An overview of rapamycin: from discovery to future perspectives.

Abstract:

:Rapamycin is an immunosuppressive metabolite produced from several actinomycete species. Besides its immunosuppressive activity, rapamycin and its analogs have additional therapeutic potentials, including antifungal, antitumor, neuroprotective/neuroregenerative, and lifespan extension activities. The core structure of rapamycin is derived from (4R,5R)-4,5-dihydrocyclohex-1-ene-carboxylic acid that is extended by polyketide synthase. The resulting linear polyketide chain is cyclized by incorporating pipecolate and further decorated by post-PKS modification enzymes. Herein, we review the discovery and biological activities of rapamycin as well as its mechanism of action, mechanistic target, biosynthesis, and regulation. In addition, we introduce the many efforts directed at enhancing the production of rapamycin and generating diverse analogs and also explore future perspectives in rapamycin research. This review will also emphasize the remarkable pilot studies on the biosynthesis and production improvement of rapamycin by Dr. Demain, one of the world's distinguished scientists in industrial microbiology and biotechnology.

authors

Yoo YJ,Kim H,Park SR,Yoon YJ

doi

10.1007/s10295-016-1834-7

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

537-553

issue

4-5

eissn

1367-5435

issn

1476-5535

pii

10.1007/s10295-016-1834-7

journal_volume

44

pub_type

杂志文章,评审
  • The performance of fungal xylan-degrading enzyme preparations in elemental chlorine-free bleaching for Eucalyptus pulp.

    abstract::Cellulase-free xylan-degrading enzyme preparations from Acrophialophora nainiana, Humicola grisea var. thermoidea and two Trichoderma harzianum strains were used as bleaching agents for Eucalyptus kraft pulp, prior to a chlorine dioxide and alkaline bleaching sequence. In comparison to the control sequence (performed ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1038/sj/jim/7000227

    authors: Medeiros RG,Silva FG Jr,Salles BC,Estelles RS,Filho EX

    更新日期:2002-04-01 00:00:00

  • Xylanase II from Trichoderma reesei QM 9414: conformational and catalytic stability to Chaotropes, Trifluoroethanol, and pH changes.

    abstract::Xylanase II, a key enzyme in the hydrolysis of xylan, was purified from cultures of Trichoderma reesei QM 9414 (anamorph of Hypocrea jecorina) grown on wheat straw as a carbon source. Xylanase treated with increasing guanidinium hydrochloride concentrations was denatured in a cooperative way regarding secondary and te...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-010-0836-0

    authors: López G,Bañares-Hidalgo A,Estrada P

    更新日期:2011-01-01 00:00:00

  • Biodegradation of acid blue-15, a textile dye, by an up-flow immobilized cell bioreactor.

    abstract::Acid blue-15, a complex and resonance-stabilized triphenylmethane (TPM) textile dye, resistant to transformation, was decolorized/degraded in an up-flow immobilized cell bioreactor. A consortium comprised of isolates belonging to Bacillus sp., Alcaligenes sp. and Aeromonas sp. formed a multispecies biofilm on refracto...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-004-0121-1

    authors: Sharma DK,Saini HS,Singh M,Chimni SS,Chadha BS

    更新日期:2004-03-01 00:00:00

  • Assessing the potential of wild yeasts for bioethanol production.

    abstract::Bioethanol fermentations expose yeasts to a new, complex and challenging fermentation medium with specific inhibitors and sugar mixtures depending on the type of carbon source. It is, therefore, suggested that the natural diversity of yeasts should be further exploited in order to find yeasts with good ethanol yield i...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-014-1544-y

    authors: Ruyters S,Mukherjee V,Verstrepen KJ,Thevelein JM,Willems KA,Lievens B

    更新日期:2015-01-01 00:00:00

  • Quantitative real-time PCR and fluorescence in situ hybridization approaches for enumerating Brevundimonas diminuta in drinking water.

    abstract::Brevundimonas diminuta is a small Gram-negative bacterium used for validation of membranes and filters used in the pharmaceutical and drinking water treatment industries. Current assays are time consuming, nonselective, and may be subject to interference by competing indigenous microorganisms. The focus of this study ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-010-0738-1

    authors: Donofrio RS,Bestervelt LL,Saha R,Bagley ST

    更新日期:2010-09-01 00:00:00

  • Sequential improvement of rimocidin production in Streptomyces rimosus M527 by introduction of cumulative drug-resistance mutations.

