Abstract:
:Recently, significant differences between rats fed a casein diet and rats fed a soybean protein diet have been observed in hepatic phospholipid fatty acid patterns (Sjöblom, L., and Eklund, A., Biochim. Biophys. Acta 1004, 187-192, 1990). The influence of these two diets on the delta 6 desaturase activity was investigated in the present study because the hepatic desaturase system is a source of unsaturated fatty acids. The rats fed a casein diet showed higher desaturase activity than those fed soybean protein when using either linoleic acid (P less than 0.005) or oleic acid (P less than 0.05) as substrates. The phosphatidylcholine fraction of hepatic microsomes showed increases in oleic acid (P less than 0.005) and 20:3 omega 9 (P less than 0.001) levels as well as decreases in stearic acid (P less than 0.001), linoleic acid (P less than 0.005) and arachidonic acid (P less than 0.005) levels in rats which were fed casein rather than soybean protein. Similar differences between the two groups were also observed in the phosphatidylethanolamine and phosphatidylinositol fractions. These data indicate that the qualitative properties of the dietary protein source may influence the fatty acid pattern of rat hepatic microsomes by interfering with delta 6 desaturase activity.
journal_name
Lipidsjournal_title
Lipidsauthors
Lindholm M,Eklund Adoi
10.1007/BF02544003subject
Has Abstractpub_date
1991-02-01 00:00:00pages
107-10issue
2eissn
0024-4201issn
1558-9307journal_volume
26pub_type
杂志文章相关文献
LIPIDS文献大全abstract::Recently, a number of inhibitors of the enzyme oxidosqualene cyclase (OSC; EC 5.4.99.7), a key enzyme in sterol biosynthesis, were shown to inhibit in mammalian cells the multiplication of Trypanosoma cruzi, the parasite agent of Chagas' disease. The gene coding for the OSC of T. cruzi has been cloned and expressed in...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-005-1493-y
更新日期:2005-12-01 00:00:00
abstract::A ubiquitously expressed member of the cytochrome P450 superfamily, CYP51, encodes lanosterol 14alpha-demethylase, the first step in the conversion of lanosterol into cholesterol in mammals. The biosynthetic intermediates of lanosterol 14alpha-demethylation are oxysterols, which inhibit HMG-CoA reductase and sterol sy...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-002-1016-x
更新日期:2002-12-01 00:00:00
abstract::The effect of dexamethasone on the incorporation and conversion of [1-14C]eicosa-8,11,14-trienoic acid to arachidonic acid in isolated hepatocytes and in hepatoma tissue culture (HTC) cells was studied. In both kinds of cells, no changes in the exogenous acid incorporation were found when the hormone was added to the ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534824
更新日期:1986-03-01 00:00:00
abstract::This study was undertaken to determine the effect of various lipid emulsions on the hepato-biliary system in rats. Rats were randomly divided into six groups and infused continuously for 48 hr with either long-chain triglycerides (LCT), medium-chain triglycerides (MCT) or a mixture of MCT and LCT. One group infused wi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536144
更新日期:1992-05-01 00:00:00
abstract::Jasmonic acid (JA) is synthesized from linolenic acid (18:3n-3) by sequential action of 13-lipoxygenase, allene oxide synthase (AOS), and allene oxide cyclase. The fungus Lasiodiplodia theobromae can produce large amounts of JA and was recently reported to form the JA precursor 12-oxophytodienoic acid. The objective o...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-011-3622-5
更新日期:2012-01-01 00:00:00
abstract::Normal phase high performance liquid chromatography methods are described for the separation of neutral lipid, fatty acid and five phospholipid classes using spectrophotometric detection at 206 nm. Separations were accomplished in less than 10 min for each lipid class. A mobile phase consisting of hexane/methyltertiar...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535282
更新日期:1988-12-01 00:00:00
abstract::Plant diseases caused by Phytophthora species are serious threats to agriculture and the natural environment. Genome sequencing has revealed the lack of a gene for canonical phospholipase C (PLC), an enzyme that was hitherto thought to be ubiquitous in eukaryotes. PLC acts in the hydrolysis of phosphatidylinositol 4,5...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1002/lipd.12093
更新日期:2018-08-01 00:00:00
