Growth inhibitory effects of liposome-associated 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine.

Abstract:

:The growth inhibitory effects of 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine (ET-18-OCH3) and various liposome compositions of ET-18-OCH3 were compared in a standardized growth inhibition assay utilizing a diverse tumor cell line panel including cell lines expressing multidrug resistance. ET-18-OCH3 and ELL-12 (4:3:1:2, dioleoylphosphatidylcholine/ cholesterol/dioleoylphosphatidylethanolamine-glutaric acid/ET-18-OCH3), an optimal liposomal ET-18-OCH3 formulation, inhibited growth in the micromolar range in drug-sensitive and -resistant cells. In general, ET-18-OCH3-liposomes were about twofold less growth inhibitory than ET-18-OCH3. However, the known hemolytic effects of ET-18-OCH3 were greatly reduced, up to 20 or more times, by liposome association. The effects of ET-18-OCH3 and ELL-12 were compared in intracellular [Ca2+] modulation and DNA fragmentation assays. ET-18-OCH3 elicited both concentration- and serum-dependent transient and permanent increases in intracellular [Ca2+]. In contrast, ELL-12 did not modulate intracellular [Ca2+]. ET-18-OCH3 and ELL-12 similarly affected DNA fragmentation, which may be indicative of apoptosis. The results suggest that, although the specific growth inhibitory effects of ET-18-OCH3 and ELL-12 are similar, associating ET-18-OCH3 with stable well-characterized liposomes eliminates nonspecific cell membrane-associated lytic effects.

journal_name

Lipids

journal_title

Lipids

authors

Peters AC,Ahmad I,Janoff AS,Pushkareva MY,Mayhew E

doi

10.1007/s11745-997-0135-8

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

1045-54

issue

10

eissn

0024-4201

issn

1558-9307

journal_volume

32

pub_type

杂志文章

相关文献

LIPIDS文献大全
  • Acetate treatment increases fatty acid content in LPS-stimulated BV2 microglia.

    abstract::Acetate supplementation increases plasma acetate, brain acetyl-CoA, histone acetylation, phosphocreatine levels, and is anti-inflammatory in models of neuroinflammation and neuroborreliosis. Although radiolabeled acetate is incorporated into the cellular lipid pools, the effect that acetate supplementation has on lipi...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-014-3911-x

    authors: Bhatt DP,Rosenberger TA

    更新日期:2014-07-01 00:00:00

  • Paraoxonase 1 activity in chylomicrons and VLDL: the effect of type 2 diabetes and meals rich in saturated fat and oleic acid.

    abstract::Paraoxonase 1 (PON 1) has antioxidant and cardioprotective properties and is abnormally low in type 2 diabetic serum. This study aimed to determine the effect of type 2 diabetes and meals rich in saturated fat and oleic acid on PON1 activity in chylomicrons and very low density lipoproteins (VLDL). PON1 arylesterase a...

    journal_title:Lipids

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s11745-011-3640-3

    authors: Manning PJ,Jong SA,Ryalls AR,Sutherland WH

    更新日期:2012-03-01 00:00:00

  • Zinc deficiency and activities of lipogenic and glycolytic enzymes in liver of rats fed coconut oil or linseed oil.

    abstract::In previous studies, zinc-deficient rats force-fed a diet with coconut oil as the major dietary fat developed a fatty liver, whereas zinc-deficient rats force-fed a diet with linseed oil did not. The present study was conducted to elucidate the reason for this phenomenon. In a bifactorial experiment, rats were fed zin...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02537043

    authors: Eder K,Kirchgessner M

    更新日期:1995-01-01 00:00:00

  • Absorption of synthetic, stereochemically defined acylglycerols in the rat.

