听力与言语-语言病理学

行为科学

医学伦理学

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  • Enhanced poly-γ-L-diaminobutanoic acid production in Bacillus pumilus by combining genome shuffling with multiple antibiotic-resistance.

    abstract::A breeding approach combining genome shuffling with multiple antibiotic-resistance including gentamicin, rifampin and lincomycin, was developed in this research to improve the poly-γ-L-diaminobutanoic acid (γ-PAB) production in Bacillus pumilus LS-1. By this unique strategy, recombinants from the third round of genome...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-020-02315-2

    authors: Li S,Wang L,Wang N

    更新日期:2020-12-01 00:00:00

  • Clean manufacturing powered by biology: how Amyris has deployed technology and aims to do it better.

    abstract::Amyris is a fermentation product company that leverages synthetic biology and has been bringing novel fermentation products to the market since 2009. Driven by breakthroughs in genome editing, strain construction and testing, analytics, automation, data science, and process development, Amyris has commercialized nine ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-020-02314-3

    authors: Hill P,Benjamin K,Bhattacharjee B,Garcia F,Leng J,Liu CL,Murarka A,Pitera D,Rodriguez Porcel EM,da Silva I,Kraft C

    更新日期:2020-11-01 00:00:00

  • Synthetic biology, combinatorial biosynthesis, and chemo‑enzymatic synthesis of isoprenoids.

    abstract::Isoprenoids are a large class of natural products with myriad applications as bioactive and commercial compounds. Their diverse structures are derived from the biosynthetic assembly and tailoring of their scaffolds, ultimately constructed from two C5 hemiterpene building blocks. The modular logic of these platforms ca...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1007/s10295-020-02306-3

    authors: Malico AA,Calzini MA,Gayen AK,Williams GJ

    更新日期:2020-10-01 00:00:00

  • Extracellular electron uptake by autotrophic microbes: physiological, ecological, and evolutionary implications.

    abstract::Microbes exchange electrons with their extracellular environment via direct or indirect means. This exchange is bidirectional and supports essential microbial oxidation-reduction processes, such as respiration and photosynthesis. The microbial capacity to use electrons from insoluble electron donors, such as redox-act...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1007/s10295-020-02309-0

    authors: Gupta D,Guzman MS,Bose A

    更新日期:2020-10-01 00:00:00

  • Identification of oleaginous yeasts that metabolize aromatic compounds.

    abstract::The valorization of lignin is critical for the economic viability of the bioeconomy. Microbial metabolism is advantageous for handling the myriad of aromatic compounds resulting from lignin chemical or enzymatic depolymerization. Coupling aromatic metabolism to fatty acid biosynthesis makes possible the production of ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-020-02269-5

    authors: Yaguchi A,Franaszek N,O'Neill K,Lee S,Sitepu I,Boundy-Mills K,Blenner M

    更新日期:2020-10-01 00:00:00

  • Investigation of secondary metabolism in the industrial butanol hyper-producer Clostridium saccharoperbutylacetonicum N1-4.

    abstract::Clostridium saccharoperbutylacetonicum N1-4 (Csa) is a historically significant anaerobic bacterium which can perform saccharolytic fermentations to produce acetone, butanol, and ethanol (ABE). Recent genomic analyses have highlighted this organism's potential to produce polyketide and nonribosomal peptide secondary m...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-020-02266-8

    authors: Li JS,Barber CC,Herman NA,Cai W,Zafrir E,Du Y,Zhu X,Skyrud W,Zhang W

    更新日期:2020-03-01 00:00:00

  • Construction of a "nutrition supply-detoxification" coculture consortium for medium-chain-length polyhydroxyalkanoate production with a glucose-xylose mixture.

    abstract::In this study, we constructed a coculture consortium comprising engineered Pseudomonas putida KT2440 and Escherichia coli MG1655. Provision of "related" carbon sources and synthesis of medium-chain-length polyhydroxyalkanoates (mcl-PHAs) were separately assigned to these strains via a modular construction strategy. To...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-020-02267-7

    authors: Liu Y,Yang S,Jia X

    更新日期:2020-03-01 00:00:00

  • Effect of dissolved oxygen on L-methionine production from glycerol by Escherichia coli W3110BL using metabolic flux analysis method.

    abstract::L-Methionine is an essential amino acid in humans, which plays an important role in the synthesis of some important amino acids and proteins. In this work, metabolic flux of batch fermentation of L-methionine with recombinant Escherichia coli W3110BL was analyzed using the flux balance analysis method, which estimated...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-020-02264-w

    authors: Niu K,Xu YY,Wu WJ,Zhou HY,Liu ZQ,Zheng YG

    更新日期:2020-03-01 00:00:00

  • Construction of advanced producers of first- and second-generation ethanol in Saccharomyces cerevisiae and selected species of non-conventional yeasts (Scheffersomyces stipitis, Ogataea polymorpha).

