Abstract:
:Natural products are a crucial source of antimicrobial agents, but reliance on low-resolution bioactivity-guided approaches has led to diminishing interest in discovery programmes. Here, we demonstrate that two in-house automated informatic platforms can be used to target classes of biologically active natural products, specifically, peptaibols. We demonstrate that mass spectrometry-based informatic approaches can be used to detect natural products with high sensitivity, identifying desired agents present in complex microbial extracts. Using our specialised software packages, we could elaborate specific branches of chemical space, uncovering new variants of trichopolyn and demonstrating a way forward in mining natural products as a valuable source of potential pharmaceutical agents.
journal_name
J Ind Microbiol Biotechnoljournal_title
Journal of industrial microbiology & biotechnologyauthors
Johnston CW,Connaty AD,Skinnider MA,Li Y,Grunwald A,Wyatt MA,Kerr RG,Magarvey NAdoi
10.1007/s10295-015-1675-9subject
Has Abstractpub_date
2016-03-01 00:00:00pages
293-8issue
2-3eissn
1367-5435issn
1476-5535pii
10.1007/s10295-015-1675-9journal_volume
43pub_type
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