Desaturation indices in liver, muscle, and bone of growing male and female mice fed trans-10,cis-12 conjugated linoleic acid.

Abstract:

:trans-10,cis-12-CLA (t10,c12-CLA) inhibits lipid deposition in adipose tissue of many species, but it also enhances lipid deposition in liver. We evaluated effects of dietary t10,c12-CLA content and gender on carcass composition, FA profile of selected tissues, and expression of FA synthase (FAS) and stearoyl-CoA desaturase-1 (SCD) mRNA in adipose tissue. Male and female (63 of each) CD-1 mice were assigned a diet containing 0.0, 0.15, or 0.30% t10,c12-CLA at 4 wk of age. Seven mice per dietary group within gender were sacrificed after 2, 4, or 6 wk. The CLA isomer caused dose-dependent reductions in dry carcass weight and fat content, without altering protein content, but carcass fat and epididymal fat pad weights of males were reduced to a greater extent than carcass fat and inguinal fat pad weights of females. FAS and SCD mRNA in adipose tissue was more abundant in females than males, but expression in both genders decreased as the t10,c12-CLA content of the diet increased. Although the weight of gastrocnemius muscle was not influenced by diet, total FA content of the muscle of both genders decreased in response to dietary t10,c12-CLA content. Femur weight of male mice increased as the t10,c12-CLA content of the diet increased, but the weight increase was associated with a reduction in total FA content. The delta 9 desaturation indices for muscle and femur suggested a linear reduction in SCD activity, whereas delta 9 indices for liver indicated linear enhancement of SCD activity. Overall, results suggested that growing male mice were more susceptible than females to t10,c12-CLA inhibition of lipid deposition.

journal_name

Lipids

journal_title

Lipids

authors

Viswanadha S,McGilliard ML,Herbein JH

doi

10.1007/s11745-006-5029-2

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

763-70

issue

8

eissn

0024-4201

issn

1558-9307

journal_volume

41

pub_type

杂志文章

相关文献

LIPIDS文献大全
  • Effect of dietary vitamin E upon fluorescent compounds of the rat uterus.

    abstract::Several water soluble and organic solvent soluble fluorescent peaks were observed in extracts of uteri from vitamin E deficient or supplemented rats following Sephadex column chromatography and spectrophotofluorometric analysis. Levels of one of the organic and two of the water soluble fluorescent peaks were found to ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534725

    authors: Csallany AS,Ayaz KL,Menken BZ

    更新日期:1984-12-01 00:00:00

  • Age-related changes in the metabolism of cholesterol in rat liver microsomes.

    abstract::The effects of aging on the hepatic metabolism of cholesterol were studied in 1-, 6- and 24-month-old male Sprague-Dawley rats. Microsomal 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity, which regulates cholesterol biosynthesis, decreased from 835 +/- 144 (SEM) pmol/min/mg protein in the youngest g...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02537197

    authors: Ståhlberg D,Angelin B,Einarsson K

    更新日期:1991-05-01 00:00:00

  • Arachidonic acid: Occurrence in the reproductive tract of the male house cricket (Acheta domesticus) and field cricket (Gryllus spp.).

    abstract::Reproductive tissues from male house and field crickets were investigated for the presence of arachidonic acid. Arachidonic acid was identified by retention behavior on 3 gas liquid chromatographic column systems-SE-30, OV 225, and Silar 10C-and by gas liquid/positive ion chemical ionization mass spectrometry. Arachid...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534928

    authors: Worthington RE,Brady UE,Thean JE,Wilson DM

    更新日期:1981-01-01 00:00:00

  • Effects of different levels of dietary trans-octadecenoate on steroid metabolism in rats.

    abstract::Rats were fed semipurified diets containing olive oil or partially hydrogenated corn oil at the 5 or 20% level for ca. 30 days. These fat diets contained the same amount of octadecenoate but differed in the geometry with respect to each fat level. Contents of t-18:1 were 26% and 41% of total fatty acids, respectively....

