Triester glycerothiophosphates of cholecalciferol (vitamin D3).

Abstract:

:Tris(N,N-dimethyl)amide of phosphorous acid activated by addition of iodine at an optimal molar ratio of 1.05:0.05 was used as a phosphorylating reagent to synthesize cholecalciferyl-3-O-(1-2-isopropylidene-rac-glycero-3-O-)-thiophos phate and cholecalciferyl-3-O-(1,2-dipalmitoyl-rac-glycero-3-O-)thiophosphat e of methyl alcohol, 2-dimethylaminoethanol, 3-dimethylamino-1-propanol and 1,2-isopropylidene-rac-glycerol in a "one-pot procedure" in overall yields of 60-80%. Activation of the reaction with an equimolar mixture of imidazole and carbon disulfide at the triester formation step permits selective phosphorylation at room temperature. The compounds synthesized represent new triester phospholipid model compounds in which (in addition to glycerol and another requisite alcohol) a steroid and an element other than oxygen are bond to phosphorus.

journal_name

Lipids

journal_title

Lipids

authors

Stamatov SD,Gronowitz S

doi

10.1007/BF02536388

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

454-7

issue

6

eissn

0024-4201

issn

1558-9307

journal_volume

27

pub_type

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