当前位置： SCI文献检索 > JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY期刊下所有文献 > An economically and environmentally acceptable synthesis of chiral drug intermediate L-pipecolic acid from biomass-derived lysine via artificially engineered microbes.

An economically and environmentally acceptable synthesis of chiral drug intermediate L-pipecolic acid from biomass-derived lysine via artificially engineered microbes.

Abstract：

:Deficiency in petroleum resources and increasing environmental concerns have pushed a bio-based economy to be built, employing a highly reproducible, metal contaminant free, sustainable and green biomanufacturing method. Here, a chiral drug intermediate L-pipecolic acid has been synthesized from biomass-derived lysine. This artificial bioconversion system involves the coexpression of four functional genes, which encode L-lysine α-oxidase from Scomber japonicus, glucose dehydrogenase from Bacillus subtilis, Δ1-piperideine-2-carboxylase reductase from Pseudomonas putida, and lysine permease from Escherichia coli. Besides, a lysine degradation enzyme has been knocked out to strengthen the process in this microbe. The overexpression of LysP improved the L-pipecolic acid titer about 1.6-folds compared to the control. This engineered microbial factory showed the highest L-pipecolic acid production of 46.7 g/L reported to date and a higher productivity of 2.41 g/L h and a yield of 0.89 g/g. This biotechnological L-pipecolic acid production is a simple, economic, and green technology to replace the presently used chemical synthesis.

journal_name

J Ind Microbiol Biotechnol

journal_title

Journal of industrial microbiology & biotechnology

authors

Cheng J,Huang Y,Mi L,Chen W,Wang D,Wang Q

doi

10.1007/s10295-018-2044-2

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

405-415

issue

6

eissn

1367-5435

issn

1476-5535

pii

10.1007/s10295-018-2044-2

journal_volume

45

pub_type

杂志文章

相关文献

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY文献大全
  • Bifunctional xylanases and their potential use in biotechnology.

    abstract：:Plant cell walls are comprised of cellulose, hemicellulose and other polymers that are intertwined. This complex structure acts as a barrier to degradation by single enzyme. Thus, a cocktail consisting of bi and multifunctional xylanases and xylan debranching enzymes is most desired combination for the efficient utili...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章,评审

    doi：10.1007/s10295-008-0342-9

    authors： Khandeparker R,Numan MT

    更新日期：2008-07-01 00:00:00

  • The carboxylic acid reduction pathway in Nocardia. Purification and characterization of the aldehyde reductase.

    abstract：:Whole cultures of Nocardia sp. NRRL 5646 reduce carboxylic acids, first to aldehydes, then to alcohols and subsequently to the corresponding acetyl esters. This work describes an NADPH-dependent reductase responsible for catalyzing the reduction of aldehyde intermediates, which was purified 3240-fold by a combination ...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1038/sj.jim.7000096

    authors： Li T,Rosazza JP

    更新日期：2000-12-01 00:00:00

  • Assessment of physiological state of microorganisms in activated sludge with flow cytometry: application for monitoring sludge production minimization.

    abstract：:Many sludge reduction processes have been studied for the minimization of sludge production in biological wastewater treatment. The investigations on most of these processes have monitored the increase of the soluble chemical oxygen demand, the sludge mass reduction, or the decrease of the floc size, but little inform...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-008-0423-9

    authors： Prorot A,Eskicioglu C,Droste R,Dagot C,Leprat P

    更新日期：2008-11-01 00:00:00

  • Microbial diversity: the importance of exploration and conservation.

    abstract：:Microbial diversity is fundamental to maintenance and conservation of global genetic resources. As extreme environments are explored, the richness of microbial diversity is increasingly evident. Measures must be taken to estimate, record, and conserve microbial diversity, not only to sustain human health but also to e...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章,评审

    doi：10.1038/sj.jim.2900390

    authors： Colwell RR

    更新日期：1997-05-01 00:00:00

  • Assessing the potential of wild yeasts for bioethanol production.

    abstract：:Bioethanol fermentations expose yeasts to a new, complex and challenging fermentation medium with specific inhibitors and sugar mixtures depending on the type of carbon source. It is, therefore, suggested that the natural diversity of yeasts should be further exploited in order to find yeasts with good ethanol yield i...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-014-1544-y

    authors： Ruyters S,Mukherjee V,Verstrepen KJ,Thevelein JM,Willems KA,Lievens B

    更新日期：2015-01-01 00:00:00

  • Comparative studies on extracellular protease secretion and glucoamylase production by free and immobilized Aspergillus niger cultures.

