当前位置： SCI文献检索 > LIPIDS期刊下所有文献 > Effects of essential fatty acid deficiency on prostaglandin synthesis and fatty acid composition in rat renal medulla.

Effects of essential fatty acid deficiency on prostaglandin synthesis and fatty acid composition in rat renal medulla.

Abstract：

:Studies are reported on the capacity of isolated rat renal papilla (inner medulla) to synthesize and release prostaglandin (PG) E from endogenous and exogenous precursor(s) during development of an essential fatty acid (EFA) deficiency in the rat. Weanling (21-day-old) male Sprague-Dawley rats were fed a fat-free diet supplemented with either 5% hydrogenated coconut oil (HCO) or 5% safflower oil (SO). At approximately 3, 6 and 7 weeks (6. 9 and 10 weeks of age), groups of animals fed each diet were killed for studies of PGE synthesis in the renal papillae. Differences in the fatty acid composition of the papillae lipids of the animals of each group were also determined. The in vitro production of PGE from endogenous precursor(s) was significantly reduced in the papillae from the 6-week-old rats fed the HCO diet compared to the control (SO) rats, and appeared to be near maximally depressed in the 10-week-old animals compared to that of animals fed an EFA deficient diet for over a year in an accessory experiment. Analyses of the fatty acids of the papillae lipids of the HCO groups showed that the levels of 18:2 and 20:4 were markedly reduced, and those of 16:1, 18:1 and 20:3 were elevated compared to the controls even in the 6-week-old animals, typical of an EFA deficiency. The papillae lipids of the animals fed the HCO diet were also depleted of their stores of 22:4 omega 6. A fatty acid believed to be derived by chain elongation of 20:3 omega 9, 22:3, was found in large concentrations in the papillae triglycerides of the EFA deficient rats. Incubations of exogenous arachidonic acid (20:4) in homogenates and tissue slices of the papillae of the HCO dietary groups showed that the PG synthetase was not impaired by an EFA deficiency. The rate of PGE synthesis in the papillae of the EFA deficient animals was generally enhanced when exogenous 20:4 was added, indicating that the concentration of available precursor(s) is a primary factor in the control of PGE synthesis in the papilla of the rat.

journal_name

Lipids

journal_title

Lipids

authors

Dunham EW,Balasingam M,Privett OS,Nickell EC

doi

10.1007/BF02533845

subject

Has Abstract

pub_date

1978-12-01 00:00:00

pages

892-7

issue

12

eissn

0024-4201

issn

1558-9307

journal_volume

13

pub_type

杂志文章

相关文献

LIPIDS文献大全
  • Enrichment of LDL with EPA and DHA decreased oxidized LDL-induced apoptosis in U937 cells.

    abstract：:Oxidized LDL (oxLDL) may contribute to the accumulation of apoptotic cells in atherosclerotic plaques. Although it is well established in monophasic chemical systems that the highly unsaturated EPA and DHA will oxidize more readily than FA that contain fewer double bonds, our previous studies showed that enrichment of...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-002-0962-7

    authors： Wu T,Geigerman C,Lee YS,Wander RC

    更新日期：2002-08-01 00:00:00

  • Hyperthyroidism affects lipid metabolism in lactating and suckling rats.

    abstract：:Two per thousand pregnant women have hyperthyroidism (HT), and although the symptoms are attenuated during pregnancy, they rebound after delivery, affecting infant development. To examine the effects of hyperthyroidism on lactation, we studied lipid metabolism in maternal mammary glands and livers of hyperthyroid rats...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-001-0787-4

    authors： Varas SM,Jahn GA,Giménez MS

    更新日期：2001-08-01 00:00:00

  • Composition of lipids of bovine optic nerve.

    abstract：:Lipids from bovine optic nerve were analyzed. The total content of 16.5% by weight included 27.2% nonpolar lipids, 26.1% glycolipids, and 46.7% phospholipids by weight. Free cholesterol was the major component of the nonpolar lipid fraction. The cerebrosides, 73.5% of total glycolipids, were separated by thin layer ch...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/BF02533745

    authors： Das SK,Steen ME,McCullough MS,Bhattacharyya DK

    更新日期：1978-10-01 00:00:00

  • Comparison of lipid composition of Aedes aegypti and Aedes albopictus cells obtained from logarithmic and stationary phases of growth.

