Preparation of defined molecular species of lactosylceramide by chemical deacylation and reacylation with N-succinimidyl fatty acid esters.

abstract：:Milk fatty acids consist of about 20-25% palmitic acid (16:0), with about 70% of 16:0 esterified to the sn-2 position of the milk triacylglycerols. Hydrolysis of dietary triacylglycerols by endogeneous lipases produces sn-2 monoacylglycerols and free fatty acids, which are absorbed, reesterified, and then secreted int...

journal_title：Lipids

authors： Innis SM,Dyer R,Nelson CM

更新日期：1994-08-01 00:00:00

abstract：:Plasma lipidomic studies using high performance liquid chromatography and mass spectroscopy offer detailed insights into metabolic processes. Taking the example of the most abundant plasma lipid class (phosphatidylcholines) we used the rich phenotypic and lipidomic data from the ongoing San Antonio Family Heart Study ...

journal_title：Lipids

authors： Kulkarni H,Meikle PJ,Mamtani M,Weir JM,Barlow CK,Jowett JB,Bellis C,Dyer TD,Johnson MP,Rainwater DL,Almasy L,Mahaney MC,Comuzzie AG,Blangero J,Curran JE

更新日期：2013-05-01 00:00:00

abstract：:The effect of dietary n-3 FA deficiency on bone tissue FA composition was evaluated in growing rats. Two mixtures combining hydrogenated coconut oil with safflower oil served as the n-3-deficient dietary treatments and provided two levels of linoleic acid (LA). The n-3 treatments were formulated with added alpha-linol...

journal_title：Lipids

authors： Li Y,Greiner RS,Salem N Jr,Watkins BA

更新日期：2003-06-01 00:00:00

abstract：:The oxidation of free DHA, DHA mixed with PC, and DHA incorporated into PC, PE, or TG was evaluated to determine which lipid provided DHA with the best protection against oxidation. DHA was either situated at the sn-1 position, sn-2 position, or both positions of the phospholipid, whereas the TG contained DHA at all p...

journal_title：Lipids

authors： Lyberg AM,Fasoli E,Adlercreutz P

更新日期：2005-09-01 00:00:00

abstract：:Diacylglycerol acyltransferase (DGAT) catalyzes the final step of triacylglycerol (TAG) synthesis, and is considered as a potential target to control hypertriglyceridemia or other metabolic disorders. In this study, we found that the extract of rose petals suppressed TAG synthesis in cultured cells, and that the extra...

journal_title：Lipids

authors： Kondo H,Hashizume K,Shibuya Y,Hase T,Murase T

更新日期：2011-08-01 00:00:00

abstract：:Dietary fat and abnormal production of various prostanoids have been linked to various disease states of the large bowel, including cancer of the colon. Studies were conducted to determine the effect of dietary fat (beef tallow or corn oil) on the lipid composition and prostanoid production of the murine colon. Female...

journal_title：Lipids

authors： Robblee NM,Farnworth ER,Bird RP

更新日期：1988-04-01 00:00:00

abstract：:Rats were fed either a high alpha-linolenate diet or a high linoleate diet from weaning to 4 mon of age. Soybean oil was used as a control. Phospholipid compositions of erythrocytes from the three dietary groups were not significantly different. However, the difference in the alpha-linolenate (18:3n-3)/linoleate (18:2...

journal_title：Lipids

authors： Sakai K,Okuyama H,Kon K,Maeda N,Sekiya M,Shiga T,Reitz RC

更新日期：1990-12-01 00:00:00

abstract：:Wistar male rats were treated for six days with broad spectrum beta-lactam antibiotics, latamoxef, and cefotaxime. On the seventh day, the number of fecal anaerobic microbes decreased, total fecal bile acids decreased, and bile acid pools increased. Secondary bile acids such as beta-hyocholic, hyodeoxycholic, lithocho...

journal_title：Lipids

authors： Hashimoto S,Igimi H,Uchida K,Satoh T,Benno Y,Takeuchi N

更新日期：1996-06-01 00:00:00

abstract：:Taurolithocholic acid and deoxycholic acid were perfused into isolated prairie dog livers. Taurolithocholic acid was 7 alpha-hydroxylated to form taurochenodeoxycholic acid, whereas deoxycholic acid was conjugated and 7 alpha-hydroxylated to form taurocholic acid. The low concentrations of secondary bile acids observe...

journal_title：Lipids

authors： Cohen BI,Singhal AK,Mongelli J,Rothschild MA,McSherry CK,Mosbach EH

更新日期：1983-12-01 00:00:00

abstract：:This paper describes a simple method for the analysis of tocopherols in tissues by which frozen tissues-70 degrees C were pulverized at dry ice temperatures (-70 degrees C) and immediately extracted with hexane. There was no need to remove the coeluting lipids from tissues by saponification, since at that level of neu...

