Abstract:
:Insulin and dietary fructose independently induce stearoyl-CoA desaturase 1 (SCD1) gene expression in diabetic mouse liver. In the present study, we again used diabetic mice and supplemented a high fructose diet with polyunsaturated fatty acids (PUFA) to determine the selective repression of SCD1 gene expression by dietary PUFA, as previously shown in normal mice. We saw dramatic repression of SCD1 mRNA expression, with trilinolenin at 3% and triarachidonin at 1% supplementation. We also observed significant repression of insulin-induced SCD1 mRNA upon supplementation of the noninducing starch diet with PUFA. In conclusion, our data demonstrate that PUFA negatively regulate hepatic gene expression through an insulin-independent mechanism.
journal_name
Lipidsjournal_title
Lipidsauthors
Waters KM,Ntambi JMdoi
10.1007/BF02637047subject
Has Abstractpub_date
1996-03-01 00:00:00pages
S33-6eissn
0024-4201issn
1558-9307journal_volume
31 Supplpub_type
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