Supplementation with evening primrose oil in atopic dermatitis: effect on fatty acids in neutrophils and epidermis.

Abstract:

:We investigated the effect of oral supplementation with evening primrose oil, containing 72% linoleic acid (18:2n-6) and 10% gamma-linolenic acid (18:3n-6), on the epidermal and neutrophil phospholipid fatty acid composition in 15 patients with atopic dermatitis (AD). Three different dose levels, 4, 8 and 12 capsules per day containing 0.5 g oil, were given to three groups of patients. The only n-6 fatty acid showing a significant (p less than 0.05) dose-related increase was dihomo-gamma-linolenic acid (20:3n-6) in neutrophil phospholipids. The highest dose increased dihomo-gamma-linolenic acid by 45% in neutrophil phospholipids, by 46% in lesion-free epidermal phosphatidylcholine, and by 15% in lesion-free epidermal phosphatidylethanolamine. In both lesional and lesion-free epidermis, supplementation resulted in a rise in the ratio between n-6 and monounsaturated fatty acids, reaching significance (p less than 0.05) in lesional epidermis. This study shows that moderate and favorable fatty acid changes can be obtained in the epidermis of AD patients, when given 6 g per day of oil rich in n-6 fatty acids. The abnormal lipid and fatty acid pattern of the atopic epidermis may be involved in the pathogenesis of the disease, and should therefore be the target for future therapeutic approaches with fatty acid supplements.

journal_name

Lipids

journal_title

Lipids

authors

Schäfer L,Kragballe K

doi

10.1007/BF02536604

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

557-60

issue

7

eissn

0024-4201

issn

1558-9307

journal_volume

26

pub_type

临床试验,杂志文章,随机对照试验

相关文献

LIPIDS文献大全
  • Decrease in alkaline triglyceride lipase in primary cultured hepatocytes from mice with sarcoma 180.

    abstract::Primary cultured hepatocytes from normal mice and mice with Sarcoma 180 were characterized. The viability of freshly isolated hepatocytes from both sources was over 90% and the cells had a relatively stable population of DNA for a minimum of three days. After incubation with (3H)leucine, the syntheses and secretions o...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534229

    authors: Masuno H,Okuda H

    更新日期:1985-07-01 00:00:00

  • Effect of dietary linoleic acid content on the distribution of triacylglycerol molecular species in rat adipose tissue.

    abstract::The present study examined the effect of varying dietary linoleate intake (0.01, 0.24, 2.4, 24, 80 or 160 g/kg diet) for 24 weeks on the distribution of triacylglycerol (TG) molecular species in rat epididymal adipose tissue. Adipose TG fractions were purified by thin-layer chromatography and separated into different ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536030

    authors: Huang YS,Lin X,Smith RS,Redden PR,Jenkins DK,Horrobin DF

    更新日期:1992-09-01 00:00:00

  • Apolipoproteins A-I and A-II downregulate neutrophil functions.

    abstract::This work reports the effect of the apolipoproteins A-I and A-II (apoA-I and apoA-II) on the release of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-8, and IL-1 receptor antagonist (IL-1Ra) and on the oxidative burst of human neutrophils. By themselves, apoA-I and apoA-II do not affect the basal liber...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-002-0981-4

    authors: Furlaneto CJ,Ribeiro FP,Hatanaka E,Souza GM,Cassatella MA,Campa A

    更新日期:2002-09-01 00:00:00

  • High-Fat Diet from Weaning until Early Adulthood Impairs T Cell Development in the Thymus.

    abstract::The growing prevalence of childhood obesity has become a serious health problem over the past few decades. Although the immune system is greatly affected by childhood obesity, whether obesity influences the T cell development in the thymus is poorly understood. In this study, we used a high-fat diet (HFD)-induced obes...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1002/lipd.12193

    authors: Li H,Wetchapinant C,Zhang L,Wu K

    更新日期:2020-01-01 00:00:00

  • Growth inhibitory effects of liposome-associated 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine.

    abstract::The growth inhibitory effects of 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine (ET-18-OCH3) and various liposome compositions of ET-18-OCH3 were compared in a standardized growth inhibition assay utilizing a diverse tumor cell line panel including cell lines expressing multidrug resistance. ET-18-OCH3 and ELL-1...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-997-0135-8

    authors: Peters AC,Ahmad I,Janoff AS,Pushkareva MY,Mayhew E

    更新日期:1997-10-01 00:00:00

  • Activation of acyl-CoA cholesterol acyltransferase: redistribution in microsomal fragments of cholesterol and its facilitated movement by methyl-beta-cyclodextrin.

