Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats.


:The effects of conjugated linoleic acid (CLA) on the levels of chemical mediators in peritoneal exudate cells, spleen and lung, and the concentration of immunoglobulins in mesenteric lymph node and splenic lymphocytes and in serum were examined in rats. After feeding diets containing either 0 (control), 0.5 or 1.0% CLA for 3 wk, there was a trend toward a reduction in the release of leukotriene B4 (LTB4) from the exudate cells in response to the dietary CLA levels. However, CLA did not appear to affect the release of histamine. A similar dose-response pattern also was observed in splenic LTB4, lung LTC4 and serum prostaglandin E2 levels, and the differences in these indices between the control and 1.0% CLA groups were all statistically significant. The reduction by CLA of the proportions of n-6 polyunsaturated fatty acids in peritoneal exudate cells and splenic lymphocyte total lipids seems to be responsible at least in part for the reduced eicosanoid levels. Splenic levels of immunoglobulin A (IgA), IgG, and IgM increased while those of IgE decreased significantly in animals fed the 1.0% CLA diet. This was reflected in the serum levels of immunoglobulins. The levels of IgA, IgG, and IgM in mesenteric lymph node lymphocytes increased in a dose-dependent manner, while IgE was reduced in those fed the higher CLA intake. However, no differences were seen in the proportion of T-lymphocyte subsets of mesenteric lymph node. These results support the view that CLA mitigates the food-induced allergic reaction.






Sugano M,Tsujita A,Yamasaki M,Noguchi M,Yamada K




Has Abstract


1998-05-01 00:00:00














  • The biosynthesis of oxylipins of linoleic and arachidonic acids by the sewage fungus Leptomitus lacteus, including the identification of 8R-Hydroxy-9Z,12Z-octadecadienoic acid.

    abstract::When the sewage fungus Leptomitus lacteus was grown in liquid culture aerobically and then transferred to medium containing long-chain fatty acids, it produced a number of oxygenated fatty acids. From linoleic acid (18:2n-6), the major metabolite produced was R-8-hydroxy-9Z,12Z-octadecadienoic acid (8R-HODE), with add...


    pub_type: 杂志文章


    authors: Fox SR,Akpinar A,Prabhune AA,Friend J,Ratledge C

    更新日期:2000-01-01 00:00:00

  • The phospholipid fatty acids of the marine spongeXestospongia muta.

    abstract::The rare phospholipid fatty acids 3,7,11-trimethyldodecanoic (1), 5,9-hexadecadienoic (2) and 12-methyl-hexadecanoic (3) were identified in the marine spongeXestospongia muta. Branched fatty acids inX. muta accounted for 35% of the total fatty acid mixture. It was observed that the occurrence of the 5,9-hexadecadienoi...


    pub_type: 杂志文章


    authors: Carballeira NM,Maldonado L

    更新日期:1988-07-01 00:00:00

  • Biosynthesis of polyunsaturated fatty acids in the developing brain: II. Metabolic transformations of intracranially administered [3-(14)C] Eicosatrienoic acid, evidence for lack of delta8 desaturase.

    abstract::[3-(14)C] Eicosatrienoic acid (delta11,14,17) chemically synthesized from [-(14)C] linolenic acid was injected intracranially into 14-day old rats and sacrificed 8 hr later. The analysis of brain fatty acids by radio-gas liquid chromatography before and after ozonolysis showed that the tetraene fraction consisted of a...


    pub_type: 杂志文章


    authors: Dhopeshiwarkar GA,Subramanian C

    更新日期:1976-09-01 00:00:00

  • Differences in delta9 desaturase activity between Jersey- and Limousin-sired cattle.

    abstract::An experiment examined delta9 desaturase activity and FA composition in subcutaneous adipose tissue in two differing breeds of cattle. Jersey-sired cattle had significantly higher rates of desaturase activity than Limousin-sired cattle (1.55 vs. 0.75 nmol/mg protein/min). This difference was also demonstrated by a low...


