Inhibition of hepatic cholesterol biosynthesis by chloroquine.

abstract：:The purpose of these experiments was to study the uptake and metabolism of exogenous triglyceride in the isolated perfused rabbit heart. When infused into the rabbit heart, [9,10-3H(N)]triolein was retained and incorporated into a lipid fraction that had the chromatographic mobility of authentic triolein. Incorporatio...

journal_title：Lipids

authors： Weis MT,Palazzo AJ,Williams JL Jr,Malik KU

更新日期：1990-08-01 00:00:00

abstract：:The reciprocal replacement of DHA by docosapentaenoic acid (DPAn-6) was studied in rats that consumed an n-3 FA-deficient or n-3 FA-adequate diet. Dams were fed the two experimental diets from weaning and throughout pregnancy and lactation. Their pups were then fed the respective diets after weaning. Cortex FA analysi...

journal_title：Lipids

authors： Greiner RS,Catalan JN,Moriguchi T,Salem N Jr

更新日期：2003-04-01 00:00:00

abstract：:The activity of the platelet-activating factor (PAF)-synthesizing enzyme, 1-O-alkyl-sn-glycero-3-phosphocholine (lysoPAF):acetyl-CoA acetyltransferase (EC 2.3.1.67) in alveolar macrophage lysate was found to be elevated after warming the cells to 37 degrees C. Such an increase in enzyme activity was detectable only wh...

journal_title：Lipids

authors： Sugiura T,Fukuda T,Cheng NN,Waku K

更新日期：1991-11-01 00:00:00

abstract：:Male and female weanling rats that were born to dams fed a diet low in linolenic acid received diets of 15% lipids by weight containing 45% elaidic acid (as trielaidin) and 8.5% or 0.1% linolenic acid for 10 weeks. Four other groups, in which palmitic or oleic acid replaced elaidic acid in the diet, served as controls...

journal_title：Lipids

authors： Astorg PO,Chevalier J

更新日期：1987-12-01 00:00:00

abstract：:The fatty acid composition of cerebrosides of developing foetal human brain and regional variations, if any, during intrauterine life were studied. While palmitic and stearic acids were the predominant normal fatty acids throughout intrauterine life, long chain fatty acids, like lignoceric and nervonic acids, which we...

journal_title：Lipids

authors： Rao PS

更新日期：1977-04-01 00:00:00

abstract：:The activity of pyruvate dehydrogenase from freshly isolated mitochondria was shown to be dependent upon the nutritional and metabolic state of the animal prior to sacrifice, such that mitochondria from the livers of 48 hr starved, diabetic, or high fat fed rats had lower enzyme activity than normal, chow fed rats. Th...

journal_title：Lipids

authors： Mapes JP,Harris RA

更新日期：1975-12-01 00:00:00

abstract：:Five groups of salmon, of initial mean weight 127 +/- 3 g, were fed increasing levels of dietary linseed oil (LO) in a regression design. The control diet contained capelin oil (FO) only, and the same oil was blended with LO to provide the experimental diets. After an initial period of 40 wk, all groups were switched ...

journal_title：Lipids

authors： Bell JG,Henderson RJ,Tocher DR,Sargent JR

更新日期：2004-03-01 00:00:00

abstract：:Four bacterial isolates, which produced polyunsaturated fatty acids (PUFA), were isolated from water samples of radioactive springs collected from Jáchymov spa. Jáchymov (Sankt Joachimsthal) is a city in northwestern Bohemia, where Marie and Pierre Curie isolated radium in 1898 from the mineral uraninite. To date, fou...

journal_title：Lipids

authors： Řezanka T,Gharwalová L,Nováková G,Kolouchová I,Uhlík O,Sigler K

更新日期：2019-02-01 00:00:00

abstract：:Flaxseed derivatives, including both oil and flax lignan, modify progression of renal injury in animal models, including Han:SPRD-cy polycystic kidney disease (PKD). Gender is a significant factor in the rates of progression of many forms of human renal disease, but the role of gender in the response to nutrition inte...

journal_title：Lipids

authors： Ogborn MR,Nitschmann E,Bankovic-Calic N,Weiler HA,Aukema HM

更新日期：2006-12-01 00:00:00

abstract：:Minimal deviation hepatoma 7288 C cells were cultured in Swim's medium containing 10% serum for 48 hr. The growth medium was replaced with serum free media containing different concentrations of [1-14C] eicosa-8,11,14-trienoic acid and the cells were incubated for 24 hr. Incorporation into cell lipids, oxidation to CO...

