Abstract：
:Amyris is a fermentation product company that leverages synthetic biology and has been bringing novel fermentation products to the market since 2009. Driven by breakthroughs in genome editing, strain construction and testing, analytics, automation, data science, and process development, Amyris has commercialized nine separate fermentation products over the last decade. This has been accomplished by partnering with the teams at 17 different manufacturing sites around the world. This paper begins with the technology that drives Amyris, describes some key lessons learned from early scale-up experiences, and summarizes the technology transfer procedures and systems that have been built to enable moving more products to market faster. Finally, the breadth of the Amyris product portfolio continues to expand; thus the steps being taken to overcome current challenges (e.g. automated strain engineering can now outpace the rest of the product commercialization timeline) are described.
journal_name
J Ind Microbiol Biotechnoljournal_title
Journal of industrial microbiology & biotechnologyauthors
Hill P,Benjamin K,Bhattacharjee B,Garcia F,Leng J,Liu CL,Murarka A,Pitera D,Rodriguez Porcel EM,da Silva I,Kraft Cdoi
10.1007/s10295-020-02314-3subject
Has Abstractpub_date
2020-11-01 00:00:00pages
965-975issue
11eissn
1367-5435issn
1476-5535pii
10.1007/s10295-020-02314-3journal_volume
47pub_type
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