A diurnal variation of hepatic acid cholesteryl ester hydrolase activity in the rat.

Abstract:

:The diurnal variation in lysosomal acid cholesteryl ester hydrolase (Acid CEH), (EC 3.1.1.13) has been examined in fed, fasted and adrenalectomized rats. The Acid CEH activity of normal rat liver exhibits a diurnal rhythm with maxima at 06.00 hours and minima at 18.00 hours, but such a rhythm was not observed in spleen and brain. This rhythm was abolished after fasting for two days, and the resulting Acid CEH activity remained constant at the minimum level. However, adrenalectomy did not abolish the diurnal rhythm. These results indicate that the Acid CEH activity varies according to a diurnal rhythm with maxima and minima separated by approximately 12 hr. Further, it is evident that the appearance of this rhythm is dependent upon dietary, but not adrenal hormone influence.

journal_name

Lipids

journal_title

Lipids

authors

Tanaka M,Yonekura R,Iio T,Tabata T

doi

10.1007/BF02534362

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

46-8

issue

1

eissn

0024-4201

issn

1558-9307

journal_volume

20

pub_type

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