Oxidized cholesterol modulates age-related change in lipid metabolism in rats.


:For three weeks, male Sprague-Dawley rats at either four weeks (young) or eight months (adult) of age were pair-fed one of the purified diets free of or containing either 0.2% of oxidized cholesterol mixture (cholesterol oxidation products) or 0.2% of cholesterol. Although the food intake was similar, dietary oxidized cholesterol lowered body weight gain in young rats, but did not increase relative liver weight, in contrast to the enlargement seen with dietary cholesterol. Oxidized cholesterol, compared to cholesterol, tended to reduce the activity of hepatic 3-hydroxy-3-methylglutaryl CoA reductase and cholesterol 7 alpha-hydroxylase, particularly the latter in aged rats, and prevented the rise in the concentration of liver cholesterol at both ages. It also tended to increase the activity of hepatic delta 6 desaturase, particularly in young rats. Moreover, oxidized cholesterol in relation to cholesterol influenced liver and serum lipid concentrations in different ways, and increased lipid peroxidation at both ages. The ratio of splenic CD4+/CD8+ T-lymphocytes increased with age, but the influence of cholesterol and oxidized cholesterol was comparable. Thus, oxidized cholesterol may specifically disturb growth and age-related changes in the lipid metabolism in rats.






Osada K,Kodama T,Noda S,Yamada K,Sugano M




Has Abstract


1995-05-01 00:00:00














  • A lack of correlation between linoleate and arachidonate in human breast milk.

    abstract::The levels of arachidonic acid and linoleic acid found in the lipid fraction of human milk samples were compared. No correlation was found between the level of precursor linoleate and product arachidonate in 80 samples of colostrum (day 3-5) or 60 samples of mature breast milk. We attempted to test the hypothesis that...


    pub_type: 杂志文章


    authors: Gibson RA,Kneebone GM

    更新日期:1984-06-01 00:00:00

  • The effect of conjugated linoleic acid isomers on fatty acid profiles of liver and adipose tissues and their conversion to isomers of 16:2 and 18:3 conjugated fatty acids in rats.

    abstract::Conjugated linoleic acid (CLA) is a collective term that describes different isomers of linoleic acid with conjugated double bonds. Although the main dietary isomer is 9cis,11trans-18:2, which is present in dairy products and ruminant fat, the biological effects of CLA generally have been studied using mixtures in whi...


    pub_type: 杂志文章


    authors: Sébédio JL,Angioni E,Chardigny JM,Grégoire S,Juanéda P,Berdeaux O

    更新日期:2001-06-01 00:00:00

  • Synthesis of a phosphatidyl derivative of vitamin E and its antioxidant activity in phospholipid bilayers.

    abstract::A novel phospholipid containing a chromanol structure at its polar head group was synthesized from egg yolk phosphatidylcholine and 2,5,7,8-tetramethyl-6-hydroxy-2-(hydroxyethyl)chroman by transphosphatidylation catalyzed by phospholipase D from Streptomyces lydicus. The structure of the product synthesized was shown ...


    pub_type: 杂志文章


    authors: Koga T,Nagao A,Terao J,Sawada K,Mukai K

    更新日期:1994-02-01 00:00:00

  • Kinetics of 14C distribution after tracer dose of 14C-lutein in an adult woman.

    abstract::Lutein is an oxygenated carotenoid (xanthophyll) found in dark green leafy vegetables. High intakes of lutein may lower the risk of age-related macular degeneration. Current understanding of human lutein metabolism as it might occur in vivo is incomplete. Therefore, we conducted a feasibility study where we dosed a no...


    pub_type: 杂志文章


    authors: de Moura FF,Ho CC,Getachew G,Hickenbottom S,Clifford AJ

    更新日期:2005-10-01 00:00:00

  • IgA immune aggregates stimulate platelet-activating factor and superoxide anion production by human neutrophils. A comparison with IgG aggregates.

    abstract::We have examined the possibility that human polymorphonuclear cells exposed to IgA immune complexes can mediate the production of platelet-activating factor (PAF) and oxygen radicals. We found that human IgA and IgG immune aggregates stimulated, to a similar extent, PAF and O2- production by human polymorphonuclear ce...


    pub_type: 杂志文章


    authors: Hernando P,Egido J,de Nicolas R,Gonzalez E

    更新日期:1991-12-01 00:00:00

  • Correcting the effects of -20 °C storage and aliquot size on erythrocyte fatty acid content in the Women's Health Initiative.

    abstract::Red blood cell (RBC) fatty acid (FA) patterns have been shown to predict risk for cardiovascular and other chronic diseases. As part of a project analyzing RBC samples from the Women's Health Initiative Memory Study (WHIMS) we observed implausibly low levels of highly unsaturated fatty acids (HUFA) suggestive of degra...


