A sardine oil-rich diet increases iron absorption but does not compensate the hypoferremia associated with inflammation.

Abstract:

:Inflammatory disorders are associated with a decrease in iron absorption because of the blockade of iron in storage organs. Fish oils, rich in n-3 PUFA, are used to prevent and treat inflammatory disorders and increase iron absorption in noninflamed rats. Here we examine whether n-3 PUFA prevent inflammation-related hypoferremia. Two groups of rats were fed isoenergetic semipurified diets (a standard diet and a sardine oil-rich diet). A carrageenan granuloma was induced in half of the rats of each dietary group. Ferrokinetic studies using 59Fe, hematological analyses, and iron store evaluation were performed in noninflamed and inflamed rats. Although dietary n-3 PUFA increased 59Fe absorption in carageenan-treated rats, they did not restore the hypoferremia associated with inflammation, which is due to several mechanisms. Among these mechanisms, the blockade of iron in storage organs is relevant. However, this blockade was less evident in the spleen of inflamed rats fed the sardine oil diet.

journal_name

Lipids

journal_title

Lipids

authors

Rodríguez MC,Sáiz MP,Mitjavila MT

doi

10.1007/s11745-003-1131-8

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

821-6

issue

8

eissn

0024-4201

issn

1558-9307

journal_volume

38

pub_type

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