Synthesis of deuterium labeled cholesterol and steroids and their use for metabolic studies.

abstract：:We recently reported the presence of various cyclopropane fatty acids-among them, cyclopropaneoctanoic acid 2-hexyl-in the adipose tissue of obese women. The aim of this study was to verify whether the presence of cyclopropaneoctanoic acid 2-hexyl in human serum was associated with obesity or chronic kidney disease (b...

journal_title：Lipids

authors： Mika A,Stepnowski P,Chmielewski M,Malgorzewicz S,Kaska L,Proczko M,Ratnicki-Sklucki K,Sledzinski M,Sledzinski T

更新日期：2016-07-01 00:00:00

abstract：:Lipases catalyze the hydrolysis and synthesis of triglycerides and their reactions are widely used in industry. The use of ionic liquids has been explored in order to improve their catalytic properties. However, the effect of these compounds on kinetic parameters of lipases has been poorly understood. A study of the k...

journal_title：Lipids

authors： Muñoz PA,Correa-Llantén DN,Blamey JM

更新日期：2015-01-01 00:00:00

abstract：:The artificial rearing model was used to investigate the effects of short-term exposure to ethanol on growth and fatty acid composition of forebrain (FB) and cerebellum (CB) during the brain growth spurt in either n-3 fatty acid-adequate (AD) or n-3 deficient (DEF) rat pups. On postnatal day 5, offspring of female rat...

journal_title：Lipids

authors： Ward GR,Xing HC,Wainwright PE

更新日期：1999-11-01 00:00:00

abstract：:Dietary fat and abnormal production of various prostanoids have been linked to various disease states of the large bowel, including cancer of the colon. Studies were conducted to determine the effect of dietary fat (beef tallow or corn oil) on the lipid composition and prostanoid production of the murine colon. Female...

journal_title：Lipids

authors： Robblee NM,Farnworth ER,Bird RP

更新日期：1988-04-01 00:00:00

abstract：:Recent work in our lab has shown that the chemoprotective fatty acid, conjugated linoleic acid (CLA), inhibits phorbol ester skin tumor promotion in mice. Because little is known about the deposition of CLA into tissues as well as its biological activity, this study compared the incorporation and biological activity o...

journal_title：Lipids

authors： Liu KL,Belury MA

更新日期：1997-07-01 00:00:00

abstract：:The purpose of the study was to compare the polyunsaturated fatty acid (PUFA) status in patients with X-linked adrenoleukodystrophy or adrenomyeloneuropathy (X-ALD/AMN) with that in disorders of peroxisome biogenesis (PB). Total fatty acids and plasmalogens were quantified in plasma and red cells from 28 patients with...

journal_title：Lipids

authors： Martinez M,Mougan I,Roig M,Ballabriga A

更新日期：1994-04-01 00:00:00

abstract：:Pycnogenol (PYC), an extract of French maritime pine bark (Pinus pinaster), is a potent antioxidant with potential health benefits. Its bioavailabilty has previously been shown by urinary excretion studies of constituents and metabolites of PYC. The aim of this study was to test the effect of PYC supplementation on me...

journal_title：Lipids

authors： Devaraj S,Vega-López S,Kaul N,Schönlau F,Rohdewald P,Jialal I

更新日期：2002-10-01 00:00:00

abstract：:A method is described for the separation, identification, and quantitative estimation of the individual molecular species occurring in natural lecithin mixtures. Purified lecithin preparations are converted into diglyceride acetates by enzymic dephosphorylation and acetylation. The diglyceride acetates are separated o...

journal_title：Lipids

authors： Kuksis A,Marai L

更新日期：1967-05-01 00:00:00

abstract：:For four weeks, groups of eight male and eight female F344/N rats were fed diets containing 15.5, 20, 30 or 40% of energy (en%) as fat. The fat was composed of corn oil and beef tallow with 9 en% from linoleate in all diets. Females had greater mean hepatic alpha-tocopherol levels, whereas males had greater plasma alp...

journal_title：Lipids

authors： Chen HW,Cook LR,Hendrich S

更新日期：1992-11-01 00:00:00

abstract：:In vivo intestinal perfusion was used to follow the absorption of three different choline glycerophospholipids (CGP) in guinea pig. These included 1-[3H]palmitoyl-2-acyl-sn-glycero-3-phosphocholine (diacyl-GPC), 1-[3H]-O-hexadecyl-2-acyl-sn-glycero-3-phosphocholine (alkylacyl-GPC) and 1,2-di-O-hexadecyl-sn-glycero-3-p...

