Age-related changes in the metabolism of cholesterol in rat liver microsomes.

abstract：:The objective of the present studies was to examine the effect of dietary fat on the lipid composition of rat colonocytes and their utilization of short-chain fatty acids (SCFA). Rats were fed 14% beef fat, fish oil or safflower oil plus 2% corn oil in a semi-synthetic base diet for 4 wk. Colonocytes were isolated and...

journal_title：Lipids

authors： Awad AB,Ferger SL,Fink CS

更新日期：1990-06-01 00:00:00

abstract：:Lipid metabolism of male Fisher 344 rats aged 2-24 months was studied. Serum and liver cholesterol levels did not display the age-related gradual increase seen in other rat strains. An increase in the serum plus liver cholesterol pool from 2 to 6 months was followed by a plateau through 18 months and then another incr...

journal_title：Lipids

authors： Story JA,Tepper SA,Kritchevsky D

更新日期：1976-08-01 00:00:00

abstract：:Over 50 years of research has sought to define the role dietary fat plays in cardiovascular disease (CVD) risk. Although optimal dietary fat quantity has been keenly pursued over past decades, attention has recently centered on the value of dietary fat quality. The purpose of the present review is to provide a critica...

journal_title：Lipids

authors： Gillingham LG,Harris-Janz S,Jones PJ

更新日期：2011-03-01 00:00:00

abstract：:Male Wistar rats were fed semipurifed diets containing 20% fat for 25 weeks. Ten different oils or oil blends were employed, including rapessed oils, simulated rapeseed-type oils, and modified rapeseed-type oils. Safflower, soybean, and hydrogenated coconut oils served as control oils. Histopathological examination of...

journal_title：Lipids

authors： McCutcheon JS,Umermura T,Bhatnager MK,Walker BL

更新日期：1976-07-01 00:00:00

abstract：:The kinetics of in vivo clearance of apolipoprotein (apo) A-I radioiodinated by the iodine monochloride (ICI) method of McFarlane [McFarlane, A.S. (1958) Efficient Trace-Labelling of Proteins with Iodine, Nature 182, 53] as modified by Bilheimer and co-workers [Bilheimer, D.W., Eisenberg, S., and Levy, R.I. (1972) The...

journal_title：Lipids

authors： Zhang B,Shimoji E,Tanaka H,Saku K

更新日期：2003-03-01 00:00:00

abstract：:Essential fatty acids are structural components of all tissues and are indispensable for cell membrane synthesis; the brain, retina and other neural tissues are particularly rich in long-chain polyunsaturated fatty acids (LC-PUFA). These fatty acids serve as specific precursors for eicosanoids, which regulate numerous...

journal_title：Lipids

authors： Uauy R,Hoffman DR,Peirano P,Birch DG,Birch EE

更新日期：2001-09-01 00:00:00

abstract：:Corn oil, peanut oil and randomized peanut oil exhibit different atherogenic potentials; peanut oil being more atherogenic than the other oils. This study was conducted to ascertain if the atherogenicity of these oils was related to their rates of lipolysis. Using both pancreatic lipase and milk lipoprotein lipase (LP...

journal_title：Lipids

authors： Kim HK,Kritchevsky D

更新日期：1983-11-01 00:00:00

abstract：:The effect of lecithin on jejunal absorption of fatty acids and octadecenoylglycerol was studied in healthy volunteers with a jejunal perfusion system which excluded pancreatic and biliary secretions from the test segment. Lecithin significantly reduced the absorption of oleic acid (P less than 0.05) and octadecenoylg...

journal_title：Lipids

authors： Ammon HV,Thomas PJ,Phillipis SF

更新日期：1979-04-01 00:00:00

abstract：:The effects of dietary stearidonic acid (18:4n-3) on inflammatory mediator release in whole blood and splenocytes was investigated in Balb/c mice, and the effects were compared with those of two other n-3 PUFA: alpha-linolenic acid (18:3n-3) and EPA (20:5n-3). TAG mixtures containing 10% of 18:4n-3, 18:3n-3, or 20:5n-...

journal_title：Lipids

authors： Ishihara K,Komatsu W,Saito H,Shinohara K

更新日期：2002-05-01 00:00:00

abstract：:Various physical fractions of the barley kernel were fed to one-day-old female and male chickens to determine their effect on hepatic beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase, cholesterol 7 alpha-hydroxylase and the lipogenic enzymes, acetyl-CoA carboxylase (ACX), malic enzyme (ME), citrate-clea...