    abstract：:The effects of cell immobilization on the secretion of extracellular proteases and glucoamylase production by Aspergillus niger were investigated under a variety of immobilization techniques and culture conditions. Immobilization was achieved by means of cell attachment on metal surfaces or spore entrapment and subseq...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1038/sj.jim.7000289

    authors： Papagianni M,Joshi N,Moo-Young M

    更新日期：2002-11-01 00:00:00

  • Ammonia oxidizing bacteria and archaea in horizontal flow biofilm reactors treating ammonia-contaminated air at 10 °C.

    abstract：:The objective of this study was to demonstrate the feasibility of novel, Horizontal Flow Biofilm Reactor (HFBR) technology for the treatment of ammonia (NH3)-contaminated airstreams. Three laboratory-scale HFBRs were used for remediation of an NH3-containing airstream at 10 °C during a 90-d trial to test the efficacy ...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-016-1740-z

    authors： Gerrity S,Clifford E,Kennelly C,Collins G

    更新日期：2016-05-01 00:00:00

  • Barriers to genome editing with CRISPR in bacteria.

    abstract：:Genome editing is essential for probing genotype-phenotype relationships and for enhancing chemical production and phenotypic robustness in industrial bacteria. Currently, the most popular tools for genome editing couple recombineering with DNA cleavage by the CRISPR nuclease Cas9 from Streptococcus pyogenes. Although...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章,评审

    doi：10.1007/s10295-019-02195-1

    authors： Vento JM,Crook N,Beisel CL

    更新日期：2019-10-01 00:00:00

  • Colanic acid is an exopolysaccharide common to many enterobacteria isolated from paper-machine slimes.

    abstract：:In this study, polysaccharide-producing bacteria were isolated from slimes collected from two Finnish and one Spanish paper mill and the exopolysaccharides (EPSs) produced by 18 isolates were characterised. Most of the isolates, selected on the bases of slimy colony morphology, were members of the family Enterobacteri...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-005-0064-1

    authors： Rättö M,Verhoef R,Suihko ML,Blanco A,Schols HA,Voragen AG,Wilting R,Siika-Aho M,Buchert J

    更新日期：2006-05-01 00:00:00

  • Bacterial assay for the rapid assessment of antifouling and fouling release properties of coatings and materials.

    abstract：:An assay has been developed to accurately quantify the growth and release behaviour of bacterial biofilms on several test reference materials and coatings, using the marine bacterium Cobetia marina as a model organism. The assay can be used to investigate the inhibition of bacterial growth and release properties of ma...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-009-0681-1

    authors： D'Souza F,Bruin A,Biersteker R,Donnelly G,Klijnstra J,Rentrop C,Willemsen P

    更新日期：2010-04-01 00:00:00

  • A strategy to prevent the occurrence of Lactobacillus strains using lactate-tolerant yeast Candida glabrata in bioethanol production.

    abstract：:Contamination of Lactobacillus sp. in the fermentation broth of bioethanol production decreases ethanol production efficiency. Although the addition of lactate to the broth can effectively inhibit the growth of Lactobacillus sp., it also greatly reduces the fermentation ability of Saccharomyces cerevisiae. To overcome...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-008-0390-1

    authors： Watanabe I,Nakamura T,Shima J

    更新日期：2008-10-01 00:00:00

  • Moderate expression of the transcriptional regulator ALsR enhances acetoin production by Bacillus subtilis.

    abstract：:Acetoin, a major extracellular catabolic product of Bacillus subtilis cultured on glucose, is widely used to add flavor to food and also serves as a precursor for chemical synthesis. The biosynthesis of acetoin from pyruvate requires the enzymes α-acetolactate synthase (ALS) and α-acetolactate decarboxylase (ALDC), bo...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-013-1303-5

    authors： Zhang X,Zhang R,Bao T,Yang T,Xu M,Li H,Xu Z,Rao Z

    更新日期：2013-09-01 00:00:00

  • A comparison of stress tolerance in YPD and industrial lignocellulose-based medium among industrial and laboratory yeast strains.

    abstract：:In general, it is believed that fermentation by yeast under harsh industrial conditions, especially if substrates such as wood hydrolysate or lignocellulosic substrates are used, requires the use of so-called industrial strains. In order to check whether this is always true, a comparison of performance was made using ...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-009-0592-1

    authors： Albers E,Larsson C

    更新日期：2009-08-01 00:00:00

  • 13C nuclear magnetic resonance studies on selectively labeled bacterial biofilms.