abstract::Liver fatty-acid-binding protein (FABP1, L-FABP) is the major cytosolic binding/chaperone protein for both precursor arachidonic acid (ARA) and the endocannabinoid (EC) products N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG). Although FABP1 regulates hepatic uptake and metabolism of ARA, almost not...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1002/lipd.12071
更新日期:2018-06-01 00:00:00
abstract::This study addresses two questions: 1) what is the maximum amount of tocopherol that can be contained in egg phosphatidylcholine liposomes, and 2) what is the stability of these vesicles in the presence of serum proteins? These liposomes, made with a French pressure cell, can contain no more than 33 mol% of tocopherol...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534254
更新日期:1985-03-01 00:00:00
abstract::The physiological role of long-chain fatty acyl-CoA is thought to be primarily in intermediary metabolism of fatty acids. However, recent data show that nM to microM levels of these lipophilic molecules are potent regulators of cell functions in vitro. Although long-chain fatty acyl-CoA are present at several hundred ...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02522684
更新日期:1996-09-01 00:00:00
abstract::Hepatocytes isolated from rainbow trout fed on diets containing either fish oil or olive oil were incubated with individual odd-chain length unsaturated fatty acids (19:1n-9, 19:2n-6, 19:3n-3, 21:2n-6, 21:3n-6, 21:4n-6, 21:3n-3, and 21:5n-3) to examine whether these fatty acids were substrates for modification by desa...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-997-0078-0
更新日期:1997-06-01 00:00:00
abstract::High-performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) approaches have enabled high selectivity and sensitivity for the identification and quantification of glucosylceramide molecular species. Here we demonstrate that HPLC-ESI-MS/MS is an efficient method for character...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-012-3725-7
更新日期:2012-12-01 00:00:00
abstract::The developmental changes in the fatty acid composition of ethanolamine phosphoglycerides (EPG) and choline phosphoglycerides (CPG) were studied in the liver and brain of 18 newborn infants with gestational ages ranging from 20 to 44 wk. A small group of five newborns receiving total parenteral nutrition (TPN) with hi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537290
更新日期:1987-03-01 00:00:00
abstract::To address the role of cell membrane neutral sphingomyelinase (EC 3.1.4.12; SMase) in the regulation of cholesterol metabolism in the liver parenchymal cell, we examined the effect of exogenous neutral SMase on the metabolism of cholesteryl esters and the secretion of VLDL and biliary lipids in isolated rat hepatocyte...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-003-1031-y
更新日期:2003-01-01 00:00:00
abstract::All fatty acids have important functions, but the term "essential" is applied only to those polyunsaturated fatty acids (PUFA) that are necessary for good health and cannot be completely synthesized in the body. The need for arachidonic acid, which is utilized for eicosanoid synthesis and is a constituent of membrane ...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02562220
更新日期:1999-01-01 00:00:00
abstract::This review explores the effects of dietary long chain polyunsaturated fatty acids (LCPUFA) on various aspects of early immune development and their potential role in the development or the prevention of immune disease. Modern diets have become increasingly rich in n-6 LCPUFA and relatively n-3 LCPUFA deficient. These...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-007-3030-z
更新日期:2007-09-01 00:00:00
abstract::Hempseed products represent potential alternative feed ingredients for poultry. However, their usage is not currently approved due to a lack of data to support their safety and efficacy. In this regard, the current study was conducted to assess the impact of dietary concentration of hempseed (HS) products and duration...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-015-4088-7
更新日期:2016-05-01 00:00:00
abstract::The composition of the glycosphingolipids of the human gastrointestinal tract was studied. The major neutral glycosphingolipids were ceramide monohexosides (e.g., GalCer, GlcCer), LacCer, Gb3Cer, Gb4Cer and more polar ones with more than four sugars, whereas neither Gg3Cer nor Gg4Cer were present. The acidic glycosphi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535996
更新日期:1993-08-01 00:00:00
abstract::Material dealing with the chemistry, biochemistry, and biological activities of oxysterols is reviewed for the period 1987-1995. Particular attention is paid to the presence of oxysterols in tissues and foods and to their physiological relevance. ...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02522641