    abstract::This review summarizes progress in the construction of efficient yeast ethanol producers from glucose/sucrose and lignocellulose. Saccharomyces cerevisiae is the major industrial producer of first-generation ethanol. The different approaches to increase ethanol yield and productivity from glucose in S. cerevisiae are ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1007/s10295-019-02242-x

    authors: Ruchala J,Kurylenko OO,Dmytruk KV,Sibirny AA

    更新日期:2020-01-01 00:00:00

  • INDISIM-Denitrification, an individual-based model for study the denitrification process.

    abstract::Denitrification is one of the key processes of the global nitrogen (N) cycle driven by bacteria. It has been widely known for more than 100 years as a process by which the biogeochemical N-cycle is balanced. To study this process, we develop an individual-based model called INDISIM-Denitrification. The model embeds a ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-019-02245-8

    authors: Araujo-Granda P,Gras A,Ginovart M,Moulton V

    更新日期:2020-01-01 00:00:00

  • Deletion of PHO13 improves aerobic L-arabinose fermentation in engineered Saccharomyces cerevisiae.

    abstract::Pentose sugars are increasingly being used in industrial applications of Saccharomyces cerevisiae. Although L-arabinose is a highlighted pentose that has been identified as next-generation biomass, arabinose fermentation has not yet undergone extensive development for industrial utilization. In this study, we integrat...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-019-02233-y

    authors: Ye S,Jeong D,Shon JC,Liu KH,Kim KH,Shin M,Kim SR

    更新日期:2019-12-01 00:00:00

  • Integrating enzyme evolution and high-throughput screening for efficient biosynthesis of L-DOPA.

    abstract::L-DOPA is a key pharmaceutical agent for treating Parkinson's, and market demand has exploded due to the aging population. There are several challenges associated with the chemical synthesis of L-DOPA, including complicated operation, harsh conditions, and serious pollution. A biocatalysis route for L-DOPA production ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-019-02237-8

    authors: Zeng W,Xu B,Du G,Chen J,Zhou J

    更新日期:2019-12-01 00:00:00

  • Promoting microbial utilization of phenolic substrates from bio-oil.

    abstract::The economic viability of the biorefinery concept is limited by the valorization of lignin. One possible method of lignin valorization is biological upgrading with aromatic-catabolic microbes. In conjunction, lignin monomers can be produced by fast pyrolysis and fractionation. However, biological upgrading of these li...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-019-02208-z

    authors: Davis K,Rover MR,Salvachúa D,Smith RG,Beckham GT,Wen Z,Brown RC,Jarboe LR

    更新日期:2019-11-01 00:00:00

  • Towards sustainable bioplastic production using the photoautotrophic bacterium Rhodopseudomonas palustris TIE-1.

    abstract::Bacterial synthesis of polyhydroxybutyrates (PHBs) is a potential approach for producing biodegradable plastics. This study assessed the ability of Rhodopseudomonas palustris TIE-1 to produce PHBs under various conditions. We focused on photoautotrophy using a poised electrode (photoelectroautotrophy) or ferrous iron ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-019-02165-7

    authors: Ranaivoarisoa TO,Singh R,Rengasamy K,Guzman MS,Bose A

    更新日期:2019-10-01 00:00:00

  • Barriers to genome editing with CRISPR in bacteria.

    abstract::Genome editing is essential for probing genotype-phenotype relationships and for enhancing chemical production and phenotypic robustness in industrial bacteria. Currently, the most popular tools for genome editing couple recombineering with DNA cleavage by the CRISPR nuclease Cas9 from Streptococcus pyogenes. Although...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1007/s10295-019-02195-1

    authors: Vento JM,Crook N,Beisel CL

    更新日期:2019-10-01 00:00:00

  • Advances in microbial culturing conditions to activate silent biosynthetic gene clusters for novel metabolite production.

    abstract::Natural products (NPs) produced by bacteria and fungi are often used as therapeutic agents due to their complex structures and wide range of bioactivities. Enzymes that build NPs are encoded by co-localized biosynthetic gene clusters (BGCs), and genome sequencing has recently revealed that many BGCs are "silent" under...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1007/s10295-019-02198-y

    authors: Tomm HA,Ucciferri L,Ross AC

    更新日期:2019-10-01 00:00:00

  • Improved production of clavulanic acid by reverse engineering and overexpression of the regulatory genes in an industrial Streptomyces clavuligerus strain.