    abstract：:The total lipids, total neutral lipids, and total phospholipids from Aedes aegypti and aedes albopictus cells cultivated in vitro in a medium containing fetal calf serum were analyzed. The mosquito cells were harvested in the logarithmic and stationary phases of growth. The fatty acid profiles of the lipids showed dif...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/BF02532163

    authors： McMeans E,Yang TK,Anderson LE,Jenkin HM

    更新日期：1975-02-01 00:00:00

  • Regulation of hepatocyte lipid metabolism and inflammatory response by 25-hydroxycholesterol and 25-hydroxycholesterol-3-sulfate.

    abstract：:Dysregulation of lipid metabolism is frequently associated with inflammatory conditions. The mechanism of this association is still not clearly defined. Recently, we identified a nuclear oxysterol, 25-hydroxycholesterol-3-sulfate (25HC3S), as an important regulatory molecule involved in lipid metabolism in hepatocytes...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-010-3451-y

    authors： Xu L,Bai Q,Rodriguez-Agudo D,Hylemon PB,Heuman DM,Pandak WM,Ren S

    更新日期：2010-09-01 00:00:00

  • High-Fat Diets Containing Different Amounts of n3 and n6 Polyunsaturated Fatty Acids Modulate Inflammatory Cytokine Production in Mice.

    abstract：:Dysregulation of adipokines is a hallmark of obesity. Polyunsaturated fatty acids in fish oil may exert anti-inflammatory effects on adipose tissue mitigating the dysregulation of adipokines thereby preventing obesity. This study investigated the effects of high-fat diets containing different amounts of n3 polyunsatur...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-015-4093-x

    authors： Sundaram S,Bukowski MR,Lie WR,Picklo MJ,Yan L

    更新日期：2016-05-01 00:00:00

  • Oxidized lipoprotein(a) increases endothelial cell monolayer permeability via ROS generation.

    abstract：:Oxidized lipoprotein(a) (oxLp(a)) is a more potent marker of atherogenesis than native Lp(a). However, the molecular mechanisms of oxLp(a) activity are not clear. Reactive oxygen species (ROS) have recently been suggested as acting as intracellular second messengers. In this study, the effects of oxLp(a) on endothelia...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-013-3795-1

    authors： Wei DH,Zhang XL,Wang R,Zeng JF,Zhang K,Yang J,Li S,Lin XL,Jiang ZS,Wang GX,Wang Z

    更新日期：2013-06-01 00:00:00

  • The role of cytochrome P450 in the regulation of cholesterol biosynthesis.

    abstract：:A ubiquitously expressed member of the cytochrome P450 superfamily, CYP51, encodes lanosterol 14alpha-demethylase, the first step in the conversion of lanosterol into cholesterol in mammals. The biosynthetic intermediates of lanosterol 14alpha-demethylation are oxysterols, which inhibit HMG-CoA reductase and sterol sy...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-002-1016-x

    authors： Gibbons GF

    更新日期：2002-12-01 00:00:00

  • Cross-sectional associations of food consumption with plasma fatty acid composition and estimated desaturase activities in Finnish children.

    abstract：:Plasma fatty acid (FA) composition is known to be an indicator of dietary fat quality, but the associations of other dietary factors with plasma FA composition remain unknown in children. We investigated the cross-sectional associations of food consumption with the proportions of FA and estimated desaturase activities...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-014-3894-7

    authors： Venäläinen T,Schwab U,Ågren J,de Mello V,Lindi V,Eloranta AM,Kiiskinen S,Laaksonen D,Lakka TA

    更新日期：2014-05-01 00:00:00

  • Intestinal absorption of ester and ether glycerophospholipids in guinea pig. Role of a phospholipase A2 from brush border membrane.

