Abstract:
:This study addresses two questions: 1) what is the maximum amount of tocopherol that can be contained in egg phosphatidylcholine liposomes, and 2) what is the stability of these vesicles in the presence of serum proteins? These liposomes, made with a French pressure cell, can contain no more than 33 mol% of tocopherol. Tocopherol changes liposomes in a manner similar to cholesterol, making them larger, less permeable to aqueous dyes and highly resistant to protein-induced disruption. The suppression of protein-induced disruption is more pronounced with tocopherol than with cholesterol, even at lower molar ratios. Thus, liposomes containing alpha tocopherol (15 to 30 mol%) may be useful for delivering physiological quantities of this vitamin to cells in culture or to tissue in vivo.
journal_name
Lipidsjournal_title
Lipidsauthors
Halks-Miller M,Guo LS,Hamilton RL Jrdoi
10.1007/BF02534254subject
Has Abstractpub_date
1985-03-01 00:00:00pages
195-200issue
3eissn
0024-4201issn
1558-9307journal_volume
20pub_type
杂志文章相关文献
LIPIDS文献大全abstract::Schizochytrium sp. is an algae-like microorganism utilized for commercial production of docosahexaenoic acid (DHA)-rich oil and dried microalgae for use as a source of DHA in foods, feeds, and nutritional supplements. Electron microscopic analysis of whole cells of Schizochytrium sp. employing sample preparation by hi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-000-0655-2
更新日期:2000-12-01 00:00:00
abstract::The mechanism of the self-assembly of the lamellar structure of natural stratum corneum lipids (SCL) has been a subject of considerable interest. We have examined this question by using a synthetic pseudo-ceramide (sphingolipid E, SLE) which was analogous to the naturally occurring ceramide type 2. The thermotropic pr...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536040
更新日期:1995-04-01 00:00:00
abstract::A group of Angus beef cattle was removed from temperate pastures and fed a very low beta-carotene cereal-based ration in a feedlot for over 300 d. Half the group was supplemented weekly with retinyl palmitate (at the rate of 60,000 IU vitamin A/100 live weight (LW)/day), sufficient to offset clinical vitamin A deficie...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5107-5
更新日期:2006-04-01 00:00:00
abstract::Serum high density lipoprotein is increasingly recognized as a negative risk for cardiovascular disease. The distribution and interrelationship of serum lipids, lipoproteins, anthropometric measurements and blood pressures were determined in some 5,000 children. Children had mean +/- S.D. alpha-lipoprotein cholesterol...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533576
更新日期:1979-01-01 00:00:00
abstract::Sphingomyelin was isolated from cysts of the brine shrimp Artemia franciscana using QAE-Sephadex A25, Florisil and Iatrobeads column chromatographies. The chemical structure was identified using thin-layer chromatography, gas-liquid chromatography, infrared spectroscopy and matrix-assisted laser desorption ionization ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-010-3438-8
更新日期:2010-07-01 00:00:00
abstract::Conjugated linoleic acid (CLA) is a collective term that describes different isomers of linoleic acid with conjugated double bonds. Although the main dietary isomer is 9cis,11trans-18:2, which is present in dairy products and ruminant fat, the biological effects of CLA generally have been studied using mixtures in whi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-001-0759-8
更新日期:2001-06-01 00:00:00
abstract::The minimum requirement of linoleic acid to prevent effects of dietary C18 trans fatty acids on eicosanoid biosynthesis in rats was assessed. In a first experiment, six groups of animals were fed diets with a high content of trans fatty acids [20% of energy (en%)], and increasing amounts of linoleic acid (0.4 to 7.1 e...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02535138
更新日期:1989-06-01 00:00:00
abstract::In vivo intestinal perfusion was used to follow the absorption of three different choline glycerophospholipids (CGP) in guinea pig. These included 1-[3H]palmitoyl-2-acyl-sn-glycero-3-phosphocholine (diacyl-GPC), 1-[3H]-O-hexadecyl-2-acyl-sn-glycero-3-phosphocholine (alkylacyl-GPC) and 1,2-di-O-hexadecyl-sn-glycero-3-p...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534872
更新日期:1987-01-01 00:00:00