    pub_type: 杂志文章


    authors: Pottala JV,Espeland MA,Polreis J,Robinson J,Harris WS

    更新日期:2012-09-01 00:00:00

  • Delayed metabolism of postprandial triglyceride-rich lipoproteins in subjects with echolucent carotid plaques.

    abstract::Subjects with echolucent carotid plaques have an increased risk of ischemic cerebrovascular events independent of degree of stenosis. Low plasma lipoprotein lipase (LPL) activity promotes a proatherogenic lipid profile, and delayed chylomicron clearance is a risk factor for atherosclerosis. This study was conducted to...


    pub_type: 杂志文章


    authors: Notø AT,Mathiesen EB,Brox J,Björkegren J,Hansen JB

    更新日期:2008-04-01 00:00:00

  • Dynamic features of the rumen metabolism of linoleic acid, linolenic acid and linseed oil measured in vitro.

    abstract::The lipid quality of ruminant products is largely determined by the extent of rumen microbial biohydrogenation (BH) of polyunsaturated fatty acids (FAs) and the substances formed thereby. In vitro batch incubations with mixed rumen bacteria were tracked over 24 h to characterize the profiles and kinetics of the BH pro...


    pub_type: 杂志文章


    authors: Jouany JP,Lassalas B,Doreau M,Glasser F

    更新日期:2007-04-01 00:00:00

  • Stearic acid stimulates FA ethyl ester synthesis in HepG2 cells exposed to ethanol.

    abstract::FA ethyl esters (FAEE) are nonoxidative metabolites of ethanol produced by the esterification of FA and ethanol. FAEE have been implicated as mediators of ethanol-induced organ damage in vivo and in vitro, and are markers of ethanol intake. Upon ethanol intake, FAEE are synthesized in the liver and pancreas in signifi...


    pub_type: 杂志文章


    authors: Hasaba A,Cluette-Brown JE,Laposata M

    更新日期:2003-10-01 00:00:00

  • Interaction of porcine pancreatic colipase with a nonionic detergent, Triton X-100: spectrophotometric studies.

    abstract::Strong perturbation of the ultraviolet spectrum of the tyrosines of porcine pancreatic colipase A is observed in the presence of Triton X-100 at concentration above the critical micellar concentration. Spectrophotometric titration of the phenolic groups of the protein shows that the apparent pKa value for two tyrosine...


    pub_type: 杂志文章


    authors: Canioni P,Julien R,Rathelot J,Sarda L

    更新日期:1980-01-01 00:00:00

  • Epidermal growth factor modulates release of arachidonic acid from embryonic cells.

    abstract::The calcium ionophore A23187 stimulates release of free [3H]arachidonic acids from radiolabeled cultures of MEPM cells which are growing, but not from those which are confluent. However, when confluent MEPM cells are pretreated with EGF or PMA, release of [3H]arachidonic acids does occur in response to A23187. Since n...


    pub_type: 杂志文章


    authors: Chepenik KP

    更新日期:1989-09-01 00:00:00

  • Effect of peanut oil and randomized peanut oil on cholesterol and oleic acid absorption, transport, and distribution in the lymph of the rat.

    abstract::Peanut oil was shown to be atherogenic in cholesterol-fed rats, rabbits, and monkeys. However, after randomization, a process in which the fatty acids in peanut oil are randomly rearranged, its atherogenicity was significantly reduced in cholesterol-fed rabbits and monkeys. The mechanism for this effect remains unknow...


    pub_type: 杂志文章


    authors: Satchithanandam S,Flynn TJ,Calvert RJ,Kritchevsky D

    更新日期:1999-12-01 00:00:00

  • Changes in cultured arterial smooth muscle cells isolated from chicks upon cholesterol feeding.

    abstract::We have developed cultures of smooth muscle cells (SMC) isolated from arterial hypercholesterolemic chicks (cholesterol-SMC). These cultures are suitable for the study at the molecular level of the changes in arterial SMC induced by a cholesterol diet. By using a strong dose of cholesterol (5%) for 10 d, we obtained v...


    pub_type: 杂志文章


    authors: Carazo A,Alejandre J,Diaz R,Ríos A,Castillo M,Linares A

    更新日期:1998-02-01 00:00:00

  • Endurance training increases leptin expression in the retroperitoneal adipose tissue of rats fed with a high-sugar diet.

    abstract::The presence of leptin receptors in white adipose tissue (WAT) suggests a type of peripheral control during the development of obesity and other metabolic disorders. Both diet composition and exercise influence serum leptin; however, the effect of their combination on long-term WAT leptin metabolism is unknown. In thi...


    pub_type: 杂志文章


    authors: de Queiroz KB,Guimarães JB,Coimbra CC,Rodovalho GV,Carneiro CM,Evangelista EA,Guerra-Sá R