journal_title：Lipids

authors： Burger WC,Qureshi AA,Prentice N,Elson CE

更新日期：1982-12-01 00:00:00

abstract：:Recently, lipases have been purified from mammalian, bacterial, fungal and plant sources by different methodologies. Purified lipases subsequently have been characterized for molecular size, metal binding capabilities, glycoside and phosphorus contents, and substrate specificities. Primary structures of several lipase...

journal_title：Lipids

authors： Antonian E

更新日期：1988-12-01 00:00:00

abstract：:Some 1,2- and 1,3-diacyl glycerols (with acyl groups as stearyl, oleyl, linoleyl, or stearolyl) were synthesized by conventional methods. The diacyl glycerols were esterified with 6-bromo-hexanoic acid to give the corresponding bromo-triacylglycerols (of the type AAB and ABA containing a bromo group at the distal part...

journal_title：Lipids

authors： Jie MS,Cheung SW,Ho JC

更新日期：2001-06-01 00:00:00

abstract：:Polar lipids of bacteria from the class Thermomicrobia are known to contain long-chain 1,2-diols instead of glycerol, although the nature of polar head groups has not been investigated. We have studied phospholipid classes of two species from the class Thermomicrobia-Sphaerobacter thermophilus and Thermomicrobia sp. W...

journal_title：Lipids

authors： Lagutin K,MacKenzie A,Houghton KM,Stott MB,Vyssotski M

更新日期：2015-03-01 00:00:00

abstract：:Ceramides are a family of signalling lipids with diverse physiological functions that include pro-differentiative and pro-apoptotic signalling. Ceramides and their derivatives are major constituents of myelin, maintaining neuronal conductivity. Ceramides are synthesized by ceramide synthases, of which there are six is...

journal_title：Lipids

authors： Couttas TA,Lim XY,Don AS

更新日期：2015-01-01 00:00:00

abstract：:Docosahexaenoic acid (DHA), a prominent long-chain fatty acid of the omega-3 family, is present at high amount in brain tissues, especially in membrane phospholipids. This polyunsaturated fatty acid is the precursor of various oxygenated lipid mediators involved in diverse physiological and pathophysiological processe...

journal_title：Lipids

authors： Jouvène C,Fourmaux B,Géloën A,Balas L,Durand T,Lagarde M,Létisse M,Guichardant M

更新日期：2018-01-01 00:00:00

abstract：:Accurate quantification of the major classes and subfractions of human serum lipoproteins is an important analytical need in the characterization and evaluation of therapy of lipid and lipoprotein abnormalities. For calibrating the analytic ultracentrifuge (AnUC), we routinely use a Beckman calibration wedge cell with...

journal_title：Lipids

authors： Kahlon TS,Adamson GL,Glines LA,Lindgren FT,Laskaris MA,Shore VG

更新日期：1984-07-01 00:00:00

abstract：:The effect of age and dietary fat type on tocopherol status was investigated using young and old C57BL/6Nia mice fed semipurified diets containing 5% (by weight) fish, corn or coconut oils and supplemented with 30, 100 or 500 ppm dl-alpha-tocopheryl acetate for 6 wk. Tocopherol levels in the diets, plasma, liver, kidn...

journal_title：Lipids

authors： Meydani SN,Shapiro AC,Meydani M,Macauley JB,Blumberg JB

更新日期：1987-05-01 00:00:00

abstract：:To examine whether dietary fat alters membrane lipid composition and peroxidation of polyunsaturated fatty acids in "non-proliferative" and "proliferative" cells in the large intestine, Sprague-Dawley rats were fed diets providing a polyunsaturated-to-saturated fatty acid ratio of 1.2 or 0.3 at a high or low level of ...

journal_title：Lipids

authors： Turini ME,Thomson AB,Clandinin MT

更新日期：1991-06-01 00:00:00

abstract：:Lecithin-cholesterol acyltransferase (LCAT, EC 2.3.1.43) was assayed in vitro in plasma from normal man, rat, rabbit and dog by following the formation of 14C-cholesteryl esters subsequent to labeling the plasma with 14C-cholesterol in vitro. In all species examined, various local anesthetics were found to inhibit LCA...

journal_title：Lipids

authors： Bell FP,Hubert EV

更新日期：1980-10-01 00:00:00

abstract：:Carbohydrate response element binding protein (ChREBP) regulates insulin-independent de novo lipogenesis. Recently, a novel ChREBPβ isoform was identified. The purpose of the current study was to define the effect of dietary carbohydrates (CHO) and obesity on the transcriptional activity of ChREBP isoforms and their r...

journal_title：Lipids

authors： Stamatikos AD,da Silva RP,Lewis JT,Douglas DN,Kneteman NM,Jacobs RL,Paton CM