    abstract：:In vivo intestinal perfusion was used to follow the absorption of three different choline glycerophospholipids (CGP) in guinea pig. These included 1-[3H]palmitoyl-2-acyl-sn-glycero-3-phosphocholine (diacyl-GPC), 1-[3H]-O-hexadecyl-2-acyl-sn-glycero-3-phosphocholine (alkylacyl-GPC) and 1,2-di-O-hexadecyl-sn-glycero-3-p...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/BF02534872

    authors： Diagne A,Mitjavila S,Fauvel J,Chap H,Douste-Blazy L

    更新日期：1987-01-01 00:00:00

  • Identification of novel nonmethylene-interrupted fatty acids, 7E,13E-20:2, 7E,13E,17Z-20:3, 9E,15E,19Z-22:3, and 4Z,9E,15E,19Z-22:4, in Ophiuroidea (brittle star) lipids.

    abstract：:Fatty acids of Ophiuroidea (brittle star) Ophiura sarsi have been investigated by gas-liquid chromatography (GLC). About 2-13% of four unidentified fatty acids were found in total fatty acids from a sample caught at a depth of 1,100 m. Structural analyses were undertaken after partial hydrogenation of their concentrat...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-001-0854-x

    authors： Sato D,Ando Y,Tsujimoto R,Kawasaki K

    更新日期：2001-12-01 00:00:00

  • Altered lipid parameters in hepatic subcellular membrane fractions induced by fumonisin B1.

    abstract：:Alteration of lipid constituents of cellular membranes has been proposed as a possible mechanism for cancer promotion by fumonisin B(1 )(FB(1)). To further investigate this hypothesis a dietary dosage which initiates and promotes liver cancer (250 mg FB(1)/kg) was fed to male Fischer rats for 21 days and the lipid com...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-007-3025-9

    authors： Burger HM,Abel S,Snijman PW,Swanevelder S,Gelderblom WC

    更新日期：2007-04-01 00:00:00

  • Measurements of Singlet Oxygen-Quenching Activity of Vitamin E Homologs and Palm Oil and Soybean Extracts in a Micellar Solution.

    abstract：:Recently, a new assay method that can quantify the singlet oxygen-absorption capacity (SOAC) of antioxidants (AO) and food extracts in homogeneous organic solvents has been proposed. In the present study, second-order rate constants (kQ ) for the reaction of singlet oxygen (1 O2 ) with vitamin E homologs (α-, β-, γ-, ...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1002/lipd.12053

    authors： Mukai K,Ishikawa E,Ouchi A,Nagaoka SI,Abe K,Suzuki T,Izumisawa K

    更新日期：2018-06-01 00:00:00

  • DGAT1, DGAT2 and PDAT expression in seeds and other tissues of epoxy and hydroxy fatty acid accumulating plants.

    abstract：:Triacylglycerol (TAG) is the main storage lipid in plants. Acyl-CoA: diacylglycerol acyltransferase (DGAT1 and DGAT2) and phospholipid: diacylglycerol acyltransferase (PDAT) can catalyze TAG synthesis. It is unclear how these three independent genes are regulated in developing seeds, and particularly if they have spec...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-010-3385-4

    authors： Li R,Yu K,Hildebrand DF

    更新日期：2010-02-01 00:00:00

  • Incorporation of lipids labeled with various fatty acids into the cytoskeleton of aggregating platelets.

    abstract：:Earlier studies showed that during the first 20 to 25 seconds of aggregation induced by thrombin (0.1 U/mL) or adenosine diphosphate (ADP) (2 microM) of rabbit or human platelets prelabeled with [3H]palmitic acid, labeled lipid became associated with the cytoskeleton (isolated after lysis with 1% Triton X-100, 5 mM EG...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/BF02536590

    authors： Packham MA,Guccione MA,Bryant NL,Livne A

    更新日期：1991-07-01 00:00:00

  • Interrelationship between dietary trans Fatty acids and the 6- and 9-desaturases in the rat.