abstract::We recently reported the presence of various cyclopropane fatty acids-among them, cyclopropaneoctanoic acid 2-hexyl-in the adipose tissue of obese women. The aim of this study was to verify whether the presence of cyclopropaneoctanoic acid 2-hexyl in human serum was associated with obesity or chronic kidney disease (b...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-016-4141-1
更新日期:2016-07-01 00:00:00
abstract::A new triterpene alcohol was isolated fron shea butter and its structure was shown to be 24-methylenelanost-9(11)-en-3beta-ol. Gas chromatographic correlations between this triterpene alcohol and other related compounds are discussed. ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532428
更新日期:1975-08-01 00:00:00
abstract::The naturally occurring (6Z)-(±)-2-methoxy-6-hexadecenoic acid (1) and (6Z)-(±)-2-methoxy-6-octadecenoic acid (2) were synthesized in 7-8 steps with 38 and 13% overall yields, respectively, by using an acetylide coupling approach, which made it possible to obtain a 100% cis-stereochemistry for the double bonds. In a s...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-017-4262-1
更新日期:2017-06-01 00:00:00
abstract::Using primary rat hepatocyte cultures, the potency of several garlic-derived organosulfur compounds to inhibit cholesterol biosynthesis in toto as well as at early and late steps of this metabolic pathway was compared. Concerning early steps, allicin significantly inhibited incorporation of [14C]acetate into nonsaponi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02587912
更新日期:1996-12-01 00:00:00
abstract::This study was designed to determine the nutritional lipid requirement of Manchurian trout and to investigate the effects of lipid concentrations on the antioxidant status in larvae with experimental diets with different lipid levels. Oxidative stress differences between different organs and tissues were also assessed...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-009-3313-7
更新日期:2009-07-01 00:00:00
abstract::Several of a series of linoleic acid amides have been reported to inhibit cholesterol-induced atherosclerosis in rabbits. The three amides which have been studied to the greatest extent are (in order of increasing activity) N-cyclohexyl linoleamide (AC23), N(alpha methylbenzyl) linoleamide (AC223), and N[aplha-phenyl-...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02532966
更新日期:1977-01-01 00:00:00
abstract::Three series of experiments demonstrated that sesame seed and its lignans cause significant elevation of alpha-tocopherol content in rats. In Experiment 1, 20% sesame seed (with a negligible amount of alpha-tocopherol) supplementing 10 (low), 50 (normal), or 250 (high) mg/kg alpha-tocopherol diets (protein and fat con...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536287
更新日期:1995-11-01 00:00:00
abstract::Glucose-sensitive liposomes were prepared by incorporating hydrophobically modified glucose oxidase (EC 1.1.3.4.) into the liposomal bilayer of dioleoylphosphatidylethanolamine and cholesteryl hemisuccinate. For the release test, calcein, a fluorescence marker, was entrapped in the liposomes. The liposomes were stable...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3223-0
更新日期:2008-10-01 00:00:00
abstract::The aim of this study was to determine the influence of long-term docosahexaenoic acid (DHA) dietary supplementation on the erythrocyte fatty acid profile and oxidative balance in soccer players after training and acute exercise. Fifteen volunteer male athletes (age 20.0 ± 0.5 years) were randomly assigned to a placeb...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-014-3976-6
更新日期:2015-02-01 00:00:00
abstract::Using an experimental model that enables the effects of alcohol to be distinguished from the effects of the nonalcoholic components present in wine, we determined whether wine has effects other than those of alcohol on the metabolism of cholesterol. Male rats were fed a standard diet and had free access to water and e...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-001-0732-6
更新日期:2001-04-01 00:00:00
abstract::The phospholipid composition of gill tissue from thermally acclimated rainbow trout, Salmo gairdneri, was determined by Iatroscan analysis following an initial development of the chromarods in a non-polar solvent to remove neutral lipids. Standard curves for all phospholipids, although linear through most of the conce...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534892
更新日期:1985-08-01 00:00:00
