Abstract:
:CLA has a range of biological properties, including effects on lipid metabolism and body composition in experimental animals. The prevalent isomer of CLA found in the human diet is 9c,11 t-CLA, and it is predominantly found in products containing fat from ruminant animals. This study investigated the effect of dietary CLA on energy balance in mice. Synthetic CLA reduced body fat in growing male BALB/c mice in a dose-dependent manner over the range 0.25-1.0% w/w CLA in the diet. Weight gain was also reduced at the highest levels of dietary CLA, being only 5.88 +/- 2.68 g/4 mice (mean +/- 1 SD) after 4 wk of 2.0% CLA in the diet, compared with weight gains of 7.51 +/- 2.22 to 8.17 +/- 2.34 g/4 mice in the 0-0.5% CLA groups. There was no significant effect on weight gain if diets contained 0.5% synthetic CLA or less. These results suggest that high levels of a synthetic mixture of CLA isomers modify energy metabolism and body composition and that high levels of synthetic CLA impair weight gain and reduce body fat pad mass in growing mice.
journal_name
Lipidsjournal_title
Lipidsauthors
Hayman A,MacGibbon A,Pack RJ,Rutherfurd K,Green JHdoi
10.1007/s11745-002-0950-ysubject
Has Abstractpub_date
2002-07-01 00:00:00pages
689-92issue
7eissn
0024-4201issn
1558-9307journal_volume
37pub_type
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