解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVE:The objective of our study was to determine the incidence rates and risk factors of aortic aneurysm and aortic dissection among patients with systemic lupus erythematosus (SLE) using a nationwide population-based data set. METHODS:We conducted a retrospective cohort study using data from the Taiwan National ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314523868
更新日期:2014-06-01 00:00:00
abstract::A dose-dependent combination of environmental exposures, estrogenic hormones and genetic predisposition is thought to be required for lupus to develop and flare, but how the environment modifies the immune system in genetically predisposed people is unclear. Current evidence indicates that environmental agents that in...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203313499419
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:The objective of this paper is to examine some solid tumors incidence in patients with systemic lupus erythematosus (SLE) derived from population-based cohort studies by means of meta-analysis. METHODS:Relevant electronic databases were searched for studies characterizing the associated risk of overall malig...
journal_title:Lupus
pub_type: 杂志文章,meta分析,评审
doi:10.1177/0961203313520060
更新日期:2014-03-01 00:00:00
abstract::Gastrointestinal manifestations of systemic lupus erythematosus (SLE) are common, occurring in about 50% of cases. They are usually mild, in the form of mouth ulcers, nausea, heartburn and mild abdominal pain, but they can be severe in cases of gastrointestinal vasculitis. In this report we describe an unusual combina...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313517150
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:The objective of this paper is to evaluate whether the different International Society of Nephrology/Renal Pathology Society (ISN/RPS) classes of proliferative lupus nephritis (LN) have a distinct baseline presentation, short-term response to immunosuppression (IS) and long-term prognosis. METHODS:Ninety-eig...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313514623
更新日期:2014-02-01 00:00:00
abstract::Azathioprine-induced aplastic anemia and fatal myelosuppression is a rare occurrence in patients with systemic lupus erythematosus (SLE). We report a case of a 53-year-old female with a normal thiopurine S-methyltransferase (TPMT) level who developed aplastic anemia within 4 weeks of azathioprine initiation, resulting...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203313504636
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Acute exercise increases IL-6, IL-10 and TNF-α levels in healthy subjects. There is no study evaluating the effect of exercise on cytokines level in systemic lupus erythematosus (SLE) patients. OBJECTIVE:Our aim was to assess IL-10, IL-6 and TNF-α levels at baseline and after acute physical exercise in pati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313508832
更新日期:2013-12-01 00:00:00
abstract:INTRODUCTION:The International Society of Nephrology/Renal Pathology Society (ISN/RPS) pathological classification criteria of lupus nephritis are limited to glomerular injury. Although the tubulointerstitium is commonly involved, the importance of such involvement is not well defined. The major objective of this study...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313507986
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:Systemic lupus erythematosus (SLE), an autoimmune condition with diverse clinical manifestations, is reported to have different expression in populations of different ancestry. Most previous studies compared patients of different ethnic groups from geographically distinct cohorts. In our study, we aimed to ch...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313500547
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Ferritin is an iron storage protein considered also as an acute phase reactant with high levels in various inflammatory conditions. Recently, a plausible role for ferritin in the pathogenesis of immune-mediated and especially autoimmune diseases has been suggested. However, the link between ferritin and the ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313504633
更新日期:2013-11-01 00:00:00
abstract::Pulmonary hypertension (PH) can occur at any time during the course of systemic lupus erythematosus (SLE), and can be independent of lupus disease activity in other systems. The pathogenesis of PH in SLE can be multifactorial, but pulmonary arterial hypertension (PAH) is the commonest cause of PH in SLE. The internati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313505010
更新日期:2013-10-01 00:00:00
abstract::A 26-year-old Japanese woman developed autoimmune pulmonary alveolar proteinosis (PAP) during glucocorticoid therapy for systemic lupus erythematosus (SLE). Intensive immunosuppressive therapy worsened the PAP. De-escalation of immunosuppressive therapy improved the PAP. Autoimmune PAP is rarely associated with system...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313498798
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:The objectives of this paper are to compare sexual function and distress in women with systemic lupus erythematosus (SLE) and in healthy controls; to determine the association between disease characteristics, quality of life, psychopathology and sexual function; and to compare sexual function and distress of ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313500370
更新日期:2013-09-01 00:00:00