    abstract::Rimocidin is a polyene macrolide that exhibits a strong inhibitory activity against a broad range of plant-pathogenic fungi. In this study, fermentation optimization and ribosome engineering technology were employed to enhance rimocidin production in Streptomyces rimosus M527. After the optimization of fermentation, r...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-019-02146-w

    authors: Zhao Y,Song Z,Ma Z,Bechthold A,Yu X

    更新日期:2019-05-01 00:00:00

  • Influence of straw types and nitrogen sources on mushroom composting emissions and compost productivity.

    abstract::The effects of different straw types and organic and inorganic nitrogen (N) sources on the chemical composition and odor concentration (OC) of mushroom composting emissions, compost parameters, and mushroom yield were examined using bench-scale and large-scale (windrows and aerated tunnels) composting systems. There w...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1038/sj.jim.7000292

    authors: Noble R,Hobbs PJ,Mead A,Dobrovin-Pennington A

    更新日期:2002-09-01 00:00:00

  • Comparative analysis of the Corynebacterium glutamicum transcriptome in response to changes in dissolved oxygen levels.

    abstract::The dissolved oxygen (DO) level of a culture of Corynebacterium glutamicum (C. glutamicum) in a bioreactor has a significant impact on the cellular redox potential and the distribution of energy and metabolites. In this study, to gain a deeper understanding of the effects of DO on the metabolism of C. glutamicum, we s...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,收录出版

    doi:10.1007/s10295-016-1854-3

    authors: Liu X,Yang S,Wang F,Dai X,Yang Y,Bai Z

    更新日期:2017-02-01 00:00:00

  • The impact of Ivan Málek's continuous culture concept on bioprocessing.

    abstract::This paper summarizes research results and their industrial applications obtained by continuous culture in the former Czechoslovakia. Past achievements as well as recent trends and developments worldwide are presented. The term "Prague School of continuous culture" is put forward and its international activity is outl...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 历史文章,杂志文章

    doi:10.1007/s10295-010-0881-8

    authors: Kyslík P,Prokop A

    更新日期:2010-12-01 00:00:00

  • Carotenoids from Rhodotorula and Phaffia: yeasts of biotechnological importance.

    abstract::Carotenoids represent a group of valuable molecules for the pharmaceutical, chemical, food and feed industries, not only because they can act as vitamin A precursors, but also for their coloring, antioxidant and possible tumor-inhibiting activity. Animals cannot synthesize carotenoids, and these pigments must therefor...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1007/s10295-008-0492-9

    authors: Frengova GI,Beshkova DM

    更新日期:2009-02-01 00:00:00

  • Evolving enzyme technology for pharmaceutical applications: case studies.

    abstract::The case studies focus on two types of enzyme applications for pharmaceutical development. Demethylmacrocin O-methyltransferase, macrocin O-methyltransferase (both putatively rate-limiting) and tylosin reductase were purified from Streptomyces fradiae, characterized and the genes manipulated for increasing tylosin bio...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1038/sj.jim.2900437

    authors: Yeh WK

    更新日期:1997-11-01 00:00:00

  • Flux to acetate and lactate excretions in industrial fermentations: physiological and biochemical implications.

    abstract::The efficiency of carbon conversion to biomass and desirable end products in industrial fermentations is diminished by the diversion of carbon to acetate and lactate excretions. In this study, the use of prototrophic and mutant strains of Escherichia coli, as well as enzyme active site directed inhibitors, revealed th...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-004-0149-2

    authors: El-Mansi M

    更新日期:2004-08-01 00:00:00

  • Expression, characterization, and improvement of a newly cloned halohydrin dehalogenase from Agrobacterium tumefaciens and its application in production of epichlorohydrin.

    abstract::A gene encoding halohydrin dehalogenase (HHDH) from Agrobacterium tumefaciens CCTCC M 87071 was cloned and expressed in Escherichia coli. To increase activity and stability of HHDH, 14 amino acid residues around the active site and substrate-binding pocket based on the structural analysis and molecular docking were se...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-014-1443-2

    authors: Liu ZQ,Gao AC,Wang YJ,Zheng YG,Shen YC

    更新日期:2014-07-01 00:00:00

  • Non-targeted metabolomic reveals the effect of salt stress on global metabolite of halotolerant yeast Candida versatilis and principal component analysis.

    abstract::As one of the major microbes in the soy sauce fermentation, Candida versatilis enriches the flavor and improves the quality of soy sauce. In this study, a combination of five different GC-MS and LC-MS-based metabolome analytical approaches was used to analyze the intracellular, extracellular and whole metabolites of C...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-014-1475-7

    authors: Qi W,Fan ZC,Wang CL,Hou LH,Liu JF,Cao XH

    更新日期:2014-10-01 00:00:00

  • Study of metabolic network of Cupriavidus necator DSM 545 growing on glycerol by applying elementary flux modes and yield space analysis.

