Abstract:
:Yeast mutant strains auxotrophic for ergosterol and blocked in mevalonate diphosphate decarboxylase (erg19) and farnesyl diphosphate (FPP) synthetase (erg20) were isolated. The main feature of the mutants blocked in FPP synthetase is their ability to excrete prenyl alcohols, such as geraniol and farnesol. The isolation of the functional ERG20 gene allowed us to show that farnesyl diphosphate synthetase could be a rate limiting enzyme in ergosterol biosynthesis in yeast.
journal_name
Lipidsjournal_title
Lipidsauthors
Chambon C,Ladeveze V,Servouse M,Blanchard L,Javelot C,Vladescu B,Karst Fdoi
10.1007/BF02536428subject
Has Abstractpub_date
1991-08-01 00:00:00pages
633-6issue
8eissn
0024-4201issn
1558-9307journal_volume
26pub_type
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