Hydroxylation of secondary bile acids in the perfused prairie dog liver.

Abstract:

:Taurolithocholic acid and deoxycholic acid were perfused into isolated prairie dog livers. Taurolithocholic acid was 7 alpha-hydroxylated to form taurochenodeoxycholic acid, whereas deoxycholic acid was conjugated and 7 alpha-hydroxylated to form taurocholic acid. The low concentrations of secondary bile acids observed in prairie dog bile are due, at least in part, to active bile acid 7 alpha-hydroxylase(s) in the liver of these animals.

journal_name

Lipids

journal_title

Lipids

authors

Cohen BI,Singhal AK,Mongelli J,Rothschild MA,McSherry CK,Mosbach EH

doi

10.1007/BF02534573

subject

Has Abstract

pub_date

1983-12-01 00:00:00

pages

909-12

issue

12

eissn

0024-4201

issn

1558-9307

journal_volume

18

pub_type

杂志文章

相关文献

LIPIDS文献大全
  • Triolein and trilinolein ameliorate oxidized low-density lipoprotein-induced oxidative stress in endothelial cells.

    abstract::Uptake of oxidized low-density lipoprotein by endothelial cells is a critical step for the initiation of atherosclerosis. Triacylglycerol uptake in these cells is understood to be a part of the process. The present investigation, comparison among the effects of simple acylglycerol, including tristearin, triolein, and ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-014-3889-4

    authors: Luo T,Deng ZY,Li XP,Rao H,Fan YW

    更新日期:2014-05-01 00:00:00

  • Use of a fluorescent radiolabeled triacylglycerol as a substrate for lipoprotein lipase and hepatic triglyceride lipase.

    abstract::A fluorescent radiolabeled triacylglycerol has been synthesized by using a fluorescent fatty acid (pyrene decanoic acid) and a radiolabeled oleic acid. This analog of the natural substrate, 1(3)pyrene decanoic-2,3 (1,2)-dioleoyl-sn-glycerol, has been tested as substrate for determining lipoprotein lipase and hepatic t...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535605

    authors: Dousset N,Negre A,Salvayre R,Rogalle P,Dang QQ,Douste-Blazy L

    更新日期:1988-06-01 00:00:00

  • Dietary fat and colon cancer: animal model studies.

    abstract::Since it was first suggested that high dietary fat is a risk factor in colon cancer, there have been several studies to test this hypothesis. Epidemiologic studies suggested a positive association between dietary fat and colon cancer. Laboratory animal model studies demonstrated that not only the amount of fat, but al...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/BF02535855

    authors: Reddy BS

    更新日期:1992-10-01 00:00:00

  • Synthesis of octadecynoic acids and [1-14C] labeled isomers of octadecenoic acids.

    abstract::Geometric and positional isomers of [1-14C] octadecenoic acids have been synthesized by modifications of published procedures. Positional isomers of octadecynoic acids also have been synthesized to obtain the geometric and positional isomers of the unlabeled octadecenoic acid analogs. The syntheses were accomplished b...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534194

    authors: Valicenti AJ,Pusch FJ,Holman RT

    更新日期:1985-04-01 00:00:00

  • Quantitation of vitamin K in human milk.

    abstract::A quantitative method was developed for the assay of vitamin K in human colostrum and milk. The procedure combines preparative and analytical chromatography on silica gel in a nitrogen atmosphere followed by reversed phase high performance liquid chromatography (HPLC). Two HPLC steps were used: gradient separation wit...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02537985

    authors: Canfield LM,Hopkinson JM,Lima AF,Martin GS,Sugimoto K,Burr J,Clark L,McGee DL

    更新日期:1990-07-01 00:00:00

  • Measurement of human chylomicron triglyceride clearance with a labeled commercial lipid emulsion.

    abstract::Human chylomicron triglyceride (TG) kinetics has been difficult to determine directly owing to technical limitations. This report describes a new method for studying chylomicron metabolism. Healthy volunteers (n = 10) sipped a drink providing 175 mg fat x kg(-1) h(-1) for 7.5 h to produce a steady-state chylomicronemi...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-001-0696-6

    authors: Park Y,Damron BD,Miles JM,Harris WS

    更新日期:2001-02-01 00:00:00

  • Sources of triacylglycerol accumulation in livers of rats fed a cholesterol-supplemented diet.

    abstract::The source of free fatty acids (FFA) and the pathways contributing to the accumulation of neutral fats in livers of rats fed a cholesterol-enriched diet were investigated in this report. Supplementation with 1% cholesterol in the diet for four weeks resulted in hepatomegaly in the rats. The contents of cholesterol and...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02537027

    authors: Liu CH,Huang MT,Huang PC

    更新日期:1995-06-01 00:00:00

  • Involvement of phospholipids in apolipoprotein B modification during low density lipoprotein oxidation.