    pub_type: 杂志文章


    authors: Siebert BD,Pitchford WS,Kruk ZA,Kuchel H,Deland MP,Bottema CD

    更新日期:2003-05-01 00:00:00

  • Supplemental conjugated linoleic acid consumption does not influence milk macronutrient contents in all healthy lactating women.

    abstract::The term "conjugated linoleic acid" (CLA) refers to a group of positional and geometric isomers that are derived from linoleic acid and are found primarily in meat and milk products from ruminant animals. Due to the array of putative benefits associated with various forms of CLA, there has been recent interest in supp...


    pub_type: 杂志文章,随机对照试验


    authors: Mosley SA,Shahin AM,Williams J,McGuire MA,McGuire MK

    更新日期:2007-08-01 00:00:00

  • Epoxidation reactions of unsaturated fatty esters with potassium peroxomonosulfate.

    abstract::Epoxidation of the double bond in methyl oleate, octadec-11E-en-9-ynoate, ricinoleate (12-hydroxy-octadec-9Z-enoate), iso-ricinoleate (9-hydroxy-octadec-12Z-enoate), and 12-oxo-octadec-9Z-enoate with potassium peroxomonosulfate (oxone, 2 KHSO5.KHSO4.K2SO4) in the presence of trifluoroacetone or methyl pyruvate gave th...


    pub_type: 杂志文章


    authors: Lie Ken Jie MS,Pasha MK

    更新日期:1998-06-01 00:00:00

  • Relationship Between Circulating Fatty Acids and Fatty Acid Ethanolamide Levels After a Single 2-h Dietary Fat Feeding in Male Sprague-Dawley Rats : Elevated levels of oleoylethanolamide, palmitoylethanolamide, linoleoylethanolamide, arachidonoylethanolam

    abstract::Previous studies show that long term variations in dietary fat consumption impact circulating fatty acid ethanolamide (FAE) concentrations, however, few studies have investigated short term effects of dietary fat feeding on FAE levels. The trial's objective was to explore the effect of acute feeding of varying amounts...


    pub_type: 杂志文章


    authors: Olatinsu AO,Sihag J,Jones PJH

    更新日期:2017-11-01 00:00:00

  • Sterol synthesis from biliary squalene in the jejunal mucosa of the rat in vivo.

    abstract::Because bile contains substantial amounts of cholesterol precursors, e.g., squalene and different methyl sterols, the fate of biliary squalene was studied by incubating isolated jejunal loops of the rat in vivo with bile containing 3H-squalene and 14C-cholesterol. After 90 min, no radioactivity was found in plasma lip...


    pub_type: 杂志文章


    authors: Strandberg TE

    更新日期:1983-08-01 00:00:00

  • Concentration-dependent effects of eicosapentaenoic acid on very low density lipoprotein secretion by the isolated perfused rat liver.

    abstract::The effects of increasing concentrations of eicosapentaenoic acid (20:5n-3; EPA) and oleic acid (18:1n-9; OA) on esterification to triacylglycerols (TG) and phospholipids (PL), and the relationship to formation and secretion of the very low density lipoproteins (VLDL) were compared in the isolated perfused rat liver. ...


    pub_type: 杂志文章


    authors: Zhang ZJ,Wilcox HG,Castellani L,Fungwe TV,Elam MB,Heimberg M

    更新日期:1993-05-01 00:00:00

  • Effects of ascorbate on membrane phospholipids and tocopherols of intact erythrocytes during peroxidation by t-butylhydroperoxide: comparison with effects of dithiothreitol.

    abstract::Peroxidation of intact human erythrocytes by t-butylhydroperoxide (tBHP)) was studied. By incubation of the erythrocytes with 1 mM tBHP, reduced glutathione (GSH) was exhausted within 1 min, and tocopherols (Toc) and phospholipids (PL) decreased to nearly their lowest levels (in this study) within 5 min. The rate of d...