    abstract::The stereochemistry of fat digestion and absorption was investigated in rats with thoracic duct fistulas, after feeding synthetic triacylglycerol or alkyldiacylglycerol. After feeding 1,2-dilauroyl-3-oleoyl-sn-glycerol, dilauroyloleoylglycerol and lauroyldioleoylglycerol were the most abundant chyle triacylglycerols. ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533725

    authors: Akesson B,Gronowitz S,Herslof B,Ohlson R

    更新日期:1978-05-01 00:00:00

  • Cholesterol synthesis and esterification in isolated enterocytes: regulation by cholesterol and cholestyramine feeding.

    abstract::The purpose of the present study was to investigate the physiological control of the main regulatory enzymes of cholesterol metabolism in isolated enterocytes obtained from chick duodenum, jejunum and ileum. Cholesterol feeding resulted in an inhibition of 3-hydroxy-3-methyl-glutaryl-CoA reductase and mevalonate 5-pyr...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536087

    authors: Iglesias J,Gonzalez-Pacanowska D,Marco C,Garcia-Peregrin E

    更新日期:1993-06-01 00:00:00

  • Oleic acid attenuates trans-10,cis-12 conjugated linoleic acid-mediated inflammatory gene expression in human adipocytes.

    abstract::The weight loss supplement conjugated linoleic acid (CLA) consists of an equal mixture of trans-10,cis-12 (10,12) and cis-9,trans-11 (9,11) isomers. However, high levels of mixed CLA isomers, or the 10,12 isomer, causes chronic inflammation, lipodystrophy, or insulin resistance. We previously demonstrated that 10,12 C...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-012-3711-0

    authors: Reardon M,Gobern S,Martinez K,Shen W,Reid T,McIntosh M

    更新日期:2012-11-01 00:00:00

  • Sesamin modulates gene expression without corresponding effects on fatty acids in Atlantic salmon (Salmo salar L.).

    abstract::This study examined the effects of sesamin inclusion in vegetable oil-based diets fed to Atlantic salmon (Salmo salar L.). The diets used differed in n-6/n-3 fatty acid (FA) ratio (0.5 and 1) and sesamin content (high 5.8 g/kg, low 1.16 g/kg and no sesamin). The oils used in the feeds were a mixture of rapeseed, linse...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-012-3697-7

    authors: Schiller Vestergren A,Wagner L,Pickova J,Rosenlund G,Kamal-Eldin A,Trattner S

    更新日期:2012-09-01 00:00:00

  • Preparation of defined molecular species of lactosylceramide by chemical deacylation and reacylation with N-succinimidyl fatty acid esters.

    abstract::A procedure for the preparation of specific molecular species of D-erythro-lactosylceramide involving deacylation and reacylation of lactosylceramide prepared from bovine brain gangliosides is described. Lactosylceramide was N-deacylated by alkaline hydrolysis and the resulting four lysolactosylceramides, which contai...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02538917

    authors: Kadowaki H,Grant MA

    更新日期:1994-10-01 00:00:00

  • Identification and production of n-8 odd-numbered polyunsaturated fatty acids by a delta12 desaturation-defective mutant of Mortierella alpina 1S-4.

    abstract::A mutant of Mortierella alpina, JT-180, which is defective in its delta12 desaturase activity but exhibits enhanced activities of delta5 and delta6 desaturases, produced a high proportion (up to 80%) of odd-chain FA when grown on 3% n-heptadecane. Following growth of the mutant on n-heptadecane, three unusual odd-chai...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-006-5011-z

    authors: Zhang S,Sakuradani E,Shimizu S

    更新日期:2006-06-01 00:00:00

  • Lipid composition and peroxide levels of mucosal cells in the rat large intestine in relation to dietary fat.

    abstract::To examine whether dietary fat alters membrane lipid composition and peroxidation of polyunsaturated fatty acids in "non-proliferative" and "proliferative" cells in the large intestine, Sprague-Dawley rats were fed diets providing a polyunsaturated-to-saturated fatty acid ratio of 1.2 or 0.3 at a high or low level of ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536069

    authors: Turini ME,Thomson AB,Clandinin MT

    更新日期:1991-06-01 00:00:00

  • Dietary docosahexaenoic acid and immunocompetence in young healthy men.