    abstract::An increased amount of phospholipids remained attached on delipidated apolipoprotein B originated from oxidized low density lipoprotein (LDL). 31P nuclear magnetic resonance analysis of such apolipoprotein showed an organic phosphorus peak at -0.55 ppm, which suggests the formation of adducts (most probably Schiff bas...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-998-0318-3

    authors: Karakatsani AI,Liapikos TA,Troganis AN,Tsoukatos DC

    更新日期:1998-12-01 00:00:00

  • CETP and LCAT Gene Polymorphisms Are Associated with High-Density Lipoprotein Subclasses and Acute Coronary Syndrome.

    abstract::We evaluated whether CETP and LCAT gene polymorphisms are statistically associated with the high-density lipoprotein (HDL) size distribution, the cholesterol level of HDL subclasses, and the acute coronary syndrome (ACS) susceptibility. Two CETP gene polymorphisms (rs4783961 and rs708272) and one LCAT polymorphism (rs...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1002/lipd.12017

    authors: Vargas-Alarcon G,Perez-Mendez O,Herrera-Maya G,Garcia-Sanchez C,Martinez-Rios MA,Peña-Duque MA,Posadas-Sanchez R,Posadas-Romero C,Escobedo G,Fragoso JM

    更新日期:2018-02-01 00:00:00

  • Dietary sunflower oil reduces plasma and liver triacylglycerols in fasting rats and is associated with decreased liver microsomal phosphatidate phosphohydrolase activity.

    abstract::Plasma and liver lipids were studied in male weanling rats fed diets containing moderate levels of fat (6% by weight) as sunflower oil (SF diet, rich in linoleic acid), salmon oil (SM diet, rich in long-chain n-3 fatty acids), or a blend of peanut and rapeseed oil (PR diet, rich in oleic acid). After nine weeks of fee...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522983

    authors: Frémont L,Gozzelino MT

    更新日期:1996-08-01 00:00:00

  • Antibacterial Activity of Hexadecynoic Acid Isomers toward Clinical Isolates of Multidrug-Resistant Staphylococcus aureus.

    abstract::In the present study, the structural characteristics that impart antibacterial activity to C16 alkynoic fatty acids (aFA) were further investigated. The syntheses of hexadecynoic acids (HDA) containing triple bonds at C-3, C-6, C-8, C-9, C-10, and C-12 were carried out in four steps and with an overall yield of 34-78%...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1002/lipd.12213

    authors: Sanabria-Ríos DJ,Morales-Guzmán C,Mooney J,Medina S,Pereles-De-León T,Rivera-Román A,Ocasio-Malavé C,Díaz D,Chorna N,Carballeira NM

    更新日期:2020-03-01 00:00:00

  • Difficulties in the assay of phosphatidate phosphohydrolase activity. Influence of ionic strength, detergent, and selection of substrate.

    abstract::In the present paper, problems in connection with assay of the activity of magnesium-dependent rat liver phosphatidate phosphohydrolase (PAP) are discussed. PAP activity is usually measured by following the production of diacylglycerol or inorganic phosphate from the substrate phosphatidate. These two methods may give...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522468

    authors: Stark M,Humble E

    更新日期:1996-10-01 00:00:00

  • DGAT1, DGAT2 and PDAT expression in seeds and other tissues of epoxy and hydroxy fatty acid accumulating plants.

    abstract::Triacylglycerol (TAG) is the main storage lipid in plants. Acyl-CoA: diacylglycerol acyltransferase (DGAT1 and DGAT2) and phospholipid: diacylglycerol acyltransferase (PDAT) can catalyze TAG synthesis. It is unclear how these three independent genes are regulated in developing seeds, and particularly if they have spec...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-010-3385-4

    authors: Li R,Yu K,Hildebrand DF

    更新日期:2010-02-01 00:00:00

  • Effects of dehydroepiandrosterone (DHEA) on hepatic lipid metabolism parameters and lipogenic gene mRNA expression in broiler chickens.

    abstract::The aim of the present study was to identify the effects of dehydroepiandrosterone (DHEA) on hepatic lipid metabolism parameters and lipogenic gene mRNA expression in broiler chickens. A total of 72 1-day-old broiler chicks received a common basal diet with DHEA added at either 0 (control), 5 or 20 mg/kg feed. In the ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-007-3104-y

    authors: Tang X,Ma H,Zou S,Chen W

    更新日期:2007-11-01 00:00:00

  • Lipopolysaccharide Alters Thermogenic and Inflammatory Genes in White Adipose Tissue in Mice Fed Diets with Distinct 18-Carbon Fatty-Acid Composition.