    abstract::Genomic analysis of the clavulanic acid (CA)-high-producing Streptomyces clavuligerus strains, OL13 and OR, developed through random mutagenesis revealed a frameshift mutation in the cas1 gene-encoding clavaminate synthase 1. Overexpression of the intact cas1 in S. clavuligerus OR enhanced the CA titer by approximatel...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-019-02196-0

    authors: Cho HS,Jo JC,Shin CH,Lee N,Choi JS,Cho BK,Roe JH,Kim CW,Kwon HJ,Yoon YJ

    更新日期:2019-08-01 00:00:00

  • Lipidomics characterization of the alterations of Trichoderma brevicompactum membrane glycerophospholipids during the fermentation phase.

    abstract::The biological membrane lipid composition has been demonstrated to greatly influence the secretion of secondary metabolites. This study was conducted to investigate the periodical alterations of whole cellular lipids and their associations with secondary products in Trichoderma brevicompactum. An electrospray ionizati...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-019-02152-y

    authors: Bai Y,Gao Y,Lu X,Wang H

    更新日期:2019-06-01 00:00:00

  • Characterization and comparative analysis of toxin-antitoxin systems in Acetobacter pasteurianus.

    abstract::Bacterial toxin-antitoxin (TA) systems play important roles in diverse cellular regulatory processes. Here, we characterize three putative type II TA candidates from Acetobacter pasteurianus and investigate the profile of type II TA systems in the genus Acetobacter. Based on the gene structure and activity detection, ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-019-02144-y

    authors: Xia K,Bao H,Zhang F,Linhardt RJ,Liang X

    更新日期:2019-06-01 00:00:00

  • Sequential improvement of rimocidin production in Streptomyces rimosus M527 by introduction of cumulative drug-resistance mutations.

    abstract::Rimocidin is a polyene macrolide that exhibits a strong inhibitory activity against a broad range of plant-pathogenic fungi. In this study, fermentation optimization and ribosome engineering technology were employed to enhance rimocidin production in Streptomyces rimosus M527. After the optimization of fermentation, r...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-019-02146-w

    authors: Zhao Y,Song Z,Ma Z,Bechthold A,Yu X

    更新日期:2019-05-01 00:00:00

  • Natural products from anaerobes.

    abstract::Natural product discovery in the microbial world has historically been biased toward aerobes. Recent in silico analysis demonstrates that genomes of anaerobes encode unexpected biosynthetic potential for natural products, however, chemical data on natural products from the anaerobic world are extremely limited. Here, ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1007/s10295-018-2086-5

    authors: Li JS,Barber CC,Zhang W

    更新日期:2019-03-01 00:00:00

  • Fabclavine biosynthesis in X. szentirmaii: shortened derivatives and characterization of the thioester reductase FclG and the condensation domain-like protein FclL.

    abstract::Fabclavines, unusual peptide-polyketide-polyamine hybrids, show broad-spectrum bioactivity against a variety of different organism like Gram-positive and -negative bacteria, fungi and protozoa. We elucidated the biosynthesis of these NRPS-PKS hybrids in Xenorhabdus szentirmaii by deletion of most genes encoded in the ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-018-02124-8

    authors: Wenski SL,Kolbert D,Grammbitter GLC,Bode HB

    更新日期:2019-03-01 00:00:00

  • Improved cell growth and biosynthesis of glycolic acid by overexpression of membrane-bound pyridine nucleotide transhydrogenase.

    abstract::The non-conventional D-xylose metabolism called the Dahms pathway which only requires the expression of at least three enzymes to produce pyruvate and glycolaldehyde has been previously engineered in Escherichia coli. Strains that rely on this pathway exhibit lower growth rates which were initially attributed to the p...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-018-2117-2

    authors: Cabulong RB,Valdehuesa KNG,Bañares AB,Ramos KRM,Nisola GM,Lee WK,Chung WJ

    更新日期:2019-02-01 00:00:00

  • Metabolic engineering of Corynebacterium glutamicum for improved L-arginine synthesis by enhancing NADPH supply.

    abstract::Corynebacterium glutamicum SNK 118 was metabolically engineered with improved L-arginine titer. Considering the crucial role of NADPH level in L-arginine production, pntAB (membrane-bound transhydrogenase) and ppnK (NAD+ kinase) were co-expressed to increase the intracellular NADPH pool. Expression of pntAB exhibited ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-018-2103-8

    authors: Zhan M,Kan B,Dong J,Xu G,Han R,Ni Y

    更新日期:2019-01-01 00:00:00

  • Heterologous production of a new lasso peptide brevunsin in Sphingomonas subterranea.