    abstract::A metabolic network consisting of 48 reactions was established to describe intracellular processes during growth and poly-3-hydroxybutyrate (PHB) production for Cupriavidus necator DSM 545. Glycerol acted as the sole carbon source during exponential, steady-state cultivation conditions. Elementary flux modes were obta...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-014-1439-y

    authors: Lopar M,Špoljarić IV,Cepanec N,Koller M,Braunegg G,Horvat P

    更新日期:2014-06-01 00:00:00

  • Biodegradation of aromatic compounds under mixed oxygen/denitrifying conditions: a review.

    abstract::Bioremediation of aromatic hydrocarbons in groundwater and sediments is often limited by dissolved oxygen. Many aromatic hydrocarbons degrade very slowly or not at all under anaerobic conditions. Nitrate is a good alternative electron acceptor to oxygen, and denitrifying bacteria are commonly found in the subsurface a...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1038/sj.jim.2900288

    authors: Wilson LP,Bouwer EJ

    更新日期:1997-02-01 00:00:00

  • Effect of 2,4,6-trinitrotoluene on soil bacterial communities.

    abstract::To gain insight into the impact of 2,4,6-trinitrotoluene (TNT) on soil microbial communities, we characterized the bacterial community of several TNT-contaminated soils from two sites with different histories of contamination and concentrations of TNT. The amount of extracted DNA, the total cell counts and the number ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-007-0289-2

    authors: George I,Eyers L,Stenuit B,Agathos SN

    更新日期:2008-04-01 00:00:00

  • Advances in microbial culturing conditions to activate silent biosynthetic gene clusters for novel metabolite production.

    abstract::Natural products (NPs) produced by bacteria and fungi are often used as therapeutic agents due to their complex structures and wide range of bioactivities. Enzymes that build NPs are encoded by co-localized biosynthetic gene clusters (BGCs), and genome sequencing has recently revealed that many BGCs are "silent" under...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1007/s10295-019-02198-y

    authors: Tomm HA,Ucciferri L,Ross AC

    更新日期:2019-10-01 00:00:00

  • Clean manufacturing powered by biology: how Amyris has deployed technology and aims to do it better.

    abstract::Amyris is a fermentation product company that leverages synthetic biology and has been bringing novel fermentation products to the market since 2009. Driven by breakthroughs in genome editing, strain construction and testing, analytics, automation, data science, and process development, Amyris has commercialized nine ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-020-02314-3

    authors: Hill P,Benjamin K,Bhattacharjee B,Garcia F,Leng J,Liu CL,Murarka A,Pitera D,Rodriguez Porcel EM,da Silva I,Kraft C

    更新日期:2020-11-01 00:00:00

  • Biotransformation of benzonitrile herbicides via the nitrile hydratase-amidase pathway in rhodococci.

    abstract::The aim of this work was to determine the ability of rhodococci to transform 3,5-dichloro-4-hydroxybenzonitrile (chloroxynil), 3,5-dibromo-4-hydroxybenzonitrile (bromoxynil), 3,5-diiodo-4-hydroxybenzonitrile (ioxynil) and 2,6-dichlorobenzonitrile (dichlobenil); to identify the products and determine their acute toxici...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-012-1184-z

    authors: Veselá AB,Pelantová H,Sulc M,Macková M,Lovecká P,Thimová M,Pasquarelli F,Pičmanová M,Pátek M,Bhalla TC,Martínková L

    更新日期:2012-12-01 00:00:00

  • Effect of growth substrate, method of fermentation, and nitrogen source on lignocellulose-degrading enzymes production by white-rot basidiomycetes.

    abstract::The exploration of seven physiologically different white rot fungi potential to produce cellulase, xylanase, laccase, and manganese peroxidase (MnP) showed that the enzyme yield and their ratio in enzyme preparations significantly depends on the fungus species, lignocellulosic growth substrate, and cultivation method....