    abstract：:Studies are reported on the effects of dietary trans fatty acids on the 6- and 9-acyl desaturase activities in the liver microsomes of rats fed essential fatty acid (EFA)-deficient and non-EFA-deficient diets. In experiment I, weanling male rats were fed a semisynthetic diet with either 10% safflower oil (SAF) or 10% ...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/BF02535118

    authors： De Schrijver R,Privett OS

    更新日期：1982-01-01 00:00:00

  • Reversed-Phase Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry for High-Throughput Molecular Profiling of Sea Cucumber Cerebrosides.

    abstract：:Usually, the chemical structures of cerebrosides in sea creatures are more complicated than those from terrestrial plants and animals. Very little is known about the method for high-throughput molecular profiling of cerebrosides in sea cucumbers. In this study, cerebrosides from four species of edible sea cucumbers, s...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-015-4039-3

    authors： Jia Z,Cong P,Zhang H,Song Y,Li Z,Xu J,Xue C

    更新日期：2015-07-01 00:00:00

  • Gamma linolenic acid attenuates cardiovascular responses to stress in borderline hypertensive rats.

    abstract：:The purpose of the present study was to investigate the effects of gamma linolenic acid (GLA) on cardiovascular responses to psychosocial stress (isolation) and to pressor hormones in the genetically borderline hypertensive rat (SHR X WKY). Adult male SHR X WKY were divided into two groups following five weeks of grou...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/BF02534282

    authors： Mills DE,Summers MR,Ward RP

    更新日期：1985-09-01 00:00:00

  • Evaluation of chromic oxide, glycerol triether, and beta-sitosterol as fecal flow markers in two species of nonhuman primates.

    abstract：:Recovery of beta-sitosterol, glycerol triether (1-hexadecyl-2,3-didodecyl glycerol triether), and chromic oxide was studied in African green monkeys and stumptail macaques consuming diets containing 0.75 mg/Cal cholesterol and 38% of calories as safflower oil or butter. Following oral administration of these compounds...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/BF02532190

    authors： St Clair RW,Lehner ND,Hamm TE

    更新日期：1975-01-01 00:00:00

  • Epoxidation reactions of unsaturated fatty esters with potassium peroxomonosulfate.

    abstract：:Epoxidation of the double bond in methyl oleate, octadec-11E-en-9-ynoate, ricinoleate (12-hydroxy-octadec-9Z-enoate), iso-ricinoleate (9-hydroxy-octadec-12Z-enoate), and 12-oxo-octadec-9Z-enoate with potassium peroxomonosulfate (oxone, 2 KHSO5.KHSO4.K2SO4) in the presence of trifluoroacetone or methyl pyruvate gave th...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-998-0250-6

    authors： Lie Ken Jie MS,Pasha MK

    更新日期：1998-06-01 00:00:00

  • The questionable role of a microsomal delta8 acyl-coA-dependent desaturase in the biosynthesis of polyunsaturated fatty acids.

    abstract：:Several experimental approaches were used to determine whether rat liver and testes express an acyl-CoA-dependent delta8 desaturase. When [1-14C]5,11,14-eicosatrienoic acid was injected via the tail vein, or directly into testes, it was incorporated into liver and testes phospholipids, but it was not metabolized to ot...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-000-0596-9

    authors： Chen Q,Yin FQ,Sprecher H

    更新日期：2000-08-01 00:00:00

  • Membrane docosahexaenoic acid vs. eicosapentaenoic acid and the beating function of the cardiomyocyte and its regulation through the adrenergic receptors.

    abstract：:The beta-adrenergic system in cardiac muscle cells is influenced by the n-3 polyunsaturated fatty acid (PUFA) content in cell membranes. This study deals with the specific effect of docosahexaenoic acid (DHA) as compared to other n-3 PUFA, without modification of the arachidonic acid content. Increasing the DHA conten...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：

    authors： Grynberg A,Fournier A,Sergiel JP,Athias P

    更新日期：1996-03-01 00:00:00

  • Monitoring the oxidation of docosahexaenoic acid in lipids.

    abstract：:The oxidation of free DHA, DHA mixed with PC, and DHA incorporated into PC, PE, or TG was evaluated to determine which lipid provided DHA with the best protection against oxidation. DHA was either situated at the sn-1 position, sn-2 position, or both positions of the phospholipid, whereas the TG contained DHA at all p...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-005-1458-1

    authors： Lyberg AM,Fasoli E,Adlercreutz P

    更新日期：2005-09-01 00:00:00

  • Dietary fat and colon cancer: animal model studies.