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534500

    authors: Watanabe M,Cho YJ,Ide T,Sugano M

    更新日期:1984-02-01 00:00:00

  • Camelina meal increases egg n-3 fatty acid content without altering quality or production in laying hens.

    abstract::Camelina sativa is an oilseed plant rich in n-3 and n-6 fatty acids and extruding the seeds results in high protein meal (*40%) containing high levels of n-3 fatty acids. In this study, we examined the effects of feeding extruded defatted camelina meal to commercial laying hens, measuring egg production, quality, and ...

    journal_title:Lipids

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11745-012-3656-3

    authors: Kakani R,Fowler J,Haq AU,Murphy EJ,Rosenberger TA,Berhow M,Bailey CA

    更新日期:2012-05-01 00:00:00

  • The effects of dehydroepiandrosterone on carcinogenesis, obesity, the immune system, and aging.

    abstract::With the passage of the U.S. Dietary Supplement Health and Education Act of 1994, dehydroepiandrosterone (DHEA, 5-androsten-3beta-ol-17-one) has become widely available, and a large and growing market has developed for this "fountain of youth." DHEA has been shown to have significant beneficial effects in animals, whi...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-000-0529-7

    authors: Williams JR

    更新日期:2000-03-01 00:00:00

  • Correcting the effects of -20 °C storage and aliquot size on erythrocyte fatty acid content in the Women's Health Initiative.

    abstract::Red blood cell (RBC) fatty acid (FA) patterns have been shown to predict risk for cardiovascular and other chronic diseases. As part of a project analyzing RBC samples from the Women's Health Initiative Memory Study (WHIMS) we observed implausibly low levels of highly unsaturated fatty acids (HUFA) suggestive of degra...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-012-3693-y

    authors: Pottala JV,Espeland MA,Polreis J,Robinson J,Harris WS

    更新日期:2012-09-01 00:00:00

  • Critical analysis of phospholipid hydrolyzing activities in ripening tomato fruits. Study by spectrofluorimetry and high-performance liquid chromatography.

    abstract::Using the spectrofluorimetric method described by Wittenauer et al. [Wittenauer, L.A., Shirai, K., Jackson, R.L., and Johnson, J.D. (1984) Biochem. Biophys. Res. Commun. 118, 894-901] for phospholipase A2 (PLA2) measurement, we have detected a phospholipase activity in Ailsa Craig and in mutant rin tomatoes at their n...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02537801

    authors: Rouet-Mayer MA,Valentova O,Simond-Côte E,Daussant J,Thévenot C

    更新日期:1995-08-01 00:00:00

  • n-3 fatty acids, inflammation, and immunity--relevance to postsurgical and critically ill patients.

    abstract::Excessive or inappropriate inflammation and immunosuppression are components of the response to surgery, trauma, injury, and infection in some individuals and these can lead, progressively, to sepsis and septic shock. The hyperinflammation is characterized by the production of inflammatory cytokines, arachidonic acid-...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-004-1342-z

    authors: Calder PC

    更新日期:2004-12-01 00:00:00

  • Fatty acids of cerebrosides in different regions of the developing foetal brain.

    abstract::The fatty acid composition of cerebrosides of developing foetal human brain and regional variations, if any, during intrauterine life were studied. While palmitic and stearic acids were the predominant normal fatty acids throughout intrauterine life, long chain fatty acids, like lignoceric and nervonic acids, which we...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533635

    authors: Rao PS

    更新日期:1977-04-01 00:00:00

  • Dietary monounsaturated fatty acids are protective against metabolic syndrome and cardiovascular disease risk factors.

    abstract::Over 50 years of research has sought to define the role dietary fat plays in cardiovascular disease (CVD) risk. Although optimal dietary fat quantity has been keenly pursued over past decades, attention has recently centered on the value of dietary fat quality. The purpose of the present review is to provide a critica...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-010-3524-y

    authors: Gillingham LG,Harris-Janz S,Jones PJ

    更新日期:2011-03-01 00:00:00

  • The activity and properties of a hepatic acid cholesteryl ester hydrolase obtained from rats of different age groups.

    abstract::The activity of lysosomal acid cholesteryl ester hydrolase (acid CEH, EC 3.1.1.13) in rat liver was determined at 3, 5, 7, 10 and 20 wk following birth. The levels of acid CEH activity showed a marked decrease as rats grew older, whereas those of other lysosomal marker enzymes, such as acid phosphatase, beta-glucuroni...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533950

    authors: Tanaka M,Iio T,Tabata T

    更新日期:1987-09-01 00:00:00

  • Effect of a salmon diet on the distribution of plasma lipoproteins and apolipoproteins in normolipidemic adult men.

    abstract::The effects of n-3 fatty acids on plasma lipids, lipoproteins and apoproteins have usually been studied in humans after feeding of purified fish oil. This study describes the effect of a natural diet, containing salmon as the source of n-3 fatty acids, on these parameters as compared to a diet very low in n-3 fatty ac...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02544001

    authors: Lindgren FT,Adamson GL,Shore VG,Nelson GJ,Schmidt PC

    更新日期:1991-02-01 00:00:00

  • Review of chemical syntheses of 7-keto-delta5-sterols.

