Abstract:
:The accumulation of (1-palmitoyl)lysophosphatidylcholine, lysolecithin, in gallbladder bile was observed during the first week of cholesterol-induced experimental cholelithiasis using the prairie dog model for cholesterol gallstone formation. Gallbladder fluid transport function decreased as bile lysolecithin concentration increased. These observations suggest that lysolecithin plays an important, early role in the etiology of gallstone disease. Furthermore, the relative activities of hepatic and gallbladder mucosa lysophosphatidylcholine acyltransferase and acylcoenzyme a hydrolases may be responsible for the turnover of gallbladder bile lysolecithin.
journal_name
Lipidsjournal_title
Lipidsauthors
Rutledge FA 2nd,Hickman DM,Dunn JJ,Frey CF,Matson RSdoi
10.1007/BF02535337subject
Has Abstractpub_date
1981-10-01 00:00:00pages
714-20issue
10eissn
0024-4201issn
1558-9307journal_volume
16pub_type
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