    abstract：:Bacterial biofilms of Pseudomonas aeruginosa selectively labeled by introduction of 2-13C-glycerol was studied by solid-state and high-resolution nuclear magnetic resonance. The 13C nuclei were mainly integrated into mannuronate and guluronate, the two monomer units forming the bacterial alginate. The signal for the C...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：

    authors： Mayer C,Lattner D,Schürks N

    更新日期：2001-01-01 00:00:00

  • Effect of dissolved oxygen on L-methionine production from glycerol by Escherichia coli W3110BL using metabolic flux analysis method.

    abstract：:L-Methionine is an essential amino acid in humans, which plays an important role in the synthesis of some important amino acids and proteins. In this work, metabolic flux of batch fermentation of L-methionine with recombinant Escherichia coli W3110BL was analyzed using the flux balance analysis method, which estimated...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-020-02264-w

    authors： Niu K,Xu YY,Wu WJ,Zhou HY,Liu ZQ,Zheng YG

    更新日期：2020-03-01 00:00:00

  • Increased ethanol production by deletion of HAP4 in recombinant xylose-assimilating Saccharomyces cerevisiae.

    abstract：:The Saccharomyces cerevisiae HAP4 gene encodes a transcription activator that plays a key role in controlling the expression of genes involved in mitochondrial respiration and reductive pathways. This work examines the effect of knockout of the HAP4 gene on aerobic ethanol production in a xylose-utilizing S. cerevisia...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-015-1695-5

    authors： Matsushika A,Hoshino T

    更新日期：2015-12-01 00:00:00

  • Detection of bacterial contamination in starch and resin-based papermaking chemicals using fluorescence techniques.

    abstract：:Rapid fluorescence techniques were evaluated for the detection of bacterial contaminants in papermaking chemicals including starch and the resin-based sizes and starch slurries used in the paper industry. Viable and non-viable bacterial cells were visualised by fluorescent probes and detected by epifluorescence micros...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-003-0046-0

    authors： Nohynek L,Saski E,Haikara A,Raaska L

    更新日期：2003-04-01 00:00:00

  • Construction of a "nutrition supply-detoxification" coculture consortium for medium-chain-length polyhydroxyalkanoate production with a glucose-xylose mixture.

    abstract：:In this study, we constructed a coculture consortium comprising engineered Pseudomonas putida KT2440 and Escherichia coli MG1655. Provision of "related" carbon sources and synthesis of medium-chain-length polyhydroxyalkanoates (mcl-PHAs) were separately assigned to these strains via a modular construction strategy. To...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-020-02267-7

    authors： Liu Y,Yang S,Jia X

    更新日期：2020-03-01 00:00:00

  • Engineering Yarrowia lipolytica for the production of cyclopropanated fatty acids.

    abstract：:Traditional synthesis of biodiesel competes with food sources and has limitations with storage, particularly due to limited oxidative stability. Microbial synthesis of lipids provides a platform to produce renewable fuel with improved properties from various renewable carbon sources. Specifically, biodiesel properties...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-018-2067-8

    authors： Markham KA,Alper HS

    更新日期：2018-10-01 00:00:00

  • The radiation resistance of ascospores and sclerotia of Pyronema domesticum.

    abstract：:The Food and Drug Administration has become aware of several instances where supposedly sterile medical surgical products made of Chinese cotton have been found to contain viable Pyronema domesticum. The aim of this research was to determine the gamma and electron beam radiation resistance values for the two dormant p...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1038/sj.jim.7000267

    authors： Richter SG,Barnard J

    更新日期：2002-08-01 00:00:00

  • Production of a thermophilic maltooligosyl-trehalose synthase in Lactococcus lactis.

    abstract：:The thermoacidophilic archaeon Sulfolobus solfataricus MT4 encodes a maltooligosyltrehalose synthase (MTS), that catalyzes an intramolecular transglycosylation process converting the glycosidic linkages at the reducing end of dextrins from alpha-1,4 into alpha-1,1. In this research the gene encoding MTS was cloned and...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-008-0384-z

    authors： Cimini D,De Rosa M,Panariello A,Morelli V,Schiraldi C

    更新日期：2008-10-01 00:00:00

  • Scalable economic extracellular synthesis of CdS nanostructured particles by a non-pathogenic thermophile.

    abstract：:We report microbially facilitated synthesis of cadmium sulfide (CdS) nanostructured particles (NP) using anaerobic, metal-reducing Thermoanaerobacter sp. The extracellular CdS crystallites were <10 nm in size with yields of ~3 g/L of growth medium/month with demonstrated reproducibility and scalability up to 24 L. Dur...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-013-1321-3

    authors： Moon JW,Ivanov IN,Duty CE,Love LJ,Rondinone AJ,Wang W,Li YL,Madden AS,Mosher JJ,Hu MZ,Suresh AK,Rawn CJ,Jung H,Lauf RJ,Phelps TJ