更新日期：2016-01-01 00:00:00

abstract：:The amount and composition of lysophosphatidate present in different rat tissues have been estimated by an internal standard method in which a synthetic unnatural isomer (1-heptadecanoyl-rac-glycerol-3-phosphate) was added to the total lipid extracts, and the fatty acid composition of purified lysophosphatidate was de...

journal_title：Lipids

authors： Das AK,Hajra AK

更新日期：1989-04-01 00:00:00

abstract：:The monoazaaromatics, pyridine (1), hexyl nicotinate (2), and quinoline (3) and diazaaromatics, pyrimidine (4) and purine (5), readily act as photo-initiators for the peroxidation of methyl linoleate in 0.50 M SDS at 37 degrees C giving free radical chain oxidations of linoleate. Quantitative kinetic runs on the order...

journal_title：Lipids

authors： Barclay LR,Crowe E,Edwards CD

更新日期：1997-03-01 00:00:00

abstract：:In view of previous reports that the activity of the Mg(++)-dependent phosphatidic acid phosphatase in adipose tissues of rat and mouse is elevated in obesity, we attempted to assay this activity in biopsies of human omental adipose tissue obtained from normal-weight and morbidly obese subjects in connection with oper...

journal_title：Lipids

authors： Björkhem I,al-Shurbaji A,Backman L,Arner P

更新日期：1989-12-01 00:00:00

abstract：:Linoleic acid was efficiently converted into the two major components of conjugated linoleic acid, 9Z,11E-octadecadienoic (1a) and 10E,12Z-octadecadienoic acid (1b) using either the superbase (n-butyllithium/potassium tert-butoxide) or by simply refluxing with KOH in 1-butanol. In turn, 1a and 1b were separated from e...

journal_title：Lipids

authors： Chen CA,Lu W,Sih CJ

更新日期：1999-08-01 00:00:00

abstract：:Potato tuber lipoxygenase (ptLOX) has been shown to catalyze the aerobic formation of at least four major oxygenated derivatives of DHA. Two of the products--7,17(S)- and 10,17(S)-dihydro(pero)xy-DHA [7,17- and 10,17-diH(P)DHA]--were formed from soybean 15-LOX-derived 17(S)-hydro(pero)xy-DHA [17(S)-H(P)DHA], whereas t...

journal_title：Lipids

authors： Butovich IA,Hamberg M,Rådmark O

更新日期：2005-03-01 00:00:00

abstract：:Because of the known advantages of coupling high performance liquid chromatography with mass spectrometry (HPLC-MS) in biological fluids, studies on the reversed-phase HPLC-MS system for direct analysis of conjugated bile acids in human bile samples are described. Ten samples of gallbladder bile of apparently healthy ...

journal_title：Lipids

authors： Mingrone G,Greco AV,Boniforti L,Passi S

更新日期：1983-01-01 00:00:00

abstract：:Acyl-CoA cholesterol acyltransferase (ACAT) (EC 2.3.1.26) in the yolk sac membrane of chicken eggs plays an important role in the transport of lipids, which serve as both structural components and as an energy source during embryogenesis. ACAT from the yolk sac membrane of chicken eggs 16 d after fertilization has hig...

journal_title：Lipids

authors： Cheng D,Tipton CL

更新日期：1999-03-01 00:00:00

abstract：:The alk-1-enyl group of 1-alk-1(1)-enyl-2-acyl-glycerophospholipids (plasmalogens) rapidly combines with mercuric chloride. At 0 C, there was a 1:1 stoichiometry for Hg binding to the reactive enol group of plasmalogens. Aldehydes were not released, indicating that the alkenyl ether bond was not cleaved. Hg binding to...

journal_title：Lipids

authors： Carey EM

更新日期：1982-09-01 00:00:00

abstract：:De novo synthesis and mitochondrial elongation of fatty acids have been demonstrated in subcellular fractions from hog and human aorta. Microsomal fatty acid elongation has been shown in hog aorta. The activity catalyzing the formation of fatty acids from acetyl and malonyl CoA was associated with a high molecular wei...

journal_title：Lipids

authors： Slakey LL,Ferrick TJ,Ness GC,Porter JW

更新日期：1979-05-01 00:00:00

abstract：:Using an experimental model that enables the effects of alcohol to be distinguished from the effects of the nonalcoholic components present in wine, we determined whether wine has effects other than those of alcohol on the metabolism of cholesterol. Male rats were fed a standard diet and had free access to water and e...

journal_title：Lipids

authors： Cascón E,Roig R,Ardèvol A,Salvadó MJ,Arola L,Bladé C

更新日期：2001-04-01 00:00:00