Abstract:
:[1-14C]alpha-Linolenic acid was incubated with a particulate fraction of homogenate of leaves of the meadow buttercup (Ranunculus acris L.). The main product was a divinyl ether fatty acid, which was identified as 12-[1'(Z),3'(Z)-hexadienyloxy]-9(Z),11(E)-dodecadienoic acid. Addition of glutathione peroxidase and reduced glutathione to incubations of alpha-linolenic acid almost completely suppressed formation of the divinyl ether acid and resulted in the appearance of 13(S)-hydroxy-9(Z), 11(E),15(Z)-octadecatrienoic acid as the main product. This result, together with the finding that 13(S)-hydroperoxy-9(Z), 11(E),15(Z)-octadecatrienoic acid served as an efficient precursor of the divinyl ether fatty acid, indicated that divinyl ether biosynthesis in leaves of R. acris occurred by a two-step pathway involving an omega6-lipoxygenase and a divinyl ether synthase. Incubations of isomeric hydroperoxides derived from alpha-linolenic and linoleic acids with the enzyme preparation from R. acris showed that 13(S)-hydroperoxy-9(Z),11(E)-octadecadienoic acid was transformed into the divinyl ether 12-[1'(Z)-hexenyloxy]-9(Z), 11(E)-dodecadienoic acid. In contrast, neither the 9(S)-hydroperoxides of linoleic or alpha-linolenic acids nor the 13(R)-hydroperoxide of alpha-linolenic acid served as precursors of divinyl ethers.
journal_name
Lipidsjournal_title
Lipidsauthors
Hamberg Mdoi
10.1007/s11745-998-0306-7subject
Has Abstractpub_date
1998-11-01 00:00:00pages
1061-71issue
11eissn
0024-4201issn
1558-9307journal_volume
33pub_type
杂志文章相关文献
LIPIDS文献大全abstract::Potato tuber lipoxygenase (ptLOX) has been shown to catalyze the aerobic formation of at least four major oxygenated derivatives of DHA. Two of the products--7,17(S)- and 10,17(S)-dihydro(pero)xy-DHA [7,17- and 10,17-diH(P)DHA]--were formed from soybean 15-LOX-derived 17(S)-hydro(pero)xy-DHA [17(S)-H(P)DHA], whereas t...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1379-z
更新日期:2005-03-01 00:00:00
abstract::The amount and composition of lysophosphatidate present in different rat tissues have been estimated by an internal standard method in which a synthetic unnatural isomer (1-heptadecanoyl-rac-glycerol-3-phosphate) was added to the total lipid extracts, and the fatty acid composition of purified lysophosphatidate was de...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535172
更新日期:1989-04-01 00:00:00
abstract::Neutral glycolipids (NGL) are promising diagnostic markers of human gliomas, but differences in NGL with age and sex have not been examined. Previous work demonstrated that ceramide dihexosides (CDH) levels in mouse kidney are age- and sex-dependent, probably due to levels of sex hormones. We quantitated CDH in 181 hu...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-999-330-7
更新日期:1999-01-01 00:00:00
abstract::Feline omental lipid extracts, previously reported to be angiogenic in the cornea of rabbits, were fractionated and the major lipid components characterized. Approximately 97% of the chloroform/methanol extract consisted of triglycerides containing primarily 16:0, 18:0, 18:1 and 18:2 fatty acids. Trace quantities of f...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533984
更新日期:1987-04-01 00:00:00
abstract::Studies are reported on the capacity of isolated rat renal papilla (inner medulla) to synthesize and release prostaglandin (PG) E from endogenous and exogenous precursor(s) during development of an essential fatty acid (EFA) deficiency in the rat. Weanling (21-day-old) male Sprague-Dawley rats were fed a fat-free diet...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533845
更新日期:1978-12-01 00:00:00
abstract::Sterols, which are biosynthesized via the cytoplasmic mevalonate (MVA) pathway, are important structural components of the plasma membrane and precursors of steroid hormones in both vertebrates and plants. Ergosterol and cholesterol are the major sterols in yeast and vertebrates, respectively. In contrast, plants prod...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-006-1000-5
更新日期:2007-02-01 00:00:00
abstract::The alk-1-enyl group of 1-alk-1(1)-enyl-2-acyl-glycerophospholipids (plasmalogens) rapidly combines with mercuric chloride. At 0 C, there was a 1:1 stoichiometry for Hg binding to the reactive enol group of plasmalogens. Aldehydes were not released, indicating that the alkenyl ether bond was not cleaved. Hg binding to...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535374
更新日期:1982-09-01 00:00:00
abstract::Sphingomyelin was isolated from cysts of the brine shrimp Artemia franciscana using QAE-Sephadex A25, Florisil and Iatrobeads column chromatographies. The chemical structure was identified using thin-layer chromatography, gas-liquid chromatography, infrared spectroscopy and matrix-assisted laser desorption ionization ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-010-3438-8