    abstract::Acyl-CoA cholesterol acyltransferase (ACAT) (EC 2.3.1.26) in the yolk sac membrane of chicken eggs plays an important role in the transport of lipids, which serve as both structural components and as an energy source during embryogenesis. ACAT from the yolk sac membrane of chicken eggs 16 d after fertilization has hig...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-999-0362-z

    authors: Cheng D,Tipton CL

    更新日期:1999-03-01 00:00:00

  • sn-position determination of phospholipid-linked fatty acids derived from erythrocytes by liquid chromatography electrospray ionization ion-trap mass spectrometry.

    abstract::The sn-position of FA in membrane lipids has an influence on the physiological function of cells, is predictive for diseases, and therefore is useful for diagnostics. The current study compares the compositions of acyl chain substituents in the sn-1 and sn-2 positions of the glycerol backbones of phospholipids derived...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-005-1377-1

    authors: Beermann C,Möbius M,Winterling N,Schmitt JJ,Boehm G

    更新日期:2005-02-01 00:00:00

  • Insect juvenile hormones and pheromones of isopentenoid biogenesis.

    abstract::In their diversity, speciation, and sheer numerical superiority, few should question that insects are the dominant life-form on earth. Their utilization of the multifunctional isopentenoids to regulate their life processes is equally diverse. To catalog or even summarize the contribution of isopentenoids in the regula...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533754

    authors: Bowers WS

    更新日期:1978-10-01 00:00:00

  • Quantitation of 1,2-diacylglycerol in rat heart by iatroscan TLC/FID.

    abstract::1,2-Diacylglycerol, which has been recognized as one of the intracellular second messengers, was measured quantitatively in the lipid extract from rat hearts using the thin layer chromatography and flame ionization detection (TLC/FID) method. Cholesterol acetate was added to the tissue as an internal standard, and the...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535467

    authors: Okumura K,Hashimoto H,Ito T,Ogawa K,Satake T

    更新日期:1988-03-01 00:00:00

  • An increased incidence of apolipoprotein E2/E2 and E4/E4 in retinitis pigmentosa.

    abstract::Previous studies from our laboratory have shown that retinitis pigmentosa (RP), a family of hereditary retinal degenerations, is often accompanied by abnormal levels of cholesterol or polyunsaturated fatty acids. The requirement of the retina for n-3 fatty acids is well known, and a defect in the supply of these lipid...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02537120

    authors: Huq L,McLachlan T,Hammer HM,Bedford D,Packard CJ,Shepherd J,Converse CA

    更新日期:1993-11-01 00:00:00

  • (S)-1,2-diacyl-3-acetins: Optically active triglycerides fromEuonymus verrucosus seed oil.

    abstract::The seed oil ofEuonymus verrucosus Scop., family Celastraceae, contains more than 90% 1,2-diacyl-3-acetins (monoacetotriglycerides). The constituent triglyceride acids, other than acetic, are the usual long-chain fatty acids.Thin-layer chromatography (TLC), infrared (IR) and hydrolysis with pancreatic lipase indicate ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02533174

    authors: Kleiman R,Miller RW,Earle FR,Wolff IA

    更新日期:1967-11-01 00:00:00

  • Biosynthesis and tissue deposition of docosahexaenoic acid (22:6n-3) in rainbow trout (Oncorhynchus mykiss).

    abstract::Rainbow trout (Oncorhynchus mykiss) weighing ca. 5 g and previously acclimated for 8 wk on a diet comprising vegetable oil (11%), fish meal (5%), and casein (48%) as the major constituents were fed a pulse of diet containing deuterated (D5) (17,17,18,18,18)-18:3n-3 ethyl ester. The synthesis and tissue distribution of...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-001-0826-1

    authors: Bell MV,Dick JR,Porter AE

    更新日期:2001-10-01 00:00:00

  • Quantitative measurement of prostaglandins E2 and E2 by selected ion monitoring.

    abstract::A method for the simultaneous quantitative analysis of prostaglandin E2 (PGE2) and PGE3 is described. The PG were analyzed by selected ion monitoring as the methyl ester-TMS ether derivatives of PGB2 and PGB3, respectively. The internal standard for the quantification of both species was [3,3,4,4-2H4]PGE2. A linear re...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535360

    authors: Ferretti A,Flanagan VP,Roman JM

    更新日期:1982-11-01 00:00:00

  • Successful utilization of lyophilized lipoprotein(a) as a biological reagent.

    abstract::Lipoprotein(a) [Lp(a)] represents a class of lipoprotein particles having as a protein moiety apoB-100 linked by a single disulfide bond to apolipoprotein(a) [apo(a)], a multikringle structure with a high degree of homology with plasminogen. A recognized feature of Lp(a) is its instability on storage caused by attenda...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-004-1268-5

    authors: Scanu AM,Hinman J,Pfaffinger D,Edelstein C

    更新日期:2004-06-01 00:00:00

  • Changes in cultured arterial smooth muscle cells isolated from chicks upon cholesterol feeding.