abstract::Chronic intestinal pseudo-obstruction (CIPO) is a rare clinical syndrome of ineffective intestinal motility characterised by clinical and radiological evidence of intestinal obstruction with no identifiable mechanical lesion. CIPO can either be idiopathic or secondary to a systemic disease, like systemic lupus erythem...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203313492873
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:The objective of this study is to determine whether serum concentrations of B cell activating factor from the tumour necrosis factor family (BAFF) and/or a proliferation-inducing ligand (APRIL) are associated with clinical manifestations of systemic lupus erythematosus (SLE). METHODS:BAFF and APRIL concen...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313496302
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:Subepidermal bullous lesions and toxic epidermal necrolysis-like (TEN-like) lesions can occur in patients with systemic lupus erythematosus (SLE). In this report, we describe a case of a patient previously diagnosed with SLE who experienced TEN-like skin lesions with unusual subacute progression in the contex...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203313492242
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:Arthritis is frequently seen in human lupus, but rarely in lupus models. Pristane-induced lupus (PIL) can be induced in various mouse strains such as BALB/c and C57BL/6. We herein characterize clinical and histological features of arthritis in the context of systemic lupus and provide a prudent comparison wit...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313492869
更新日期:2013-07-01 00:00:00
abstract::Antiphospholipid syndrome (APS) is a distinct autoimmune prothrombotic disorder due to pathogenic autoantibodies directed against proteins that bind to phospholipids. APS is characterized by arterial and venous thrombosis and their clinical sequelae. Catastrophic antiphospholipid syndrome (CAPS) is a rare and often fa...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313491024
更新日期:2013-07-01 00:00:00
abstract::Variations at the ITGAM gene, which encodes for the CD11b chain of the Mac-1 (alphaMbeta2; CD11b/CD18; complement receptor-3) integrin, is one of the strongest genetic risk factors for systemic lupus erythematosus (SLE). More specifically, a genetic variant (rs1143679) which results in an arginine to histidine substit...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203313491851
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Plasma mycophenolic acid (MPA) concentrations may predict therapeutic response in active lupus nephritis (LN). We determined the efficacy and safety of a concentration-controlled MPA regime in the treatment of severely active LN. METHODS:In this prospective study, 19 biopsy-proven class III/IV LN patients w...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1177/0961203313486949
更新日期:2013-06-01 00:00:00
abstract::Lupus nephritis (LN) is usually associated with widespread effacement of the podocytes' foot processes leading to proteinuria. Induction of urokinase receptor (uPAR) signaling in podocytes leads to foot process effacement and urinary protein loss via promoting podocytes' motility and kidney permeability in the glomeru...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313480398
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:Systemic lupus erythematosus (SLE) is a chronic, relapsing-remitting autoimmune disorder that involves multiple organ systems including the central nervous system. Among the items included in the nomenclature for neuropsychiatric SLE, mood disorders have been identified. The aim of this paper is to review the...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203313477227
更新日期:2013-04-01 00:00:00
abstract::This is a case report on an uncommon correlation between periodic lateralized epileptiform discharges (PLEDs) and white-matter lesions in cerebral lupus, and with a reduced cerebral blood flow (CBF) in single-photon emission computed tomography (SPECT). A 47-year-old woman with a long-term history of systemic lupus er...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312474705
更新日期:2013-04-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with multiple organ involvement. B-lymphocyte activity plays a pivotal role in the development and course of the disease. A newly developed agent called belimumab has recently been approved to treat active, autoantibody positive SLE as an add-on to st...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313476154
更新日期:2013-04-01 00:00:00
abstract::Anti-tumor necrosis factor-alpha (TNF-α) immunotherapy is currently used in the treatment of various inflammatory diseases such as rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis and Crohn's disease. Infliximab is a chimeric monoclonal antibody that binds to transmembrane-bound and soluble...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313479423
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:Fatigue in systemic lupus erythematosus (SLE) is burdensome and must be assessed using validated scales. Although the psychometric properties of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale in SLE have been evaluated previously, its content validity in this disease remain...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313476360
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:Impaired function of polymorphonuclear cells (PMNs) in systemic lupus erythematosus (SLE) leads to severe gram-positive and gram-negative bacterial infection, and to major morbidity and mortality. Few studies have focused on the association of impaired function of PMNs and SLE patients' susceptibility to inf...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312474704
