Suppression of cholesterogenesis by plant constituents: review of Wisconsin contributions to NC-167.

Abstract:

:In animals, non-sterol metabolites of the mevalonate pathway act independently from receptor-mediated cholesterol uptake in the multivalent feedback regulation of mevalonate biosynthesis. Studies leading to the isolation and characterization of plant-borne suppressors of mevalonate biosynthesis are reviewed. We propose that one cardio-protective component of the vegetarian diet consists of a variety of non-sterol, post-mevalonate metabolites. These products of plant branches of the mevalonate pathway, discarded as animals evolved, continue to influence animal sterol metabolism. It is through this action, we propose, that the cholesterol-suppressive action of plant materials is expressed.

journal_name

Lipids

journal_title

Lipids

authors

Qureshi AA,Burger WC,Peterson DM,Elson C

doi

10.1007/BF02534407

subject

Has Abstract

pub_date

1985-11-01 00:00:00

pages

817-24

issue

11

eissn

0024-4201

issn

1558-9307

journal_volume

20

pub_type

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