oxo-octadec-9Z-enoate with potassium peroxomonosulfate (oxone, 2 KHSO5.KHSO4.K2SO4) in the presence of trifluoroacetone or methyl pyruvate gave th...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-998-0250-6
更新日期:1998-06-01 00:00:00
abstract::The effects of hyper- and hypothyroidism on enzyme activities involved in phospholipid metabolism in the rat liver were studied. Hyperthyroidism significantly decreases activities of both microsomal acyl-CoA:glycero-3-phosphate acyltransferase (GPAT) (34%, p less than 0.01) and microsomal acyl-CoA:1-acylglycero-3-phos...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534774
更新日期:1985-12-01 00:00:00
abstract::A fast and efficient shotgun lipidomics strategy was applied to analyze phospholipids (PL) in the oyster Crassostrea plicatula, including 29 species of phosphatidylcholine (PtdCho), 23 species of phosphatidylethanolamine (PtdEtn), 11 species of phosphatidylserine (PtdSer), 6 species of phosphatidylinositol (PtdIns), a...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-017-4305-7
更新日期:2017-12-01 00:00:00
abstract::Normal phase high performance liquid chromatography methods are described for the separation of neutral lipid, fatty acid and five phospholipid classes using spectrophotometric detection at 206 nm. Separations were accomplished in less than 10 min for each lipid class. A mobile phase consisting of hexane/methyltertiar...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535282
更新日期:1988-12-01 00:00:00
abstract::The objective of the present study was to investigate the effect of three modified milk fats with different melting profiles on fasting and postprandial lipid responses and on fecal fat content in guinea pigs. We hypothesized that the consumption of modified milk fat with a high m.p. results in reduced fasting and pos...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-004-1320-5
更新日期:2004-10-01 00:00:00
abstract::Dysregulation of adipokines is a hallmark of obesity. Polyunsaturated fatty acids in fish oil may exert anti-inflammatory effects on adipose tissue mitigating the dysregulation of adipokines thereby preventing obesity. This study investigated the effects of high-fat diets containing different amounts of n3 polyunsatur...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-015-4093-x
更新日期:2016-05-01 00:00:00
abstract::Flaxseed derivatives, including both oil and flax lignan, modify progression of renal injury in animal models, including Han:SPRD-cy polycystic kidney disease (PKD). Gender is a significant factor in the rates of progression of many forms of human renal disease, but the role of gender in the response to nutrition inte...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5064-z
更新日期:2006-12-01 00:00:00
abstract::Peroxisome proliferator-activated receptor alpha (PPARalpha) belongs to the nuclear receptor superfamily that regulates multiple target genes involved in lipid metabolism. Cholesterol ester transfer protein (CETP) is a secreted glycoprotein that modifies high-density lipoprotein (HDL) particles. In humans, plasma CETP...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3187-0
更新日期:2008-07-01 00:00:00
abstract::Two new fatty acid metabolites, 5(Z),7(E),9(E),14(Z),17(Z)-icosapentaenoic acid and 5(E),7(E),9(E),14(Z),17(Z)-icosapentaenoic acid, have been isolated from the temperate red marine alga, Ptilota filicina (Ceramiales, Rhodophyta). The structures of these new compounds, isolated as their methyl ester derivatives, have ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537301
更新日期:1987-03-01 00:00:00
abstract::The schweinfurthins have potent antiproliferative activity in multiple glioblastoma multiforme (GBM) cell lines; however, the mechanism by which growth is impeded is not fully understood. Previously, we demonstrated that the schweinfurthins reduce the level of key isoprenoid intermediates in the cholesterol biosynthet...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-015-4083-z
更新日期:2015-12-01 00:00:00
abstract::Triglycerides from normal liver, host liver, and heptoma of rats maintained on chow and fat-free diets were subjected to sterospecific analysis. Normal and host liver triglycerides from animals on the same diet did not exhibit significant differences. Fat-free diet reduced polyunsaturated fatty acids in normal and i...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532444
更新日期:1975-07-01 00:00:00
abstract::The beneficial roles of dietary fish oil in lowering serum TAG levels in animals and humans have been attributed in part to the high content of two n-3 polyunsaturated very long-chain FA, EPA, and DHA. Recent studies show that EPA induces mitochondrial beta-oxidation in hepatocytes, which might contribute to the syste...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1443-8
更新日期:2005-08-01 00:00:00
abstract::A protocol using a dry column method was modified for the extraction of total lipids and the simultaneous separation and quantitation of neutral and polar lipids in human milk. The triacylglycerol, cholesterol, phospholipid and vitamin E contents of the lipid extracts were determined and compared with lipids extracted...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535216
更新日期:1989-08-01 00:00:00
abstract::Plasma lipidomic studies using high performance liquid chromatography and mass spectroscopy offer detailed insights into metabolic processes. Taking the example of the most abundant plasma lipid class (phosphatidylcholines) we used the rich phenotypic and lipidomic data from the ongoing San Antonio Family Heart Study ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-013-3781-7
更新日期:2013-05-01 00:00:00