abstract::The purpose of these experiments was to study the uptake and metabolism of exogenous triglyceride in the isolated perfused rabbit heart. When infused into the rabbit heart, [9,10-3H(N)]triolein was retained and incorporated into a lipid fraction that had the chromatographic mobility of authentic triolein. Incorporatio...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02538094
更新日期:1990-08-01 00:00:00
abstract::The triacylglycerols of very low density lipoproteins (VLDL-TG) were analyzed in samples from normal subjects and patients with Frederickson's Type III and Type IV hyperlipoproteinemia. VLDL were obtained by conventional ultracentrifugation, and the triacylglycerols were isolated by thin-layer chromatography (TLC). Re...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534528
更新日期:1984-09-01 00:00:00
abstract::This study was carried out to investigate the effects of a dietary oxidized oil on lipid metabolism in rats, particularly the desaturation of fatty acids. Two groups of rats were fed initially for a period of 35 d diets containing 10% of either fresh oil or thermally treated oil (150 degrees C, 6 d). The dietary fats ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-999-0418-0
更新日期:1999-07-01 00:00:00
abstract::Material dealing with the chemistry, biochemistry, and biological activities of oxysterols is reviewed for the period 1987-1995. Particular attention is paid to the presence of oxysterols in tissues and foods and to their physiological relevance. ...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02522641
更新日期:1996-05-01 00:00:00
abstract::A ubiquitously expressed member of the cytochrome P450 superfamily, CYP51, encodes lanosterol 14alpha-demethylase, the first step in the conversion of lanosterol into cholesterol in mammals. The biosynthetic intermediates of lanosterol 14alpha-demethylation are oxysterols, which inhibit HMG-CoA reductase and sterol sy...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-002-1016-x
更新日期:2002-12-01 00:00:00
abstract::The tissue distribution of newly synthesized 22:6n-3 and intermediate PUFA was examined in rainbow trout to further our understanding of the metabolism of this EFA in fish. Rainbow trout were fed a pulse of deuterated linolenic acid (D5-17,17,18,18,18-18:3n-3), and the tissue distribution of deuterated anabolites was ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-003-1146-1
更新日期:2003-09-01 00:00:00
abstract::The beta-adrenergic system in cardiac muscle cells is influenced by the n-3 polyunsaturated fatty acid (PUFA) content in cell membranes. This study deals with the specific effect of docosahexaenoic acid (DHA) as compared to other n-3 PUFA, without modification of the arachidonic acid content. Increasing the DHA conten...
journal_title:Lipids
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract::Gallstone formation and dissolution were studied in a prairie dog model of cholesterol (CH) cholelithiasis. Gallstones were induced in 49 prairie dogs by feeding 1.2% CH in a nutritionally adequate semisynthetic diet for 6 wk (period 1). At 6 wk, gallstones had developed in all animals examined. The diets were modifie...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02534055
更新日期:1986-09-01 00:00:00
abstract::Red blood cell (RBC) fatty acid (FA) patterns have been shown to predict risk for cardiovascular and other chronic diseases. As part of a project analyzing RBC samples from the Women's Health Initiative Memory Study (WHIMS) we observed implausibly low levels of highly unsaturated fatty acids (HUFA) suggestive of degra...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-012-3693-y
更新日期:2012-09-01 00:00:00
abstract::While there are many reports of studies that fed arachidonic acid (AA) to animals, there are very few reports of AA feeding to humans under controlled conditions. This 130-d study was conceived as a controlled, symmetrical crossover design with healthy, adult male volunteers. They lived in the metabolic research unit ...
journal_title:Lipids
pub_type: 临床试验,杂志文章
doi:10.1007/s11745-997-0054-8
更新日期:1997-04-01 00:00:00
abstract::Lipoprotein(a) [Lp(a)] represents a class of lipoprotein particles having as a protein moiety apoB-100 linked by a single disulfide bond to apolipoprotein(a) [apo(a)], a multikringle structure with a high degree of homology with plasminogen. A recognized feature of Lp(a) is its instability on storage caused by attenda...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-004-1268-5
更新日期:2004-06-01 00:00:00