The effect of lysophosphatidylcholine on coronary and renal circulation in the rabbit.

Abstract:

:It has been shown that different lysophosphatidylcholines (LPC) possess relaxing properties in vascular strips. We report on the effect of intraatrial injection of LPC micelles into white New Zealand rabbits. Changes in renal and coronary flow were determined by radioactive microspheres. Coronary blood flow increased significantly following administration of LPC, while no significant changes were observed in renal blood flow, cardiac output and myocardial contractility. Coronary, renal and total vascular resistance, as well as mean arterial pressure, dropped significantly. Cardiac arrhythmia and hemolysis were not noted. The results demonstrate the vasorelaxant effect of LPC in vivo.

journal_name

Lipids

journal_title

Lipids

authors

Wolf A,Saito T,Dudek R,Bing RJ

doi

10.1007/BF02543975

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

223-6

issue

3

eissn

0024-4201

issn

1558-9307

journal_volume

26

pub_type

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