更新日期:2010-07-01 00:00:00
abstract::Oxidized low density lipoprotein (Ox-LDL) is a well-established risk factor in atherosclerosis and lysophosphatidylcholine (LysoPtdCho) is considered to be one of the major atherogenic component of Ox-LDL. The purpose of this work was to investigate the effects of two membrane n-3 long chain polyunsaturated fatty acid...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-009-3284-8
更新日期:2009-03-01 00:00:00
abstract::Liver fatty-acid-binding protein (FABP1, L-FABP) is the major cytosolic binding/chaperone protein for both precursor arachidonic acid (ARA) and the endocannabinoid (EC) products N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG). Although FABP1 regulates hepatic uptake and metabolism of ARA, almost not...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1002/lipd.12071
更新日期:2018-06-01 00:00:00
abstract::N6 -methyladenosine (m6 A) regulates gene expression and affects cellular metabolism. In this study, we checked whether the regulation of lipid metabolism by curcumin is associated with m6 A RNA methylation. We investigated the effects of dietary curcumin supplementation on lipopolysaccharide (LPS)-induced liver injur...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1002/lipd.12023
更新日期:2018-01-01 00:00:00
abstract::This is the first report of stereospecific analyses of plant triglycerides isolated from seeds of distinct genotypes rather than from commerically refined oils. Triglycerides from six maize inbreds were analyzed. The strains exhibited a wide range of fatty acid compositions (palmitic acid 7.8-19.1%, oleic acid 17.0-43...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02531130
更新日期:1971-08-01 00:00:00
abstract::The pulp from unerupted calves' teeth was found to contain low levels of glycerol ester hydrolase activity. Solutions in Tris buffer cleared tributyrylglycerol agar and hydrolyzed emulsified olive oil. The average quantity of free fatty acids released in five assays with olive oil was: 2.8, S.D.+/-1.4. Specific activi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533302
更新日期:1977-02-01 00:00:00
abstract::A pilot study was undertaken to determine if moderate changes in linoleate (18:2 omega 6) intake would modulate the prostaglandin E turnover concurrently with, or independently of, changes in the plasma prostaglandin (PG) precursor levels. Four adult male volunteers in good health were fed two controlled diets contain...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534258
更新日期:1985-05-01 00:00:00
abstract::Strong perturbation of the ultraviolet spectrum of the tyrosines of porcine pancreatic colipase A is observed in the presence of Triton X-100 at concentration above the critical micellar concentration. Spectrophotometric titration of the phenolic groups of the protein shows that the apparent pKa value for two tyrosine...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534109
更新日期:1980-01-01 00:00:00
abstract::In a search for a preferred source of gamma-linolenic (all-cis-6,9,12-octadecatrienoic) acid, seed oils of 33 species of Boraginaceae were examined. The desired triene was found primarily in the subfamily Boraginoideae in amounts ranging from 0.2 to 18%. Oils of this subfamily also contain 0.2 to 15% of the tetraene, ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02530967
更新日期:1968-01-01 00:00:00
abstract::The importance of n-6 and n-3 polyunsaturated fatty acids (PUFA) in neonatal development, particularly with respect to the developing brain and retina, is well known. This review combines recent information from basic science and clinical studies to highlight recent advances in knowledge on PUFA metabolism and areas w...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-999-0348-x
更新日期:1999-02-01 00:00:00
abstract::An improved headspace capillary gas chromatographic (GC) method was developed to measure the oxidative susceptibility of human red blood cell (RBC) membranes. This method analyzed volatile peroxidation products of both n-6 (hexanal and pentane) and n-3 (propanal) polyunsaturated fatty acids. Oxidative susceptibility t...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536076
更新日期:1991-06-01 00:00:00
abstract::The purpose of these experiments was to study the uptake and metabolism of exogenous triglyceride in the isolated perfused rabbit heart. When infused into the rabbit heart, [9,10-3H(N)]triolein was retained and incorporated into a lipid fraction that had the chromatographic mobility of authentic triolein. Incorporatio...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02538094