    abstract::Steroids bearing ketone functionality at carbon-7 are found commonly in nature, and the most prevalent of these are the 7-keto-delta5-sterols. These substances have diverse biological properties and are present in biological samples and food products. For the purpose of studying this class of oxysterols, many chemical...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-004-1299-y

    authors: Parish EJ,Kizito SA,Qiu Z

    更新日期:2004-08-01 00:00:00

  • Preferential redistribution of lipoprotein-unassociated apoA-IV to an HDL subpopulation with a high degree of LCAT modification.

    abstract::The relationship between LCAT mediated HDL modification and the redistribution of lipoprotein-unassociated apoA-IV to HDL was investigated in vitro. Immunoaffinity-isolated rat lipoprotein-unassociated apoA-IV was added to apoB-, apoE-, apoA-IV depleted, [3H]cholesterol labelled rat plasma and incubated at 37 degrees ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02544075

    authors: Lefevre M,Goudey-Lefevre JC,Roheim PS

    更新日期:1989-12-01 00:00:00

  • Kinetics of carnitine palmitoyltransferase I (CPT I) in Chinese sucker (Myxocyprinus asiaticus) change with its development.

    abstract::The present study was conducted to evaluate the ontogeny and kinetic of CPT I in several tissues of the Chinese sucker Myxocyprinus asiaticus. To this end, liver, muscle and intestine tissues were examined at five various developmental stages of Chinese sucker: newly-hatched larvae, 68-day-old, 4-month-old, 1- and 2-y...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-013-3864-5

    authors: Liu CX,Luo Z,Hu W,Tan XY,Zheng JL,Chen QL,Zhu QL

    更新日期:2014-02-01 00:00:00

  • Lipolysis of corn, peanut and randomized peanut oils.

    abstract::Corn oil, peanut oil and randomized peanut oil exhibit different atherogenic potentials; peanut oil being more atherogenic than the other oils. This study was conducted to ascertain if the atherogenicity of these oils was related to their rates of lipolysis. Using both pancreatic lipase and milk lipoprotein lipase (LP...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534645

    authors: Kim HK,Kritchevsky D

    更新日期:1983-11-01 00:00:00

  • Intestinal absorption of ester and ether glycerophospholipids in guinea pig. Role of a phospholipase A2 from brush border membrane.

    abstract::In vivo intestinal perfusion was used to follow the absorption of three different choline glycerophospholipids (CGP) in guinea pig. These included 1-[3H]palmitoyl-2-acyl-sn-glycero-3-phosphocholine (diacyl-GPC), 1-[3H]-O-hexadecyl-2-acyl-sn-glycero-3-phosphocholine (alkylacyl-GPC) and 1,2-di-O-hexadecyl-sn-glycero-3-p...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534872

    authors: Diagne A,Mitjavila S,Fauvel J,Chap H,Douste-Blazy L

    更新日期:1987-01-01 00:00:00

  • (S)-1,2-diacyl-3-acetins: Optically active triglycerides fromEuonymus verrucosus seed oil.

    abstract::The seed oil ofEuonymus verrucosus Scop., family Celastraceae, contains more than 90% 1,2-diacyl-3-acetins (monoacetotriglycerides). The constituent triglyceride acids, other than acetic, are the usual long-chain fatty acids.Thin-layer chromatography (TLC), infrared (IR) and hydrolysis with pancreatic lipase indicate ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533174

    authors: Kleiman R,Miller RW,Earle FR,Wolff IA

    更新日期:1967-11-01 00:00:00

  • Effect of acute ethanol ingestion on fat absorption.

    abstract::A test meal (300 mg casein, 600 mg sucrose, 100 mg corn oil, tracer dose of 9.10(3)H oleic acid) was given to fasting adult rats with intestinal lymph fistulas. One group received an acute oral dose of ethanol (3.2 g/kg body weight) simultaneously with the test meal. Controls received 2.5 ml of water instead of ethano...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532991

    authors: Boquillon M

    更新日期:1976-12-01 00:00:00

  • Essentiality of fatty acids.

    abstract::All fatty acids have important functions, but the term "essential" is applied only to those polyunsaturated fatty acids (PUFA) that are necessary for good health and cannot be completely synthesized in the body. The need for arachidonic acid, which is utilized for eicosanoid synthesis and is a constituent of membrane ...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/BF02562220

    authors: Spector AA

    更新日期:1999-01-01 00:00:00

  • Seasonal variations of lipid content and composition in Perna viridis.