journal_title：Lipids

authors： Diagne A,Mitjavila S,Fauvel J,Chap H,Douste-Blazy L

更新日期：1987-01-01 00:00:00

abstract：:Arachidonic acid was reduced by hydrazine to yield isomeric eicosatrienoic acids with other products. Methylcis,cis,cis-5,8,11-eicosatrienoate was isolated from the products by silver ion chromatography and preparative gas liquid chromatography in 8% yield. The structure was confirmed by spectral studies and oxidative...

journal_title：Lipids

authors： Ghosh A,Koley M,Dutta J

更新日期：1982-04-01 00:00:00

abstract：:Plasma and liver lipids were studied in male weanling rats fed diets containing moderate levels of fat (6% by weight) as sunflower oil (SF diet, rich in linoleic acid), salmon oil (SM diet, rich in long-chain n-3 fatty acids), or a blend of peanut and rapeseed oil (PR diet, rich in oleic acid). After nine weeks of fee...

journal_title：Lipids

authors： Frémont L,Gozzelino MT

更新日期：1996-08-01 00:00:00

abstract：:Male weanling rats were fed semi-synthetic diets high in saturated fat (beef tallow) vs high in linoleic acid (safflower oil) with or without high levels of alpha-linolenic acid (linseed oil) for a period of 28 days. The effect of feeding these diets on cholesterol content and fatty acid composition of serum and liver...

journal_title：Lipids

authors： Garg ML,Wierzbicki AA,Thomson AB,Clandinin MT

更新日期：1989-04-01 00:00:00

abstract：:The Ca and Mg content of flax and corn phosphatidyl inositol fractions has been determined. Procedures were devised to prepare various salt forms of phosphatidyl inositol. The divalent cations were exchanged for monovalent ions (Na or K) on chelating resin columns. With the Folch wash procedure the Na or K forms of ph...

journal_title：Lipids

authors： Carter HE,Weber EJ

更新日期：1966-01-01 00:00:00

abstract：:We have studied the effect of various diets on the phospholipid fatty acid composition and in vitro delta 5 desaturase activity of hepatic microsomes derived either from the normal or streptozotocin-induced diabetic rat. The diets studied were the standard rat chow diet and a basal fat-free diet supplemented either wi...

journal_title：Lipids

authors： Dang AQ,Kemp K,Faas FH,Carter WJ

更新日期：1989-10-01 00:00:00

abstract：:Taurolithocholic acid and deoxycholic acid were perfused into isolated prairie dog livers. Taurolithocholic acid was 7 alpha-hydroxylated to form taurochenodeoxycholic acid, whereas deoxycholic acid was conjugated and 7 alpha-hydroxylated to form taurocholic acid. The low concentrations of secondary bile acids observe...

journal_title：Lipids

authors： Cohen BI,Singhal AK,Mongelli J,Rothschild MA,McSherry CK,Mosbach EH

更新日期：1983-12-01 00:00:00

abstract：:We have examined the possibility that human polymorphonuclear cells exposed to IgA immune complexes can mediate the production of platelet-activating factor (PAF) and oxygen radicals. We found that human IgA and IgG immune aggregates stimulated, to a similar extent, PAF and O2- production by human polymorphonuclear ce...

journal_title：Lipids

authors： Hernando P,Egido J,de Nicolas R,Gonzalez E

更新日期：1991-12-01 00:00:00

abstract：:Maternal smoking during pregnancy has been associated with a reduced content of n-3 long-chain PUFA (LC-PUFA) in breast milk, thereby reducing the intake of key nutrients by the infants. We postulated that the mammary gland is affected by maternal smoking in the process of n-3 LC-PUFA secretion into milk. This prompte...

journal_title：Lipids

authors： Marangoni F,Colombo C,De Angelis L,Gambaro V,Agostoni C,Giovannini M,Galli C

更新日期：2004-07-01 00:00:00

abstract：:Since it was first suggested that high dietary fat is a risk factor in colon cancer, there have been several studies to test this hypothesis. Epidemiologic studies suggested a positive association between dietary fat and colon cancer. Laboratory animal model studies demonstrated that not only the amount of fat, but al...

journal_title：Lipids

authors： Reddy BS

更新日期：1992-10-01 00:00:00

abstract：:Type 2 diabetes and dyslipidemia are risk factors for cardiovascular disease. However, mechanisms by which hypertriglyceridemia influences atherogenesis remain unclear. We examined effects of dyslipidemic diabetic serum on macrophage lipid accumulation as a model of foam cell formation. Normal human macrophages were c...