    abstract::The purpose of this study was to examine the effect of dietary docosahexaenoic acid (DHA), in the absence of eicosapentaenoic acid, on human immune response (IR). A 120-d study with 11 healthy men was conducted at the Metabolic Research Unit of the Western Human Nutrition Research Center. Four subjects (control group)...

    journal_title:Lipids

    pub_type: 临床试验,杂志文章

    doi:10.1007/s11745-998-0240-8

    authors: Kelley DS,Taylor PC,Nelson GJ,Mackey BE

    更新日期:1998-06-01 00:00:00

  • The effect of an energy restricted low glycemic index diet on blood lipids, apolipoproteins and lipoprotein (a) among adolescent girls with excess weight: a randomized clinical trial.

    abstract::Some studies focused on the effect of the dietary glycemic index on lipoproteins and apolipoproteins in adults; however, little evidence exists among adolescents regarding the effect of a low glycemic index (LGI) diet on apolipoproteins and lipoprotein (a) (Lpa). This study was conducted to evaluate the effect of an L...

    journal_title:Lipids

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11745-013-3834-y

    authors: Rouhani MH,Kelishadi R,Hashemipour M,Esmaillzadeh A,Azadbakht L

    更新日期:2013-12-01 00:00:00

  • Variations of trans octadecenoic acid in milk fat induced by feeding different starch-based diets to cows.

    abstract::The impact of starch sources differing in their velocities of ruminal degradation on the milk fat of dairy cows was studied. The animals received diets containing a slowly degradable (potatoes) or rapidly degradable (wheat) starch concentrate (40% of the dry matter) in a total mixed diet. Milk fat was the only animal ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-004-1196-4

    authors: Jurjanz S,Monteils V,Juaneda P,Laurent F

    更新日期:2004-01-01 00:00:00

  • The activity and properties of a hepatic acid cholesteryl ester hydrolase obtained from rats of different age groups.

    abstract::The activity of lysosomal acid cholesteryl ester hydrolase (acid CEH, EC 3.1.1.13) in rat liver was determined at 3, 5, 7, 10 and 20 wk following birth. The levels of acid CEH activity showed a marked decrease as rats grew older, whereas those of other lysosomal marker enzymes, such as acid phosphatase, beta-glucuroni...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533950

    authors: Tanaka M,Iio T,Tabata T

    更新日期:1987-09-01 00:00:00

  • Blood polyunsaturated fatty acids in patients with peroxisomal disorders. A multicenter study.

    abstract::The purpose of the study was to compare the polyunsaturated fatty acid (PUFA) status in patients with X-linked adrenoleukodystrophy or adrenomyeloneuropathy (X-ALD/AMN) with that in disorders of peroxisome biogenesis (PB). Total fatty acids and plasmalogens were quantified in plasma and red cells from 28 patients with...

    journal_title:Lipids

    pub_type: 杂志文章,多中心研究

    doi:10.1007/BF02536332

    authors: Martinez M,Mougan I,Roig M,Ballabriga A

    更新日期:1994-04-01 00:00:00

  • The effect of short-term lipid infusion on liver function and biliary secretion in rats.

    abstract::This study was undertaken to determine the effect of various lipid emulsions on the hepato-biliary system in rats. Rats were randomly divided into six groups and infused continuously for 48 hr with either long-chain triglycerides (LCT), medium-chain triglycerides (MCT) or a mixture of MCT and LCT. One group infused wi...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536144

    authors: Rubin M,Halpern Z,Livoff A,Wennberg A,Tietz A,Antebi E,Lichtenberg D

    更新日期:1992-05-01 00:00:00

  • Regulation of hepatocyte lipid metabolism and inflammatory response by 25-hydroxycholesterol and 25-hydroxycholesterol-3-sulfate.

