Inhibition of inflammatory cells delays retinal degeneration in experimental retinal vein occlusion in mice.

abstract：:Spinal cord injury (SCI) is a cause of major neurological disability, and no satisfactory treatment is currently available. Traumatic SCI directly damages the cell bodies and/or processes of neurons and triggers a series of endogenous processes, including neuroinflammatory response and reactive astrogliosis. In this s...

journal_title：Glia

authors： Su Z,Yuan Y,Cao L,Zhu Y,Gao L,Qiu Y,He C

更新日期：2010-06-01 00:00:00

abstract：:Propagation of intercellular calcium waves (ICW) between astrocytes depends on the diffusion of signaling molecules through gap junction channels and diffusion through the extracellular space of neuroactive substances acting on plasmalemmal receptors. The relative contributions of these two pathways vary in different ...

journal_title：Glia

authors： Suadicani SO,De Pina-Benabou MH,Urban-Maldonado M,Spray DC,Scemes E

更新日期：2003-04-15 00:00:00

abstract：:The consequences of sublytic terminal complement complex (TCC) assembly on Schwann cell proliferation and apoptosis were examined by using purified complement proteins (C5*-9) or antibody-sensitized Schwann cells in the presence of a serum that was depleted of the seventh component of complement (C7dHS) and reconstitu...

journal_title：Glia

authors： Dashiell SM,Rus H,Koski CL

更新日期：2000-04-01 00:00:00

abstract：:Pharmacological and biochemical data suggest that noradrenaline (NA)-containing fibers not only regulate the activity of cortical neurons but also influence the functional state of non-neuronal elements. In the present study, immunocytochemistry with an antiserum against NA, followed by silver-gold intensification of ...

journal_title：Glia

authors： Paspalas CD,Papadopoulos GC

更新日期：1996-06-01 00:00:00

abstract：:Astrocyte proliferation is tightly controlled during development and in the adult nervous system. In the present study, we find that a high-molecular-weight (MW) form of the glycosaminoglycan hyaluronan (HA) is found in rat spinal cord tissue and becomes degraded soon after traumatic spinal cord injury. Newly synthesi...

journal_title：Glia

authors： Struve J,Maher PC,Li YQ,Kinney S,Fehlings MG,Kuntz C 4th,Sherman LS

更新日期：2005-10-01 00:00:00

abstract：:The electron donors glutathione and thioredoxin play many vital roles in the mechanisms of cells to cope with oxidative stress. Critical to such antioxidant functions are the ability to synthesize glutathione and keep it reduced via glutathione reductase and the ability to reduce oxidized-thioredoxin via thioredoxin r...

journal_title：Glia

authors： Eftekharpour E,Holmgren A,Juurlink BH

更新日期：2000-09-01 00:00:00

abstract：:Minocycline, a derivative of the antibiotic tetracycline, displays neuroprotective properties in various models of neurodegenerative diseases and is now used in clinical trials, because of its relative safety and tolerability. Minocycline passes the blood-brain barrier and is presumed to inhibit microglial activation....

journal_title：Glia

authors： Familian A,Boshuizen RS,Eikelenboom P,Veerhuis R

更新日期：2006-02-01 00:00:00

abstract：:The role of microglia, the brain resident macrophages, in glioma biology is still ill-defined. Despite their cytotoxic potential, these cells that significantly infiltrate the tumor mass seem to support tumor growth rather than tumor eradication. A proper activation of microglia anti-tumor activities within the tumor ...

journal_title：Glia

authors： Mora R,Abschuetz A,Kees T,Dokic I,Joschko N,Kleber S,Geibig R,Mosconi E,Zentgraf H,Martin-Villalba A,Régnier-Vigouroux A

更新日期：2009-04-01 00:00:00

abstract：:Microglia are key players of the immune response in the central nervous system (CNS) and, being the resident innate immune cells, they are responsible for the early control of infections and for the recruitment of cells of the adaptive immune system required for pathogen clearance. The innate and adaptive immune respo...

journal_title：Glia

authors： Lehnardt S

更新日期：2010-02-01 00:00:00

abstract：:GABA receptors are distributed widely throughout the central nervous system on a variety of cell types. It has become increasingly clear that astrocytes, both in cell culture and tissue slices, express abundant GABAA receptors. In astrocytes, GABA activates Cl(-)-specific channels that are modulated by barbiturates an...