journal_title：Lipids

authors： Wong BX,Kyle RA,Myhill PC,Croft KD,Quinn CM,Jessup W,Yeap BB

更新日期：2011-10-01 00:00:00

abstract：:The uptake of lipid from the yolk by the yolk sac membrane of the chick embryo is accompanied by the rapid esterification of a large proportion of the yolk cholesterol. This could arise from enhanced acyl-CoA:cholesterol acyltransferase (ACAT) activity and/or inhibition of cholesteryl ester hydrolase (CEH) activity. T...

journal_title：Lipids

authors： Shand JH,West DW,McCartney RJ,Noble RC,Speake BK

更新日期：1993-07-01 00:00:00

abstract：:trans-10,cis-12-CLA (t10,c12-CLA) inhibits lipid deposition in adipose tissue of many species, but it also enhances lipid deposition in liver. We evaluated effects of dietary t10,c12-CLA content and gender on carcass composition, FA profile of selected tissues, and expression of FA synthase (FAS) and stearoyl-CoA desa...

journal_title：Lipids

authors： Viswanadha S,McGilliard ML,Herbein JH

更新日期：2006-08-01 00:00:00

abstract：:The combustion method has been modified to increase the recovery of tritiated water after combustion of a tritium-labeled tissue sample. This was accomplished by cooling the bottom of the combustion flask in a dry ice-acetone bath while irradiating the top with an infrared lamp. The procedure resulted in at least 92% ...

journal_title：Lipids

authors： Parekh CK,Eigen E

更新日期：1968-05-01 00:00:00

abstract：:Triacylglycerols containing linoleate and linolenate found in vegetable oils were synthesized in gram quantities for oxidation studies. Two acylation methods were examined to convert diacylglycerols or monoacylglycerols to the desired triacylglycerols. Acylations with fatty acid and 1,1'-dicyclohexylcarbodiimide in th...

journal_title：Lipids

authors： Awl RA,Frankel EN,Weisleder D

更新日期：1989-10-01 00:00:00

abstract：:Three groups of male rats were fed either a corn oil-enriched diet (17%, w/w), a salmon oil-enriched diet (12.5%) supplemented with corn oil (4.5%) or a low-fat diet (4.4%) for eight wk to investigate the possible relationships between dietary fatty acids and lipid composition, and prostaglandin E2 level and phospholi...

journal_title：Lipids

authors： Grataroli R,Léonardi J,Charbonnier M,Lafont R,Lafont H,Nalbone G

更新日期：1988-07-01 00:00:00

abstract：:Mevalonic acid-derived intermediates in the cholesterol biosynthetic pathway have been recognized as being critical to the isoprenylation of a variety of growth-regulating proteins, including those of the RAS superfamily. Treatment of cells with lovastatin, a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibi...

journal_title：Lipids

authors： Ownby SE,Hohl RJ

更新日期：2002-02-01 00:00:00

abstract：:Decreased triacylglycerol synthesis within hepatocytes due to decreased diacylglycerol acyltransferase (DGAT) activity has been suggested to be an important mechanism by which diets rich in fish oil lower plasma triacylglycerol levels. New findings suggest that eicosapentaenoic acid (EPA), and not docosahexaenoic acid...

journal_title：Lipids

authors： Madsen L,Rustan AC,Vaagenes H,Berge K,Dyrøy E,Berge RK

更新日期：1999-09-01 00:00:00

abstract：:Starting at 21 days of age, groups of six rats each were fed a basal Torula yeast diet supplemented with 0.4% L-methionine and varying amounts of vitamin E as dl-alpha tocopherol acetate, selenium as sodium selenite, and with either 10% stripped corn oil, stripped lard, or coconut oil. By 7 wk, pentane production by r...

journal_title：Lipids

authors： Dillard CJ,Litov RE,Tappel AL

更新日期：1978-06-01 00:00:00

abstract：:Male Wistar rats were fed semipurifed diets containing 20% fat for 25 weeks. Ten different oils or oil blends were employed, including rapessed oils, simulated rapeseed-type oils, and modified rapeseed-type oils. Safflower, soybean, and hydrogenated coconut oils served as control oils. Histopathological examination of...

journal_title：Lipids

authors： McCutcheon JS,Umermura T,Bhatnager MK,Walker BL

更新日期：1976-07-01 00:00:00

abstract：:Cholesterol biosynthesis from acetate-2-(14)C by the livers of suckling rats, which is known to be relatively slow, was increased 2-3-fold within 24 hours after severing the bile duct. Cholesterol synthesis by sham-operated litter mates showed no change under similar treatment. Mevalonate biosynthesis from acetate-2-(...

journal_title：Lipids

authors： Harris RA,Rivera ER,Villemez CL Jr,Quackenbush FW

更新日期：1967-03-01 00:00:00