    abstract::We have developed cultures of smooth muscle cells (SMC) isolated from arterial hypercholesterolemic chicks (cholesterol-SMC). These cultures are suitable for the study at the molecular level of the changes in arterial SMC induced by a cholesterol diet. By using a strong dose of cholesterol (5%) for 10 d, we obtained v...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-998-0194-x

    authors: Carazo A,Alejandre J,Diaz R,Ríos A,Castillo M,Linares A

    更新日期:1998-02-01 00:00:00

  • The effect of conjugated linoleic acid isomers on fatty acid profiles of liver and adipose tissues and their conversion to isomers of 16:2 and 18:3 conjugated fatty acids in rats.

    abstract::Conjugated linoleic acid (CLA) is a collective term that describes different isomers of linoleic acid with conjugated double bonds. Although the main dietary isomer is 9cis,11trans-18:2, which is present in dairy products and ruminant fat, the biological effects of CLA generally have been studied using mixtures in whi...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-001-0759-8

    authors: Sébédio JL,Angioni E,Chardigny JM,Grégoire S,Juanéda P,Berdeaux O

    更新日期:2001-06-01 00:00:00

  • Molecular genetics of plant sterol backbone synthesis.

    abstract::Sterols, which are biosynthesized via the cytoplasmic mevalonate (MVA) pathway, are important structural components of the plasma membrane and precursors of steroid hormones in both vertebrates and plants. Ergosterol and cholesterol are the major sterols in yeast and vertebrates, respectively. In contrast, plants prod...

    journal_title:Lipids

    pub_type: 杂志文章,评审

    doi:10.1007/s11745-006-1000-5

    authors: Suzuki M,Muranaka T

    更新日期:2007-02-01 00:00:00

  • Regulation of very low density lipoprotein apo B metabolism by dietary fat saturation and chain length in the guinea pig.

    abstract::Studies investigated the effects of dietary fatty acid composition and saturation on the regulation of very low density lipoprotein (VLDL) apo B flux, clearance, and conversion to low density lipoprotein (LDL) in guinea pigs fed semipurified diets containing 15% (w/w) corn oil (CO), lard (LA), or palm kernel oil (PK)....

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-998-0176-z

    authors: Abdel-Fattah G,Fernandez ML,McNamara DJ

    更新日期:1998-01-01 00:00:00

  • Simvastatin therapy reduces prooxidant-antioxidant balance: results of a placebo-controlled cross-over trial.

    abstract::Oxidative stress is thought to play an important role in atherogenesis. The statin group of cholesterol-lowering drugs have been shown to reduce cardiovascular events and possess antioxidant properties. We aimed to assess the effects of simvastatin on a novel measure of prooxidant-antioxidant balance (PAB) in dyslipid...

    journal_title:Lipids

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11745-010-3517-x

    authors: Parizadeh SM,Azarpazhooh MR,Moohebati M,Nematy M,Ghayour-Mobarhan M,Tavallaie S,Rahsepar AA,Amini M,Sahebkar A,Mohammadi M,Ferns GA

    更新日期:2011-04-01 00:00:00

  • Determination of the phospholipid composition of trout gill by Iatroscan TLC/FID: effect of thermal acclimation.

    abstract::The phospholipid composition of gill tissue from thermally acclimated rainbow trout, Salmo gairdneri, was determined by Iatroscan analysis following an initial development of the chromarods in a non-polar solvent to remove neutral lipids. Standard curves for all phospholipids, although linear through most of the conce...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534892

    authors: Hazel JR

    更新日期:1985-08-01 00:00:00

  • Moderate changes in linoleate intake do not influence the systemic production of E prostaglandins.

    abstract::A pilot study was undertaken to determine if moderate changes in linoleate (18:2 omega 6) intake would modulate the prostaglandin E turnover concurrently with, or independently of, changes in the plasma prostaglandin (PG) precursor levels. Four adult male volunteers in good health were fed two controlled diets contain...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534258

    authors: Ferretti A,Judd JT,Marshall MW,Flanagan VP,Roman JM,Matusik EJ Jr

    更新日期:1985-05-01 00:00:00

  • Separation and identification of phospholipid peroxidation products.

    abstract::The molecular species in mixtures of phospholipid hydroperoxides are difficult to separate and identify by typical chromatographic and mass spectrometric techniques. As reported by Havrilla and coworkers, silver ion coordination ion-spray mass spectrometry (CIS-MS) has proven to be a powerful technique for the identif...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-001-0841-2

    authors: Milne GL,Porter NA

    更新日期:2001-11-01 00:00:00

  • Dexamethasone blocks arachidonate biosynthesis in isolated hepatocytes and cultured hepatoma cells.

