Abstract:
:It has been shown that different lysophosphatidylcholines (LPC) possess relaxing properties in vascular strips. We report on the effect of intraatrial injection of LPC micelles into white New Zealand rabbits. Changes in renal and coronary flow were determined by radioactive microspheres. Coronary blood flow increased significantly following administration of LPC, while no significant changes were observed in renal blood flow, cardiac output and myocardial contractility. Coronary, renal and total vascular resistance, as well as mean arterial pressure, dropped significantly. Cardiac arrhythmia and hemolysis were not noted. The results demonstrate the vasorelaxant effect of LPC in vivo.
journal_name
Lipidsjournal_title
Lipidsauthors
Wolf A,Saito T,Dudek R,Bing RJdoi
10.1007/BF02543975subject
Has Abstractpub_date
1991-03-01 00:00:00pages
223-6issue
3eissn
0024-4201issn
1558-9307journal_volume
26pub_type
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