Abstract:
:In animals, non-sterol metabolites of the mevalonate pathway act independently from receptor-mediated cholesterol uptake in the multivalent feedback regulation of mevalonate biosynthesis. Studies leading to the isolation and characterization of plant-borne suppressors of mevalonate biosynthesis are reviewed. We propose that one cardio-protective component of the vegetarian diet consists of a variety of non-sterol, post-mevalonate metabolites. These products of plant branches of the mevalonate pathway, discarded as animals evolved, continue to influence animal sterol metabolism. It is through this action, we propose, that the cholesterol-suppressive action of plant materials is expressed.
journal_name
Lipidsjournal_title
Lipidsauthors
Qureshi AA,Burger WC,Peterson DM,Elson Cdoi
10.1007/BF02534407subject
Has Abstractpub_date
1985-11-01 00:00:00pages
817-24issue
11eissn
0024-4201issn
1558-9307journal_volume
20pub_type
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