Effects of eicosatetraynoic acid on membrane lipids of trout liver and intestine.

Abstract:

:After two months feeding either an (n-3) or an (n-6) fatty acid-rich diet, two groups of trout were switched to the (n-6) or the (n-3) fatty acid-rich diet, respectively. Half of each group was treated with 0.03% 5,8,11,14-eicosatetraynoic acid (ETYA) in the diet. Liver and intestinal brush border membrane lipids were analyzed. No effect was observed on their cholesterol content. ETYA induced an accumulation of 18:2(n-6), and it did not affect the 20:4(n-6) content but decreased the 22:5(n-6) content. ETYA induced an increase of 18:3(n-3) content in the brush border membrane and a decrease of the 22:6(n-3) content in the liver. Those results suggest that ETYA blocks mainly the delta 6-desaturase, which should have two different sites in the liver and one in the intestine.

journal_name

Lipids

journal_title

Lipids

authors

Pelletier X,Leray C

doi

10.1007/BF02536450

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

1053-6

issue

12

eissn

0024-4201

issn

1558-9307

journal_volume

22

pub_type

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