    abstract::A shuttle vector pHSG396Sp was constructed to perform gene expression using Sphingomonas subterranea as a host. A new lasso peptide biosynthetic gene cluster, derived from Brevundimonas diminuta, was amplified by PCR and integrated to afford a expression vector pHSG396Sp-12697L. The new lasso peptide brevunsin was suc...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-018-2077-6

    authors: Kodani S,Hemmi H,Miyake Y,Kaweewan I,Nakagawa H

    更新日期:2018-11-01 00:00:00

  • Engineering Yarrowia lipolytica for the production of cyclopropanated fatty acids.

    abstract::Traditional synthesis of biodiesel competes with food sources and has limitations with storage, particularly due to limited oxidative stability. Microbial synthesis of lipids provides a platform to produce renewable fuel with improved properties from various renewable carbon sources. Specifically, biodiesel properties...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-018-2067-8

    authors: Markham KA,Alper HS

    更新日期:2018-10-01 00:00:00

  • Dynamic metabolic control: towards precision engineering of metabolism.

    abstract::Advances in metabolic engineering have led to the synthesis of a wide variety of valuable chemicals in microorganisms. The key to commercializing these processes is the improvement of titer, productivity, yield, and robustness. Traditional approaches to enhancing production use the "push-pull-block" strategy that modu...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-018-2013-9

    authors: Liu D,Mannan AA,Han Y,Oyarzún DA,Zhang F

    更新日期:2018-07-01 00:00:00

  • Corrections to: Enhanced lincomycin production by co‑overexpression of metK1 and metK2 in Streptomyces lincolnensis.

    abstract::In the online published article, row value "pIB139-metK1-metK2" in table 1 has been processed incorrectly. The correct table is given below. ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s10295-018-2036-2

    authors: Xu Y,Tan G,Ke M,Li J,Tang Y,Meng S,Niu J,Wang Y,Liu R,Wu H,Bai L,Zhang L,Zhang B

    更新日期:2018-06-01 00:00:00

  • An economically and environmentally acceptable synthesis of chiral drug intermediate L-pipecolic acid from biomass-derived lysine via artificially engineered microbes.

    abstract::Deficiency in petroleum resources and increasing environmental concerns have pushed a bio-based economy to be built, employing a highly reproducible, metal contaminant free, sustainable and green biomanufacturing method. Here, a chiral drug intermediate L-pipecolic acid has been synthesized from biomass-derived lysine...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-018-2044-2

    authors: Cheng J,Huang Y,Mi L,Chen W,Wang D,Wang Q

    更新日期:2018-06-01 00:00:00

  • Rapid and stable production of 2,3-butanediol by an engineered Saccharomyces cerevisiae strain in a continuous airlift bioreactor.

    abstract::Utilization of renewable feedstocks for the production of bio-based bulk chemicals, such as 2,3-butanediol (2,3-BDO), by engineered strains of the non-pathogenic yeast, Saccharomyces cerevisiae, has recently become an attractive option. In this study, to realize rapid production of 2,3-BDO, a flocculent, 2,3-BDO-produ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-018-2033-5

    authors: Yamada R,Nishikawa R,Wakita K,Ogino H

    更新日期:2018-05-01 00:00:00

  • Discovery of a new diol-containing polyketide by heterologous expression of a silent biosynthetic gene cluster from Streptomyces lavendulae FRI-5.

    abstract::The genome of streptomycetes has the ability to produce many novel and potentially useful bioactive compounds, but most of which are not produced under standard laboratory cultivation conditions and are referred to as silent/cryptic secondary metabolites. Streptomyces lavendulae FRI-5 produces several types of bioacti...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-017-1997-x

    authors: Pait IGU,Kitani S,Roslan FW,Ulanova D,Arai M,Ikeda H,Nihira T

    更新日期:2018-02-01 00:00:00

  • Manganese and cobalt recovery by surface display of metal binding peptide on various loops of OmpC in Escherichia coli.

    abstract::In a cell-surface display (CSD) system, successful display of a protein or peptide is highly dependent on the anchoring motif and the position of the display in that anchoring motif. In this study, a recombinant bacterial CSD system for manganese (Mn) and cobalt (Co) recovery was developed by employing OmpC as an anch...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-017-1989-x

    authors: Maruthamuthu MK,Selvamani V,Nadarajan SP,Yun H,Oh YK,Eom GT,Hong SH

    更新日期:2018-01-01 00:00:00

  • Microaerophilic alkane degradation in Pseudomonas extremaustralis: a transcriptomic and physiological approach.