    更新日期：2013-11-01 00:00:00

  • Engineering of isoamylase: improvement of protein stability and catalytic efficiency through semi-rational design.

    abstract：:Isoamylase catalyzes the hydrolysis of α-1,6-glycosidic linkages in glycogen, amylopectin and α/β-limit dextrins. A semi-rational design strategy was performed to improve catalytic properties of isoamylase from Bacillus lentus. Three residues in vicinity of the essential residues, Arg505, Asn513, and Gly608, were chos...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-015-1708-4

    authors： Li Y,Zhang L,Ding Z,Gu Z,Shi G

    更新日期：2016-01-01 00:00:00

  • Automated quantification of budding Saccharomyces cerevisiae using a novel image cytometry method.

    abstract：:The measurements of concentration, viability, and budding percentages of Saccharomyces cerevisiae are performed on a routine basis in the brewing and biofuel industries. Generation of these parameters is of great importance in a manufacturing setting, where they can aid in the estimation of product quality, quantity, ...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-013-1263-9

    authors： Laverty DJ,Kury AL,Kuksin D,Pirani A,Flanagan K,Chan LL

    更新日期：2013-06-01 00:00:00

  • Selection of an autochthonous Saccharomyces strain starter for alcoholic fermentation of Sherry base wines.

    abstract：:Several indigenous Saccharomyces strains from musts were isolated in the Jerez de la Frontera region, at the end of spontaneous fermentation, in order to select the most suitable autochthonous yeast starter, during the 2007 vintage. Five strains were chosen for their oenological abilities and fermentative kinetics to ...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-013-1251-0

    authors： Rodríguez-Palero MJ,Fierro-Risco J,Codón AC,Benítez T,Valcárcel MJ

    更新日期：2013-06-01 00:00:00

  • Spatial expression of a mercury-inducible green fluorescent protein within a nanoporous latex-based biosensor coating.

    abstract：:Optimizing the reactivity of cell coatings developed as biosensors or biocatalysts requires measurements of gene expression in the immobilized cells. To quantify and localize gene expression within a latex-based mercury biosensor, a plasmid, pmerGFP, was constructed, which contains the green fluorescent protein (GFP) ...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-007-0288-3

    authors： Schottel JL,Orwin PM,Anderson CR,Flickinger MC

    更新日期：2008-04-01 00:00:00

  • Engineering of Rhodococcus cell catalysts for tolerance improvement by sigma factor mutation and active plasmid partition.

    abstract：:Tolerance to various stresses is a key phenotype for cell catalysts, which are used widely in bioproduction of diverse valuable chemicals. Using the Rhodococcus ruber TH strain, which exhibits high nitrile hydratase activity, as the target cell catalyst for acrylamide production, we established a method to improve cel...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-012-1146-5

    authors： Ma Y,Yu H

    更新日期：2012-10-01 00:00:00

  • A genetic overhaul of Saccharomyces cerevisiae 424A(LNH-ST) to improve xylose fermentation.

    abstract：:Robust microorganisms are necessary for economical bioethanol production. However, such organisms must be able to effectively ferment both hexose and pentose sugars present in lignocellulosic hydrolysate to ethanol. Wild type Saccharomyces cerevisiae can rapidly ferment hexose, but cannot ferment pentose sugars. Consi...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-010-0806-6

    authors： Bera AK,Ho NW,Khan A,Sedlak M

    更新日期：2011-05-01 00:00:00

  • Integrating enzyme evolution and high-throughput screening for efficient biosynthesis of L-DOPA.

    abstract：:L-DOPA is a key pharmaceutical agent for treating Parkinson's, and market demand has exploded due to the aging population. There are several challenges associated with the chemical synthesis of L-DOPA, including complicated operation, harsh conditions, and serious pollution. A biocatalysis route for L-DOPA production ...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1007/s10295-019-02237-8

    authors： Zeng W,Xu B,Du G,Chen J,Zhou J

    更新日期：2019-12-01 00:00:00

  • The mycinose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.

    abstract：:The tylE-J region of the tylosin-biosynthetic gene cluster of Streptomyces fradiae contains six open reading frames. The products of tylJ and tylD are nucleoside diphospho (NDP)-deoxyhexose 3-epimerase and NDP-deoxyhexose 4-ketoreductase, respectively, involved in the synthesis of NDP-6-deoxyallose from NDP-4-keto, 6-...

    journal_title：Journal of industrial microbiology & biotechnology

    pub_type： 杂志文章

    doi：10.1038/sj.jim.2900707

    authors： Bate N,Cundliffe E

    更新日期：1999-08-01 00:00:00