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:The objective of this report is to assess the presence and viral load of JC polyomavirus (JCV) DNA in cerebrospinal fluid (CSF) and plasma from neuropsychiatric systemic lupus erythematosus (NPSLE) patients in comparison to controls and to investigate if different types of immunosuppressive treatments were co...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312470977
更新日期:2013-03-01 00:00:00
abstract::Integrin very late antigen-4 (VLA4) is induced during inflammation and can regulate monocyte migration. It has been implicated in atherogenesis, a significant concern in systemic lupus erythematosus (SLE). The aim of this study was to define VLA4 expression in SLE monocytes. Flow cytometry, reverse transcription polym...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313475691
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Complement activation plays a role in pathogenesis of the antiphospholipid syndrome (APS), but the involvement of the C5b-9 membrane attack complex (MAC) is unknown. Here we studied the effects of human polyclonal antiphospholipid (aPL) antibodies on thrombosis and tissue factor (TF) up-regulation in C6 defi...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312458839
更新日期:2012-12-01 00:00:00
abstract::The F(1) progeny of the (SWR × NZB) cross develop a lupus-like disease with high serum titers of autoantibodies, and increased frequency and severity of immune complex-mediated glomerulonephritis in females. In previous work, we found that an idiotypic peptide corresponding to aa62-73 (p62-73) of the heavy chain varia...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312461964
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:To determine the frequency and the time to complete recovery identified by Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and the time to partial recovery identified by the SLEDAI-2K Responder Index 50 (SRI-50) in three laboratory systems over 10 years. METHODS:This is a retrospective ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312454344
更新日期:2012-10-01 00:00:00
abstract::The occurrence of ataxic sensory neuronopathy (ASN) is rare in patients with connective tissue diseases (CTDs). ASN has been described in case reports and case series in patients with CTDs, mostly Sjögren's syndrome, and most often occurring during middle or old age. ASN in association with systemic lupus erythematosu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311434105
更新日期:2012-07-01 00:00:00
abstract::Results for lupus anticoagulant (LA) are expressed as ratio of patient-to-normal clotting times (LA-ratio) according to the equation LA-ratio = (Patient(Clotting time)/Normal(Clotting time)). However, numerical results vary according to the method used for testing, thus making difficult the between-method and between-...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312438114
更新日期:2012-06-01 00:00:00
abstract::The aim of this study was to investigate two patients with antiphospholipid syndrome (APS) who suffered from multiple repeated pregnancy losses of probably genetically impaired embryos. Sera from these patients contained high levels of IgG antibodies against cardiolipin, IgG and IgM phosphatidyl inositol, IgG phosphat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312442581
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To investigate the predictive value of serum C3 and C4 complement component levels in relation to pregnancy outcome in patients with antiphospholipid syndrome (APS). MATERIALS AND METHODS:A prospective study of 47 pregnancies associated with APS was performed. Pregnancy outcome was analyzed in terms of: feta...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312444172
更新日期:2012-06-01 00:00:00
abstract::We report the experience from the Antiphospholipid Antibodies (aPL) Regional Consortium in northwest Italy, meant to support clinical research and foster collaboration among health professionals regarding the diagnosis and management of antiphospholipid syndrome (APS) patients. This cohort-study (APS Piedmont Cohort) ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312446974
更新日期:2012-06-01 00:00:00
abstract::A 26-year-old Japanese female presented to us with a 2-year history of multiple arc-shaped erythematous lesions on her scalp and the right side of her forehead. Histopathological examination of two of the lesions showed lobular and septal panniculitis with deposits of IgG in the basement membrane zone. We diagnosed th...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203311433917
更新日期:2012-05-01 00:00:00
abstract::The immunopathogenesis of systemic lupus erythematosus has been thoroughly investigated recently, and genome-wide association studies have identified genes statistically associated with lupus. However, the progression to overt disease is dependent on the activation of environmental factors ('triggers'), among which oe...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311433138
更新日期:2012-05-01 00:00:00
abstract:INTRODUCTION:Anti-ganglioside antibodies (AGA) have been associated with several peripheral neuropathies, such as Miller-Fisher syndrome, Guillain-Barré syndrome and multifocal motor neuropathy. They have also been studied in patients with systemic lupus erythematosus (SLE), focusing on neuropsychiatric manifestations ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312436856
更新日期:2012-05-01 00:00:00