    更新日期:2014-01-01 00:00:00

  • Phospholipids from the free-living nematode Caenorhabditis elegans.

    abstract::The phospholipid and the fatty chain compositions of diacyl, alkylacyl and alkenylacyl glycerophospholipids of the free-living nematode, Caenorhabditis elegans, were investigated. The phospholipids were comprised of 54.5% ethanolamine glycerophospholipid (EGP), 32.3% choline glycerophospholipid (CGP), 8.1% sphingomyel...


    pub_type: 杂志文章


    authors: Satouchi K,Hirano K,Sakaguchi M,Takehara H,Matsuura F

    更新日期:1993-09-01 00:00:00

  • Regulatory function of pyruvate dehydrogenase and the mitochondrion in lipogenesis.

    abstract::The activity of pyruvate dehydrogenase from freshly isolated mitochondria was shown to be dependent upon the nutritional and metabolic state of the animal prior to sacrifice, such that mitochondria from the livers of 48 hr starved, diabetic, or high fat fed rats had lower enzyme activity than normal, chow fed rats. Th...


    pub_type: 杂志文章


    authors: Mapes JP,Harris RA

    更新日期:1975-12-01 00:00:00

  • A comparison of pyrrolidide and picolinyl ester derivatives for the identification of fatty acids in natural samples by gas chromatography-mass spectrometry.

    abstract::The pyrrolidide and picolinyl ester derivatives of the fatty acids in two natural lipid samples rich in unsaturated fatty acids, pig testis lipids and cod liver oil were satisfactorily resolved on capillary columns of fused silica coated with stationary phases of varying polarity. The picolinyl esters, in particular, ...


    pub_type: 杂志文章


    authors: Christie WW,Brechany EY,Johnson SB,Holman RT

    更新日期:1986-10-01 00:00:00

  • Human placental lipid metabolism. III. Synthesis and hydrolysis of phospholipids.

    abstract::Both diacyl GPC (glycerylphosphorylcholine) and diacyl GPE (glycerylphosphorylethanolamine) are synthesized in human placental tissue from their respective monoacyl precursors. The origin of the monacyl phosphatides is apparently not the result of placental phosphatide acyl-hydrolase activity. The most likely source i...


    pub_type: 杂志文章


    authors: Robertson A,Sprecher H

    更新日期:1967-09-01 00:00:00

  • Lysophosphatidylcholine acyltransferase activity in Saccharomyces cerevisiae: regulation by a high-affinity Zn2+ binding site.

    abstract::Saccharomyces cerevisiae cells were demonstrated to contain lysophosphatidylcholine (lysoPtdCho) acyltransferase (E.C. activity. The enzyme displayed Km(app) of 69 microM for lysoPtdCho and 152 microM for oleoyl CoA. Enzyme activity was not affected by the addition of 1 mM Mg2+, Mn2+, Ca2+, or 200 mM EDTA. H...


    pub_type: 杂志文章


    authors: Richard MG,McMaster CR

    更新日期:1998-12-01 00:00:00

  • Lipids of the Tail Gland, Body and Muzzle Fur of the Red Fox, Vulpes vulpes.

    abstract::The tail gland of the red fox (Vulpes vulpes) secretes lipids containing volatile terpenes used in social communication. We have analysed lipids extracted from fur of the tail gland, body (flanks) and muzzle of foxes. GC-MS showed a novel group of iso-valerate and tiglate monoesters of alkane-1,2-diols (C18:0-22:0). T...


    pub_type: 杂志文章


    authors: McLean S,Davies NW,Nichols DS

    更新日期:2017-07-01 00:00:00

  • The structure-activity relationship of lipoxygenase products of long-chain polyunsaturated fatty acids: effects on human platelet aggregation.

    abstract::The effect of hydroperoxy and hydroxy derivatives of various fatty acids on human platelet aggregation was determined to delineate potencies and structure-activity function. In this regard, the 22-carbon n-3 fatty acids are the most potent inhibitors in comparison to the n-6 lipoxygenase derivatives. Submicromolar lev...


    pub_type: 杂志文章


    authors: Karanian JW,Kim HY,Salem N Jr

    更新日期:1996-03-01 00:00:00

  • Conjugated linoleic acid isomers reduce cholesterol accumulation in acetylated LDL-induced mouse RAW264.7 macrophage-derived foam cells.

    abstract::Synthetic activators of peroxisome proliferator-activated receptors (PPAR)-alpha and -gamma are capable of reducing macrophage foam cell cholesterol accumulation through the activation of genes involved in cholesterol homeostasis. Since conjugated linoleic acids (CLA) were also demonstrated to activate PPARalpha and P...


    pub_type: 杂志文章


    authors: Ringseis R,Wen G,Saal D,Eder K

    更新日期:2008-10-01 00:00:00

  • Monitoring the oxidation of docosahexaenoic acid in lipids.

