解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Cancer stem cells (CSC) are essential for tumorigenesis. The transcription factor Sox2 is overexpressed in brain gliomas, and is essential to maintain CSC. In mouse high-grade glioma pHGG cells in culture, Sox2 deletion causes cell proliferation arrest and inability to reform tumors after transplantation in vivo; in S...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23914
更新日期:2021-03-01 00:00:00
abstract::The crosstalk between glial cells and neurons represents an exceptional feature for maintaining the normal function of the central nervous system (CNS). Increasing evidence has revealed the importance of glial progenitor cells in adult neurogenesis, reestablishment of cellular pools, neuroregeneration, and axonal (re)...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.23922
更新日期:2021-03-01 00:00:00
abstract::Stellate ganglion neurons, important mediators of cardiopulmonary neurotransmission, are surrounded by satellite glial cells (SGCs), which are essential for the function, maintenance, and development of neurons. However, it remains unknown whether SGCs in adult sympathetic ganglia exhibit any functional diversity, and...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23965
更新日期:2021-01-12 00:00:00
abstract::Increasing evidence has suggested that astrocytes demonstrate striking regionally allocated functional heterogeneity. Here, we discuss how this spatiotemporally encoded diversity determines the astrocytic phenotype along a finely grained spectrum from neuroprotective to deleterious states. With increasing recognition ...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.23877
更新日期:2021-01-01 00:00:00
abstract::Unlike microglia and NG2 glia, astrocytes are incapable of migrating to sites of injury in the posttraumatic cerebral cortex, instead relying on proliferation to replenish their numbers and distribution in the affected region. However, neither the spectrum of their proliferative repertoire nor their postinjury distrib...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23893
更新日期:2021-01-01 00:00:00
abstract::Microglia are innate immune cells of the central nervous system that sense extracellular cues. Brain injuries, inflammation, and pathology evoke dynamic structural responses in microglia, altering their morphology and motility. The dynamic motility of microglia is hypothesized to be a critical first step in sensing lo...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.23961
更新日期:2020-12-28 00:00:00
abstract::IQSEC3, a guanine nucleotide exchange factor for ADP-ribosylation factors (ARF-GEFs) is specifically expressed at GABAergic synapses, and its loss increases seizure susceptibility in mice. However, the contribution of microglia to initiation and/or progression of seizures in IQSEC3-deficient mice has not been investig...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23876
更新日期:2020-12-01 00:00:00
abstract::The Alzheimer disease-associated multifunctional low-density lipoprotein receptor-related protein-1 is expressed in the brain. Recent studies uncovered a role of this receptor for the appropriate functioning of neural stem cells, oligodendrocytes, and neurons. The constitutive knock-out (KO) of the receptor is embryon...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23869
更新日期:2020-12-01 00:00:00
abstract::Focal ischemic stroke (FIS) is a leading cause of human death. Glial scar formation largely caused by reactive astrogliosis in peri-infarct region (PIR) is the hallmark of FIS. Glial cell-derived neurotrophic factor (GDNF) was originally isolated from a rat glioma cell-line supernatant and is a potent survival neurotr...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23848
更新日期:2020-11-01 00:00:00
abstract::Microglial erythrophagocytosis is crucial in injury response to hemorrhagic stroke. We hypothesized that regulation of microglial erythrophagocytosis via HO-1/CO depends on a pathway involving reactive oxygen species (ROS) and CD36 surface-expression. The microglial BV-2 cell line and primary microglia (PMG) were incu...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23864
更新日期:2020-11-01 00:00:00
abstract::Pruning, the elimination of excess synapses is a phenomenon of fundamental importance for correct wiring of the central nervous system. The establishment of the cerebellar climbing fiber (CF)-to-Purkinje cell (PC) synapse provides a suitable model to study pruning and pruning-relevant processes during early postnatal ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23842
更新日期:2020-11-01 00:00:00
abstract::In the last decade, microRNAs have been increasingly recognized as key modulators of glial development. Recently, we identified miR-125a-3p as a new player in oligodendrocyte physiology, regulating in vitro differentiation of oligodendrocyte precursor cells (OPCs). Here, we show that miR-125a-3p is upregulated in acti...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23819
更新日期:2020-10-01 00:00:00
abstract::Aging is a major risk factor for the development of neurodegenerative diseases. Alzheimer's disease and other neurodegenerative diseases are characterized by abnormal and prominent protein aggregation in the brain, partially due to deficiency in protein clearance. It has been proposed that alterations in microglia pha...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23804
更新日期:2020-09-01 00:00:00