journal_title：Lipids

authors： Kramer JK,Blais L,Fouchard RC,Melnyk RA,Kallury KM

更新日期：1997-03-01 00:00:00

abstract：:The biosynthesis of [14C] CDP-diglyceride was studied using rat liver microsomes which were endogenously labeled with [14C] phosphatidic acid by preincubation of unlabeled microsomes with sn-[14C] glycerol-3-phosphate and appropriate cofactors. The formation of CDP-diglyceride from radioactive phosphatidate showed an ...

journal_title：Lipids

authors： Holub BJ,Piekarski J

更新日期：1976-04-01 00:00:00

abstract：:CLA has a range of biological properties, including effects on lipid metabolism and body composition in experimental animals. The prevalent isomer of CLA found in the human diet is 9c,11 t-CLA, and it is predominantly found in products containing fat from ruminant animals. This study investigated the effect of dietary...

journal_title：Lipids

authors： Hayman A,MacGibbon A,Pack RJ,Rutherfurd K,Green JH

更新日期：2002-07-01 00:00:00

abstract：:We examined the initial transport of a long-chain unsaturated fatty acid, linoleic acid, by brush border membrane vesicles isolated from rabbit small intestine. This preparation allowed us to examine the transport of linoleic acid across the brush border membrane without the effect of the unstirred water layer or cyto...

journal_title：Lipids

authors： Ling KY,Lee HY,Hollander D

更新日期：1989-01-01 00:00:00

abstract：:Dyslipoproteinemia of the Nagase analbuminemic rat (NAR) is characterized by elevated concentrations of VLDL and LDL attributed to increased rates of liver lipoprotein synthesis. Increased lysophosphatidylcholine (LPC) in NAR HDL has been attributed to high plasma LCAT activity. We show here that, as compared with Spr...

journal_title：Lipids

authors： Catanozi S,Rocha JC,Passarelli M,Mesquita CH,Suguiama VY,Guzzo ML,dos Santos Filho A,Quintão EC,Nakandakare ER

更新日期：2006-07-01 00:00:00

abstract：:We have studied the effect of various diets on the phospholipid fatty acid composition and in vitro delta 5 desaturase activity of hepatic microsomes derived either from the normal or streptozotocin-induced diabetic rat. The diets studied were the standard rat chow diet and a basal fat-free diet supplemented either wi...

journal_title：Lipids

authors： Dang AQ,Kemp K,Faas FH,Carter WJ

更新日期：1989-10-01 00:00:00

abstract：:Separation of thecis- andtrans-isomers of 1,2-benzylidene glyceryl esters has not yet been achieved by column or gas liquid chromatography. However these isomers were separated by thin layer chromatography in the present study and the parent cyclic alcohols regenerated by alkaline hydrolysis. ...

journal_title：Lipids

authors： Johnson CB

更新日期：1973-08-01 00:00:00

abstract：:If an increased consumption of alpha-linolenic acid (ALA) is to be promoted in parallel with that of n-3 long-chain-rich food, it is necessary to consider to what extent dietary ALA can be absorbed, transported, stored, and converted into long-chain derivatives. We investigated these processes in male hamsters, over a...

journal_title：Lipids

authors： Morise A,Combe N,Boué C,Legrand P,Catheline D,Delplanque B,Fénart E,Weill P,Hermier D

更新日期：2004-04-01 00:00:00

abstract：:The aim of this study was to determine the influence of long-term docosahexaenoic acid (DHA) dietary supplementation on the erythrocyte fatty acid profile and oxidative balance in soccer players after training and acute exercise. Fifteen volunteer male athletes (age 20.0 ± 0.5 years) were randomly assigned to a placeb...

journal_title：Lipids

authors： Martorell M,Capó X,Bibiloni MM,Sureda A,Mestre-Alfaro A,Batle JM,Llompart I,Tur JA,Pons A

更新日期：2015-02-01 00:00:00

abstract：:The cholesterol-suppressive action of the tocotrienol-rich-fraction (TRF) of palm oil may be due to the effect of its constituent tocotrienols on beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase activity. The tocotrienols, modulate HMG-CoA reductase activity via a post-transcriptional mechanism. As a co...

journal_title：Lipids

authors： Yu SG,Thomas AM,Gapor A,Tan B,Qureshi N,Qureshi AA

更新日期：2006-05-01 00:00:00

abstract：:Observational evidence suggests that in populations consuming low levels of n-3 highly unsaturated fatty acids, women have higher blood levels of docosahexaenoic acid (DHA; 22:3n-6) as compared with men. Increased conversion of alpha-linolenic acid (ALA; 18:3n-3) to DHA by females has been confirmed in fatty acid stab...