    abstract::The oxidation of free DHA, DHA mixed with PC, and DHA incorporated into PC, PE, or TG was evaluated to determine which lipid provided DHA with the best protection against oxidation. DHA was either situated at the sn-1 position, sn-2 position, or both positions of the phospholipid, whereas the TG contained DHA at all p...


    pub_type: 杂志文章


    authors: Lyberg AM,Fasoli E,Adlercreutz P

    更新日期:2005-09-01 00:00:00

  • Protective Effect of Unsaturated Fatty Acids on Palmitic Acid-Induced Toxicity in Skeletal Muscle Cells is not Mediated by PPARδ Activation.

    abstract::Unsaturated free fatty acids (FFA) are able to prevent deleterious effects of saturated FFA in skeletal muscle cells although the mechanisms involved are still not completely understood. FFA act as endogenous ligands of peroxisome proliferator-activated receptors (PPAR), transcription factors regulating the expression...


    pub_type: 杂志文章


    authors: Tumova J,Malisova L,Andel M,Trnka J

    更新日期:2015-10-01 00:00:00

  • Fast transmethylation of total lipids in dried blood by microwave irradiation and its application to a population study.

    abstract::A methodology combining finger-pricked blood sampling, microwave accelerated fatty acid assay, fast gas chromatography data acquisition, and automated data processing was developed, evaluated and applied to a population study. Finger-pricked blood was collected on filter paper previously impregnated with 0.05 mg of th...


    pub_type: 杂志文章


    authors: Lin YH,Hanson JA,Strandjord SE,Salem NM,Dretsch MN,Haub MD,Hibbeln JR

    更新日期:2014-08-01 00:00:00

  • Lactoperoxidase-catalyzed iodination of arachidonic acid: formation of macrolides.

    abstract::In the presence of iodide and hydrogen peroxide, lactoperoxidase catalyzed the conversion of arachidonic acid into several iodinated products; the major one was previously identified as an iodo-delta-lactone. Two minor and less polar products have now been characterized as 15-iodo-14-hydroxyeicosatrienoic acid, omega-...


    pub_type: 杂志文章


    authors: Boeynaems JM,Reagan D,Hubbard WC

    更新日期:1981-04-01 00:00:00

  • Effect of conjugated linoleic acid on Cyprinus carpio var. Jian regarding growth, immunity, and disease resistance to Aeromonas hydrophila.

    abstract::The present study was performed to investigate the effect of dietary conjugated linoleic acid (CLA) on the growth performance, immune parameters and disease resistance to Aeromonas hydrophila of juvenile Jian carp. A total of 900 juvenile Jian carp (10.71 +/- 0.02 g) were randomly allocated into six groups of each thr...


    pub_type: 杂志文章


    authors: Jiang J,Zhao MJ,Lin F,Yang L,Zhou XQ

    更新日期:2010-06-01 00:00:00

  • Fatty acids bound to Fasciola hepatica 12 kDa fatty acid-binding protein, a candidate vaccine, differ from fatty acids in extracts of adult flukes.

    abstract::The FA composition of Fasciola hepatica 12 kDA purified native FA-binding protein (nFh12), a candidate vaccine against fascioliasis, is described. The FA chain lengths ranged between 12 and 24 carbons. The principal FA were 16:0, 18:1n-9, 18:0, 20:4n-6, and 20:1n-9. The acids 16:0, 18:1n-9, and 18:0 comprised over hal...


    pub_type: 杂志文章


    authors: Carballeira NM,Cruz H,Hillyer GV

    更新日期:2003-07-01 00:00:00

  • Highly unsaturated fatty acid synthesis in marine fish: cloning, functional characterization, and nutritional regulation of fatty acyl delta 6 desaturase of Atlantic cod (Gadus morhua L.).

    abstract::This study reports the cloning, functional characterization, tissue expression, and nutritional regulation of a delta6 fatty acyl desaturase of Atlantic cod (Gadus morhua). PCR primers were designed based on the sequences of conserved motifs in available fish desaturases and used to isolate a cDNA fragment from cod li...


    pub_type: 杂志文章


    authors: Tocher DR,Zheng X,Schlechtriem C,Hastings N,Dick JR,Teale AJ

    更新日期:2006-11-01 00:00:00

  • Apparent lack of effect of obesity on the soluble phosphatidic acid phosphatase activity in human adipose tissue.

    abstract::In view of previous reports that the activity of the Mg(++)-dependent phosphatidic acid phosphatase in adipose tissues of rat and mouse is elevated in obesity, we attempted to assay this activity in biopsies of human omental adipose tissue obtained from normal-weight and morbidly obese subjects in connection with oper...


    pub_type: 杂志文章


    authors: Björkhem I,al-Shurbaji A,Backman L,Arner P

    更新日期:1989-12-01 00:00:00