    abstract::Diesel fuel is one of the most important sources of hydrocarbon contamination worldwide. Its composition consists of a complex mixture of n-alkanes, branched alkanes and aromatic compounds. Hydrocarbon degradation in Pseudomonas species has been mostly studied under aerobic conditions; however, a dynamic spectrum of o...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-017-1987-z

    authors: Tribelli PM,Rossi L,Ricardi MM,Gomez-Lozano M,Molin S,Raiger Iustman LJ,Lopez NI

    更新日期:2018-01-01 00:00:00

  • Model-based biotechnological potential analysis of Kluyveromyces marxianus central metabolism.

    abstract::The non-conventional yeast Kluyveromyces marxianus is an emerging industrial producer for many biotechnological processes. Here, we show the application of a biomass-linked stoichiometric model of central metabolism that is experimentally validated, and mass and charge balanced for assessing the carbon conversion effi...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-017-1946-8

    authors: Pentjuss A,Stalidzans E,Liepins J,Kokina A,Martynova J,Zikmanis P,Mozga I,Scherbaka R,Hartman H,Poolman MG,Fell DA,Vigants A

    更新日期:2017-08-01 00:00:00

  • Insights from the complete genome sequence of Clostridium tyrobutyricum provide a platform for biotechnological and industrial applications.

    abstract::Genetic research enables the evolution of novel biochemical reactions for the production of valuable chemicals from environmentally-friendly raw materials. However, the choice of appropriate microorganisms to support these reactions, which must have strong robustness and be capable of a significant product output, is ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-017-1956-6

    authors: Wu Q,Liu T,Zhu L,Huang H,Jiang L

    更新日期:2017-08-01 00:00:00

  • Rapidly directional biotransformation of tauroursodeoxycholic acid through engineered Escherichia coli.

    abstract::Bear bile powder is a precious medicinal material. It is characterized by high content of tauroursodeoxycholic acid (TUDCA) at a ratio of 1.0-1.5 to taurochenodeoxycholic acid (TCDCA). Here, we reported the biotransformation of tauroursodeoxycholic acid (TUDCA) through Escherichia coli engineered with a two-step mimic...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-017-1935-y

    authors: Shi J,Wang J,Yu L,Yang L,Zhao S,Wang Z

    更新日期:2017-07-01 00:00:00

  • Effects of acetoacetyl-CoA synthase expression on production of farnesene in Saccharomyces cerevisiae.

    abstract::Efficient production of sesquiterpenes in Saccharomyces cerevisiae requires a high flux through the mevalonate pathway. To achieve this, the supply of acetyl-CoA plays a crucial role, partially because nine moles of acetyl-CoA are necessary to produce one mole of farnesyl diphosphate, but also to overcome the thermody...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-017-1911-6

    authors: Tippmann S,Ferreira R,Siewers V,Nielsen J,Chen Y

    更新日期:2017-06-01 00:00:00

  • An overview of rapamycin: from discovery to future perspectives.

    abstract::Rapamycin is an immunosuppressive metabolite produced from several actinomycete species. Besides its immunosuppressive activity, rapamycin and its analogs have additional therapeutic potentials, including antifungal, antitumor, neuroprotective/neuroregenerative, and lifespan extension activities. The core structure of...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1007/s10295-016-1834-7

    authors: Yoo YJ,Kim H,Park SR,Yoon YJ

    更新日期:2017-05-01 00:00:00

  • Madurastatin B3, a rare aziridine derivative from actinomycete Nocardiopsis sp. LS150010 with potent anti-tuberculosis activity.

    abstract::Since the discovery of the first antibiotic, natural products have played an important role in chemistry, biology and medicine. To explore the potential of bioactive compounds from microbes isolated from the southeast of Tibet, China, a crude extract library was constructed and screened against Staphylococcus aureus. ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-017-1908-1

    authors: Zhang X,He H,Ma R,Ji Z,Wei Q,Dai H,Zhang L,Song F

    更新日期:2017-05-01 00:00:00

  • A comparative study of glycerol and sorbitol as co-substrates in methanol-induced cultures of Pichia pastoris: temperature effect and scale-up simulation.

    abstract::The production of recombinant proteins by Pichia pastoris under AOX1 promoter is usually performed using methanol together with either glycerol or sorbitol as co-substrate. Although both co-substrates have been widely used, comparative studies are scarce. In addition, these comparisons have been performed at different...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-016-1895-7

    authors: Berrios J,Flores MO,Díaz-Barrera A,Altamirano C,Martínez I,Cabrera Z

    更新日期:2017-03-01 00:00:00

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