    pub_type: 杂志文章


    authors: Mawatari S,Murakami K

    更新日期:2001-01-01 00:00:00

  • Changes in liver fatty acid unsaturation after partial hepatectomy in the rat.

    abstract::The purpose of this study was to assess changes in the degree of fatty acid unsaturation in rat liver after partial hepatectomy. This is the first study in which liver fatty acid unsaturation has been analyzed over a long period of regeneration until day 28 after operation. The relationship between changes in unsatura...


    pub_type: 杂志文章


    authors: Kishino T,Tanno M,Yamada H,Saito S,Matsumoto S

    更新日期:2000-04-01 00:00:00

  • Structural characterization of a "signature" phosphatidylethanolamine as the major 10-hydroxy stearic acid-containing lipid of Cryptosporidium parvum oocysts.

    abstract::A 10-hydroxy stearic acid-containing lipid from Cryptosporidium parvum was purified by thin-layer chromatography and analyzed by infrared spectroscopy, fast-atom bombardment mass spectrometry, 1H and 31P nuclear magnetic resonance spectroscopy, and was identified as phosphatidyl-ethanolamine. ...


    pub_type: 杂志文章


    authors: Schrum DP,Alugupalli S,Kelly ST,White DC,Fayer R

    更新日期:1997-07-01 00:00:00

  • Monocarboxylic acids from oxidation of acyclic isoprenoid alkanes by Mycobacterium fortuitum.

    abstract::Mycobacterium fortuitum utilizes certain stereoisometric mixtures of individual multimethyl branched alkanes as sole carbon source, including 2,6(R), 10(S), 14(RS)-tetramethylhexadecane; 2.6(R), 10(S), 14(RS)-tetramethylheptadecane; 2,6(RS), 10(RS)-trimethyltetradecane, and 2,6(R), 10(S)-trimethylpentadecane. Products...


    pub_type: 杂志文章


    authors: Cox RE,Maxwell JR,Myers RN

    更新日期:1976-01-01 00:00:00

  • Polyunsaturated fatty acids of serum lipids in myocardial infarction.

    abstract::Two groups of volunteers had blood drawn for serum analysis of fatty acids. The first group was comprised of patients admitted to the hospital with possible myocardial infarction (MI). Blood was drawn at admission and at 12, 24 and 48 hr. These patients were subsequently divided into three groups, those with MI, those...


    pub_type: 杂志文章


    authors: Crofts JW,Ogburn PL Jr,Johnson SB,Holman RT

    更新日期:1988-06-01 00:00:00

  • Molecular genetics of plant sterol backbone synthesis.

    abstract::Sterols, which are biosynthesized via the cytoplasmic mevalonate (MVA) pathway, are important structural components of the plasma membrane and precursors of steroid hormones in both vertebrates and plants. Ergosterol and cholesterol are the major sterols in yeast and vertebrates, respectively. In contrast, plants prod...


    pub_type: 杂志文章,评审


    authors: Suzuki M,Muranaka T

    更新日期:2007-02-01 00:00:00

  • Cigarette smoke affects lipolytic activity in isolated rat lungs.

    abstract::Isolated perfused rat lungs liberated fatty acids at a rate of 15 mumol/hr during perfusion of triglyceride-rich medium through the pulmonary vascular bed. About 80% of this activity seemed to result from lipoprotein lipase and 20% to hormone-sensitive lipase. Ventilation of the lungs with cigarette smoke instead of a...


    pub_type: 杂志文章


    authors: Hartiala J,Viikari J,Hietanen E,Toivonen H,Uotila P

    更新日期:1980-07-01 00:00:00

  • Identification of steroids by chemical ionization mass spectrometry.

    abstract::Chemical ionization (CI) mass spectra of various natural and synthetic steroids have been studied using methane, isobutane, ammonia, trideuterioammonia and hydroxy anion as reagent gases. The CI spectra of steroids give simple and well characterized ions, which provide information about molicular weight as well as fun...


