Polyunsaturated fatty acids inhibit hepatic stearoyl-CoA desaturase-1 gene in diabetic mice.

Abstract:

:Insulin and dietary fructose independently induce stearoyl-CoA desaturase 1 (SCD1) gene expression in diabetic mouse liver. In the present study, we again used diabetic mice and supplemented a high fructose diet with polyunsaturated fatty acids (PUFA) to determine the selective repression of SCD1 gene expression by dietary PUFA, as previously shown in normal mice. We saw dramatic repression of SCD1 mRNA expression, with trilinolenin at 3% and triarachidonin at 1% supplementation. We also observed significant repression of insulin-induced SCD1 mRNA upon supplementation of the noninducing starch diet with PUFA. In conclusion, our data demonstrate that PUFA negatively regulate hepatic gene expression through an insulin-independent mechanism.

journal_name

Lipids

journal_title

Lipids

authors

Waters KM,Ntambi JM

doi

10.1007/BF02637047

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

S33-6

eissn

0024-4201

issn

1558-9307

journal_volume

31 Suppl

pub_type

杂志文章

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