Sex- and age-related differences in ceramide dihexosides of primary human brain tumors.

Abstract:

:Neutral glycolipids (NGL) are promising diagnostic markers of human gliomas, but differences in NGL with age and sex have not been examined. Previous work demonstrated that ceramide dihexosides (CDH) levels in mouse kidney are age- and sex-dependent, probably due to levels of sex hormones. We quantitated CDH in 181 human gliomas and found significant differences with sex and age, particularly menopause and male puberty. This emphasizes the importance of assessing results of studies on glycolipids in disease states with respect to age and sex in order to avoid erroneous conclusions concerning the relationship of glycolipid composition with diagnosis and pathogenesis.

journal_name

Lipids

journal_title

Lipids

authors

Yates AJ,Franklin TK,Scheithauer BW,Burger PC,Pearl DK

doi

10.1007/s11745-999-330-7

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

1-4

issue

1

eissn

0024-4201

issn

1558-9307

journal_volume

34

pub_type

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