    pub_type: 杂志文章


    authors: Lin YY

    更新日期:1980-09-01 00:00:00

  • Seasonal changes in leaf lipid and fatty acid composition of nine plants consumed by two African herbivores.

    abstract::In the wild, nutrients from plants provide for the requirements of all herbivores and ultimately all animals, yet little work has been published on how such nutrients change with environmental conditions. Plant lipids are nutritionally important for browsing mammals, initially with respect to taste and palatability, b...


    pub_type: 杂志文章


    authors: Davidson BC

    更新日期:1998-01-01 00:00:00

  • Effect of dietary linseed oil on tumoricidal activity and eicosanoid production in murine macrophages.

    abstract::Diets that contain high levels of n-3 fatty acids from fish oil have been shown to significantly effect macrophage cytolytic capacity, tumor necrosis factor alpha production and eicosanoid production. The present study was undertaken to determine whether n-3 fatty acids from vegetable origin [linseed oil (LIN)] would ...


    pub_type: 杂志文章


    authors: Hubbard NE,Chapkin RS,Erickson KL

    更新日期:1994-09-01 00:00:00

  • The effect of modest vitamin E supplementation on lipid peroxidation products and other cardiovascular risk factors in diabetic patients.

    abstract::Among many factors, elevated lipids and lipid peroxide levels in blood are major risk factors in the development of cardiovascular disease in diabetic patients. This study has examined whether oral supplementation of vitamin E, an antioxidant, has any effect on blood lipid peroxidation products (LP) and lipid profile ...


    pub_type: 临床试验,杂志文章


    authors: Jain SK,McVie R,Jaramillo JJ,Palmer M,Smith T,Meachum ZD,Little RL

    更新日期:1996-03-01 00:00:00

  • Use of a fluorescent radiolabeled triacylglycerol as a substrate for lipoprotein lipase and hepatic triglyceride lipase.

    abstract::A fluorescent radiolabeled triacylglycerol has been synthesized by using a fluorescent fatty acid (pyrene decanoic acid) and a radiolabeled oleic acid. This analog of the natural substrate, 1(3)pyrene decanoic-2,3 (1,2)-dioleoyl-sn-glycerol, has been tested as substrate for determining lipoprotein lipase and hepatic t...


    pub_type: 杂志文章


    authors: Dousset N,Negre A,Salvayre R,Rogalle P,Dang QQ,Douste-Blazy L

    更新日期:1988-06-01 00:00:00

  • Novel Non-methylene-Interrupted Dienoic and Trienoic Fatty Acids with a Terminal Double Bond in Ovaries of the Limpet Cellana toreuma.

    abstract::In this study, to obtain further information on the structural diversity of non-methylene-interrupted (NMI) fatty acids (FA) in the gonads of the limpet Cellana toreuma, previously unreported minor NMI FA, fractionated by argentation thin-layer chromatography (TLC), in the ovaries were characterized by gas chromatogra...


    pub_type: 杂志文章


    authors: Kawashima H

    更新日期:2020-05-01 00:00:00

  • The incorporation of ethanolamine into ether-containing lipids in rat brain.

    abstract::After intracerebral injection of C(14)-ethanolamine into rats, the ethanolamine phosphoglycerides were isolated and hydrolyzed with mild alkali and acid. The specific radioactivity of the diacyl, acyl alkenyl, and acyl alkyl glyceryl-3-phosphorylethanolamine, the diacyl and acyl alkenyl glyceryl-3-phosphorylcholine, a...


    pub_type: 杂志文章


    authors: Horrocks LA,Ansell GB

    更新日期:1967-07-01 00:00:00

  • Glycerol ester hydrolase activity in the pulp of unerupted calves' teeth.

    abstract::The pulp from unerupted calves' teeth was found to contain low levels of glycerol ester hydrolase activity. Solutions in Tris buffer cleared tributyrylglycerol agar and hydrolyzed emulsified olive oil. The average quantity of free fatty acids released in five assays with olive oil was: 2.8, S.D.+/-1.4. Specific activi...