    abstract::The effect of dexamethasone on the incorporation and conversion of [1-14C]eicosa-8,11,14-trienoic acid to arachidonic acid in isolated hepatocytes and in hepatoma tissue culture (HTC) cells was studied. In both kinds of cells, no changes in the exogenous acid incorporation were found when the hormone was added to the ...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02534824

    authors: Marra CA,de Alaniz MJ,Brenner RR

    更新日期:1986-03-01 00:00:00

  • Mechanism of Phospholipid Hydrolysis for Oyster Crassostrea plicatula Phospholipids During Storage Using Shotgun Lipidomics.

    abstract::A fast and efficient shotgun lipidomics strategy was applied to analyze phospholipids (PL) in the oyster Crassostrea plicatula, including 29 species of phosphatidylcholine (PtdCho), 23 species of phosphatidylethanolamine (PtdEtn), 11 species of phosphatidylserine (PtdSer), 6 species of phosphatidylinositol (PtdIns), a...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-017-4305-7

    authors: Chen Q,Wang X,Cong P,Liu Y,Wang Y,Xu J,Xue C

    更新日期:2017-12-01 00:00:00

  • Dietary saturated fat level alters the competition between alpha-linolenic and linoleic acid.

    abstract::Male weanling rats were fed semi-synthetic diets high in saturated fat (beef tallow) vs high in linoleic acid (safflower oil) with or without high levels of alpha-linolenic acid (linseed oil) for a period of 28 days. The effect of feeding these diets on cholesterol content and fatty acid composition of serum and liver...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02535173

    authors: Garg ML,Wierzbicki AA,Thomson AB,Clandinin MT

    更新日期:1989-04-01 00:00:00

  • A unique pool of free arachidonate serves as substrate for both cyclooxygenase and lipoxygenase in platelets.

    abstract::Stimulation of platelets induces a rapid release of arachidonate from specific phospholipids and subsequent remodeling of arachidonate-containing phospholipids. This process is accompanied by transformation of released arachidonate by cyclooxygenase and lipoxygenase enzymes. We addressed the question of whether the cy...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536506

    authors: Chevy F,Wolf C,Colard O

    更新日期:1991-12-01 00:00:00

  • Characterization of the diacylglycerol acyltransferase activity in the membrane fraction from a fungus.

    abstract::In an attempt to clarify the mechanism of lipid accumulation inMortierella ramanniana var.angulispora, diacylglycerol acyltransferase (DGAT) in the membrane fraction from this fungus was characterized. The enzyme had an optimum pH of 7.0-7.5, and enzyme activity was blocked by SH-reagents. Metal ions were not essentia...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536050

    authors: Kamisaka Y,Yokochi T,Nakahara T,Suzuki O

    更新日期:1993-07-01 00:00:00

  • Thermotropic behavior of stratum corneum lipids containing a pseudo-ceramide.

    abstract::The mechanism of the self-assembly of the lamellar structure of natural stratum corneum lipids (SCL) has been a subject of considerable interest. We have examined this question by using a synthetic pseudo-ceramide (sphingolipid E, SLE) which was analogous to the naturally occurring ceramide type 2. The thermotropic pr...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536040

    authors: Mizushima H,Fukasawa J,Suzuki T

    更新日期:1995-04-01 00:00:00

  • Polyunsaturated fatty acids in tissues of rats fed trielaidin and high or low levels of linolenic acid.

    abstract::Male and female weanling rats that were born to dams fed a diet low in linolenic acid received diets of 15% lipids by weight containing 45% elaidic acid (as trielaidin) and 8.5% or 0.1% linolenic acid for 10 weeks. Four other groups, in which palmitic or oleic acid replaced elaidic acid in the diet, served as controls...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/BF02536444

    authors: Astorg PO,Chevalier J

    更新日期:1987-12-01 00:00:00

  • Effect of conjugated linoleic acid on Cyprinus carpio var. Jian regarding growth, immunity, and disease resistance to Aeromonas hydrophila.

    abstract::The present study was performed to investigate the effect of dietary conjugated linoleic acid (CLA) on the growth performance, immune parameters and disease resistance to Aeromonas hydrophila of juvenile Jian carp. A total of 900 juvenile Jian carp (10.71 +/- 0.02 g) were randomly allocated into six groups of each thr...

    journal_title:Lipids

    pub_type: 杂志文章

    doi:10.1007/s11745-010-3425-0

    authors: Jiang J,Zhao MJ,Lin F,Yang L,Zhou XQ

    更新日期:2010-06-01 00:00:00