Age-related changes in biological parameters in Zucker rats.

Abstract:

:Changes in a number of morphological and biochemical parameters were observed in genetically obese Zucker rats and in lean controls between 3 and 58 weeks of age. By 3 weeks, the genetically obese rats had higher proportional (wt/100 g body wt) and absolute amounts of adipose tissue, hyperlipemia affecting all the lipid fractions, and hyperproteinemia compared to lean controls. Obesity, hepatomegaly, high concentrations of hepatic lipids and hyperinsulinemia did not appear until the fifth week. In obese animals, liver lipid concentration reached a maximum at 17 weeks of age and then declined. During this time, the triacylglycerol concentration in the serum remained stable, whereas the cholesterol and phospholipid concentrations continued to increase. The glycogen concentration in obese animals increased, both absolutely and compared to lean controls, between the 12th and 43rd weeks of age. From weaning, the Zucker rats, compared to lean controls, exhibited characteristics of obesity (accumulation of adipose tissue, hyperlipemia and hyperproteinemia), which persisted to the age of 58 weeks.

journal_name

Lipids

journal_title

Lipids

authors

Bach A,Schirardin H,Bauer M,Schaeffer A,Weryha A

doi

10.1007/BF02535040

subject

Has Abstract

pub_date

1981-11-01 00:00:00

pages

841-8

issue

11

eissn

0024-4201

issn

1558-9307

journal_volume

16

pub_type

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