Effects of dietary corn oil and salmon oil on lipids and prostaglandin E2 in rat gastric mucosa.

Abstract:

:Three groups of male rats were fed either a corn oil-enriched diet (17%, w/w), a salmon oil-enriched diet (12.5%) supplemented with corn oil (4.5%) or a low-fat diet (4.4%) for eight wk to investigate the possible relationships between dietary fatty acids and lipid composition, and prostaglandin E2 level and phospholipase A2 activity in the rat gastric mucosa. High-fat diets induced no important variation in total protein, phospholipid and cholesterol contents of gastric mucosa. Compared with a low-fat diet, corn oil produced a higher n-6/n-3 ratio in mucosal lipids, whereas this ratio was markedly lowered by a fish oil diet. In comparison with the low-fat diet, the production of prostaglandin E2(PGE2) in gastric mucosa of rats fed salmon oil was significantly decreased by a factor of 2.8. In the corn oil group, PGE2 production tended to decrease, but not significantly. In comparison with the low-fat diet, both specific and total gastric mucosal phospholipase A2 activities were increased (+ 18 and 23%, respectively) in the salmon oil group; they were unchanged in the corn oil group. It is suggested that the decrease of gastric PGE2 in rats fed fish oil is not provoked by a decrease in phospholipase A2 activity but may be the result of the substitution of arachidonic acid by n-3 PUFA or activation of PGE2 catabolism.

journal_name

Lipids

journal_title

Lipids

authors

Grataroli R,Léonardi J,Charbonnier M,Lafont R,Lafont H,Nalbone G

doi

10.1007/BF02535665

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

666-70

issue

7

eissn

0024-4201

issn

1558-9307

journal_volume

23

pub_type

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