Abstract:
:Lipoprotein(a) [Lp(a)] represents a class of lipoprotein particles having as a protein moiety apoB-100 linked by a single disulfide bond to apolipoprotein(a) [apo(a)], a multikringle structure with a high degree of homology with plasminogen. A recognized feature of Lp(a) is its instability on storage caused by attendant protein and lipid modifications that affect the structural, functional, and immunological properties of this lipoprotein. Here we present data showing that, under appropriate conditions of cryopreservation, Lp(a) retains the properties of the freshly isolated product, and we provide examples supporting the stability of this cryopreserved product as a primary standard in immunoassay settings and in cell culture systems.
journal_name
Lipidsjournal_title
Lipidsauthors
Scanu AM,Hinman J,Pfaffinger D,Edelstein Cdoi
10.1007/s11745-004-1268-5subject
Has Abstractpub_date
2004-06-01 00:00:00pages
589-93issue
6eissn
0024-4201issn
1558-9307journal_volume
39pub_type
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