    abstract::Dysregulation of lipid metabolism is frequently associated with inflammatory conditions. The mechanism of this association is still not clearly defined. Recently, we identified a nuclear oxysterol, 25-hydroxycholesterol-3-sulfate (25HC3S), as an important regulatory molecule involved in lipid metabolism in hepatocytes...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-010-3451-y

    authors: Xu L,Bai Q,Rodriguez-Agudo D,Hylemon PB,Heuman DM,Pandak WM,Ren S

    更新日期:2010-09-01 00:00:00

  • Vitamin E transfer from lipid emulsions to plasma lipoproteins: mediation by multiple mechanisms.

    abstract::The present study determined alpha-tocopherol mass transfer from an alpha-tocopherol-rich emulsion to LDL and HDL, and assessed the potential of different mechanisms to modulate alpha-tocopherol transfers. Emulsion particles rich in alpha-tocopherol were incubated in vitro with physiological concentrations of LDL or H...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-008-3184-3

    authors: Hacquebard M,Vandenbranden M,Malaisse WJ,Ruysschaert JM,Deckelbaum RJ,Carpentier YA

    更新日期:2008-07-01 00:00:00

  • Involvement of phospholipids in apolipoprotein B modification during low density lipoprotein oxidation.

    abstract::An increased amount of phospholipids remained attached on delipidated apolipoprotein B originated from oxidized low density lipoprotein (LDL). 31P nuclear magnetic resonance analysis of such apolipoprotein showed an organic phosphorus peak at -0.55 ppm, which suggests the formation of adducts (most probably Schiff bas...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-998-0318-3

    authors: Karakatsani AI,Liapikos TA,Troganis AN,Tsoukatos DC

    更新日期:1998-12-01 00:00:00

  • Alveolar lavage and lavaged lung tissue phosphatidylcholine composition during fetal rabbit development.

    abstract::Pulmonary surfactant, the major surface-active component of which in the adult is dipalmitoylglycerophosphocholine, can be obtained by lavaging lungs with physiological saline. We have previously shown that there is an increase in the amount of phosphatidylcholine in fetal rabbit lung lavage during the latter part of ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533333

    authors: Rooney SA,Gobran LI

    更新日期:1977-12-01 00:00:00

  • An Unprecedented Occurrence of Δ5,9- and Δ9,15-Dienoic Fatty Acids in Ovaries of the Archaeogastropod Limpet Cellana toreuma.

    abstract::A detailed structural diversity of dienoic fatty acids (FA), including non-methylene-interrupted dienoic FA, of triacylglycerols and polar lipids in ovaries of Cellana toreuma was clarified for the first time by using capillary gas chromatography-mass spectrometry of their 3-pyridylcarbinol esters and argentation thin...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-015-4107-8

    authors: Kawashima H,Ohnishi M

    更新日期:2016-02-01 00:00:00

  • Purification and properties of aortic cholesteryl ester hydrolase.

    abstract::The enzyme(s) present in acetonedried powder of rat and rabbit aortas, which catalyzes the synthesis and hydrolysis of cholesteryl ester, was purified partially by acid precipitation, acetone fractionation, O-(diethylaminoethyl) cellulose chromatography, and Sephadex G-100 filtration. The synthetic activity was purifi...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02532453

    authors: Kothari HV

    更新日期:1975-06-01 00:00:00

  • Stereospecific analysis of maize triglycerides.

    abstract::This is the first report of stereospecific analyses of plant triglycerides isolated from seeds of distinct genotypes rather than from commerically refined oils. Triglycerides from six maize inbreds were analyzed. The strains exhibited a wide range of fatty acid compositions (palmitic acid 7.8-19.1%, oleic acid 17.0-43...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02531130

    authors: Weber EJ,De La Roche A,Alexander DE

    更新日期:1971-08-01 00:00:00

  • Identification of a novel all-cis-5,9,12-heptadecatrienoic acid in the cellular slime mold Polysphondylium pallidum.