journal_title：Lipids

authors： Gaspar G,de Alaniz MJ,Brenner RR

更新日期：1975-12-01 00:00:00

abstract：:The synthesis of phosphoglycerides is reviewed. Emphasis is placed upon precursor and intermediate compounds, phosphatidic acid, phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl serine, monoacylphosphoglycerides, purification and proof of structure. Suggestions are made for large scale synthesis of phosph...

journal_title：Lipids

authors： Jensen RG,Gordon DT

更新日期：1972-09-01 00:00:00

abstract：:It has been shown that different lysophosphatidylcholines (LPC) possess relaxing properties in vascular strips. We report on the effect of intraatrial injection of LPC micelles into white New Zealand rabbits. Changes in renal and coronary flow were determined by radioactive microspheres. Coronary blood flow increased ...

journal_title：Lipids

authors： Wolf A,Saito T,Dudek R,Bing RJ

更新日期：1991-03-01 00:00:00

abstract：:The subcellular distribution of the enzymes of triacylglycerol biosynthesis has been studied in developing oilseed rape. All in vitro enzymatic activities from oleoyl-CoA to triacylglycerol were sufficient to account for the known rate of oleate deposition in triacylglycerol in vivo. The enzymatic activities from oleo...

journal_title：Lipids

authors： Murphy DJ

更新日期：1988-03-01 00:00:00

abstract：:Lifibrol, a new hypocholesterolemic agent with activity in humans, was examined in normal rats for its short-term and long-term effects on lipid homeostasis. Cholesterol (Chol) synthesis inhibition by lifibrol was demonstrated in vitro in liver minces from normal rats by following [1-14C]acetate ([14C]Ac) and DL-[2-14...

journal_title：Lipids

authors： Bell FP,St John LC

更新日期：1993-12-01 00:00:00

abstract：:Oxidized low density lipoprotein (Ox-LDL) is a well-established risk factor in atherosclerosis and lysophosphatidylcholine (LysoPtdCho) is considered to be one of the major atherogenic component of Ox-LDL. The purpose of this work was to investigate the effects of two membrane n-3 long chain polyunsaturated fatty acid...

journal_title：Lipids

authors： Tardivel S,Gousset-Dupont A,Robert V,Pourci ML,Grynberg A,Lacour B

更新日期：2009-03-01 00:00:00

abstract：:There have been a limited number of studies investigating surfactant lipid changes in lung with trace elements. The present investigation was designed to examine the effect of moderate zinc deficiency on the lipid metabolism in rat lung. We also evaluated whether zinc deficiency, which is a wide-spread problem, could ...

journal_title：Lipids

authors： Gomez NN,Ojeda MS,Gimenez MS

更新日期：2002-03-01 00:00:00

abstract：:In this paper, evidence is presented on the capacity of Ehrlich ascites cells to synthesize in vitro monounsaturated fatty acids from radioactive palmitate. Localization of the double bond was determined by ozonolysis and subsequent reduction of the ozonides to aldesters followed by gas liquid chromatography. These re...

journal_title：Lipids

authors： Mercuri O,De Tomás ME,de Antueno RJ

更新日期：1981-12-01 00:00:00

abstract：:The sciatic nerve of rats fed sunflower oil (6 mg 18:3-n-3/100 g of diet) presented dramatic alterations in the long chain polyunsaturated fatty acids in comparison with those fed soy oil (130 mg 18:3n-3/100 g of diet). In both 15-day-old and 60-day-old animals fed sunflower oil, 22:6n-3 (cervonic acid) was four-fold ...

journal_title：Lipids

authors： Bourre JM,Youyou A,Durand G,Pascal G

更新日期：1987-07-01 00:00:00

abstract：:The concentrations of the major neutral lipid and phospholipid classes in the plasma of rats bearing hepatoma 7288CTC were determined at various times after transplantation. The fatty acid composition of each lipid class was also analyzed quantitatively as tumor growth progressed. Generally, most lipid classes exhibit...

journal_title：Lipids

authors： Matocha M,Wood R

更新日期：1980-06-01 00:00:00

abstract：:Two electrophoretically different forms of sterol ester hydrolase (EC 3.1.1.13) were obtained from the cytoplasmic extract of the mycelia of Fusarium oxysporum. The entities, estimated at 60,000 (I) and 15,000 (II) molecular weights, were obtained in Sephadex G100 column chromatography of the ammonium sulfate precipit...

journal_title：Lipids

authors： Madhosingh C,Orr W

更新日期：1981-02-01 00:00:00

abstract：:The effects of beta-muricholic acid and hyocholic acid on cholesterol cholelithiasis were examined in two animal models. The following experiments were carried out: A) In a gallstone prevention study, prairie dogs were fed the lithogenic diet with or without 0.1% beta-muricholic or 0.1% hyocholic acid for eight weeks....