    abstract：:Since it was first suggested that high dietary fat is a risk factor in colon cancer, there have been several studies to test this hypothesis. Epidemiologic studies suggested a positive association between dietary fat and colon cancer. Laboratory animal model studies demonstrated that not only the amount of fat, but al...

    journal_title：Lipids

    pub_type： 杂志文章,评审

    doi：10.1007/BF02535855

    authors： Reddy BS

    更新日期：1992-10-01 00:00:00

  • Long-chain polyunsaturated fatty acids in plasma lipids of obese children.

    abstract：:Fatty acid composition of plasma phospholipids (PL), triglycerides (TG), and sterol esters (STE) was determined by high-resolution capillary gas-liquid chromatography in 22 obese children (age: 13.7 +/- 1.4 y, body weight relative to normal weight for height: 170 +/- 24%, mean +/- SD) and compared with data obtained i...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/BF02529877

    authors： Decsi T,Molnár D,Koletzko B

    更新日期：1996-03-01 00:00:00

  • Fast transmethylation of total lipids in dried blood by microwave irradiation and its application to a population study.

    abstract：:A methodology combining finger-pricked blood sampling, microwave accelerated fatty acid assay, fast gas chromatography data acquisition, and automated data processing was developed, evaluated and applied to a population study. Finger-pricked blood was collected on filter paper previously impregnated with 0.05 mg of th...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-014-3918-3

    authors： Lin YH,Hanson JA,Strandjord SE,Salem NM,Dretsch MN,Haub MD,Hibbeln JR

    更新日期：2014-08-01 00:00:00

  • Dietary cod liver oil decreases arachidonic acid in rat gastric mucosa and increases stress-induced gastric erosions.

    abstract：:The purpose of this study was to examine the influence of long-term feeding of dietary fat rich in either n-3 or n-6 fatty acids on the availability of arachidonic acid (20:4n-6) in major phospholipids of gastric mucosa in rats. Three groups of male Wistar rats were fed either a standard diet, a cod liver oil-enriched...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/s11745-000-0562-6

    authors： Olafsson SO,Hallgrimsson J,Gudbjarnason S

    更新日期：2000-06-01 00:00:00

  • Antagonism of platelet-activating factor in isolated rat colon: possible mechanism.

    abstract：:The contractions of three different regions of rat colon in response to platelet-activating factor (PAF) were compared. The ascending colon was found to be the most responsive. The slow contraction of the ascending colon induced by PAF was dependent on external Ca2+. CV-3988, a structural analog of PAF, slowly induced...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/BF02536563

    authors： Tokumura A,Yube N,Terao M,Tsukatani H

    更新日期：1991-12-01 00:00:00

  • Polyphosphoinositide formation in isolated cardiac plasma membranes.

    abstract：:Phosphatidylinositol (PtdIns) and phosphatidylinositol 4-phosphate (PtdIns4P) kinase activities in plasma membranes isolated from canine left ventricle were partially characterized, and their sensitivity to a number of intracellular variables was established. PtdIns and PtdIns4P kinase activities were estimated by the...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/BF02544590

    authors： Kasinathan C,Xu ZC,Kirchberger MA

    更新日期：1989-09-01 00:00:00

  • Sesame seed and its lignans produce marked enhancement of vitamin E activity in rats fed a low alpha-tocopherol diet.

    abstract：:Three series of experiments demonstrated that sesame seed and its lignans cause significant elevation of alpha-tocopherol content in rats. In Experiment 1, 20% sesame seed (with a negligible amount of alpha-tocopherol) supplementing 10 (low), 50 (normal), or 250 (high) mg/kg alpha-tocopherol diets (protein and fat con...

    journal_title：Lipids

    pub_type： 杂志文章

    doi：10.1007/BF02536287

    authors： Yamashita K,Iizuka Y,Imai T,Namiki M

    更新日期：1995-11-01 00:00:00