journal_title：Glia

authors： Fraser DD,Mudrick-Donnon LA,MacVicar BA

更新日期：1994-06-01 00:00:00

abstract：:When central nervous system (CNS) homeostasis is altered, microglial cells become rapidly activated, proliferate and release a broad range of molecules. Among the plethora of molecules involved in the regulation of microglial activation, cytokines are considered crucial. Although production of interleukin-10 (IL-10) h...

journal_title：Glia

authors： Recasens M,Shrivastava K,Almolda B,González B,Castellano B

更新日期：2019-04-01 00:00:00

abstract：:Segments from adult fish and rat retinae were explanted on myelin-marker expressing oligodendrocytes derived from the regenerating goldfish optic nerve. Fish axons grew in high density and even rat retinal axons regenerated to considerable length on the surface of the fish oligodendrocytes, suggesting that this type o...

journal_title：Glia

authors： Bastmeyer M,Bähr M,Stuermer CA

更新日期：1993-05-01 00:00:00

abstract：:Astrocytes play a key role regulating aspects of inflammation in the central nervous system (CNS). Several enzymes, such as the inducible nitric oxide synthase (iNOS) or the cyclooxygenase-2 (COX-2), along with different inflammatory mediators such as the free radical nitric oxide (NO) or proinflammatory cytokines, ha...

journal_title：Glia

authors： Ortega-Gutiérrez S,Molina-Holgado E,Guaza C

更新日期：2005-11-01 00:00:00

abstract：:Oligodendrocyte precursor cells (OPCs) of the optic nerve are generated in the preoptic area, from where they migrate to colonize it entirely. Sonic hedgehog (Shh) induces the proliferation of these cells as well as influencing their migration, acting through its canonical receptor (Ptc-1). However, the multiligand re...

journal_title：Glia

authors： Ortega MC,Cases O,Merchán P,Kozyraki R,Clemente D,de Castro F

更新日期：2012-05-01 00:00:00

abstract：:Transplantation of oligodendrocyte precursor cells (OPCs) results in efficient remyelination in animal models of demyelination. However, the experiments so far undertaken have not addressed the need for tissue-type matching to achieve graft-mediated remyelination. Examination of MHC expression (main determinant of all...

journal_title：Glia

authors： Tepavcević V,Blakemore WF

更新日期：2006-12-01 00:00:00

abstract：:Gamma-secretase is an aspartyl protease composed of four proteins: presenilin (PS), nicastrin (Nct), APH1, and PEN2. These proteins assemble into a membrane complex that cleaves a variety of substrates within the transmembrane domain. The gamma-secretase cleavage products play an important role in various biological p...

journal_title：Glia

authors： Nadler Y,Alexandrovich A,Grigoriadis N,Hartmann T,Rao KS,Shohami E,Stein R

更新日期：2008-04-01 00:00:00

abstract：:Neurosteroids, such as progesterone, influence central nervous system development and function by regulating a broad spectrum of physiological processes. Here, we investigated membrane-initiated actions of progesterone in the retina and identified the membrane-associated progesterone receptor component 1 (PGRMC1). We ...

journal_title：Glia

authors： Swiatek-De Lange M,Stampfl A,Hauck SM,Zischka H,Gloeckner CJ,Deeg CA,Ueffing M

更新日期：2007-08-01 00:00:00

abstract：:Transcriptional regulation of the glial fibrillary acidic protein gene (GFAP) is of interest because of its astrocyte specificity and its upregulation in response to CNS injuries. We have used a transgenic approach instead of cell transfection to identify promoter elements of the human GFAP gene, since previous observ...

journal_title：Glia

authors： Yeo S,Bandyopadhyay S,Messing A,Brenner M

更新日期：2013-09-01 00:00:00

abstract：:Superoxide dismutase (SOD) is considered to be a major factor in protection of nervous tissue against excitotoxic and ischemic/hypoxic lesion. Controversial reports about the localization of SOD after such an insult prompted us to re-investigate immunocytochemically the localization of the enzyme in the brain and spin...

journal_title：Glia

authors： Lindenau J,Noack H,Possel H,Asayama K,Wolf G

更新日期：2000-01-01 00:00:00

abstract：:The failure of the adult injured spinal cord to support axonal regeneration is in part attributed to the glial scar. Reactive astrocytes constitute a major cellular component of the glial scar and are heterogeneous with respect to the extracellular matrix proteins that they secrete. Astrocytes may produce antiregenera...