    abstract::The total lipid content, composition of main lipid classes, composition of sterols and composition of fatty acids in the main glycerolipids of Perna viridis were analyzed through four seasons using TLC-FID and GLC. Mussel samples were collected during different seasons between 2003 and 2004 from Shengsi Island, Zhejia...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-007-3078-9

    authors: Li D,Zhang Y,Sinclair AJ

    更新日期:2007-08-01 00:00:00

  • Cell proliferation and long chain polyunsaturated fatty acid metabolism in a cell line from southern bluefin tuna (Thunnus maccoyii).

    abstract::Southern bluefin tuna (SBT, Thunnus maccoyii) aquaculture is a highly valuable industry, but research on these fish is hampered by strict catch quotas and the limited success of captive breeding. To address these limitations, we have developed a SBT cell line (SBT-E1) and here we report on fatty acid metabolism in thi...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-014-3910-y

    authors: Scholefield AM,Schuller KA

    更新日期:2014-07-01 00:00:00

  • Lactation curves and effect of pup removal on milk fat of C57Bl/6J mice fed different diet fats.

    abstract::Groups of C57Bl/6J mice, fed either a cis (C-Diet) or trans diet (T-Diet) were milked without preconditioning at 6, 8, 10 and 12 days postpartum. On day 10, groups of mice were also milked 4, 6 and 18 h after separation of the pups. Except for the 18-h separation, all T-Diet fed animals produced milk of lower fat cont...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535872

    authors: Teter BB,Sampugna J,Keeney M

    更新日期:1992-11-01 00:00:00

  • Inhibition of 12- and 15-lipoxygenase activities and protection of human and tilapia low density lipoprotein oxidation by I-Tiao-Gung (Glycine tomentella).

    abstract::I-Tiao-Gung, Glycine tomentella, has been used extensively as a traditional herbal medicine to relieve physical pain, but its bioactivity has not been studied systematically. Ninety-five percent ethanol extracts of G. tomentella (GT-E) showed antioxidant activity in human plasma by prolonging the lag phase (+Tlag) of ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-005-1482-1

    authors: Chen TY,Shiao MS,Pan BS

    更新日期:2005-11-01 00:00:00

  • Protein engineering and applications of Candida rugosa lipase isoforms.

    abstract::Commercial preparations of Candida rugosa lipase (CRL) are mixtures of lipase isoforms used for the hydrolysis and synthesis of various esters. The presence of variable isoforms and the amount of lipolytic protein in the crude lipase preparations lead to a lack of reproducibility of biocatalytic reactions. Purificatio...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-004-1258-7

    authors: Akoh CC,Lee GC,Shaw JF

    更新日期:2004-06-01 00:00:00

  • HPLC analysis of desmosterol, 7-dehydrocholesterol, and cholesterol.

    abstract::A simple and sensitive method to analyze mixtures of desmosterol, 7-dehydrocholesterol and cholesterol is described. The method involves the oxidative conversion of the sterols with cholesterol oxidase, followed by high performance liquid chromatographic (HPLC) analysis. A C18 reversed phase column (3 microns, 75 X 4....

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535083

    authors: Goh EH,Colles SM,Otte KD

    更新日期:1989-07-01 00:00:00

  • Sulfur-substituted and alpha-methylated fatty acids as peroxisome proliferator-activated receptor activators.

    abstract::FA with varying chain lengths and an alpha-methyl group and/or a sulfur in the beta-position were tested as peroxisome proliferator-activated receptor (PPAR)alpha, -delta(beta), and -gamma ligands by transient transfection in COS-1 cells using chimeric receptor expression plasmids, containing cDNAs encoding the ligand...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-005-1359-3

    authors: Larsen LN,Granlund L,Holmeide AK,Skattebøl L,Nebb HI,Bremer J

    更新日期:2005-01-01 00:00:00

  • Metabolism of meadowfoam oil fatty acids in mice.

    abstract::Meadowfoam oil is unusual because over 95% of the fatty acids are 20- and 22-carbon aliphatic acids with cis double bonds located principally at the 5- and/or 13-position. Since little information is available on the metabolism of the 5c-20:1 and 5c,13c-22:2 fatty acids, an exploratory study in mice was conducted to i...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535623

    authors: Emken EA,Adlof RO,Abraham S

    更新日期:1991-09-01 00:00:00

  • Relationship between mouse liver delta 9 desaturase activity and plasma lipids.

    abstract::This study was undertaken to investigate the total plasma fatty acid composition and the relationship between plasma triacylglycerol (TG) levels and liver delta 9 desaturase activity in mice fed n-3 and/or n-6 fatty acid or hydrogenated coconut oil (HCO) (maximum 25 mg/g) supplemented diets. Generally, plasma TG level...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536312

    authors: de Antueno RJ,Cantrill RC,Huang YS,Elliot M,Horrobin DF

    更新日期:1993-04-01 00:00:00