abstract::During axonal ensheathment, noncompact myelin channels formed at lateral edges of the myelinating process become arranged into tight paranodal spirals that resemble loops when cut in cross section. These adhere to the axon, concentrating voltage-dependent sodium channels at nodes of Ranvier and patterning the surround...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23809
更新日期:2020-09-01 00:00:00
abstract::Epilepsy is characterized by unpredictable recurrent seizures resulting from hypersynchronous discharges from neuron assemblies. Increasing evidence indicates that aberrant astrocyte signaling to neurons plays an important role in driving the network hyperexcitability. Purinergic signaling is central in neuron-glia an...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.23747
更新日期:2020-09-01 00:00:00
abstract::Schwann cells develop from neural crest cells in an ordered series of events and give rise to myelinating and nonmyelinating subtypes. In their mature state, myelinating Schwann cells produce myelin sheaths that provide trophic support to axons and allow saltatory conduction in the vertebrate peripheral nervous system...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23766
更新日期:2020-08-01 00:00:00
abstract::Oligodendrocyte precursor cells (OPCs) differentiate and mature into oligodendrocytes, which produce myelin in the central nervous system. Prior studies have shown that the mechanistic target of rapamycin (mTOR) is necessary for proper myelination of the mouse spinal cord and that bone morphogenetic protein (BMP) sign...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23776
更新日期:2020-06-01 00:00:00
abstract::Microglia, the innate immune cells of the brain, have recently been removed from the position of mere sentinels and promoted to the role of active sculptors of developing circuits and cells. Alongside their functions in normal brain development, microglia coordinate sexual differentiation of the brain, a set of proces...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.23740
更新日期:2020-06-01 00:00:00
abstract::Human astrocytes provide trophic as well as structural support to the surrounding brain cells. Furthermore, they have been implicated in many physiological processes important for central nervous system function. Traditionally astrocytes have been considered to be a homogeneous class of cells, however, it has increasi...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23771
更新日期:2020-04-01 00:00:00
abstract::Cells of the adaptive and innate immune systems in the brain parenchyma and in the meningeal spaces contribute to physiologic functions and disease states in the central nervous system (CNS). Animal studies have demonstrated the involvement of immune constituents, along with major histocompatibility complex (MHC) mole...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23746
更新日期:2020-04-01 00:00:00
abstract::The role of microglia in retinal inflammation is still ambiguous. Branch retinal vein occlusion initiates an inflammatory response whereby resident microglia cells are activated. They trigger infiltration of neutrophils that exacerbate blood-retina barrier damage, regulate postischemic inflammation and irreversible lo...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23739
更新日期:2020-03-01 00:00:00
abstract::Microglia are the resident macrophages of the brain. Over the past decade, our understanding of the function of these cells has significantly improved. Microglia do not only play important roles in the healthy brain but are involved in almost every brain pathology. Gene expression profiling allowed to distinguish micr...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23717
更新日期:2020-02-01 00:00:00
abstract::Apart from dedicated oligodendroglial progenitor cells, adult neural stem cells (aNSCs) can also give rise to new oligodendrocytes in the adult central nervous system (CNS). This process mainly confers myelinating glial cell replacement in pathological situations and can hence contribute to glial heterogeneity. Our pr...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23724
更新日期:2020-02-01 00:00:00
abstract::Neuroprotective M2-skewed microglia appear as promising to alter the course of neurodegenerative diseases and G protein-coupled receptors (GPCRs) are potential targets to achieve such microglial polarization. A common feature of adenosine A2A (A2A R) and cannabinoid CB2 (CB2 R) GPCRs in microglia is that their express...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23694
更新日期:2019-12-01 00:00:00
abstract::Myelination is an evolutionary recent differentiation program that has been independently acquired in vertebrates by Schwann cells in the peripheral nervous system and oligodendrocytes in the central nervous system. Therefore, it is not surprising that regulating transcription factors differ substantially between both...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.23636
更新日期:2019-11-01 00:00:00
abstract::An organism's response to stress requires activation of multiple brain regions. This can have long-lasting effects on synaptic transmission and plasticity that likely provide adaptive benefits. Recent evidence implicates not only neurones, but also glial cells in the regulation of the central response to stress. Inten...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.23610
更新日期:2019-10-01 00:00:00
abstract::Microglia transform from homeostatic to disease-associated-microglia (DAM) profiles in neurodegeneration. Within DAM, we recently identified distinct pro-inflammatory and anti-inflammatory sub-profiles although transcriptional regulators of homeostatic and distinct DAM profiles remain unclear. Informed by these studie...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23678