    abstract::Fatty acids are involved in the regulation of inflammatory responses in obesity. However, despite being the largest dietary fatty-acid class, effects of 18-carbon fatty acids with different degrees of saturation on inflammatory, metabolic, and thermogenic markers have not been well studied. Therefore, the objective of...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1002/lipd.12101

    authors: Shin S,Ajuwon KM

    更新日期:2018-09-01 00:00:00

  • Changes in lipid content, fatty acid composition and lipoprotein lipase activity in dry goat omental adipose tissue according to tissue site.

    abstract::Water and lipid contents, fatty acid distribution, and lipoprotein lipase activity were determined in 11 samples taken from the Omentum Majus of five dry Alpine goats. Samples were chosen to standardize sampling sites using geometric guide marks representative of different adipose tissue sites. Sample location explain...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536391

    authors: Bas P,Gallouin F,Morand-Fehr P

    更新日期:1992-06-01 00:00:00

  • The questionable role of a microsomal delta8 acyl-coA-dependent desaturase in the biosynthesis of polyunsaturated fatty acids.

    abstract::Several experimental approaches were used to determine whether rat liver and testes express an acyl-CoA-dependent delta8 desaturase. When [1-14C]5,11,14-eicosatrienoic acid was injected via the tail vein, or directly into testes, it was incorporated into liver and testes phospholipids, but it was not metabolized to ot...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-000-0596-9

    authors: Chen Q,Yin FQ,Sprecher H

    更新日期:2000-08-01 00:00:00

  • Hydrocarbon chain distribution of ether phospholipids of the ascidian Halocynthia roretzi and the sea urchin Strongylocentrotus intermedius.

    abstract::The contents and compositions of the 1-O-alk-1'-enyl-2-acyl, 1-O-alkyl-2-acyl, and 1,2-diacyl glycerophospholipids in the muscle and viscera of the ascidian Halocynthia roretzi, and of the gonad of the sea urchin Strongylocentrotus intermedius, which are eaten to some extent in Alaska and in Asia, were analyzed by gas...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522404

    authors: Jeong BY,Ohshima T,Koizumi C

    更新日期:1996-01-01 00:00:00

  • Evaluation of lipophilic antioxidant efficacy in vivo by the biomarkers hydroxyoctadecadienoic acid and isoprostane.

    abstract::The evaluation of antioxidant activity in vivo is difficult. In this study, the effects of dietary natural and synthetic antioxidants on the lipid peroxidation in mice were assessed using a biomarker, total hydroxyoctadecadienoic acid (tHODE). Biological samples such as plasma, erythrocytes, and tissues were first red...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-007-3043-7

    authors: Yoshida Y,Hayakawa M,Habuchi Y,Itoh N,Niki E

    更新日期:2007-05-01 00:00:00

  • Activation of acyl-CoA cholesterol acyltransferase: redistribution in microsomal fragments of cholesterol and its facilitated movement by methyl-beta-cyclodextrin.

    abstract::Acyl-CoA cholesterol acyltransferase (ACAT) (EC 2.3.1.26) in the yolk sac membrane of chicken eggs plays an important role in the transport of lipids, which serve as both structural components and as an energy source during embryogenesis. ACAT from the yolk sac membrane of chicken eggs 16 d after fertilization has hig...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-999-0362-z

    authors: Cheng D,Tipton CL

    更新日期:1999-03-01 00:00:00

  • Lysophosphatidylcholine acyltransferase activity during experimental cholelithiasis.

    abstract::The accumulation of (1-palmitoyl)lysophosphatidylcholine, lysolecithin, in gallbladder bile was observed during the first week of cholesterol-induced experimental cholelithiasis using the prairie dog model for cholesterol gallstone formation. Gallbladder fluid transport function decreased as bile lysolecithin concentr...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535337

    authors: Rutledge FA 2nd,Hickman DM,Dunn JJ,Frey CF,Matson RS

    更新日期:1981-10-01 00:00:00

  • Isolation of sarcolemmal plasma membranes by mechanically skinning rat skeletal muscle fibers for phospholipid analysis.

    abstract::Membrane phospholipid (PL) composition has been shown to affect cellular function by altering membrane physical structure. The sarcolemma plasma membrane (SLpm) is integral to skeletal muscle function and health. Previous studies assessing SLpm PL composition have demonstrated contamination from transverse (t)-tubule,...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-013-3770-x

    authors: Fajardo VA,McMeekin L,Basic A,Lamb GD,Murphy RM,LeBlanc PJ

    更新日期:2013-04-01 00:00:00

  • Uptake and metabolism of exogenous eicosa-8,11,14-trienoic acid in minimal deviation hepatoma 7288 C cells.

