Lysophosphatidylcholine acyltransferase activity during experimental cholelithiasis.

Abstract:

:The accumulation of (1-palmitoyl)lysophosphatidylcholine, lysolecithin, in gallbladder bile was observed during the first week of cholesterol-induced experimental cholelithiasis using the prairie dog model for cholesterol gallstone formation. Gallbladder fluid transport function decreased as bile lysolecithin concentration increased. These observations suggest that lysolecithin plays an important, early role in the etiology of gallstone disease. Furthermore, the relative activities of hepatic and gallbladder mucosa lysophosphatidylcholine acyltransferase and acylcoenzyme a hydrolases may be responsible for the turnover of gallbladder bile lysolecithin.

journal_name

Lipids

journal_title

Lipids

authors

Rutledge FA 2nd,Hickman DM,Dunn JJ,Frey CF,Matson RS

doi

10.1007/BF02535337

subject

Has Abstract

pub_date

1981-10-01 00:00:00

pages

714-20

issue

10

eissn

0024-4201

issn

1558-9307

journal_volume

16

pub_type

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