journal_title：Glia

authors： Gris P,Tighe A,Levin D,Sharma R,Brown A

更新日期：2007-08-15 00:00:00

abstract：:Painful neuropathy is one of the most common complications of diabetes, one hallmark of which is tactile allodynia (pain hypersensitivity to innocuous stimulation). The underlying mechanisms of tactile allodynia are, however, poorly understood. Emerging evidence indicates that, following nerve injury, activated microg...

journal_title：Glia

authors： Tsuda M,Ueno H,Kataoka A,Tozaki-Saitoh H,Inoue K

更新日期：2008-03-01 00:00:00

abstract：:The crosstalk between glial cells and neurons represents an exceptional feature for maintaining the normal function of the central nervous system (CNS). Increasing evidence has revealed the importance of glial progenitor cells in adult neurogenesis, reestablishment of cellular pools, neuroregeneration, and axonal (re)...

journal_title：Glia

authors： Martins-Macedo J,Lepore AC,Domingues HS,Salgado AJ,Gomes ED,Pinto L

更新日期：2021-03-01 00:00:00

abstract：:Herpes simplex virus Type I (HSV-1) is a neurotropic virus that is capable of infecting not only neurons, but also microglia and astrocytes and can establish latent infection in the central nervous system (CNS). We investigated whether IFN lambda (IFN-λ), a newly identified member of IFN family, has the ability to inh...

journal_title：Glia

authors： Li J,Hu S,Zhou L,Ye L,Wang X,Ho J,Ho W

更新日期：2011-01-01 00:00:00

abstract：:Adult Sprague-Dawley rats were given a single dose of trimethyltin chloride (TMT). Three days following treatment, a neuronal alteration was observed in the CA3c pyramidal cell layer of hippocampus which was not accompanied by any apparent astrocyte reaction. At 1 as well as 2 weeks after treatment, a gliosis in hippo...

journal_title：Glia

authors： Andersson H,Luthman J,Olson L

更新日期：1994-08-01 00:00:00

abstract：:Increasing evidence supports an essential role for interleukin-6 (IL-6) in the development, differentiation, as well as de- and re-generation of neurons in the central nervous system (CNS). Both IL-6 and its specific receptor (IL-6R) are expressed on neurons and glial cells including astrocytes. In this study, we have...

journal_title：Glia

authors： März P,Heese K,Dimitriades-Schmutz B,Rose-John S,Otten U

更新日期：1999-05-01 00:00:00

abstract：:The substantia nigra pars reticulata (SNr) is a major output nucleus of the basal ganglia circuitry particularly sensitive to pathological dopamine depletion. Indeed, hyperactivity of SNr neurons is known to be responsible for some motor disorders characteristic of Parkinson's disease. The neuronal processing of basal...

journal_title：Glia

authors： Bosson A,Boisseau S,Buisson A,Savasta M,Albrieux M

更新日期：2015-04-01 00:00:00

abstract：:Neuroadapted Sindbis Virus (NSV) is a neuronotropic virus that causes hindlimb paralysis in susceptible mice and rats. The authors and others have demonstrated that though death of infected motor neurons occurs, bystander death of uninfected neurons also occurs and both contribute to the paralysis that ensues followin...

journal_title：Glia

authors： Carmen J,Gowing G,Julien JP,Kerr D

更新日期：2006-08-01 00:00:00

abstract：:Theiler's murine encephalomyelitis virus (TMEV) is known to interact with cells of the central nervous system (CNS). Here we report that, interestingly, it is a potent inductor of interleukin-6 (IL-6) in the CNS of infected animals and in pure cultures of astrocytes. Maximal IL-6 gene transcription in glial cells, as ...

journal_title：Glia

authors： Rubio N,Sierra A

更新日期：1993-09-01 00:00:00

abstract：:Astrocytic response in the immediate vicinity of freeze- and cobalt-induced lesions has been examined at the light and ultrastructural level. However, the temporal and spatial distribution of astrocytic reactivity throughout the rat cerebral cortex, using glial fibrillary acidic protein (GFAP) immunolabeling, has not ...

journal_title：Glia

authors： Anders JJ,Niedermair S,Ellis E,Salopek M

更新日期：1990-01-01 00:00:00

abstract：:Neurons from embryonic (E18) rat hippocampus were chosen to identify and characterize neurite growth-stimulating proteins accumulating in serum-free conditioned media (CM) obtained from primary or secondary cultures of cerebral astrocytes (less than 5% nonglial cells) using a quantitative cell culture bioassay. CM wer...

journal_title：Glia

authors： Matthiessen HP,Schmalenbach C,Müller HW

更新日期：1989-01-01 00:00:00