    abstract::Minimal deviation hepatoma 7288 C cells were cultured in Swim's medium containing 10% serum for 48 hr. The growth medium was replaced with serum free media containing different concentrations of [1-14C] eicosa-8,11,14-trienoic acid and the cells were incubated for 24 hr. Incorporation into cell lipids, oxidation to CO...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532312

    authors: Gaspar G,de Alaniz MJ,Brenner RR

    更新日期:1975-12-01 00:00:00

  • A method for the quantitative analysis of molecular species of alkylacylglycerol and diacylglycerol.

    abstract::We describe a method for the quantitative analysis of molecular species of diacylglycerol and alkylacylglycerol as their diradylglycerobenzoate derivatives. Synthetic internal standards were used to provide quantitative determinations of the low levels of diacylglycerol and alkylacylglycerol and their individual molec...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02544045

    authors: Warne TR,Robinson M

    更新日期:1990-11-01 00:00:00

  • An in vitro method for studying the proliferation and differentiation of Atlantic salmon preadipocytes.

    abstract::The aim of the present study was to develop a cell culture system for studying the proliferation and differentiation of preadipocytes isolated from Atlantic salmon adipose tissue. The expression of proliferating cell nuclear antigen (PCNA) was used as a marker for cell proliferation. The cells started to proliferate w...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-003-1063-3

    authors: Vegusdal A,Sundvold H,Gjøen T,Ruyter B

    更新日期:2003-03-01 00:00:00

  • Slow recovery of the fatty acid composition of sciatic nerve in rats fed a diet initially low in n-3 fatty acids.

    abstract::The sciatic nerve of rats fed sunflower oil (6 mg 18:3-n-3/100 g of diet) presented dramatic alterations in the long chain polyunsaturated fatty acids in comparison with those fed soy oil (130 mg 18:3n-3/100 g of diet). In both 15-day-old and 60-day-old animals fed sunflower oil, 22:6n-3 (cervonic acid) was four-fold ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02540371

    authors: Bourre JM,Youyou A,Durand G,Pascal G

    更新日期:1987-07-01 00:00:00

  • Comparison of ultracentrifugation and gel filtration for the isolation of bovine lipoproteins.

    abstract::Lipoproteins from the plasma of three nonlactating Holstein cows were isolated using either preparative ultracentrifugation or gel filtration chromatography. Lipoprotein classes obtained by ultracentrifugation were very low density plus chylomicra, less than 1.006 g/ml; low density, 1.007-1.039 g/ml; high density1, 1....

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534638

    authors: Grummer RR,Davis CL,Hegarty HM

    更新日期:1983-11-01 00:00:00

  • Insect juvenile hormones and pheromones of isopentenoid biogenesis.

    abstract::In their diversity, speciation, and sheer numerical superiority, few should question that insects are the dominant life-form on earth. Their utilization of the multifunctional isopentenoids to regulate their life processes is equally diverse. To catalog or even summarize the contribution of isopentenoids in the regula...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533754

    authors: Bowers WS

    更新日期:1978-10-01 00:00:00

  • Postprandial lipemia is modified by the presence of the APOB-516C/T polymorphism in a healthy Caucasian population.

    abstract::Apolipoprotein (apoB) plays a fundamental role in the transport and metabolism of plasma triacylglycerols (TAGs) and cholesterol. Several apoB polymorphic sites have been studied for their potential use as markers for coronary heart disease in the population. In view of the importance of apoB in postprandial metabolis...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-007-3027-7

    authors: Pérez-Martínez P,Pérez-Jiménez F,Ordovás JM,Moreno JA,Marín C,Moreno R,Jiménez-Gómez Y,Paniagua JA,López-Miranda J

    更新日期:2007-03-01 00:00:00

  • An increased incidence of apolipoprotein E2/E2 and E4/E4 in retinitis pigmentosa.

    abstract::Previous studies from our laboratory have shown that retinitis pigmentosa (RP), a family of hereditary retinal degenerations, is often accompanied by abnormal levels of cholesterol or polyunsaturated fatty acids. The requirement of the retina for n-3 fatty acids is well known, and a defect in the supply of these lipid...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02537120

    authors: Huq L,McLachlan T,Hammer HM,Bedford D,Packard CJ,Shepherd J,Converse CA

    更新日期:1993-11-01 00:00:00