更新日期:1990-08-01 00:00:00
abstract::All fatty acids have important functions, but the term "essential" is applied only to those polyunsaturated fatty acids (PUFA) that are necessary for good health and cannot be completely synthesized in the body. The need for arachidonic acid, which is utilized for eicosanoid synthesis and is a constituent of membrane ...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02562220
更新日期:1999-01-01 00:00:00
abstract::The catfish, Ictalurus punctatus, is an important model for studying the biochemical mechanisms of taste at the peripheral level. The type, amount and metabolic activity of the lipids within this tissue play important roles in taste transduction by forming the matrix in which the receptors for taste stimuli are imbedd...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535745
更新日期:1990-04-01 00:00:00
abstract::Bioassay-guided fractionation of a collection of Moorea bouillonii from Papua New Guinea led to the isolation of a new alkyl amide, mooreamide A (1), along with the cytotoxic apratoxins A-C and E. The planar structure of 1 was elucidated by NMR spectroscopy and mass spectrometry analysis. Structural homology between m...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3949-9
更新日期:2014-11-01 00:00:00
abstract::The enzyme(s) present in acetonedried powder of rat and rabbit aortas, which catalyzes the synthesis and hydrolysis of cholesteryl ester, was purified partially by acid precipitation, acetone fractionation, O-(diethylaminoethyl) cellulose chromatography, and Sephadex G-100 filtration. The synthetic activity was purifi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532453
更新日期:1975-06-01 00:00:00
abstract::Apolipoprotein (apoB) plays a fundamental role in the transport and metabolism of plasma triacylglycerols (TAGs) and cholesterol. Several apoB polymorphic sites have been studied for their potential use as markers for coronary heart disease in the population. In view of the importance of apoB in postprandial metabolis...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-007-3027-7
更新日期:2007-03-01 00:00:00
abstract::The effect of hydroperoxy and hydroxy derivatives of various fatty acids on human platelet aggregation was determined to delineate potencies and structure-activity function. In this regard, the 22-carbon n-3 fatty acids are the most potent inhibitors in comparison to the n-6 lipoxygenase derivatives. Submicromolar lev...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02637097
更新日期:1996-03-01 00:00:00
abstract::The reaction products of alpha-tocopherol and its model compound, 2,2,5,7,8-pentamethylchroman-6-ol, during the autoxidation of methyl linoleate at 37 C were investigated. Two isomeric trimers were obtained as the major reaction products of alpha-tocopherol, and a trimer was obtained as that of its model chroman. The ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536221
更新日期:1988-08-01 00:00:00
abstract::Analysis of cheek cell lipids has been suggested as a noninvasive method for monitoring the fatty acid composition of diets in humans. In a pilot study conducted to determine the validity of the method, cheek cell samples were collected from subjects consuming a low fat (20% of calories) diet consisting of fatty acids...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535293
更新日期:1988-02-01 00:00:00
abstract::Trans FA (TFA) have at least one trans double bond and comprise several isomers and types, including many of the CLA (e.g., c9,t11-18:2 CLA). Some TFA may have adverse effects (e.g., cardiovascular disease), whereas some are thought to have beneficial effects (e.g., anticarcinogenicity). The presence of TFA in human t...
journal_title:Lipids
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11745-006-5082-x
更新日期:2006-02-01 00:00:00
abstract::Olive oil, a major component of the Mediterranean diet, has been associated in some small clinical trials and cross-sectional studies with a reduction in blood pressure. The objective of this study was to assess the association of olive oil consumption with the incidence of hypertension in an epidemiologic cohort, the...
journal_title:Lipids
pub_type: 临床试验,杂志文章
doi:10.1007/s11745-004-1352-x
更新日期:2004-12-01 00:00:00
abstract::Southern bluefin tuna (SBT, Thunnus maccoyii) aquaculture is a highly valuable industry, but research on these fish is hampered by strict catch quotas and the limited success of captive breeding. To address these limitations, we have developed a SBT cell line (SBT-E1) and here we report on fatty acid metabolism in thi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3910-y
更新日期:2014-07-01 00:00:00