journal_title：Lipids

authors： Kitson AP,Stroud CK,Stark KD

更新日期：2010-03-01 00:00:00

abstract：:Two simple methods for the synthesis of phosphatidylcholine (lecithin) isotopically labeled in the methyl group of the choline moiety are described. Phosphatidylcholine is converted to phosphatidyl-ethanolamine by enzymic transphosphatidylation, and this is methylated using either methyl iodide or diazomethane to give...

journal_title：Lipids

authors： Smith GA,Montecucco C,Bennett JP

更新日期：1978-01-01 00:00:00

abstract：:Developing rat brain has the capacity for either delta 9 or delta 6 desaturation of fatty acids. In liver, evidence supports the existence of separate enzymes for each reaction, but it is not known whether in brain delta 9 or delta 6 desaturation of saturated fatty acids involves distinct enzymes. We have used fatty a...

journal_title：Lipids

authors： Cook HW

更新日期：1979-09-01 00:00:00

abstract：:A new spectrophotometric assay for determining the activity of acylglycerol hydrolases (lipases, E.C. 3.1.1.3) was developed and optimized for yeast lipase (Candida cylindracea). Studies with porcine pancreatic lipase were also conducted and the influence of various detergents and divalent cations on the assay was eva...

journal_title：Lipids

authors： Rogel AM,Stone WL,Adebonojo FO

更新日期：1989-06-01 00:00:00

abstract：:Vegetable oils are an extremely important agricultural commodity. Their use has risen inexorably for the last 50 years and will undoubtedly be even more prevalent in the future. They have a role not only in foodstuffs but also as renewable chemicals. However, our understanding of their metabolism, and particularly its...

journal_title：Lipids

authors： Chen G,Woodfield HK,Pan X,Harwood JL,Weselake RJ

更新日期：2015-11-01 00:00:00

abstract：:The evaluation of antioxidant activity in vivo is difficult. In this study, the effects of dietary natural and synthetic antioxidants on the lipid peroxidation in mice were assessed using a biomarker, total hydroxyoctadecadienoic acid (tHODE). Biological samples such as plasma, erythrocytes, and tissues were first red...

journal_title：Lipids

authors： Yoshida Y,Hayakawa M,Habuchi Y,Itoh N,Niki E

更新日期：2007-05-01 00:00:00

abstract：:Competitive inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase improve hypercholesterolemia. However, reports about the effects of these agents on bile acid synthesis, the metabolic pathway of cholesterol, are conflicting. We studied the short-term effect on one of these agents, pravastatin, on bile acid synthesis...

journal_title：Lipids

authors： Yoshida T,Honda A,Shoda J,Abei M,Matsuzaki Y,Tanaka N,Miyazaki H,Osuga T

更新日期：1997-08-01 00:00:00

abstract：:Although hypocholesterolemia is a reported finding in sickle cell disease (SCD), low-density lipoprotein (LDL)/high-density lipoprotein (HDL) subfractions and HDL-associated enzymes have not been determined in SCD patients. Blood was collected from 38 hemoglobin (Hb)A volunteers and 45 homozygous HbSS patients who had...

journal_title：Lipids

authors： Ozturk OH,Can Y,Yonden Z,Motor S,Oktay G,Kaya H,Aslan M

更新日期：2013-12-01 00:00:00

abstract：:Dietary fatty acids have different effects on fat deposition in pigs. To clarify the underlying mechanisms of this difference, we compared the metabolism of palmitic (PAM, saturated), oleic (OLA, monounsaturated) and linoleic acid (LNA, polyunsaturated) in porcine adipocytes treated with 100 μM PAM, OLA or LNA. We obs...

journal_title：Lipids

authors： Yu C,Xi L,Chen J,Jiang Q,Yi H,Wang Y,Wang X

更新日期：2017-11-01 00:00:00

abstract：:The aim of this study was to develop a simple method for simultaneous determination of selected cis/cis PUFA-LNA (18:2), ALA (18:3), GLA (18:3), EPA (20:5), and DHA (22:6) by silver ion high-performance liquid chromatography coupled to a diode array detector (Ag-HPLC-DAD). The separation was performed on three Luna SC...

journal_title：Lipids

authors： Czajkowska-Mysłek A,Siekierko U,Gajewska M

更新日期：2016-04-01 00:00:00

abstract：:The ganglioside levels in atherosclerotic lesions of human aorta are considerably higher than those in unaffected areas of aorta, and atherosclerotic patients frequently have increased concentrations of serum gangliosides. The present review summarizes recent findings that suggest the possible involvement of aortic ga...

journal_title：Lipids

authors： Prokazova NV,Bergelson LD

更新日期：1994-01-01 00:00:00