更新日期:1996-05-01 00:00:00
abstract::An improved headspace capillary gas chromatographic (GC) method was developed to measure the oxidative susceptibility of human red blood cell (RBC) membranes. This method analyzed volatile peroxidation products of both n-6 (hexanal and pentane) and n-3 (propanal) polyunsaturated fatty acids. Oxidative susceptibility t...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536076
更新日期:1991-06-01 00:00:00
abstract::Hydrolysis of synthetic triglycerides by rattlesnake and leopard shark pancreatic enzymes revealed striking differences in specificity, depending on the presence or absence of sodium taurocholate. Without added sodium taurocholate the classical specificity of pancreatic lipase was expressed. Rattlesnake enzymes, in th...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532361
更新日期:1975-09-01 00:00:00
abstract::Stimulation of platelets induces a rapid release of arachidonate from specific phospholipids and subsequent remodeling of arachidonate-containing phospholipids. This process is accompanied by transformation of released arachidonate by cyclooxygenase and lipoxygenase enzymes. We addressed the question of whether the cy...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536506
更新日期:1991-12-01 00:00:00
abstract::Eighteen-month-old Nebraska strain minipigs were fed diets containing 2% cholesterol and 20% corn oil, lard, or coconut oil for 12 to 18 months. Concentrations of serum total lipid, total cholesterol, and total phospholipid increased 200 to 300% with each diet. Changes in serum concentrations of Sf 20+ and Sf 0-20 lip...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533395
更新日期:1978-03-01 00:00:00
abstract::Two electrophoretically different forms of sterol ester hydrolase (EC 3.1.1.13) were obtained from the cytoplasmic extract of the mycelia of Fusarium oxysporum. The entities, estimated at 60,000 (I) and 15,000 (II) molecular weights, were obtained in Sephadex G100 column chromatography of the ammonium sulfate precipit...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535686
更新日期:1981-02-01 00:00:00
abstract::By means of cellulose acetate electrophoresis and measurement of radio-activity, lipoproteins (d less than or equal to 1,006) of lymph collected from rats fed a diet containing fats added to labeled fatty acids for 20-24 hr, have been separated into two kinds differing in their size. Fats with different saturated and ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535449
更新日期:1977-06-01 00:00:00
abstract::The formation of hydroxy radicals, hexanal, and 2,4-decadienal was demonstrated from the autocatalytic dimer peroxide which had been reported by us in autoxidizing linoleate (Morita and Tokita in Lipids 41:91-95, 2006). Then, autoxidizing linoleate containing eleostearate was investigated for new autocatalytic substan...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3170-9
更新日期:2008-07-01 00:00:00
abstract::The effect of apo very low density lipoprotein (apo VLDL) and apoprotein C-II on the phospholipase A1 activity associated with lipoprotein lipase (E.C.3.1.1.3) was studied using purified bovine milk lipoprotein lipase. The enzyme degraded 14C phosphatidylcholine (PC) to 14C 2-acyl lysophosphatidylcholine at a rate of ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02540967
更新日期:1980-03-01 00:00:00
abstract::A recent study on the metabolism of 1-14C-alpha-linolenic acid in the guinea pig revealed that the fur had the highest specific activity of all tissues examined, 48 h after dosing. The present study investigated the pattern of tissue lipid labeling following an oral dose of 1-14C-linoleic acid after the animals had be...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-001-0715-7
更新日期:2001-03-01 00:00:00
abstract::The ganglioside levels in atherosclerotic lesions of human aorta are considerably higher than those in unaffected areas of aorta, and atherosclerotic patients frequently have increased concentrations of serum gangliosides. The present review summarizes recent findings that suggest the possible involvement of aortic ga...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02537083
更新日期:1994-01-01 00:00:00
abstract::Conjugated linoleic acid (CLA) has been demonstrated to reduce body fat in animals. However, the mechanism by which this reduction occurs is unknown. Leptin may mediate the effect of CLA to decrease body fat. We assessed the effects of 64 d of CLA supplementation (3 g/d) on circulating leptin, insulin, glucose, and la...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-000-0586-y
更新日期:2000-07-01 00:00:00