    abstract::The all-cis-5,9,12-heptadecatrienoic acid was identified in the cellular slime mold Polysphondylium pallidum. The structural elucidation was accomplished by capillary gas chromatography, argentation thin-layer chromatography, and gas chromatography/mass spectrometry. This fatty acid has not been reported previously. ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02522934

    authors: Saito T,Ochiai H

    更新日期:1996-04-01 00:00:00

  • The simultaneous separation and quantitation of human milk lipids.

    abstract::A protocol using a dry column method was modified for the extraction of total lipids and the simultaneous separation and quantitation of neutral and polar lipids in human milk. The triacylglycerol, cholesterol, phospholipid and vitamin E contents of the lipid extracts were determined and compared with lipids extracted...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535216

    authors: Collins SE,Jackson MB,Lammi-Keefe CJ,Jensen RG

    更新日期:1989-08-01 00:00:00

  • Intermembrane cholesterol transfer: role of sterol carrier proteins and phosphatidylserine.

    abstract::The effect of phosphatidylserine and sterol carrier proteins on cholesterol exchange was determined using an assay not requiring separation of donor and acceptor membrane vesicles. Sterol carrier protein-2 (SCP2, also called nonspecific lipid transfer protein), but not fatty acid binding protein (FABP, also called ste...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02544032

    authors: Schroeder F,Butko P,Hapala I,Scallen TJ

    更新日期:1990-11-01 00:00:00

  • Dose effect of alpha-linolenic acid on PUFA conversion, bioavailability, and storage in the hamster.

    abstract::If an increased consumption of alpha-linolenic acid (ALA) is to be promoted in parallel with that of n-3 long-chain-rich food, it is necessary to consider to what extent dietary ALA can be absorbed, transported, stored, and converted into long-chain derivatives. We investigated these processes in male hamsters, over a...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-004-1236-0

    authors: Morise A,Combe N,Boué C,Legrand P,Catheline D,Delplanque B,Fénart E,Weill P,Hermier D

    更新日期:2004-04-01 00:00:00

  • A diurnal variation of hepatic acid cholesteryl ester hydrolase activity in the rat.

    abstract::The diurnal variation in lysosomal acid cholesteryl ester hydrolase (Acid CEH), (EC 3.1.1.13) has been examined in fed, fasted and adrenalectomized rats. The Acid CEH activity of normal rat liver exhibits a diurnal rhythm with maxima at 06.00 hours and minima at 18.00 hours, but such a rhythm was not observed in splee...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534362

    authors: Tanaka M,Yonekura R,Iio T,Tabata T

    更新日期:1985-01-01 00:00:00

  • Effects of dietary cholesterol on tissue ceramides and oxidation products of apolipoprotein B-100 in ApoE-deficient mice.

    abstract::Oxidized LDL (oxLDL) has been shown to activate the sphingomyelinase pathway producing ceramide in vascular smooth muscle cells. Therefore ceramide, which is a biologically active lipid causing apoptosis in a variety of cells, may be involved in the apoptotic action of oxLDL. In this study, we examined whether cholest...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-007-3067-z

    authors: Ichi I,Takashima Y,Adachi N,Nakahara K,Kamikawa C,Harada-Shiba M,Kojo S

    更新日期:2007-10-01 00:00:00

  • 3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines.

    abstract::The schweinfurthins have potent antiproliferative activity in multiple glioblastoma multiforme (GBM) cell lines; however, the mechanism by which growth is impeded is not fully understood. Previously, we demonstrated that the schweinfurthins reduce the level of key isoprenoid intermediates in the cholesterol biosynthet...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-015-4083-z

    authors: Kuder CH,Weivoda MM,Zhang Y,Zhu J,Neighbors JD,Wiemer DF,Hohl RJ

    更新日期:2015-12-01 00:00:00