    pub_type: 杂志文章


    authors: McMahon KE,Pitas RE,Jensen RG

    更新日期:1977-02-01 00:00:00

  • Quantitative determination of butylated hydroxyanisole, butylated hydroxytoluene, and tert-butyl hydroquinone in oils, foods, and biological fluids by high-performance liquid chromatography with fluorometric detection.

    abstract::Concentrations of synthetic antioxidants butylated hydroxyanisole, butylated hydroxytoluene, and tert-butyl hydroquinone were quantified using a high-performance liquid chromatograph with spectrofluorometric detector. The antioxidants were separated and eluted on a reversed-phase column by gradient of a mixture of H2O...


    pub_type: 杂志文章


    authors: Yankah VV,Ushio H,Ohshima T,Koizumi C

    更新日期:1998-11-01 00:00:00

  • Effects of aging on the composition and metabolism of docosahexaenoate-containing lipids of retina.

    abstract::The amount of docosahexaenoate (22:6n-3)-containing phospholipid species decreases with aging in the rat retina. Most lipids, but especially choline and serine glycerophospholipids, show a significant fall in 22:6n-3, which is not compensated by increases in other polyenoic fatty acids. The decrease not only affects 2...


    pub_type: 杂志文章


    authors: Rotstein NP,Ilincheta de Boschero MG,Giusto NM,Aveldaño MI

    更新日期:1987-04-01 00:00:00

  • Effect of dietary cholesterol and fat on cell cholesterol transfer to postprandial plasma in hyperlipidemic men.

    abstract::Postprandial chylomicrons are potent ultimate acceptors of cell membrane cholesterol and are believed to accelerate reverse cholesterol transport (RCT). We compared the effects of meals rich in polyunsaturated fat (PUFA) and either high (605 mg) or low (151 mg) in cholesterol and a meal rich in dairy fat (DF) in the f...


    pub_type: 杂志文章,随机对照试验


    authors: Sutherland WH,de Jong SA,Walker RJ

    更新日期:2007-10-01 00:00:00

  • Lysophosphatidic acid produced by hen egg white lysophospholipase D induces vascular development on extraembryonic membranes.

    abstract::Lysophosphatidic acid (lysoPtdOH), a lysophospholipid mediator, exerts diverse physiological effects, including angiogenesis, through its specific G-protein-coupled receptors. Previously, we showed that unfertilized hen egg white contains polyunsaturated fatty acid-rich lysoPtdOH and lysophospholipase D (lysoPLD). Her...


    pub_type: 杂志文章


    authors: Morishige J,Uto Y,Hori H,Satouchi K,Yoshiomoto T,Tokumura A

    更新日期:2013-03-01 00:00:00

  • Transformations of 5-HETE by activated keratinocyte 15-lipoxygenase and the activation mechanism.

    abstract::There is convincing evidence that normal cultured human keratinocytes possess a 15-lipoxygenase activity which, however, does not appear to manifest itself without cell membrane damage. When "activated", this enzyme transforms arachidonic acid into 15-hydroxyeicosatetraenoic acid (15-HETE), and linoleic acid into 13-h...


    pub_type: 杂志文章


    authors: Green FA

    更新日期:1990-10-01 00:00:00

  • Conjugated linoleic acids and CLA-containing phospholipids inhibit NO formation in aortic endothelial cells.

    abstract::This study examined the effects of five CLA isomers and the non-conjugated LA on nitric oxide (NO) production, an important modulator of vasodilation, inflammation, and cytotoxicity. Bovine aortic endothelial cells (BAECs) were pretreated with pure CLAs (c9, c11-, c9, t11-, t9, t11-, t10, c12-, c11, c13-CLA) and the n...


    pub_type: 杂志文章


    authors: Jenko KJ,Vanderhoek JY

    更新日期:2008-04-01 00:00:00