更新日期:2019-10-01 00:00:00
abstract::Secondary progressive multiple sclerosis (SPMS) is an autoimmune disease of the central nervous system (CNS) characterized by progressive motor dysfunction, sensory deficits, and visual problems. The pathological mechanism of SPMS remains poorly understood. In this study, we investigated the role of microglia, immune ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23640
更新日期:2019-09-01 00:00:00
abstract::Gliomas are a heterogenous group of malignant primary brain tumors that arise from glia cells or their progenitors and rely on accurate diagnosis for prognosis and treatment strategies. Although recent developments in the molecular biology of glioma have improved diagnosis, classical histological methods and biomarker...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23594
更新日期:2019-08-01 00:00:00
abstract::Abnormal neuronal activity in sensory ganglia contributes to chronic pain. There is evidence that signals can spread between cells in these ganglia, which may contribute to this activity. Satellite glial cells (SGCs) in sensory ganglia undergo activation following peripheral injury and participate in cellular communic...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23603
更新日期:2019-07-01 00:00:00
abstract::Neural progenitor cells (NPCs) are sequentially specified into neurons and glia during the development of central nervous system. WNT/β-catenin signaling is known to regulate the balance between the proliferation and differentiation of NPCs during neurogenesis. However, the function of WNT/β-catenin signaling during g...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23608
更新日期:2019-07-01 00:00:00
abstract::Astrocytes are arranged in highly organized gap junction-coupled networks, communicating via the propagation of Ca2+ waves. Astrocytes are gap junction-coupled not only to neighboring astrocytes, but also to oligodendrocytes, forming so-called panglial syncytia. It is not known, however, whether glial cells in panglia...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23613
更新日期:2019-07-01 00:00:00
abstract::Cortical spreading depression (CSD) is a slowly propagating wave of depolarization of gray matter. This phenomenon is believed to underlie the migraine aura and similar waves of depolarization may exacerbate injury in a number of neurological disease states. CSD is characterized by massive ion dyshomeostasis, cell swe...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23604
更新日期:2019-06-01 00:00:00
abstract::Glioblastoma (GBM) is an aggressive primary tumor, causing thousands of deaths worldwide every year. The mean survival of patients with GBM remains below 20 months despite current available therapies. GBM cells' interactions with their stromal counterparts are crucial for tumor development. Astrocytes are glial cells ...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.23520
更新日期:2019-05-01 00:00:00
abstract::When central nervous system (CNS) homeostasis is altered, microglial cells become rapidly activated, proliferate and release a broad range of molecules. Among the plethora of molecules involved in the regulation of microglial activation, cytokines are considered crucial. Although production of interleukin-10 (IL-10) h...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23573
更新日期:2019-04-01 00:00:00
abstract::Williams-Beuren syndrome (WBS) is a microdeletion disorder with cognitive phenotype. NSUN5 gene, which encodes a cytosine-5 RNA methyltransferase, is located in WBS deletion locus. To investigate the influence of NSUN5 deletion on cognitive behaviors, we produced single-gene Nsun5 knockout (Nsun5-KO) mice. Here, we re...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23565
更新日期:2019-04-01 00:00:00
abstract::Transgenic Tg2576 mice expressing human amyloid precursor protein (hAPP) with the Swedish mutation are among the most frequently used animal models to study the amyloid pathology related to Alzheimer's disease (AD). The transgene expression in this model is considered to be neuron-specific. Using a novel hAPP-specific...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23550
更新日期:2019-02-01 00:00:00
abstract::Schwann cells (SCs), the primary glia in the peripheral nervous system (PNS), display remarkable plasticity in that fully mature SCs undergo dedifferentiation and convert to repair SCs upon nerve injury. Dedifferentiated SCs provide essential support for PNS regeneration by producing signals that enhance the survival ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23547
更新日期:2019-02-01 00:00:00
abstract::Th17 cells and interleukin-17 (IL-17) have been found to play an important role in the pathology of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Response to IL-17, reactive astrocytes accompany with immune cells infiltration and axonal damage in MS/EAE. However, the ro...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23530
更新日期:2019-01-01 00:00:00
abstract::Accumulating evidence indicates that astrocytes are actively involved in the physiological and pathophysiological functions of the brain. Intracellular Ca2+ signaling, especially Ca2+ release from the endoplasmic reticulum (ER), is considered to be crucial for the regulation of astrocytic functions. Mice with genetic ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23531
更新日期:2019-01-01 00:00:00