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-008-0454-2

    authors: Elisashvili V,Kachlishvili E,Penninckx M

    更新日期:2008-11-01 00:00:00

  • Enteric virus contamination of foods through industrial practices: a primer on intervention strategies.

    abstract::Hepatitis A and E viruses, rotaviruses, Norwalk-like caliciviruses, and astroviruses are among the enteric viruses known to cause food- and waterborne illness. These viruses are spread by the fecal-oral route and are a major cause of morbidity and mortality worldwide. Foods may be contaminated at any time pre- or post...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1038/sj.jim.7000095

    authors: Richards GP

    更新日期:2001-08-01 00:00:00

  • Effects of water potential on spore germination and viability of Fusarium species.

    abstract::Germination of macroconidia and/or microconidia of 24 strains of Fusarium solani, F. chlamydosporum, F. culmorum, F. equiseti, F. verticillioides, F. sambucinum, F. oxysporum and F. proliferatum isolated from fluvial channels and sea beds of the south-eastern coast of Spain, and three control strains (F. oxysporum iso...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-008-0441-7

    authors: Palmero Llamas D,de Cara Gonzalez M,Iglesias Gonzalez C,Ruíz Lopez G,Tello Marquina JC

    更新日期:2008-11-01 00:00:00

  • Enhanced thermostability of keratinase by computational design and empirical mutation.

    abstract::Keratinases are proteolytic enzymes capable of degrading insoluble keratins. The importance of these enzymes is being increasingly recognized in fields as diverse as animal feed production, textile processing, detergent formulation, leather manufacture, and medicine. To enhance the thermostability of Bacillus lichenif...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-013-1268-4

    authors: Liu B,Zhang J,Fang Z,Gu L,Liao X,Du G,Chen J

    更新日期:2013-07-01 00:00:00

  • Muscodor albus and its biological promise.

    abstract::We have found a novel fungal genus that produces extremely bioactive volatile organic compounds (VOCs). This fungal isolate was initially discovered as an endophyte in Cinnamomum zeylanicum in a botanical garden in Honduras. This endophytic fungus, Muscodor albus, produces a mixture of VOCs that are lethal to a wide v...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1007/s10295-006-0090-7

    authors: Strobel G

    更新日期:2006-07-01 00:00:00

  • Deletion of PHO13 improves aerobic L-arabinose fermentation in engineered Saccharomyces cerevisiae.

    abstract::Pentose sugars are increasingly being used in industrial applications of Saccharomyces cerevisiae. Although L-arabinose is a highlighted pentose that has been identified as next-generation biomass, arabinose fermentation has not yet undergone extensive development for industrial utilization. In this study, we integrat...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-019-02233-y

    authors: Ye S,Jeong D,Shon JC,Liu KH,Kim KH,Shin M,Kim SR

    更新日期:2019-12-01 00:00:00

  • Production of bioethanol from organic whey using Kluyveromyces marxianus.

    abstract::Ethanol production by K. marxianus in whey from organic cheese production was examined in batch and continuous mode. The results showed that no pasteurization or freezing of the whey was necessary and that K. marxianus was able to compete with the lactic acid bacteria added during cheese production. The results also s...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-010-0771-0

    authors: Christensen AD,Kádár Z,Oleskowicz-Popiel P,Thomsen MH

    更新日期:2011-02-01 00:00:00

  • Antimicrobial susceptibility of Lactobacillus species isolated from commercial ethanol plants.

    abstract::Bacterial contamination of commercial fermentation cultures is a common and costly problem to the fuel ethanol industry. Antimicrobials such as virginiamycin (VIR) and penicillin (PEN) are frequently used to control contamination but there are little data available on the susceptibility of bacterial contaminants to th...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-007-0250-4

    authors: Bischoff KM,Skinner-Nemec KA,Leathers TD

    更新日期:2007-11-01 00:00:00

  • Bacillus thuringiensis: from biodiversity to biotechnology.

    abstract::Bacillus thuringiensis is a Gram-positive bacterium, widely used in agriculture as a biological pesticide. The biocidal activity mainly resides in a parasporal protein inclusion body, or crystal. The inclusion is composed of one or more types of delta-endotoxins (Cry and Cyt proteins). Cry proteins are selectively tox...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1038/sj.jim.2900460

    authors: Prieto-Samsónov DL,Vázquez-Padrón RI,Ayra-Pardo C,González-Cabrera J,de la Riva GA

    更新日期:1997-09-01 00:00:00

  • The radiation resistance of ascospores and sclerotia of Pyronema domesticum.

    abstract::The Food and Drug Administration has become aware of several instances where supposedly sterile medical surgical products made of Chinese cotton have been found to contain viable Pyronema domesticum. The aim of this research was to determine the gamma and electron beam radiation resistance values for the two dormant p...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1038/sj.jim.7000267

    authors: Richter SG,Barnard J

    更新日期:2002-08-01 00:00:00