Synthesis of phosphatidylcholine and phosphatidylethanolamine at different ages in the rat brain in vitro.

Abstract:

:The de novo synthesis of choline and ethanolamine phosphoglycerides in brain microsomes from 18 month-old male rats was investigated in vitro by using labeled cytidine-5'-diphosphate choline and cytidine-5'-diphosphate ethanolamine as lipid precursors. The rate of synthesis of the two phospholipid classes was found to be noticeably decreased, as compared to that of adult animals. The addition of exogenous diacyl glycerols to microsomes from ageing rat brain brings the rate of synthesis nearly to the adult levels. The synthesis of choline and ethanolamine phosphoglycerides is not affected in the liver microsomes of ageing rats. The molar distribution of fatty acids in brain microsomal diacyl glycerols of ageing rats is noticeably different from that of adult animals. The content of monoenoic and dienoic species is increased, whereas that of the tetraenoic species is decreased. Base exchange reaction for choline and ethanolamine incorporation into respective phospholipids is not affected in the brain microsomes of the aged rats.

journal_name

Lipids

journal_title

Lipids

authors

Brunetti M,Gaiti A,Porcellati G

doi

10.1007/BF02533507

subject

Has Abstract

pub_date

1979-11-01 00:00:00

pages

925-31

issue

11

eissn

0024-4201

issn

1558-9307

journal_volume

14

pub_type

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