journal_title：Lipids

authors： Cohen BI,Mikami T,Ayyad N,Ohshima A,Infante R,Mosbach EH

更新日期：1995-09-01 00:00:00

abstract：:Bdellovibrionales is a phylogenetically diverse group of predatory prokaryotes, which consists of the two families Bdellovibrionaceae and Bacteriovoracaceae. We describe LPS and lipid A of the type strain Bacteriovorax stolpii DSM 12778, representing the first characterized endotoxin of a Bacteriovoracaceae member. It...

journal_title：Lipids

authors： Beck S,Müller FD,Strauch E,Brecker L,Linscheid MW

更新日期：2010-02-01 00:00:00

abstract：:Potato tuber lipoxygenase (ptLOX) has been shown to catalyze the aerobic formation of at least four major oxygenated derivatives of DHA. Two of the products--7,17(S)- and 10,17(S)-dihydro(pero)xy-DHA [7,17- and 10,17-diH(P)DHA]--were formed from soybean 15-LOX-derived 17(S)-hydro(pero)xy-DHA [17(S)-H(P)DHA], whereas t...

journal_title：Lipids

authors： Butovich IA,Hamberg M,Rådmark O

更新日期：2005-03-01 00:00:00

abstract：:Four Canadian varieties of potatoes were examined for their lipid composition. Lipids, extracted with chloroformmethanol, were shown by TLC and column chromatography to consist of 16.5% neutral lipids, 45.5% phospholipids and 38.1% glycolipids. Among the phospholipids and glycolipids, phosphatidyl choline, phosphatidy...

journal_title：Lipids

authors： Lepage M

更新日期：1968-11-01 00:00:00

abstract：:To address the role of cell membrane neutral sphingomyelinase (EC 3.1.4.12; SMase) in the regulation of cholesterol metabolism in the liver parenchymal cell, we examined the effect of exogenous neutral SMase on the metabolism of cholesteryl esters and the secretion of VLDL and biliary lipids in isolated rat hepatocyte...

journal_title：Lipids

authors： Liza M,Chico Y,Fresnedo O,Ochoa B

更新日期：2003-01-01 00:00:00

abstract：:This study investigated the effect of triticale dried distillers' grain with solubles (DDGS), flax (FS) and sunflower (SS) seed on growth and the fatty acid profile of subcutaneous (SQ) fat in individually housed steers (n = 15 per diet) fed ad libitum (DM basis); (1) control (CON) 90% barley grain + 10% barley silage...

journal_title：Lipids

authors： He ML,Sultana H,Oba M,Kastelic JP,Dugan ME,McKinnon JJ,McAllister TA

更新日期：2012-12-01 00:00:00

abstract：:De novo synthesis and mitochondrial elongation of fatty acids have been demonstrated in subcellular fractions from hog and human aorta. Microsomal fatty acid elongation has been shown in hog aorta. The activity catalyzing the formation of fatty acids from acetyl and malonyl CoA was associated with a high molecular wei...

journal_title：Lipids

authors： Slakey LL,Ferrick TJ,Ness GC,Porter JW

更新日期：1979-05-01 00:00:00

abstract：:In offspring exposed in utero to a maternal diet high in fat (HF), we have previously demonstrated that despite similar birth weights, HF adult offspring at 6 months of age had significantly higher body weights, greater adiposity, and increased triacylglycerol (TAG) levels as compared to controls. We hypothesized that...

journal_title：Lipids

authors： Seet EL,Yee JK,Jellyman JK,Han G,Ross MG,Desai M

更新日期：2015-06-01 00:00:00

abstract：:1,2-Diacylglycerol, which has been recognized as one of the intracellular second messengers, was measured quantitatively in the lipid extract from rat hearts using the thin layer chromatography and flame ionization detection (TLC/FID) method. Cholesterol acetate was added to the tissue as an internal standard, and the...

journal_title：Lipids

authors： Okumura K,Hashimoto H,Ito T,Ogawa K,Satake T

更新日期：1988-03-01 00:00:00

abstract：:Neutrophils play a major role in inflammation by releasing large amounts of reactive oxygen species (ROS) produced by NADPH oxidase (NOX) and myeloperoxidase (MPO). This ROS overproduction is mediated by phosphorylation of the NOX subunits in an uncontrolled manner. Therefore, targeting neutrophil subunits would repre...

journal_title：Lipids

authors： Liu M,Boussetta T,Makni-Maalej K,Fay M,Driss F,El-Benna J,Lagarde M,Guichardant M

更新日期：2014-01-01 00:00:00